Aliases for ZZZ3 Gene

Aliases for ZZZ3 Gene

  • Zinc Finger ZZ-Type Containing 3 2 3 5
  • ZZ-Type Zinc Finger-Containing Protein 3 3 4
  • ATAC1 2 3
  • ATAC Component 1 Homolog (Drosophila) 2
  • Zinc Finger, ZZ Domain Containing 3 3
  • ATAC Component 1 Homolog 3
  • DKFZP564I052 2
  • ZZZ3 5

External Ids for ZZZ3 Gene

Previous GeneCards Identifiers for ZZZ3 Gene

  • GC01M077452
  • GC01M077450
  • GC01M077742
  • GC01M078028
  • GC01M076161

Summaries for ZZZ3 Gene

GeneCards Summary for ZZZ3 Gene

ZZZ3 (Zinc Finger ZZ-Type Containing 3) is a Protein Coding gene. Diseases associated with ZZZ3 include Buruli Ulcer and Branchiootorenal Syndrome 2. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot Summary for ZZZ3 Gene

  • Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Wiki entry for ZZZ3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZZZ3 Gene

Genomics for ZZZ3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZZZ3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZZZ3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZZZ3

Top Transcription factor binding sites by QIAGEN in the ZZZ3 gene promoter:
  • Elk-1
  • GATA-1
  • GATA-2
  • GATA-3
  • HFH-1
  • NF-AT
  • Nkx2-5
  • USF-1
  • USF1

Genomic Locations for ZZZ3 Gene

Latest Assembly
chr1:77,561,526-77,683,440
(GRCh38/hg38)
Size:
121,915 bases
Orientation:
Minus strand

Previous Assembly
chr1:78,028,101-78,149,083
(GRCh37/hg19 by Entrez Gene)
Size:
120,983 bases
Orientation:
Minus strand

chr1:78,028,101-78,149,104
(GRCh37/hg19 by Ensembl)
Size:
121,004 bases
Orientation:
Minus strand

Genomic View for ZZZ3 Gene

Genes around ZZZ3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZZZ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZZZ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZZZ3 Gene

Proteins for ZZZ3 Gene

  • Protein details for ZZZ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYH5-ZZZ3_HUMAN
    Recommended name:
    ZZ-type zinc finger-containing protein 3
    Protein Accession:
    Q8IYH5
    Secondary Accessions:
    • B7WPC6
    • Q6N004
    • Q6N070
    • Q8IYP0
    • Q8IYR1
    • Q8TEK4
    • Q9Y4U0

    Protein attributes for ZZZ3 Gene

    Size:
    903 amino acids
    Molecular mass:
    102023 Da
    Quaternary structure:
    • Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

    Three dimensional structures from OCA and Proteopedia for ZZZ3 Gene

    Alternative splice isoforms for ZZZ3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZZZ3 Gene

Post-translational modifications for ZZZ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZZZ3 Gene

Domains & Families for ZZZ3 Gene

Protein Domains for ZZZ3 Gene

InterPro:
Blocks:
  • Myb DNA-binding domain
  • Zn-finger, ZZ type

Suggested Antigen Peptide Sequences for ZZZ3 Gene

GenScript: Design optimal peptide antigens:
  • ZZ-type zinc finger-containing protein 3 (ZZZ3_HUMAN)
genes like me logo Genes that share domains with ZZZ3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZZZ3 Gene

Function for ZZZ3 Gene

Molecular function for ZZZ3 Gene

UniProtKB/Swiss-Prot Function:
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Phenotypes From GWAS Catalog for ZZZ3 Gene

Gene Ontology (GO) - Molecular Function for ZZZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 20562830
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZZZ3: view
genes like me logo Genes that share phenotypes with ZZZ3: view

Animal Models for ZZZ3 Gene

MGI Knock Outs for ZZZ3:
  • Zzz3 Zzz3<tm1a(EUCOMM)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZZZ3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZZZ3 Gene

Localization for ZZZ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZZZ3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZZZ3 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleoli rim (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZZZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA,IBA 21873635
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZZZ3: view

Pathways & Interactions for ZZZ3 Gene

PathCards logo

SuperPathways for ZZZ3 Gene

genes like me logo Genes that share pathways with ZZZ3: view

Pathways by source for ZZZ3 Gene

Gene Ontology (GO) - Biological Process for ZZZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043967 histone H4 acetylation IBA 21873635
genes like me logo Genes that share ontologies with ZZZ3: view

No data available for SIGNOR curated interactions for ZZZ3 Gene

Drugs & Compounds for ZZZ3 Gene

No Compound Related Data Available

Transcripts for ZZZ3 Gene

mRNA/cDNA for ZZZ3 Gene

11 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZZZ3

Alternative Splicing Database (ASD) splice patterns (SP) for ZZZ3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
SP1: - - -
SP2: - - - - - - - - - - - - - - -
SP3: - -
SP4: - -
SP5:
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - -
SP11: - - - - - - -
SP12:
SP13: -
SP14: - - - -

ExUns: 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ZZZ3 Gene

GeneLoc Exon Structure for
ZZZ3

Expression for ZZZ3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZZZ3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZZZ3 Gene

This gene is overexpressed in Fetal Liver (35.5) and Spleen (26.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZZZ3 Gene



Protein tissue co-expression partners for ZZZ3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZZZ3

SOURCE GeneReport for Unigene cluster for ZZZ3 Gene:

Hs.480506

Evidence on tissue expression from TISSUES for ZZZ3 Gene

  • Nervous system(4.6)
  • Spleen(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ZZZ3: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZZZ3 Gene

Orthologs for ZZZ3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZZZ3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZZZ3 29 30
  • 99.82 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZZZ3 29 30
  • 95.35 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZZZ3 29 30
  • 94.75 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zzz3 29
  • 88.84 (n)
Mouse
(Mus musculus)
Mammalia Zzz3 29 16 30
  • 88 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZZZ3 30
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 72 (a)
OneToMany
-- 30
  • 66 (a)
OneToMany
-- 30
  • 62 (a)
OneToMany
Chicken
(Gallus gallus)
Aves ZZZ3 29 30
  • 81.61 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZZZ3 30
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zzz3 29
  • 66.14 (n)
Str.3772 29
Zebrafish
(Danio rerio)
Actinopterygii zzz3 29 30
  • 59.99 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Atac1 29 30
  • 48.9 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 46 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.536 29
Species where no ortholog for ZZZ3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZZZ3 Gene

ENSEMBL:
Gene Tree for ZZZ3 (if available)
TreeFam:
Gene Tree for ZZZ3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZZZ3: view image
Alliance of Genome Resources:
Additional Orthologs for ZZZ3

Paralogs for ZZZ3 Gene

No data available for Paralogs for ZZZ3 Gene

Variants for ZZZ3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZZZ3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1027354 Benign: not provided 77,565,748(-) T/C
NM_015534.6(ZZZ3):c.2604A>G (p.Gln868=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs1570429085 Uncertain Significance: not provided 77,584,594(-) C/A
NM_015534.6(ZZZ3):c.1567G>T (p.Asp523Tyr)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs200866808 Benign: not provided 77,579,636(-) A/G
NM_015534.6(ZZZ3):c.1981-8T>C
INTRON
VAR_035718 A colorectal cancer sample p.Pro456Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZZZ3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZZZ3 Gene

Variant ID Type Subtype PubMed ID
nsv1533 CNV deletion 18451855
nsv470719 CNV gain 18288195
nsv546591 CNV gain 21841781
nsv830303 CNV loss 17160897

Variation tolerance for ZZZ3 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZZZ3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZZZ3
Leiden Open Variation Database (LOVD)
ZZZ3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZZZ3 Gene

Disorders for ZZZ3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZZZ3 Gene - From: COP

Disorder Aliases PubMed IDs
buruli ulcer
  • buruli ulcer, susceptibility to
branchiootorenal syndrome 2
  • bor2
mulibrey nanism
  • muscle-liver-brain-eye nanism
- elite association - COSMIC cancer census association via MalaCards
Search ZZZ3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZZZ3

genes like me logo Genes that share disorders with ZZZ3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZZZ3 Gene

Publications for ZZZ3 Gene

  1. NF-Y affects histone acetylation and H2A.Z deposition in cell cycle promoters. (PMID: 21304275) Gatta R … Mantovani R (Epigenetics 2011) 2 3
  2. Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in Drosophila. (PMID: 16428443) Guelman S … Workman JL (Molecular and cellular biology 2006) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3

Products for ZZZ3 Gene

Sources for ZZZ3 Gene