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Aliases for ZZZ3 Gene

Aliases for ZZZ3 Gene

  • Zinc Finger ZZ-Type Containing 3 2 3 5
  • ZZ-Type Zinc Finger-Containing Protein 3 3
  • ATAC Component 1 Homolog (Drosophila) 2
  • Zinc Finger, ZZ Domain Containing 3 3
  • ATAC Component 1 Homolog 3
  • ATAC1 3

External Ids for ZZZ3 Gene

Previous GeneCards Identifiers for ZZZ3 Gene

  • GC01M077452
  • GC01M077450
  • GC01M077742
  • GC01M078028
  • GC01M076161

Summaries for ZZZ3 Gene

GeneCards Summary for ZZZ3 Gene

ZZZ3 (Zinc Finger ZZ-Type Containing 3) is a Protein Coding gene. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for ZZZ3 Gene

  • Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Wiki entry for ZZZ3 Gene

Additional gene information for ZZZ3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZZZ3 Gene

Genomics for ZZZ3 Gene

GeneHancer (GH) Regulatory Elements for ZZZ3 Gene

Promoters and enhancers for ZZZ3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I077680 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 575.8 +0.5 529 4 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZZZ3 FUBP1 RPL17P6 ENSG00000273338 NEXN GIPC2 AK5 DNAJB4 RN7SL370P
GH01I077640 Promoter 0.7 EPDnew 560.9 +43.7 43663 0.1 JUNB RUNX3 ZZZ3 RN7SL370P RNA5SP20
GH01I078619 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 53.7 -937.5 -937526 3.8 PKNOX1 SMAD1 NFIB ZNF529 ZNF195 ZNF366 ZNF350 ETV6 BCLAF1 IKZF2 IFI44L ZZZ3 ENSG00000273338 NSRP1P1 FUBP1 USP33 IFI44
GH01I078002 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 -323.5 -323503 8.6 HDGF HNRNPUL1 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 DNAJB4 NSRP1P1 FUBP1 ENSG00000273338 USP33 ZZZ3 GIPC2 NEXN LOC100131495
GH01I077975 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.7 -294.9 -294856 5.5 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 SSRP1 ZNF610 GIPC2 DNAJB4 FUBP1 NSRP1P1 ENSG00000273338 USP33 ZZZ3 NEXN NEXN-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZZZ3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZZZ3 gene promoter:

Genomic Locations for ZZZ3 Gene

Genomic Locations for ZZZ3 Gene
chr1:77,561,521-77,683,426
(GRCh38/hg38)
Size:
121,906 bases
Orientation:
Minus strand
chr1:78,028,101-78,149,104
(GRCh37/hg19)

Genomic View for ZZZ3 Gene

Genes around ZZZ3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZZZ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZZZ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZZZ3 Gene

Proteins for ZZZ3 Gene

  • Protein details for ZZZ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYH5-ZZZ3_HUMAN
    Recommended name:
    ZZ-type zinc finger-containing protein 3
    Protein Accession:
    Q8IYH5
    Secondary Accessions:
    • B7WPC6
    • Q6N004
    • Q6N070
    • Q8IYP0
    • Q8IYR1
    • Q8TEK4
    • Q9Y4U0

    Protein attributes for ZZZ3 Gene

    Size:
    903 amino acids
    Molecular mass:
    102023 Da
    Quaternary structure:
    • Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

    Three dimensional structures from OCA and Proteopedia for ZZZ3 Gene

    Alternative splice isoforms for ZZZ3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZZZ3 Gene

Post-translational modifications for ZZZ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZZZ3 Gene

Domains & Families for ZZZ3 Gene

Gene Families for ZZZ3 Gene

Protein Domains for ZZZ3 Gene

Suggested Antigen Peptide Sequences for ZZZ3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZZZ3: view

No data available for UniProtKB/Swiss-Prot for ZZZ3 Gene

Function for ZZZ3 Gene

Molecular function for ZZZ3 Gene

UniProtKB/Swiss-Prot Function:
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Phenotypes From GWAS Catalog for ZZZ3 Gene

Gene Ontology (GO) - Molecular Function for ZZZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 20562830
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZZZ3: view
genes like me logo Genes that share phenotypes with ZZZ3: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZZZ3 Gene

Localization for ZZZ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZZZ3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZZZ3 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZZZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZZZ3: view

Pathways & Interactions for ZZZ3 Gene

genes like me logo Genes that share pathways with ZZZ3: view

Pathways by source for ZZZ3 Gene

Gene Ontology (GO) - Biological Process for ZZZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZZZ3: view

No data available for SIGNOR curated interactions for ZZZ3 Gene

Drugs & Compounds for ZZZ3 Gene

No Compound Related Data Available

Transcripts for ZZZ3 Gene

Unigene Clusters for ZZZ3 Gene

Zinc finger, ZZ-type containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZZZ3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
SP1: - - -
SP2: - - - - - - - - - - - - - - -
SP3: - -
SP4: - -
SP5:
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - -
SP11: - - - - - - -
SP12:
SP13: -
SP14: - - - -

ExUns: 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ZZZ3 Gene

GeneLoc Exon Structure for
ZZZ3
ECgene alternative splicing isoforms for
ZZZ3

Expression for ZZZ3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZZZ3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZZZ3 Gene

This gene is overexpressed in Fetal Liver (35.5) and Spleen (26.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZZZ3 Gene



Protein tissue co-expression partners for ZZZ3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZZZ3 Gene:

ZZZ3

SOURCE GeneReport for Unigene cluster for ZZZ3 Gene:

Hs.480506

Evidence on tissue expression from TISSUES for ZZZ3 Gene

  • Nervous system(4.6)
  • Spleen(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ZZZ3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZZZ3 Gene

Orthologs for ZZZ3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZZZ3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZZZ3 33 34
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia ZZZ3 33 34
  • 95.35 (n)
cow
(Bos Taurus)
Mammalia ZZZ3 33 34
  • 94.75 (n)
rat
(Rattus norvegicus)
Mammalia Zzz3 33
  • 88.84 (n)
mouse
(Mus musculus)
Mammalia Zzz3 33 16 34
  • 88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZZZ3 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 72 (a)
OneToMany
-- 34
  • 66 (a)
OneToMany
-- 34
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZZZ3 33 34
  • 81.61 (n)
lizard
(Anolis carolinensis)
Reptilia ZZZ3 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zzz3 33
  • 66.14 (n)
Str.3772 33
zebrafish
(Danio rerio)
Actinopterygii zzz3 33 34
  • 59.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta Atac1 33 34
  • 48.9 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.536 33
Species where no ortholog for ZZZ3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZZZ3 Gene

ENSEMBL:
Gene Tree for ZZZ3 (if available)
TreeFam:
Gene Tree for ZZZ3 (if available)

Paralogs for ZZZ3 Gene

No data available for Paralogs for ZZZ3 Gene

Variants for ZZZ3 Gene

Sequence variations from dbSNP and Humsavar for ZZZ3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035718 A colorectal cancer sample p.Pro456Ser
rs1000002490 -- 77,595,624(-) T/C intron_variant
rs1000009242 -- 77,584,181(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000037638 -- 77,682,935(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000052235 -- 77,619,577(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZZZ3 Gene

Variant ID Type Subtype PubMed ID
nsv1533 CNV deletion 18451855
nsv470719 CNV gain 18288195
nsv546591 CNV gain 21841781
nsv830303 CNV loss 17160897

Variation tolerance for ZZZ3 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZZZ3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZZZ3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZZZ3 Gene

Disorders for ZZZ3 Gene

Additional Disease Information for ZZZ3

No disorders were found for ZZZ3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZZZ3 Gene

Publications for ZZZ3 Gene

  1. NF-Y affects histone acetylation and H2A.Z deposition in cell cycle promoters. (PMID: 21304275) Gatta R … Mantovani R (Epigenetics 2011) 2 3 58
  2. Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in Drosophila. (PMID: 16428443) Guelman S … Workman JL (Molecular and cellular biology 2006) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZZZ3 Gene

Sources for ZZZ3 Gene

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