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Aliases for ZZEF1 Gene

Aliases for ZZEF1 Gene

  • Zinc Finger ZZ-Type And EF-Hand Domain Containing 1 2 3 5
  • Zinc Finger, ZZ-Type With EF Hand Domain 1 2 3
  • Zinc Finger ZZ-Type And EF-Hand Domain-Containing Protein 1 3
  • KIAA0399 4
  • ZZZ4 3

External Ids for ZZEF1 Gene

Previous GeneCards Identifiers for ZZEF1 Gene

  • GC17M004115
  • GC17M003854

Summaries for ZZEF1 Gene

GeneCards Summary for ZZEF1 Gene

ZZEF1 (Zinc Finger ZZ-Type And EF-Hand Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CUL9.

Additional gene information for ZZEF1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZZEF1 Gene

Genomics for ZZEF1 Gene

GeneHancer (GH) Regulatory Elements for ZZEF1 Gene

Promoters and enhancers for ZZEF1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I004133 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 567.4 +3.5 3478 12.4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CYB5D2 ZZEF1 ZNF232 PELP1 MYBBP1A LOC101927979 ANKFY1 INCA1 LOC105371492 PIR51897
GH17I003885 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.9 +252.5 252484 10.9 HDGF PKNOX1 CLOCK ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ZNF213 CAMKK1 ANKFY1 MYBBP1A PELP1 ENSG00000235085 LOC105371492 ZZEF1 P2RX1 SHPK NCBP3
GH17I003534 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 30 +607.2 607180 2.3 HDGF PKNOX1 ATF1 ARNT SIN3A GLI4 ZNF2 GLIS2 ZNF302 ZNF143 GC17M003518 TRPV3 RN7SL608P ZZEF1 ANKFY1 LOC105371592 LOC105371492 OR3A3 P2RX5 SPATA22
GH17I004965 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.7 -825.6 -825596 5.4 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 SPAG7 ENSG00000262429 MIR6864 MIR6865 PIR49988 ZNF232 NUP88 MIS12 INCA1 CHRNE
GH17I003959 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.4 +179.5 179451 9 HDGF CLOCK SMAD1 FOXA2 ARID4B NEUROD1 SIN3A ZBTB7B YY1 SLC30A9 ATP2A3 ZZEF1 NCBP3 CYB5D2 LINC01975 P2RX1 CTNS GC17P003938
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZZEF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZZEF1 gene promoter:

Genomic Locations for ZZEF1 Gene

Genomic Locations for ZZEF1 Gene
138,576 bases
Minus strand

Genomic View for ZZEF1 Gene

Genes around ZZEF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZZEF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZZEF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZZEF1 Gene

Proteins for ZZEF1 Gene

  • Protein details for ZZEF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger ZZ-type and EF-hand domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A7MBM5
    • Q6NXG0
    • Q6ZRA1
    • Q6ZSF4
    • Q9NVB9

    Protein attributes for ZZEF1 Gene

    2961 amino acids
    Molecular mass:
    331075 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA23695.4; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91834.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZZEF1 Gene


neXtProt entry for ZZEF1 Gene

Post-translational modifications for ZZEF1 Gene

  • Ubiquitination at isoforms=2501
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZZEF1 Gene

Domains & Families for ZZEF1 Gene

Gene Families for ZZEF1 Gene

Suggested Antigen Peptide Sequences for ZZEF1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZZEF1: view

No data available for UniProtKB/Swiss-Prot for ZZEF1 Gene

Function for ZZEF1 Gene

Phenotypes From GWAS Catalog for ZZEF1 Gene

Gene Ontology (GO) - Molecular Function for ZZEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZZEF1: view
genes like me logo Genes that share phenotypes with ZZEF1: view

Animal Models for ZZEF1 Gene

MGI Knock Outs for ZZEF1:

Animal Model Products

CRISPR Products

miRNA for ZZEF1 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZZEF1 Gene

Localization for ZZEF1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZZEF1 gene
Compartment Confidence
plasma membrane 3
cytosol 3
extracellular 2
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZZEF1 Gene

Pathways & Interactions for ZZEF1 Gene

SuperPathways for ZZEF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZZEF1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZZEF1 Gene

Drugs & Compounds for ZZEF1 Gene

No Compound Related Data Available

Transcripts for ZZEF1 Gene

Unigene Clusters for ZZEF1 Gene

Zinc finger, ZZ-type with EF-hand domain 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZZEF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP4: - -
SP9: -
SP10: - -

ExUns: 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32a · 32b · 32c ^ 33 ^
SP2: - - -
SP5: - -
SP6: - -
SP7: -
SP8: -
SP12: -
SP14: -

ExUns: 34 ^ 35 ^ 36

Relevant External Links for ZZEF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZZEF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZZEF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZZEF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.7) and Synovial fluid (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZZEF1 Gene

Protein tissue co-expression partners for ZZEF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZZEF1 Gene:


SOURCE GeneReport for Unigene cluster for ZZEF1 Gene:


mRNA Expression by UniProt/SwissProt for ZZEF1 Gene:

Tissue specificity: Expressed at low levels in cerebellum.

Evidence on tissue expression from TISSUES for ZZEF1 Gene

  • Nervous system(4.6)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZZEF1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZZEF1 Gene

Orthologs for ZZEF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZZEF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZZEF1 33 34
  • 99.55 (n)
(Bos Taurus)
Mammalia ZZEF1 33 34
  • 89.43 (n)
(Rattus norvegicus)
Mammalia Zzef1 33
  • 88.34 (n)
(Mus musculus)
Mammalia Zzef1 33 16 34
  • 88.17 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
-- 34
  • 80 (a)
-- 34
  • 66 (a)
(Canis familiaris)
Mammalia ZZEF1 33 34
  • 86.5 (n)
(Monodelphis domestica)
Mammalia ZZEF1 34
  • 68 (a)
(Gallus gallus)
Aves ZZEF1 33 34
  • 73.41 (n)
(Anolis carolinensis)
Reptilia ZZEF1 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zzef1 33
  • 66.11 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21226 33
(Danio rerio)
Actinopterygii zzef1 33 34
  • 63.11 (n)
Dr.14071 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 15 (a)
Species where no ortholog for ZZEF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZZEF1 Gene

Gene Tree for ZZEF1 (if available)
Gene Tree for ZZEF1 (if available)

Paralogs for ZZEF1 Gene

Paralogs for ZZEF1 Gene

genes like me logo Genes that share paralogs with ZZEF1: view

Variants for ZZEF1 Gene

Sequence variations from dbSNP and Humsavar for ZZEF1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000003314 -- 4,055,046(-) A/G intron_variant
rs1000007857 -- 4,034,965(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000015306 -- 4,017,053(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000086002 -- 4,011,577(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000100248 -- 4,094,598(-) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZZEF1 Gene

Variant ID Type Subtype PubMed ID
dgv3086n100 CNV gain 25217958
dgv557e214 CNV gain 21293372
esv1086827 CNV insertion 17803354
esv1422120 CNV deletion 17803354
esv1786350 CNV deletion 17803354
esv2391084 CNV deletion 18987734
esv25456 CNV loss 19812545
esv2656666 CNV deletion 23128226
esv2660488 CNV deletion 23128226
esv2676873 CNV deletion 23128226
esv2715546 CNV deletion 23290073
esv2715547 CNV deletion 23290073
esv2715548 CNV deletion 23290073
esv2751682 CNV gain 17911159
esv28297 CNV gain 19812545
esv3304335 CNV mobile element insertion 20981092
esv3310090 CNV mobile element insertion 20981092
esv3362445 CNV insertion 20981092
esv3392132 CNV insertion 20981092
esv3554030 CNV deletion 23714750
esv3639766 CNV loss 21293372
esv3639767 CNV loss 21293372
esv989391 CNV deletion 20482838
nsv1065237 CNV gain 25217958
nsv1065665 CNV gain 25217958
nsv1070797 CNV deletion 25765185
nsv1950 CNV insertion 18451855
nsv457647 CNV gain 19166990
nsv574266 CNV gain 21841781
nsv827861 CNV gain 20364138
nsv827862 CNV loss 20364138
nsv833344 CNV gain 17160897
nsv954568 CNV deletion 24416366
nsv954603 CNV deletion 24416366

Variation tolerance for ZZEF1 Gene

Residual Variation Intolerance Score: 0.639% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.07; 96.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZZEF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZZEF1 Gene

Disorders for ZZEF1 Gene

Additional Disease Information for ZZEF1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZZEF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZZEF1 Gene

Publications for ZZEF1 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ZZEF1 Gene

Sources for ZZEF1 Gene

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