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Aliases for ZYX Gene

Aliases for ZYX Gene

  • Zyxin 2 3 3 5
  • Zyxin-2 3 4
  • ESP-2 3
  • HED-2 3

External Ids for ZYX Gene

Previous GeneCards Identifiers for ZYX Gene

  • GC07P141404
  • GC07P142472
  • GC07P142549
  • GC07P142595
  • GC07P142791
  • GC07P143078
  • GC07P137415
  • GC07P143381
  • GC07P143456
  • GC07P143555
  • GC07P143691
  • GC07P143827

Summaries for ZYX Gene

Entrez Gene Summary for ZYX Gene

  • Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZYX Gene

ZYX (Zyxin) is a Protein Coding gene. Diseases associated with ZYX include Hypotonia-Cystinuria Syndrome and Ewing Sarcoma. Among its related pathways are Focal Adhesion and E-cadherin signaling in keratinocytes. An important paralog of this gene is LPP.

UniProtKB/Swiss-Prot for ZYX Gene

  • Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).

Gene Wiki entry for ZYX Gene

Additional gene information for ZYX Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZYX Gene

Genomics for ZYX Gene

GeneHancer (GH) Regulatory Elements for ZYX Gene

Promoters and enhancers for ZYX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J143378 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 700.3 +7.9 7865 15.9 MLX YBX1 YY1 ZNF213 ZNF143 SP3 MEF2D GLIS1 RCOR2 NR2C1 ZYX FAM131B CASP2 LOC154761 OR2A1 RN7SL535P EPHA1-AS1 EPHA1 TCAF2 CLCN1
GH07J143361 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 650.4 -16.0 -15996 1.4 KLF17 SIN3A KLF14 ZNF2 ZNF335 ZNF121 GLIS2 ZNF213 ZNF366 EGR2 LOC101928397 ZYX FAM131B CLCN1
GH07J143282 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 10 -91.8 -91782 7.1 HDGF FOXA2 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CASP2 GC07M143288 LOC105375545 PIR32183 TMEM139 LOC154761 RN7SL535P ZYX TRPV6
GH07J142961 Promoter/Enhancer 1.4 EPDnew ENCODE 12.5 -416.0 -416008 2.1 HDGF HNRNPUL1 PKNOX1 ATF1 ARNT TCF12 POLR2B GATA2 NCOA1 REST KEL EPHA1-AS1 ZYX LOC154761 CASP2 LLCFC1
GH07J143258 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.1 -119.1 -119060 2.2 HDAC1 FOXA2 YY1 FOS SP3 RXRA CAVIN1 ZEB2 ZNF592 SP1 TMEM139 LOC105375545 CASP2 RN7SL535P EPHA1 EPHA1-AS1 FAM131B HINT1P1 CLCN1 ZYX
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZYX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZYX gene promoter:

Genomic Locations for ZYX Gene

Genomic Locations for ZYX Gene
chr7:143,378,329-143,391,111
(GRCh38/hg38)
Size:
12,783 bases
Orientation:
Plus strand
chr7:143,078,173-143,088,204
(GRCh37/hg19)

Genomic View for ZYX Gene

Genes around ZYX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZYX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZYX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZYX Gene

Proteins for ZYX Gene

  • Protein details for ZYX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15942-ZYX_HUMAN
    Recommended name:
    Zyxin
    Protein Accession:
    Q15942
    Secondary Accessions:
    • A4D2G6
    • B4DQX7
    • Q6I9S4

    Protein attributes for ZYX Gene

    Size:
    572 amino acids
    Molecular mass:
    61277 Da
    Quaternary structure:
    • Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2). Interacts with SYNPO2.

    Alternative splice isoforms for ZYX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZYX Gene

Post-translational modifications for ZYX Gene

  • Ubiquitination at isoforms=2265
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZYX Gene

Domains & Families for ZYX Gene

Gene Families for ZYX Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ZYX Gene

Blocks:
InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15942

UniProtKB/Swiss-Prot:

ZYX_HUMAN :
  • Belongs to the zyxin/ajuba family.
Family:
  • Belongs to the zyxin/ajuba family.
genes like me logo Genes that share domains with ZYX: view

Function for ZYX Gene

Molecular function for ZYX Gene

UniProtKB/Swiss-Prot Function:
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).
GENATLAS Biochemistry:
zyxin component of cell junction matrix,concentrated at adhesion plaques and along actin-filament bundles,ubiquitous but most prominent in blood cells and tissues rich in smooth muscle and endothelial cells,involved in the spatial control of actin assembly and in communication between the adhesive membrane and the cell nucleus

Phenotypes From GWAS Catalog for ZYX Gene

Gene Ontology (GO) - Molecular Function for ZYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 10831611
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZYX: view
genes like me logo Genes that share phenotypes with ZYX: view

Animal Models for ZYX Gene

MGI Knock Outs for ZYX:
  • Zyx Zyx<tm1Mbk>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZYX

Clone Products

  • Addgene plasmids for ZYX

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZYX Gene

Localization for ZYX Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZYX Gene

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, focal adhesion. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZYX gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 18297730
GO:0005634 nucleus IEA,IDA 24036928
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ZYX: view

Pathways & Interactions for ZYX Gene

genes like me logo Genes that share pathways with ZYX: view

Pathways by source for ZYX Gene

SIGNOR curated interactions for ZYX Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ZYX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 8940160
GO:0007160 cell-matrix adhesion IC 24036928
GO:0007165 signal transduction TAS 8940160
GO:0007179 transforming growth factor beta receptor signaling pathway IMP 24036928
GO:0007229 integrin-mediated signaling pathway IMP 24036928
genes like me logo Genes that share ontologies with ZYX: view

Drugs & Compounds for ZYX Gene

(4) Drugs for ZYX Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Approved, Investigational Pharma Target, ligand 100

(3) Additional Compounds for ZYX Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZYX: view

Transcripts for ZYX Gene

Unigene Clusters for ZYX Gene

Zyxin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZYX

Clone Products

  • Addgene plasmids for ZYX

Alternative Splicing Database (ASD) splice patterns (SP) for ZYX Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: -
SP5: - -
SP6: - - - - - - - - - - - - - - -
SP7: - - - - -
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ZYX Gene

GeneLoc Exon Structure for
ZYX
ECgene alternative splicing isoforms for
ZYX

Expression for ZYX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZYX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZYX Gene

This gene is overexpressed in Whole Blood (x10.8).

Protein differential expression in normal tissues from HIPED for ZYX Gene

This gene is overexpressed in Platelet (14.3), Bone marrow stromal cell (10.1), and Amniocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZYX Gene



Protein tissue co-expression partners for ZYX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZYX Gene:

ZYX

SOURCE GeneReport for Unigene cluster for ZYX Gene:

Hs.490415

Evidence on tissue expression from TISSUES for ZYX Gene

  • Blood(4.7)
  • Skin(4.7)
  • Kidney(4.5)
  • Liver(4.3)
  • Nervous system(4.1)
  • Lung(3.8)
  • Pancreas(3)
  • Eye(2.8)
  • Intestine(2.8)
  • Muscle(2.8)
  • Heart(2.6)
genes like me logo Genes that share expression patterns with ZYX: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZYX Gene

Orthologs for ZYX Gene

This gene was present in the common ancestor of animals.

Orthologs for ZYX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZYX 34 33
  • 99.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZYX 34 33
  • 87.22 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZYX 34 33
  • 86.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zyx 16 34 33
  • 84.82 (n)
rat
(Rattus norvegicus)
Mammalia Zyx 33
  • 84.64 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 80 (a)
OneToMany
-- 34
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZYX 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZYX 34
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZYX 34
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3057 33
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7234 33
zebrafish
(Danio rerio)
Actinopterygii zyx 34
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Zyx102EF 35
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea zyx-1 34 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
OneToMany
Cin.8432 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8432 33
Species where no ortholog for ZYX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZYX Gene

ENSEMBL:
Gene Tree for ZYX (if available)
TreeFam:
Gene Tree for ZYX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZYX: view image

Paralogs for ZYX Gene

Paralogs for ZYX Gene

(8) SIMAP similar genes for ZYX Gene using alignment to 10 proteins:

  • ZYX_HUMAN
  • B4DQR8_HUMAN
  • B4DQX7_HUMAN
  • C9IZ41_HUMAN
  • C9JJK5_HUMAN
  • H0Y2Y8_HUMAN
  • H7C3D3_HUMAN
  • H7C3R3_HUMAN
  • Q96AF9_HUMAN
  • Q9BUS0_HUMAN

Pseudogenes.org Pseudogenes for ZYX Gene

genes like me logo Genes that share paralogs with ZYX: view

Variants for ZYX Gene

Sequence variations from dbSNP and Humsavar for ZYX Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000019148 -- 143,381,249(+) T/C coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, upstream_transcript_variant
rs1000033513 -- 143,387,966(+) A/G intron_variant
rs1001786095 -- 143,388,058(+) C/T intron_variant
rs1002274320 -- 143,386,484(+) G/A intron_variant
rs1002560859 -- 143,381,476(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZYX Gene

Variant ID Type Subtype PubMed ID
nsv1075065 CNV deletion 25765185
nsv482115 CNV gain 20164927
nsv517520 CNV loss 19592680
nsv608681 CNV loss 21841781
nsv949967 CNV deletion 24416366

Variation tolerance for ZYX Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.65; 65.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZYX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZYX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZYX Gene

Disorders for ZYX Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZYX Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypotonia-cystinuria syndrome
  • cystinuria with mitochondrial disease
ewing sarcoma
  • es
- elite association - COSMIC cancer census association via MalaCards
Search ZYX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZYX

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZYX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZYX Gene

Publications for ZYX Gene

  1. Molecular characterization of human zyxin. (PMID: 8940160) Macalma T … Beckerle MC (The Journal of biological chemistry 1996) 2 3 4 22 58
  2. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. (PMID: 12695497) Garvalov BK … Way M (The Journal of cell biology 2003) 3 4 22 58
  3. Interaction of zyxin, a focal adhesion protein, with the e6 protein from human papillomavirus type 6 results in its nuclear translocation. (PMID: 11689660) Degenhardt YY … Silverstein S (Journal of virology 2001) 3 4 22 58
  4. Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. (PMID: 10801818) Drees B … Golsteyn RM (The Journal of biological chemistry 2000) 3 4 22 58
  5. A zyxin-related protein whose synthesis is reduced in virally transformed fibroblasts. (PMID: 8917469) Zumbrunn J … Trueb B (European journal of biochemistry 1996) 2 3 4 58

Products for ZYX Gene

Sources for ZYX Gene

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