Aliases for ZYG11A Gene

Aliases for ZYG11A Gene

  • Zyg-11 Family Member A, Cell Cycle Regulator 2 3 5
  • ZYG11 2 3 4
  • Protein Zyg-11 Homolog A 3 4
  • ZYG-11A Early Embryogenesis Protein 3
  • Zyg-11 Homolog A (C. Elegans) 2
  • Zyg-11 Homolog A 3
  • ZYG11A 5

External Ids for ZYG11A Gene

Previous GeneCards Identifiers for ZYG11A Gene

  • GC01P053022
  • GC01P053080
  • GC01P053308
  • GC01P051424

Summaries for ZYG11A Gene

GeneCards Summary for ZYG11A Gene

ZYG11A (Zyg-11 Family Member A, Cell Cycle Regulator) is a Protein Coding gene. Diseases associated with ZYG11A include Hemophagocytic Lymphohistiocytosis, Familial, 1. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is ZYG11B.

UniProtKB/Swiss-Prot Summary for ZYG11A Gene

  • Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.

Additional gene information for ZYG11A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZYG11A Gene

Genomics for ZYG11A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZYG11A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J052842 Promoter/Enhancer 1.3 Ensembl ENCODE 600.7 +1.0 1049 3.9 BRCA1 RNF2 ARHGAP35 SP1 HNRNPL PRDM10 ZNF629 RFX1 LEF1 IKZF1 ZYG11A PRPF38A TUT4 ECHDC2 ZFYVE9 ZYG11B piR-43650
GH01J053394 Enhancer 0.8 Ensembl ENCODE 11.2 +551.2 551182 1 CTCF IKZF1 LARP7 ZNF143 REST RAD21 IKZF2 TRIM22 NRF1 SMC3 LRP8 ENSG00000228838 ENSG00000234578 LINC01771 ZYG11A HSALNG0003700 lnc-LRP8-5 DMRTB1
GH01J052725 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 4.3 -115.7 -115710 3.2 RNF2 ARHGAP35 PRDM10 ZNF629 ZNF512 LEF1 SOX13 IKZF1 KDM1A BACH1 ZYG11B MAGOH ORC1 ENSG00000266993 KTI12 RPS13P2 ECHDC2 ENSG00000230953 PRPF38A TUT4
GH01J053139 Enhancer 1 Ensembl ENCODE dbSUPER 5.2 +297.8 297790 2.6 ZNF600 CEBPA EP300 CEBPB CTBP1 HDAC2 FOS FOSL1 FOXP1 FOSL2 lnc-C1orf123-2 piR-32285-004 SLC1A7 PODN ZYG11A
GH01J052770 Enhancer 0.3 Ensembl 5.6 -72.0 -72010 1 ZBTB17 ZYG11B ZYG11A RPS13P2 RF00017-216
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZYG11A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZYG11A

Top Transcription factor binding sites by QIAGEN in the ZYG11A gene promoter:
  • Evi-1
  • HTF
  • Nkx2-5
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • POU2F1
  • POU2F1a

Genomic Locations for ZYG11A Gene

Genomic Locations for ZYG11A Gene
chr1:52,842,511-52,894,998
(GRCh38/hg38)
Size:
52,488 bases
Orientation:
Plus strand
chr1:53,308,183-53,360,670
(GRCh37/hg19)
Size:
52,488 bases
Orientation:
Plus strand

Genomic View for ZYG11A Gene

Genes around ZYG11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZYG11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZYG11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZYG11A Gene

Proteins for ZYG11A Gene

  • Protein details for ZYG11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6WRX3-ZY11A_HUMAN
    Recommended name:
    Protein zyg-11 homolog A
    Protein Accession:
    Q6WRX3
    Secondary Accessions:
    • A6NCK5

    Protein attributes for ZYG11A Gene

    Size:
    759 amino acids
    Molecular mass:
    85808 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZYG11A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZYG11A Gene

Post-translational modifications for ZYG11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZYG11A Gene

Domains & Families for ZYG11A Gene

Gene Families for ZYG11A Gene

Protein Domains for ZYG11A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZYG11A Gene

GenScript: Design optimal peptide antigens:
  • Protein zyg-11 homolog A (ZY11A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6WRX3

UniProtKB/Swiss-Prot:

ZY11A_HUMAN :
  • Belongs to the zyg-11 family.
Family:
  • Belongs to the zyg-11 family.
genes like me logo Genes that share domains with ZYG11A: view

Function for ZYG11A Gene

Molecular function for ZYG11A Gene

UniProtKB/Swiss-Prot Function:
Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.

Phenotypes From GWAS Catalog for ZYG11A Gene

genes like me logo Genes that share phenotypes with ZYG11A: view

Animal Model Products

CRISPR Products

miRNA for ZYG11A Gene

miRTarBase miRNAs that target ZYG11A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZYG11A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZYG11A Gene

Localization for ZYG11A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZYG11A gene
Compartment Confidence
cytosol 2
plasma membrane 1
cytoskeleton 1
nucleus 1
extracellular 0
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZYG11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031462 Cul2-RING ubiquitin ligase complex IBA 21873635
genes like me logo Genes that share ontologies with ZYG11A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZYG11A Gene

Pathways & Interactions for ZYG11A Gene

PathCards logo

SuperPathways for ZYG11A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZYG11A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZYG11A Gene

Drugs & Compounds for ZYG11A Gene

No Compound Related Data Available

Transcripts for ZYG11A Gene

mRNA/cDNA for ZYG11A Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZYG11A

Alternative Splicing Database (ASD) splice patterns (SP) for ZYG11A Gene

No ASD Table

Relevant External Links for ZYG11A Gene

GeneLoc Exon Structure for
ZYG11A

Expression for ZYG11A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZYG11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZYG11A Gene

This gene is overexpressed in Testis (x11.8), Thyroid (x6.3), and Liver (x4.0).

Protein differential expression in normal tissues from HIPED for ZYG11A Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZYG11A Gene



Protein tissue co-expression partners for ZYG11A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZYG11A

SOURCE GeneReport for Unigene cluster for ZYG11A Gene:

Hs.658458
genes like me logo Genes that share expression patterns with ZYG11A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZYG11A Gene

Orthologs for ZYG11A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZYG11A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZYG11A 30 31
  • 99.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZYG11A 30 31
  • 91.31 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZYG11A 30 31
  • 88.34 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zyg11a 30 17 31
  • 79.95 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zyg11a 30
  • 78.22 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZYG11A 31
  • 69 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 56 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia ZYG11A 31
  • 55 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii zyg11 31
  • 51 (a)
ManyToMany
si:ch1073-82l19.1 31
  • 42 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea zyg-11 31
  • 20 (a)
OneToMany
Species where no ortholog for ZYG11A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ZYG11A Gene

ENSEMBL:
Gene Tree for ZYG11A (if available)
TreeFam:
Gene Tree for ZYG11A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZYG11A: view image

Paralogs for ZYG11A Gene

Paralogs for ZYG11A Gene

(1) SIMAP similar genes for ZYG11A Gene using alignment to 1 proteins:

  • ZY11A_HUMAN

Pseudogenes.org Pseudogenes for ZYG11A Gene

genes like me logo Genes that share paralogs with ZYG11A: view

Variants for ZYG11A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZYG11A Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
787746 Benign: not provided 52,857,112(+) G/A MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ZYG11A Gene

Structural Variations from Database of Genomic Variants (DGV) for ZYG11A Gene

Variant ID Type Subtype PubMed ID
esv24261 CNV loss 19812545
esv2668074 CNV deletion 23128226
esv3586055 CNV loss 21293372
nsv1001535 CNV gain 25217958
nsv1122345 CNV deletion 24896259
nsv1125462 CNV tandem duplication 24896259
nsv829859 CNV loss 17160897
nsv866 CNV deletion 18451855

Variation tolerance for ZYG11A Gene

Gene Damage Index Score: 3.83; 58.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZYG11A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZYG11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZYG11A Gene

Disorders for ZYG11A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZYG11A Gene - From: DISEASES

Disorder Aliases PubMed IDs
hemophagocytic lymphohistiocytosis, familial, 1
  • fhl1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZYG11A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZYG11A Gene

Publications for ZYG11A Gene

  1. Meiotic human sperm cells express a leucine-rich homologue of Caenorhabditis elegans early embryogenesis gene, Zyg-11. (PMID: 11719588) Féral C … Guellaën G (Molecular human reproduction 2001) 2 3
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. (PMID: 27433848) Malik S … Nakanishi A (Cell cycle (Georgetown, Tex.) 2016) 3
  4. The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage. (PMID: 27810909) Balachandran RS … Kipreos ET (The Journal of cell biology 2016) 3
  5. ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression. (PMID: 26771237) Wang X … Ren B (Oncotarget 2016) 3

Products for ZYG11A Gene

Sources for ZYG11A Gene