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Aliases for ZYG11A Gene

Aliases for ZYG11A Gene

  • Zyg-11 Family Member A, Cell Cycle Regulator 2 3 5
  • ZYG11 3 4
  • ZYG-11A Early Embryogenesis Protein 3
  • Zyg-11 Homolog A (C. Elegans) 2
  • Protein Zyg-11 Homolog A 3
  • Zyg-11 Homolog A 3

External Ids for ZYG11A Gene

Previous GeneCards Identifiers for ZYG11A Gene

  • GC01P053022
  • GC01P053080
  • GC01P053308
  • GC01P051424

Summaries for ZYG11A Gene

GeneCards Summary for ZYG11A Gene

ZYG11A (Zyg-11 Family Member A, Cell Cycle Regulator) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is ZYG11B.

UniProtKB/Swiss-Prot for ZYG11A Gene

  • Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.

Additional gene information for ZYG11A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZYG11A Gene

Genomics for ZYG11A Gene

GeneHancer (GH) Regulatory Elements for ZYG11A Gene

Promoters and enhancers for ZYG11A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I052842 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.3 1323 3.4 PKNOX1 ARNT SIN3A FEZF1 ZNF2 POLR2B ZNF213 ZNF207 ZNF143 KLF13 ZYG11A ECHDC2 PRPF38A MAGOH ENSG00000272100 ZFYVE9 ZYG11B ZCCHC11 KTI12 PIR36649
GH01I052725 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.3 -115.6 -115610 2.2 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 E2F8 SP3 ZNF592 ZYG11B PRPF38A ORC1 MAGOH RPS13P2 ECHDC2 ENSG00000230953 ENSG00000266993 ZYG11A GC01P052729
GH01I053393 Enhancer 0.7 ENCODE 11.2 +551.3 551296 0.8 CTCF RB1 RAD21 ZBTB40 CC2D1A ZFHX2 ARID2 ZNF207 SMC3 ZNF143 LRP8 ENSG00000228838 LOC105378728 LINC01771 ZYG11A ENSG00000230138 LOC105378733
GH01I053139 Enhancer 1.1 Ensembl ENCODE dbSUPER 5.2 +297.8 297790 1.9 BCOR ZMYM3 PYGO2 CEBPG FOSL1 CTBP1 ADNP TRIM24 FOSL2 FOS SLC1A7 PODN ZYG11A GC01P053132
GH01I052833 Enhancer 0.8 ENCODE 0.4 -8.8 -8797 0.2 PKNOX1 ATF1 TCF12 CREM ZNF362 ZBTB2 ZBTB11 ZEB2 ZNF592 MEF2D ZYG11A GC01P052823
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZYG11A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZYG11A gene promoter:

Genomic Locations for ZYG11A Gene

Genomic Locations for ZYG11A Gene
52,488 bases
Plus strand

Genomic View for ZYG11A Gene

Genes around ZYG11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZYG11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZYG11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZYG11A Gene

Proteins for ZYG11A Gene

  • Protein details for ZYG11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein zyg-11 homolog A
    Protein Accession:
    Secondary Accessions:
    • A6NCK5

    Protein attributes for ZYG11A Gene

    759 amino acids
    Molecular mass:
    85808 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZYG11A Gene


neXtProt entry for ZYG11A Gene

Post-translational modifications for ZYG11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZYG11A Gene

Domains & Families for ZYG11A Gene

Gene Families for ZYG11A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZYG11A Gene

Suggested Antigen Peptide Sequences for ZYG11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zyg-11 family.
  • Belongs to the zyg-11 family.
genes like me logo Genes that share domains with ZYG11A: view

Function for ZYG11A Gene

Molecular function for ZYG11A Gene

UniProtKB/Swiss-Prot Function:
Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.

Phenotypes From GWAS Catalog for ZYG11A Gene

Gene Ontology (GO) - Molecular Function for ZYG11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with ZYG11A: view
genes like me logo Genes that share phenotypes with ZYG11A: view

miRNA for ZYG11A Gene

miRTarBase miRNAs that target ZYG11A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZYG11A Gene

Localization for ZYG11A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZYG11A gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZYG11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031462 Cul2-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with ZYG11A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZYG11A Gene

Pathways & Interactions for ZYG11A Gene

SuperPathways for ZYG11A Gene

No Data Available

Interacting Proteins for ZYG11A Gene

Gene Ontology (GO) - Biological Process for ZYG11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0051438 regulation of ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with ZYG11A: view

No data available for Pathways by source and SIGNOR curated interactions for ZYG11A Gene

Drugs & Compounds for ZYG11A Gene

No Compound Related Data Available

Transcripts for ZYG11A Gene

mRNA/cDNA for ZYG11A Gene

(11) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZYG11A Gene

Zyg-11 family member A, cell cycle regulator:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZYG11A Gene

No ASD Table

Relevant External Links for ZYG11A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZYG11A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZYG11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZYG11A Gene

This gene is overexpressed in Testis (x11.8), Thyroid (x6.3), and Liver (x4.0).

Protein differential expression in normal tissues from HIPED for ZYG11A Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZYG11A Gene

Protein tissue co-expression partners for ZYG11A Gene

NURSA nuclear receptor signaling pathways regulating expression of ZYG11A Gene:


SOURCE GeneReport for Unigene cluster for ZYG11A Gene:

genes like me logo Genes that share expression patterns with ZYG11A: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZYG11A Gene

Orthologs for ZYG11A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZYG11A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZYG11A 33 34
  • 99.34 (n)
(Canis familiaris)
Mammalia ZYG11A 33 34
  • 91.31 (n)
(Bos Taurus)
Mammalia ZYG11A 33 34
  • 88.34 (n)
(Mus musculus)
Mammalia Zyg11a 33 16 34
  • 79.95 (n)
(Rattus norvegicus)
Mammalia Zyg11a 33
  • 78.22 (n)
(Monodelphis domestica)
Mammalia ZYG11A 34
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 56 (a)
-- 34
  • 55 (a)
(Anolis carolinensis)
Reptilia ZYG11A 34
  • 55 (a)
(Danio rerio)
Actinopterygii zyg11 34
  • 51 (a)
si:ch1073-82l19.1 34
  • 42 (a)
(Caenorhabditis elegans)
Secernentea zyg-11 34
  • 20 (a)
Species where no ortholog for ZYG11A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZYG11A Gene

Gene Tree for ZYG11A (if available)
Gene Tree for ZYG11A (if available)

Paralogs for ZYG11A Gene

Paralogs for ZYG11A Gene

(1) SIMAP similar genes for ZYG11A Gene using alignment to 1 proteins: Pseudogenes for ZYG11A Gene

genes like me logo Genes that share paralogs with ZYG11A: view

Variants for ZYG11A Gene

Sequence variations from dbSNP and Humsavar for ZYG11A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000031748 -- 52,858,422(+) C/T intron_variant
rs1000050537 -- 52,852,269(+) GAACTCCTGACCTCATGA/GA intron_variant
rs1000067368 -- 52,872,209(+) C/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000118360 -- 52,864,793(+) C/T intron_variant
rs1000212812 -- 52,894,258(+) T/G 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZYG11A Gene

Variant ID Type Subtype PubMed ID
esv24261 CNV loss 19812545
esv2668074 CNV deletion 23128226
esv3586055 CNV loss 21293372
nsv1001535 CNV gain 25217958
nsv1122345 CNV deletion 24896259
nsv1125462 CNV tandem duplication 24896259
nsv829859 CNV loss 17160897
nsv866 CNV deletion 18451855

Variation tolerance for ZYG11A Gene

Gene Damage Index Score: 3.83; 58.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZYG11A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZYG11A Gene

Disorders for ZYG11A Gene

Additional Disease Information for ZYG11A

No disorders were found for ZYG11A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZYG11A Gene

Publications for ZYG11A Gene

  1. Meiotic human sperm cells express a leucine-rich homologue of Caenorhabditis elegans early embryogenesis gene, Zyg-11. (PMID: 11719588) Féral C … Guellaën G (Molecular human reproduction 2001) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression. (PMID: 26771237) Wang X … Ren B (Oncotarget 2016) 3 58
  4. The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage. (PMID: 27810909) Balachandran RS … Kipreos ET (The Journal of cell biology 2016) 3 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58

Products for ZYG11A Gene

Sources for ZYG11A Gene

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