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Aliases for ZXDA Gene

Aliases for ZXDA Gene

  • Zinc Finger, X-Linked, Duplicated A 2 3 5
  • Zinc Finger Protein 896 2 3
  • Zinc Finger X-Linked Protein ZXDA 3
  • ZNF896 3

External Ids for ZXDA Gene

Previous GeneCards Identifiers for ZXDA Gene

  • GC0XM054714
  • GC0XM055912
  • GC0XM056539
  • GC0XM056902
  • GC0XM056900
  • GC0XM057817
  • GC0XM057949
  • GC0XM054990

Summaries for ZXDA Gene

Entrez Gene Summary for ZXDA Gene

  • This gene encodes one of two duplicated zinc finger genes on chromosome Xp11. This gene is the telomeric copy; GeneID 158586 ZXDB is the more centromeric copy. The two genes have 98% nucleotide sequence similarity, and the predicted proteins contain 10 tandem zinc finger motifs. [provided by RefSeq, Nov 2009]

GeneCards Summary for ZXDA Gene

ZXDA (Zinc Finger, X-Linked, Duplicated A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and C2H2 zinc finger domain binding. An important paralog of this gene is ZXDB.

UniProtKB/Swiss-Prot for ZXDA Gene

  • Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

Additional gene information for ZXDA Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZXDA Gene

Genomics for ZXDA Gene

GeneHancer (GH) Regulatory Elements for ZXDA Gene

Promoters and enhancers for ZXDA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI057908 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 +0.5 543 2.7 KLF1 JUN ZIC2 HIC1 GLIS2 PATZ1 ATF7 FOS ZBTB20 STAT1 ZXDA MTHFD1P1 FAAH2 GC0XP057893
GH0XI057821 Enhancer 0.6 ENCODE 12.3 +88.9 88917 0.2 CTCF STAT1 ZNF654 TRIM22 MAX REST RAD21 SMC3 ZNF143 DEK ZXDA LOC392477 GC0XP057893
GH0XI057906 Enhancer 0.3 Ensembl 0.8 +4.1 4131 1 JUND FAAH2 ZXDA GC0XP057893
GH0XI057905 Enhancer 0.5 Ensembl 0.4 +5.5 5519 0.6 PRDM6 ZNF629 CEBPB FEZF1 PRDM1 ZNF843 ZXDA GC0XP057893
GH0XI057907 Enhancer 0.2 Ensembl 0.8 +3.1 3119 1 ZXDA GC0XP057893
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZXDA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZXDA gene promoter:

Genomic Locations for ZXDA Gene

Genomic Locations for ZXDA Gene
5,391 bases
Minus strand

Genomic View for ZXDA Gene

Genes around ZXDA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZXDA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZXDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZXDA Gene

Proteins for ZXDA Gene

  • Protein details for ZXDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger X-linked protein ZXDA
    Protein Accession:
    Secondary Accessions:
    • Q9UJP7

    Protein attributes for ZXDA Gene

    799 amino acids
    Molecular mass:
    84771 Da
    Quaternary structure:
    • Self-associates. Interacts with ZXDC and CIITA.
    • Sequence=AAC37521.1; Type=Frameshift; Positions=753; Evidence={ECO:0000305};

neXtProt entry for ZXDA Gene

Post-translational modifications for ZXDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZXDA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZXDA Gene

Domains & Families for ZXDA Gene

Gene Families for ZXDA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZXDA Gene


Suggested Antigen Peptide Sequences for ZXDA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZXD family.
  • Belongs to the ZXD family.
genes like me logo Genes that share domains with ZXDA: view

Function for ZXDA Gene

Molecular function for ZXDA Gene

GENATLAS Biochemistry:
zinc finger protein (C2H2 type),X linked,duplicated A
UniProtKB/Swiss-Prot Function:
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

Phenotypes From GWAS Catalog for ZXDA Gene

Gene Ontology (GO) - Molecular Function for ZXDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 DNA binding transcription factor activity IMP 17493635
GO:0005515 protein binding IPI 17493635
GO:0046872 metal ion binding IEA --
GO:0070742 C2H2 zinc finger domain binding IPI 17493635
genes like me logo Genes that share ontologies with ZXDA: view

Phenotypes for ZXDA Gene

genes like me logo Genes that share phenotypes with ZXDA: view

miRNA for ZXDA Gene

miRTarBase miRNAs that target ZXDA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZXDA Gene

Localization for ZXDA Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZXDA Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZXDA gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZXDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZXDA: view

Pathways & Interactions for ZXDA Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZXDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045893 positive regulation of transcription, DNA-templated IMP 17493635
genes like me logo Genes that share ontologies with ZXDA: view

No data available for Pathways by source and SIGNOR curated interactions for ZXDA Gene

Drugs & Compounds for ZXDA Gene

No Compound Related Data Available

Transcripts for ZXDA Gene

mRNA/cDNA for ZXDA Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZXDA Gene

Zinc finger, X-linked, duplicated A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZXDA Gene

No ASD Table

Relevant External Links for ZXDA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZXDA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZXDA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZXDA Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZXDA Gene

Protein tissue co-expression partners for ZXDA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZXDA Gene:


SOURCE GeneReport for Unigene cluster for ZXDA Gene:


mRNA Expression by UniProt/SwissProt for ZXDA Gene:

Tissue specificity: May be expressed in brain, heart, kidney, liver, lung, muscle and placenta.

Evidence on tissue expression from TISSUES for ZXDA Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZXDA: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZXDA Gene

Orthologs for ZXDA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZXDA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZXDA 33 34
  • 98.83 (n)
(Bos Taurus)
Mammalia -- 34
  • 82 (a)
-- 34
  • 82 (a)
(Canis familiaris)
Mammalia -- 34
  • 75 (a)
(Mus musculus)
Mammalia Zxdb 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 61 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
(Gallus gallus)
Aves -- 34
  • 49 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
(Danio rerio)
Actinopterygii ZXDC 34
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9609 34
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACE2 34
  • 8 (a)
SWI5 34
  • 7 (a)
Species where no ortholog for ZXDA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZXDA Gene

Gene Tree for ZXDA (if available)
Gene Tree for ZXDA (if available)

Paralogs for ZXDA Gene

Paralogs for ZXDA Gene

(4) SIMAP similar genes for ZXDA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZXDA: view

Variants for ZXDA Gene

Sequence variations from dbSNP and Humsavar for ZXDA Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000033789 -- 57,907,602(-) A/T 3_prime_UTR_variant
rs1000187148 -- 57,906,608(-) C/T 3_prime_UTR_variant
rs1003409086 -- 57,907,424(-) T/C 3_prime_UTR_variant
rs1003582238 -- 57,906,064(-) G/A 3_prime_UTR_variant
rs1004485075 -- 57,910,449(-) C/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZXDA Gene

Variant ID Type Subtype PubMed ID
nsv518933 CNV gain 19592680

Variation tolerance for ZXDA Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.30; 81.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZXDA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZXDA Gene

Disorders for ZXDA Gene

Additional Disease Information for ZXDA

No disorders were found for ZXDA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZXDA Gene

Publications for ZXDA Gene

  1. The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription. (PMID: 17493635) Al-Kandari W … Fontes JD (Journal of molecular biology 2007) 3 4 22 58
  2. Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies. (PMID: 8268913) Greig GM … Willard HF (Human molecular genetics 1993) 2 3 4 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Homozygous missense mutation in the LMAN2L gene segregates with intellectual disability in a large consanguineous Pakistani family. (PMID: 26566883) Rafiullah R … Berkel S (Journal of medical genetics 2016) 4 58

Products for ZXDA Gene

Sources for ZXDA Gene

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