Aliases for ZWINT Gene
External Ids for ZWINT Gene
Previous GeneCards Identifiers for ZWINT Gene
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZWINT Gene
ZWINT (ZW10 Interacting Kinetochore Protein) is a Protein Coding gene. Diseases associated with ZWINT include Roberts Syndrome and Pediatric Ependymoma. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding.
UniProtKB/Swiss-Prot Summary for ZWINT Gene
Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.