This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a... See more...

Aliases for ZWINT Gene

Aliases for ZWINT Gene

  • ZW10 Interacting Kinetochore Protein 2 3 5
  • ZW10 Interactor 2 3 4
  • SNAP25 Interacting Protein Of 30 KDa 2 3
  • KNTC2AP 2 3
  • Zwint-1 3 4
  • SIP30 2 3
  • ZW10 Interactor, Kinetochore Protein 3
  • Human ZW10 Interacting Protein-1 3
  • ZW10-Interacting Protein 1 4
  • HZwint-1 3
  • ZWINT1 3
  • Zwint1 2
  • ZWINT 5

External Ids for ZWINT Gene

Previous GeneCards Identifiers for ZWINT Gene

  • GC10M056945
  • GC10M057122
  • GC10M058009
  • GC10M057461
  • GC10M057787
  • GC10M058116
  • GC10M052100

Summaries for ZWINT Gene

Entrez Gene Summary for ZWINT Gene

  • This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZWINT Gene

ZWINT (ZW10 Interacting Kinetochore Protein) is a Protein Coding gene. Diseases associated with ZWINT include Roberts Syndrome and Pediatric Ependymoma. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding.

UniProtKB/Swiss-Prot Summary for ZWINT Gene

  • Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.

Gene Wiki entry for ZWINT Gene

Additional gene information for ZWINT Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZWINT Gene

Genomics for ZWINT Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZWINT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J056359 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 612.7 0.0 -13 3 SP1 CREB1 ZNF629 LEF1 IKZF1 POLR2A FOS ZHX2 JUND PRDM1 ZWINT ENSG00000287016 lnc-PCDH15-2
GH10J057218 Enhancer 0.8 Ensembl ENCODE 4.2 -857.0 -857028 1 CREB1 FOXA1 CTBP1 PKNOX1 ZNF217 GATAD2B CUX1 HCFC1 GATA3 DPF2 ZWINT lnc-ZWINT-2 piR-32325-016
GH10J057101 Enhancer 0.5 Ensembl ENCODE 5.1 -741.4 -741428 2.2 FOXA2 SP1 piR-39858-062 ZWINT piR-38351-047 lnc-ZWINT-2
GH10J055978 Enhancer 0.4 Ensembl ENCODE 4.7 +381.9 381872 1.6 NANOG piR-37586-009 ZWINT lnc-MTRNR2L5-6 piR-59928-018 PCDH15
GH10J057133 Enhancer 0.2 Ensembl 6.4 -772.3 -772328 0.8 ZWINT piR-39858-062 piR-32325-016 lnc-ZWINT-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZWINT on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZWINT

Genomic Locations for ZWINT Gene

Genomic Locations for ZWINT Gene
chr10:56,357,227-56,361,273
(GRCh38/hg38)
Size:
4,047 bases
Orientation:
Minus strand
chr10:58,116,989-58,121,036
(GRCh37/hg19)
Size:
4,048 bases
Orientation:
Minus strand

Genomic View for ZWINT Gene

Genes around ZWINT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZWINT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZWINT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZWINT Gene

Proteins for ZWINT Gene

  • Protein details for ZWINT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95229-ZWINT_HUMAN
    Recommended name:
    ZW10 interactor
    Protein Accession:
    O95229
    Secondary Accessions:
    • A6NNV6
    • Q0D2I3
    • Q9BWD0

    Protein attributes for ZWINT Gene

    Size:
    277 amino acids
    Molecular mass:
    31293 Da
    Quaternary structure:
    • Interacts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis. Also interacts with KNL1, CETN3, DSN1 and PMF1.

    Alternative splice isoforms for ZWINT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZWINT Gene

Post-translational modifications for ZWINT Gene

  • Ubiquitination at Lys93, Lys100, Lys111, Lys116, Lys141, Lys162, and Lys196
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for ZWINT
  • Boster Bio Antibodies for ZWINT
  • Santa Cruz Biotechnology (SCBT) Antibodies for ZWINT

No data available for DME Specific Peptides for ZWINT Gene

Domains & Families for ZWINT Gene

Gene Families for ZWINT Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZWINT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZWINT Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60420, highly similar to ZW10 interactor (A6NH27_HUMAN)
  • ZW10-interacting protein 1 (ZWINT_HUMAN)
genes like me logo Genes that share domains with ZWINT: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZWINT Gene

Function for ZWINT Gene

Molecular function for ZWINT Gene

UniProtKB/Swiss-Prot Function:
Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.

Phenotypes From GWAS Catalog for ZWINT Gene

Gene Ontology (GO) - Molecular Function for ZWINT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15502821
GO:0047485 protein N-terminus binding IPI 15485811
genes like me logo Genes that share ontologies with ZWINT: view
genes like me logo Genes that share phenotypes with ZWINT: view

Animal Model Products

CRISPR Products

miRNA for ZWINT Gene

miRTarBase miRNAs that target ZWINT

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZWINT

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZWINT Gene

Localization for ZWINT Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZWINT Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZWINT gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (4)
  • Nucleoplasm (4)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZWINT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IDA 11682612
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZWINT: view

Pathways & Interactions for ZWINT Gene

genes like me logo Genes that share pathways with ZWINT: view

Pathways by source for ZWINT Gene

Gene Ontology (GO) - Biological Process for ZWINT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IBA,IDA 15485811
GO:0007049 cell cycle IEA --
GO:0007093 mitotic cell cycle checkpoint IBA,IDA 15485811
GO:0051301 cell division IEA --
GO:0051649 establishment of localization in cell IBA,IDA 15485811
genes like me logo Genes that share ontologies with ZWINT: view

No data available for SIGNOR curated interactions for ZWINT Gene

Drugs & Compounds for ZWINT Gene

No Compound Related Data Available

Transcripts for ZWINT Gene

mRNA/cDNA for ZWINT Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZWINT

Alternative Splicing Database (ASD) splice patterns (SP) for ZWINT Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2:
SP3:

Relevant External Links for ZWINT Gene

GeneLoc Exon Structure for
ZWINT

Expression for ZWINT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZWINT Gene

mRNA differential expression in normal tissues according to GTEx for ZWINT Gene

This gene is overexpressed in Testis (x5.0).

Protein differential expression in normal tissues from HIPED for ZWINT Gene

This gene is overexpressed in Testis (42.3) and Fetal ovary (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZWINT Gene



Protein tissue co-expression partners for ZWINT Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZWINT

SOURCE GeneReport for Unigene cluster for ZWINT Gene:

Hs.591363

Evidence on tissue expression from TISSUES for ZWINT Gene

  • Intestine(4.4)
  • Muscle(4.1)
  • Liver(2.4)
  • Skin(2.3)
  • Nervous system(2.1)
  • Blood(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with ZWINT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZWINT Gene

Orthologs for ZWINT Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZWINT Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZWINT 30 31
  • 99.04 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC477579 30
  • 79.4 (n)
ZWINT 31
  • 63 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ZWINT 30
  • 78.84 (n)
-- 31
  • 69 (a)
OneToMany
-- 31
  • 69 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Zwint 30 17 31
  • 72.06 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zwint 30
  • 70.57 (n)
Lizard
(Anolis carolinensis)
Reptilia ZWINT 31
  • 32 (a)
OneToOne
Species where no ortholog for ZWINT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZWINT Gene

ENSEMBL:
Gene Tree for ZWINT (if available)
TreeFam:
Gene Tree for ZWINT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZWINT: view image

Paralogs for ZWINT Gene

No data available for Paralogs for ZWINT Gene

Variants for ZWINT Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZWINT Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
715021 Benign: not provided 56,359,679(-) G/A INTRON_VARIANT
790629 Benign: not provided 56,358,454(-) A/G SYNONYMOUS_VARIANT
rs11005328 - p.Ala4Ser
rs2241666 - p.Arg187Gly

Additional dbSNP identifiers (rs#s) for ZWINT Gene

Structural Variations from Database of Genomic Variants (DGV) for ZWINT Gene

Variant ID Type Subtype PubMed ID
dgv864n100 CNV gain 25217958
esv3623381 CNV gain 21293372
esv3623382 CNV gain 21293372
esv3891822 CNV loss 25118596
nsv1035842 CNV loss 25217958
nsv831883 CNV gain+loss 17160897

Variation tolerance for ZWINT Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.22; 69.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZWINT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZWINT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZWINT Gene

Disorders for ZWINT Gene

MalaCards: The human disease database

(4) MalaCards diseases for ZWINT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
roberts syndrome
  • rbs
pediatric ependymoma
  • childhood ependymoma
syringomyelia
primary autosomal recessive microcephaly
  • mcph
- elite association - COSMIC cancer census association via MalaCards
Search ZWINT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZWINT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZWINT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZWINT Gene

Publications for ZWINT Gene

  1. HZwint-1, a novel human kinetochore component that interacts with HZW10. (PMID: 10806105) Starr DA … Goldberg ML (Journal of cell science 2000) 2 3 4 23
  2. Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. (PMID: 16732327) Lin YT … Lee WH (Oncogene 2006) 3 4 23
  3. Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. (PMID: 15094189) Musio A … Vezzoni P (Gene 2004) 3 4 23
  4. Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. (PMID: 15485811) Wang H … Yao X (The Journal of biological chemistry 2004) 3 4 23
  5. Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study. (PMID: 19008095) Brendle A … Försti A (European journal of cancer (Oxford, England : 1990) 2009) 3 41

Products for ZWINT Gene

Sources for ZWINT Gene