This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011] See more...

Aliases for ZW10 Gene

Aliases for ZW10 Gene

  • Zw10 Kinetochore Protein 2 3 5
  • Centromere/Kinetochore Protein Zw10 Homolog 3 4
  • KNTC1AP 2 3
  • ZW10 (Drosophila) Homolog, Centromere/Kinetochore Protein 2
  • ZW10, Kinetochore Associated, Homolog (Drosophila) 2
  • ZW10 Homolog, Centromere/Kinetochore Protein 3
  • ZW10, Kinetochore Associated, Homolog 3
  • Zeste White 10 Homolog 3
  • HZW10 3
  • ZW10 5

External Ids for ZW10 Gene

Previous GeneCards Identifiers for ZW10 Gene

  • GC11M115956
  • GC11M115115
  • GC11M113637
  • GC11M113141
  • GC11M113110
  • GC11M113603
  • GC11M109532

Summaries for ZW10 Gene

Entrez Gene Summary for ZW10 Gene

  • This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZW10 Gene

ZW10 (Zw10 Kinetochore Protein) is a Protein Coding gene. Diseases associated with ZW10 include Polyposis Syndrome, Hereditary Mixed, 1 and Hereditary Mixed Polyposis Syndrome. Among its related pathways are Signaling by GPCR and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include centromeric DNA binding.

UniProtKB/Swiss-Prot Summary for ZW10 Gene

  • Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241).

Gene Wiki entry for ZW10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZW10 Gene

Genomics for ZW10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZW10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZW10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZW10

Top Transcription factor binding sites by QIAGEN in the ZW10 gene promoter:
  • CUTL1
  • Evi-1
  • GATA-2
  • HNF-1
  • HNF-1A
  • Lmo2
  • POU2F1
  • POU2F1a
  • USF-1
  • USF1

Genomic Locations for ZW10 Gene

Latest Assembly
chr11:113,733,183-113,773,735
(GRCh38/hg38)
Size:
40,553 bases
Orientation:
Minus strand

Previous Assembly
chr11:113,603,909-113,644,414
(GRCh37/hg19 by Entrez Gene)
Size:
40,506 bases
Orientation:
Minus strand

chr11:113,603,909-113,644,533
(GRCh37/hg19 by Ensembl)
Size:
40,625 bases
Orientation:
Minus strand

Genomic View for ZW10 Gene

Genes around ZW10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZW10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZW10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZW10 Gene

Proteins for ZW10 Gene

  • Protein details for ZW10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43264-ZW10_HUMAN
    Recommended name:
    Centromere/kinetochore protein zw10 homolog
    Protein Accession:
    O43264
    Secondary Accessions:
    • A1A528

    Protein attributes for ZW10 Gene

    Size:
    779 amino acids
    Molecular mass:
    88829 Da
    Quaternary structure:
    • Interacts with NBAS and KNTC1/ROD; the interactions are mutually exclusive and indicative for its association in two different vesicle tethering complexes (PubMed:11590237, PubMed:15824131, PubMed:20462495). Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH (PubMed:12686595, PubMed:20462495). Component of the NRZ complex composed of NBAS, ZW10 and RINT1/TIP20L; NRZ associates with SNAREs STX18, USE1L, BNIP1/SEC20L and SEC22B (the assembly has been described as syntaxin 18 complex). Interacts directly with RINT1/TIP20L bound to BNIP1/SEC20L (PubMed:15029241, PubMed:15272311, PubMed:20462495, PubMed:19369418). Interacts with C19orf25 and ZWINT (PubMed:15485811, PubMed:15824131., PubMed:16732327). Interacts with ZFYVE1 (PubMed:30970241). Interacts with RAB18 and this interaction is enhanced in the presence of ZFYVE1 (PubMed:30970241).
    Miscellaneous:
    • Overexpression as well as silencing of ZW10 disrupts the morphology of the ER-Golgi intermediate compartment as well as the Golgi apparatus and slows down ER-Golgi transport.

    Alternative splice isoforms for ZW10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZW10 Gene

Post-translational modifications for ZW10 Gene

  • Ubiquitination at Lys624
  • Modification sites at PhosphoSitePlus

Other Protein References for ZW10 Gene

Antibodies for research

  • Abcam antibodies for ZW10

No data available for DME Specific Peptides for ZW10 Gene

Domains & Families for ZW10 Gene

Gene Families for ZW10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ZW10 Gene

InterPro:
Blocks:
  • Centromerekinetochore Zw10
ProtoNet:

Suggested Antigen Peptide Sequences for ZW10 Gene

GenScript: Design optimal peptide antigens:
  • ZW10 protein (A1A528_HUMAN)
  • Centromere/kinetochore protein zw10 homolog (ZW10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43264

UniProtKB/Swiss-Prot:

ZW10_HUMAN :
  • Belongs to the ZW10 family.
Family:
  • Belongs to the ZW10 family.
genes like me logo Genes that share domains with ZW10: view

Function for ZW10 Gene

Molecular function for ZW10 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241).
GENATLAS Biochemistry:
zeste-white 10,Drosophila homolog,moving from the centromere/kinetochore at prometaphase to kinetochore microtubule at metaphase and then back to the centromere/kinetochore at anaphase,recruiting dynein and dynactin to the centromere

Phenotypes From GWAS Catalog for ZW10 Gene

Gene Ontology (GO) - Molecular Function for ZW10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11146660
GO:0019237 centromeric DNA binding TAS 9700164
genes like me logo Genes that share ontologies with ZW10: view
genes like me logo Genes that share phenotypes with ZW10: view

miRNA for ZW10 Gene

miRTarBase miRNAs that target ZW10

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZW10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZW10 Gene

Localization for ZW10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZW10 Gene

Cytoplasm. Endoplasmic reticulum membrane. Peripheral membrane protein. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Lipid droplet. Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm (PubMed:15029241). In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone (PubMed:11590237). {ECO:0000269 PubMed:11590237, ECO:0000269 PubMed:15029241}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZW10 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
golgi apparatus 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZW10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA,IDA 11682612
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000922 spindle pole IDA 11146660
GO:0005634 nucleus IEA,IDA 15485811
genes like me logo Genes that share ontologies with ZW10: view

Pathways & Interactions for ZW10 Gene

genes like me logo Genes that share pathways with ZW10: view

Pathways by source for ZW10 Gene

1 GeneGo (Thomson Reuters) pathway for ZW10 Gene
  • Cell cycle_Spindle assembly and chromosome separation

Gene Ontology (GO) - Biological Process for ZW10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IDA 11146660
GO:0000132 establishment of mitotic spindle orientation IMP 19468067
GO:0000278 mitotic cell cycle IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IMP 15029241
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
genes like me logo Genes that share ontologies with ZW10: view

No data available for SIGNOR curated interactions for ZW10 Gene

Drugs & Compounds for ZW10 Gene

No Compound Related Data Available

Transcripts for ZW10 Gene

mRNA/cDNA for ZW10 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZW10

Alternative Splicing Database (ASD) splice patterns (SP) for ZW10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2: - - -
SP3:

Relevant External Links for ZW10 Gene

GeneLoc Exon Structure for
ZW10

Expression for ZW10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZW10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZW10 Gene

This gene is overexpressed in Bone (50.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZW10 Gene



Protein tissue co-expression partners for ZW10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZW10

SOURCE GeneReport for Unigene cluster for ZW10 Gene:

Hs.503886

mRNA Expression by UniProt/SwissProt for ZW10 Gene:

O43264-ZW10_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for ZW10 Gene

  • Blood(4.3)
  • Nervous system(2.9)
  • Skin(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with ZW10: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZW10 Gene

Orthologs for ZW10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZW10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZW10 30 31
  • 99.74 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZW10 30 31
  • 91.06 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZW10 30 31
  • 89.09 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zw10 30 17 31
  • 84.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zw10 30
  • 84.68 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ZW10 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZW10 30
  • 70.17 (n)
Lizard
(Anolis carolinensis)
Reptilia ZW10 31
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zw10 30
  • 68 (n)
Str.350 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.14398 30
Zebrafish
(Danio rerio)
Actinopterygii zw10 30 31
  • 60.97 (n)
OneToOne
zgc55782 30
Fruit Fly
(Drosophila melanogaster)
Insecta mit(1)15 31 32
  • 22 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea czw-1 30 31
  • 41.94 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ATZW10 30
  • 39.98 (n)
Rice
(Oryza sativa)
Liliopsida Os11g0545700 30
  • 42.11 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1167 31
  • 33 (a)
OneToOne
Species where no ortholog for ZW10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZW10 Gene

ENSEMBL:
Gene Tree for ZW10 (if available)
TreeFam:
Gene Tree for ZW10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZW10: view image

Paralogs for ZW10 Gene

No data available for Paralogs for ZW10 Gene

Variants for ZW10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZW10 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs2271796 - p.Ile77Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZW10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZW10 Gene

Variant ID Type Subtype PubMed ID
nsv820035 CNV loss 19587683

Variation tolerance for ZW10 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZW10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZW10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZW10 Gene

Disorders for ZW10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZW10 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search ZW10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZW10

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZW10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZW10 Gene

Publications for ZW10 Gene

  1. Conservation of the centromere/kinetochore protein ZW10. (PMID: 9298984) Starr DA … Goldberg ML (The Journal of cell biology 1997) 2 3 4 23
  2. Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. (PMID: 20462495) Civril F … Musacchio A (Structure (London, England : 1993) 2010) 3 4 23
  3. Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. (PMID: 16732327) Lin YT … Lee WH (Oncogene 2006) 3 4 23
  4. Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. (PMID: 15485811) Wang H … Yao X (The Journal of biological chemistry 2004) 3 4 23
  5. Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. (PMID: 15094189) Musio A … Vezzoni P (Gene 2004) 3 4 23

Products for ZW10 Gene

Sources for ZW10 Gene