Aliases for ZW10 Gene
External Ids for ZW10 Gene
Previous GeneCards Identifiers for ZW10 Gene
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
GeneCards Summary for ZW10 Gene
ZW10 (Zw10 Kinetochore Protein) is a Protein Coding gene. Diseases associated with ZW10 include Roberts Syndrome and Polyposis Syndrome, Hereditary Mixed, 1. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include centromeric DNA binding.
UniProtKB/Swiss-Prot Summary for ZW10 Gene
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241).