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Aliases for ZUFSP Gene

Aliases for ZUFSP Gene

  • Zinc Finger With UFM1 Specific Peptidase Domain 2 3 5
  • C6orf113 3 4
  • Zinc Finger With UFM1-Specific Peptidase Domain Protein 3
  • Chromosome 6 Open Reading Frame 113 2
  • DJ412I7.3 3

External Ids for ZUFSP Gene

Previous HGNC Symbols for ZUFSP Gene

  • C6orf113

Previous GeneCards Identifiers for ZUFSP Gene

  • GC06M117064
  • GC06M116956
  • GC06M114536

Summaries for ZUFSP Gene

GeneCards Summary for ZUFSP Gene

ZUFSP (Zinc Finger With UFM1 Specific Peptidase Domain) is a Protein Coding gene.

Additional gene information for ZUFSP Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZUFSP Gene

Genomics for ZUFSP Gene

GeneHancer (GH) Regulatory Elements for ZUFSP Gene

Promoters and enhancers for ZUFSP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I116665 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 563.2 +1.3 1308 3.8 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZUFSP CALHM5 KPNA5 RWDD1 DSE GC06P116597
GH06I116276 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 +389.6 389625 5.6 HDGF FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 TSPYL1 ENSG00000240050 PIR59102 DSE CALHM6 TSPYL4 CALHM4 TRAPPC3L KRT18P22 CBX3P9
GH06I116461 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 2.6 +205.2 205156 4.5 MXI1 MAX BACH1 BMI1 E2F1 CTBP1 ZNF316 POLR2A SCRT2 IKZF2 CALHM6 ENSG00000244158 DSE ENSG00000234117 TRAPPC3L RWDD1 TSPYL1 ZUFSP
GH06I116679 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 2 -12.8 -12776 3.2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B KPNA5 GC06M116680 DSE ENSG00000240050 RWDD1 ENSG00000237021 CALHM6 ZUFSP TSPYL1 TSPYL4
GH06I116384 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2.6 +279.4 279354 9.7 PKNOX1 MZF1 BATF IRF4 ZNF366 ATF7 ETV6 FOS BCLAF1 IKZF2 DSE CALHM6 CALHM4 CBX3P9 KRT18P22 ENSG00000244158 ENSG00000234117 TRAPPC3L ENSG00000240050 TSPYL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZUFSP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZUFSP gene promoter:

Genomic Locations for ZUFSP Gene

Genomic Locations for ZUFSP Gene
33,193 bases
Minus strand

Genomic View for ZUFSP Gene

Genes around ZUFSP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZUFSP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZUFSP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZUFSP Gene

Proteins for ZUFSP Gene

  • Protein details for ZUFSP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger with UFM1-specific peptidase domain protein
    Protein Accession:
    Secondary Accessions:
    • Q5TD92
    • Q6PJH7
    • Q96NV6

    Protein attributes for ZUFSP Gene

    578 amino acids
    Molecular mass:
    65959 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI20499.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZUFSP Gene


neXtProt entry for ZUFSP Gene

Post-translational modifications for ZUFSP Gene

  • Ubiquitination at posLast=262262, isoforms=276, isoforms=301, posLast=356356, posLast=525525, and isoforms=2534
  • Modification sites at PhosphoSitePlus

Other Protein References for ZUFSP Gene

No data available for DME Specific Peptides for ZUFSP Gene

Domains & Families for ZUFSP Gene

Gene Families for ZUFSP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZUFSP Gene

Suggested Antigen Peptide Sequences for ZUFSP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZUFSP: view

No data available for UniProtKB/Swiss-Prot for ZUFSP Gene

Function for ZUFSP Gene

Phenotypes From GWAS Catalog for ZUFSP Gene

Gene Ontology (GO) - Molecular Function for ZUFSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZUFSP: view
genes like me logo Genes that share phenotypes with ZUFSP: view

Animal Model Products

CRISPR Products

miRNA for ZUFSP Gene

miRTarBase miRNAs that target ZUFSP

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZUFSP Gene

Localization for ZUFSP Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZUFSP gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZUFSP Gene

Pathways & Interactions for ZUFSP Gene

SuperPathways for ZUFSP Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZUFSP Gene


No data available for Pathways by source and SIGNOR curated interactions for ZUFSP Gene

Drugs & Compounds for ZUFSP Gene

No Compound Related Data Available

Transcripts for ZUFSP Gene

Unigene Clusters for ZUFSP Gene

Zinc finger with UFM1-specific peptidase domain:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZUFSP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP2: -

Relevant External Links for ZUFSP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZUFSP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZUFSP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZUFSP Gene

This gene is overexpressed in Fetal Brain (42.2), Platelet (17.1), and Brain (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZUFSP Gene

Protein tissue co-expression partners for ZUFSP Gene

NURSA nuclear receptor signaling pathways regulating expression of ZUFSP Gene:


SOURCE GeneReport for Unigene cluster for ZUFSP Gene:


Evidence on tissue expression from TISSUES for ZUFSP Gene

  • Liver(4.6)
  • Heart(4.2)
  • Intestine(4.1)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with ZUFSP: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZUFSP Gene

Orthologs for ZUFSP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZUFSP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZUFSP 33 34
  • 99.6 (n)
(Canis familiaris)
Mammalia ZUFSP 33 34
  • 90.24 (n)
(Bos Taurus)
Mammalia ZUFSP 33 34
  • 90.08 (n)
(Mus musculus)
Mammalia Zufsp 33 16 34
  • 86.56 (n)
(Rattus norvegicus)
Mammalia Zufsp 33
  • 83.59 (n)
(Ornithorhynchus anatinus)
Mammalia ZUFSP 34
  • 70 (a)
(Monodelphis domestica)
Mammalia ZUFSP 34
  • 66 (a)
(Gallus gallus)
Aves ZUFSP 33 34
  • 71.78 (n)
(Anolis carolinensis)
Reptilia ZUFSP 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zufsp 33
  • 60.81 (n)
Str.3949 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19781 33
(Danio rerio)
Actinopterygii zufsp 33 34
  • 54.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009608 33
  • 44.23 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mug105 33
  • 46.97 (n)
Species where no ortholog for ZUFSP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZUFSP Gene

Gene Tree for ZUFSP (if available)
Gene Tree for ZUFSP (if available)

Paralogs for ZUFSP Gene

No data available for Paralogs for ZUFSP Gene

Variants for ZUFSP Gene

Sequence variations from dbSNP and Humsavar for ZUFSP Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000004685 -- 116,636,011(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000006489 -- 116,638,972(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000106954 -- 116,643,467(-) A/C genic_downstream_transcript_variant, intron_variant
rs1000138104 -- 116,643,318(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000202045 -- 116,657,930(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZUFSP Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV gain 19592680
nsv5448 CNV insertion 18451855
nsv830783 CNV gain 17160897

Variation tolerance for ZUFSP Gene

Residual Variation Intolerance Score: 41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.94; 83.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZUFSP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZUFSP Gene

Disorders for ZUFSP Gene

Additional Disease Information for ZUFSP

No disorders were found for ZUFSP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZUFSP Gene

Publications for ZUFSP Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58

Products for ZUFSP Gene

Sources for ZUFSP Gene

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