Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZSWIM8 Gene

Aliases for ZSWIM8 Gene

  • Zinc Finger SWIM-Type Containing 8 2 3 5
  • KIAA0913 2 3 4
  • Zinc Finger SWIM Domain-Containing Protein 8 3 4

External Ids for ZSWIM8 Gene

Previous HGNC Symbols for ZSWIM8 Gene

  • KIAA0913

Previous GeneCards Identifiers for ZSWIM8 Gene

  • GC10P075546
  • GC10P075549
  • GC10P075555

Summaries for ZSWIM8 Gene

GeneCards Summary for ZSWIM8 Gene

ZSWIM8 (Zinc Finger SWIM-Type Containing 8) is a Protein Coding gene. An important paralog of this gene is ZSWIM6.

Additional gene information for ZSWIM8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM8 Gene

Genomics for ZSWIM8 Gene

GeneHancer (GH) Regulatory Elements for ZSWIM8 Gene

Promoters and enhancers for ZSWIM8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J073784 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 600.7 +0.5 485 2.7 HDGF SP1 ZFX MNT SIX5 ZNF148 NKRF CEBPG CDC5L MAFK GC10P073789 GC10P073790 ZSWIM8 SEC24C BMS1P4 ENSG00000272140 MYOZ1 ENSG00000242288 RPL17P50 AP3M1
GH10J073792 Promoter 0.5 EPDnew 600.4 +7.2 7195 0.1 ENSG00000280238 ZSWIM8 ENSG00000224195 CAMK2G FUT11 SEC24C ENSG00000229990 C10orf55 ZSWIM8-AS1
GH10J073243 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 36.2 -539.3 -539344 5.5 ZFX CC2D1A ELF3 ZKSCAN8 MNT CBFA2T2 ZNF148 NKRF POLR2A MLLT1 DNAJC9 DNAJC9-AS1 ZSWIM8 SEC24C NDST2 NUDT13 ZSWIM8-AS1 GLUD1P3 ECD DNAJB12
GH10J073809 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 34.2 +25.4 25441 3.5 SP1 ELF3 ZFX MNT SIX5 CBFA2T2 NKRF POLR2A MLLT1 ZNF384 NDST2 ENSG00000272916 ECD ZSWIM8 DUSP8P5 SEC24C FUT11 ENSG00000272140 GLUD1P3 ENSG00000242288
GH10J073250 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 32.7 -533.2 -533184 3.6 SP1 ZFX ELF3 MNT SIX5 NKRF POLR2A MLLT1 CEBPG GTF2F1 ENSG00000227540 MRPS16 DNAJB12 NUDT13 ZSWIM8 ECD GLUD1P3 ZSWIM8-AS1 NDST2 SEC24C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSWIM8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZSWIM8 Gene

Genomic Locations for ZSWIM8 Gene
chr10:73,785,577-73,801,798
(GRCh38/hg38)
Size:
16,222 bases
Orientation:
Plus strand
chr10:75,545,340-75,561,556
(GRCh37/hg19)
Size:
16,217 bases
Orientation:
Plus strand

Genomic View for ZSWIM8 Gene

Genes around ZSWIM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSWIM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSWIM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM8 Gene

Proteins for ZSWIM8 Gene

  • Protein details for ZSWIM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A7E2V4-ZSWM8_HUMAN
    Recommended name:
    Zinc finger SWIM domain-containing protein 8
    Protein Accession:
    A7E2V4
    Secondary Accessions:
    • B2RP37
    • O94987
    • Q17RS8
    • Q2TAB8
    • Q6P439
    • Q8IW81
    • Q8NB34
    • Q9H8F3

    Protein attributes for ZSWIM8 Gene

    Size:
    1837 amino acids
    Molecular mass:
    197297 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI37250.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAI37251.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA74936.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA74936.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAB14664.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03709.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZSWIM8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSWIM8 Gene

Post-translational modifications for ZSWIM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSWIM8 Gene

Domains & Families for ZSWIM8 Gene

Gene Families for ZSWIM8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZSWIM8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZSWIM8 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger SWIM domain-containing protein KIAA0913 (K0913_HUMAN)
  • KIAA0913 protein (Q8N420_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZSWIM8: view

No data available for UniProtKB/Swiss-Prot for ZSWIM8 Gene

Function for ZSWIM8 Gene

Phenotypes From GWAS Catalog for ZSWIM8 Gene

Gene Ontology (GO) - Molecular Function for ZSWIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSWIM8: view
genes like me logo Genes that share phenotypes with ZSWIM8: view

Animal Model Products

CRISPR Products

miRNA for ZSWIM8 Gene

miRTarBase miRNAs that target ZSWIM8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSWIM8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSWIM8 Gene

Localization for ZSWIM8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSWIM8 gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSWIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031462 Cul2-RING ubiquitin ligase complex IBA 21873635
genes like me logo Genes that share ontologies with ZSWIM8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZSWIM8 Gene

Pathways & Interactions for ZSWIM8 Gene

PathCards logo

SuperPathways for ZSWIM8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSWIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902667 regulation of axon guidance IBA 21873635
genes like me logo Genes that share ontologies with ZSWIM8: view

No data available for Pathways by source and SIGNOR curated interactions for ZSWIM8 Gene

Drugs & Compounds for ZSWIM8 Gene

No Compound Related Data Available

Transcripts for ZSWIM8 Gene

Unigene Clusters for ZSWIM8 Gene

Zinc finger, SWIM-type containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSWIM8

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM8 Gene

No ASD Table

Relevant External Links for ZSWIM8 Gene

GeneLoc Exon Structure for
ZSWIM8
ECgene alternative splicing isoforms for
ZSWIM8

Expression for ZSWIM8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSWIM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZSWIM8 Gene

This gene is overexpressed in Brain (53.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZSWIM8 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZSWIM8 Gene:

ZSWIM8

SOURCE GeneReport for Unigene cluster for ZSWIM8 Gene:

Hs.65135

Evidence on tissue expression from TISSUES for ZSWIM8 Gene

  • Nervous system(4.7)
  • Skin(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with ZSWIM8: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSWIM8 Gene

Orthologs for ZSWIM8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZSWIM8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0913 35
  • 100 (a)
OneToOne
ZSWIM8 34
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia ZSWIM8 35 34
  • 94.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZSWIM8 35 34
  • 93.38 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zswim8 17 35 34
  • 91.24 (n)
oppossum
(Monodelphis domestica)
Mammalia ZSWIM8 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zswim8 34
  • 90.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZSWIM8 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0913 35 34
  • 73.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZSWIM8 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zswim8 34
  • 70.94 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13157 34
zebrafish
(Danio rerio)
Actinopterygii zswim8 35 34
  • 70.27 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34401 35
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToOne
Species where no ortholog for ZSWIM8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZSWIM8 Gene

ENSEMBL:
Gene Tree for ZSWIM8 (if available)
TreeFam:
Gene Tree for ZSWIM8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSWIM8: view image

Paralogs for ZSWIM8 Gene

Paralogs for ZSWIM8 Gene

(1) SIMAP similar genes for ZSWIM8 Gene using alignment to 10 proteins:

  • ZSWM8_HUMAN
  • H0YCW2_HUMAN
  • H7BZ52_HUMAN
  • H7C453_HUMAN
  • S4R393_HUMAN
  • S4R3B3_HUMAN
  • S4R3H3_HUMAN
  • S4R3S6_HUMAN
  • S4R3U7_HUMAN
  • S4R410_HUMAN
genes like me logo Genes that share paralogs with ZSWIM8: view

Variants for ZSWIM8 Gene

Sequence variations from dbSNP and Humsavar for ZSWIM8 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000017397 -- 73,798,973(+) C/A/T genic_downstream_transcript_variant, intron_variant
rs1000035989 -- 73,793,182(+) G/A intron_variant
rs1000108319 -- 73,799,875(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000176467 -- 73,798,184(+) GG/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000419857 -- 73,786,457(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZSWIM8 Gene

Variant ID Type Subtype PubMed ID
dgv46n21 CNV loss 19592680
nsv1035634 CNV gain 25217958
nsv551516 CNV loss 21841781
nsv551517 CNV loss 21841781
nsv825468 CNV gain 20364138
nsv831912 CNV gain 17160897

Variation tolerance for ZSWIM8 Gene

Residual Variation Intolerance Score: 0.675% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSWIM8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSWIM8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSWIM8 Gene

Disorders for ZSWIM8 Gene

Additional Disease Information for ZSWIM8

No disorders were found for ZSWIM8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSWIM8 Gene

Publications for ZSWIM8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 58
  3. Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability. (PMID: 29576527) Kwasna D … Kulathu Y (Molecular cell 2018) 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. (PMID: 29229926) Lu H … Bohr VA (Nature communications 2017) 3 58

Products for ZSWIM8 Gene

Sources for ZSWIM8 Gene

Content
Loading form....