Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZSWIM5 Gene

Aliases for ZSWIM5 Gene

  • Zinc Finger SWIM-Type Containing 5 2 3 5
  • KIAA1511 4

External Ids for ZSWIM5 Gene

Previous GeneCards Identifiers for ZSWIM5 Gene

  • GC01M044895
  • GC01M045151
  • GC01M045254
  • GC01M045482
  • GC01M043594

Summaries for ZSWIM5 Gene

GeneCards Summary for ZSWIM5 Gene

ZSWIM5 (Zinc Finger SWIM-Type Containing 5) is a Protein Coding gene. An important paralog of this gene is ZSWIM6.

Additional gene information for ZSWIM5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM5 Gene

Genomics for ZSWIM5 Gene

GeneHancer (GH) Regulatory Elements for ZSWIM5 Gene

Promoters and enhancers for ZSWIM5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I045205 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 564.9 +99.9 99917 2.6 PKNOX1 SIN3A DMAP1 ZNF2 ZNF48 YY1 ZNF121 ZNF766 ZNF213 KLF13 ZSWIM5 BEST4 PTCH2 GC01P045223 PIR54881
GH01I044325 Enhancer 1.6 UCNEbase Ensembl ENCODE 36.8 +978.3 978326 4 PKNOX1 FOXA2 NEUROD1 SIN3A FEZF1 ZNF2 YY1 ZNF213 FOS KLF13 ZSWIM5 SZT2 PTCH2 LOC101929609 DMAP1 ERI3 HYI ERI3-IT1 ARTN GC01P044305
GH01I044774 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.1 +530.0 529991 3.7 ZFP64 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 MCM3 SP3 RPS8 ENSG00000225721 GC01P044811 GC01P044822 GC01P044828 GC01P044830 GC01P044833 SNORD38A SNORD46 SNORD55
GH01I045520 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 20.8 -215.6 -215641 3.7 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 PRDX1 CCDC163 TOE1 LRRC41 MUTYH GPBP1L1 RPS8 RPL7AP16 NASP ZSWIM5
GH01I044404 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 20.1 +900.6 900638 2 ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF416 ZNF143 MCM3 KAT8 MIER3 RNF220 LOC101929609 TOE1 ZSWIM5 DMAP1 RPS8 PTCH2 MUTYH ATP6V0B MIR5584
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZSWIM5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZSWIM5 gene promoter:

Genomic Locations for ZSWIM5 Gene

Genomic Locations for ZSWIM5 Gene
chr1:45,016,399-45,306,209
(GRCh38/hg38)
Size:
289,811 bases
Orientation:
Minus strand
chr1:45,482,071-45,771,881
(GRCh37/hg19)

Genomic View for ZSWIM5 Gene

Genes around ZSWIM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSWIM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSWIM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM5 Gene

Proteins for ZSWIM5 Gene

  • Protein details for ZSWIM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P217-ZSWM5_HUMAN
    Recommended name:
    Zinc finger SWIM domain-containing protein 5
    Protein Accession:
    Q9P217
    Secondary Accessions:
    • Q5SXQ9

    Protein attributes for ZSWIM5 Gene

    Size:
    1185 amino acids
    Molecular mass:
    130634 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA96035.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZSWIM5 Gene

Post-translational modifications for ZSWIM5 Gene

No Post-translational modifications

Other Protein References for ZSWIM5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZSWIM5 Gene

Domains & Families for ZSWIM5 Gene

Gene Families for ZSWIM5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZSWIM5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZSWIM5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZSWIM5: view

No data available for UniProtKB/Swiss-Prot for ZSWIM5 Gene

Function for ZSWIM5 Gene

Phenotypes From GWAS Catalog for ZSWIM5 Gene

Gene Ontology (GO) - Molecular Function for ZSWIM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSWIM5: view

Phenotypes for ZSWIM5 Gene

genes like me logo Genes that share phenotypes with ZSWIM5: view

Animal Models for ZSWIM5 Gene

MGI Knock Outs for ZSWIM5:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZSWIM5 Gene

Localization for ZSWIM5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSWIM5 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSWIM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
genes like me logo Genes that share ontologies with ZSWIM5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZSWIM5 Gene

Pathways & Interactions for ZSWIM5 Gene

SuperPathways for ZSWIM5 Gene

No Data Available

Interacting Proteins for ZSWIM5 Gene

Gene Ontology (GO) - Biological Process for ZSWIM5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZSWIM5 Gene

Drugs & Compounds for ZSWIM5 Gene

No Compound Related Data Available

Transcripts for ZSWIM5 Gene

mRNA/cDNA for ZSWIM5 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSWIM5 Gene

Zinc finger, SWIM-type containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM5 Gene

No ASD Table

Relevant External Links for ZSWIM5 Gene

GeneLoc Exon Structure for
ZSWIM5
ECgene alternative splicing isoforms for
ZSWIM5

Expression for ZSWIM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSWIM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZSWIM5 Gene

This gene is overexpressed in Adrenal Gland (x4.9).

Protein differential expression in normal tissues from HIPED for ZSWIM5 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZSWIM5 Gene



Protein tissue co-expression partners for ZSWIM5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZSWIM5 Gene:

ZSWIM5

SOURCE GeneReport for Unigene cluster for ZSWIM5 Gene:

Hs.656613

Evidence on tissue expression from TISSUES for ZSWIM5 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZSWIM5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSWIM5 Gene

Orthologs for ZSWIM5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZSWIM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSWIM5 33 34
  • 99.75 (n)
cow
(Bos Taurus)
Mammalia ZSWIM5 33 34
  • 92.63 (n)
mouse
(Mus musculus)
Mammalia Zswim5 33 16 34
  • 91.34 (n)
rat
(Rattus norvegicus)
Mammalia Zswim5 33
  • 91.07 (n)
dog
(Canis familiaris)
Mammalia ZSWIM5 33 34
  • 89.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 87 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 88 (a)
ManyToMany
ZSWIM5 33
  • 79.16 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 74 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zswim5 33
  • 74.03 (n)
zebrafish
(Danio rerio)
Actinopterygii zswim5 33
  • 75.2 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010062 33
  • 57.63 (n)
worm
(Caenorhabditis elegans)
Secernentea ebax-1 34
  • 13 (a)
OneToMany
Species where no ortholog for ZSWIM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZSWIM5 Gene

ENSEMBL:
Gene Tree for ZSWIM5 (if available)
TreeFam:
Gene Tree for ZSWIM5 (if available)

Paralogs for ZSWIM5 Gene

Paralogs for ZSWIM5 Gene

(2) SIMAP similar genes for ZSWIM5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZSWIM5 Gene

genes like me logo Genes that share paralogs with ZSWIM5: view

Variants for ZSWIM5 Gene

Sequence variations from dbSNP and Humsavar for ZSWIM5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000002089 -- 45,096,722(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000021270 -- 45,099,867(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000031836 -- 45,150,663(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000035603 -- 45,114,269(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000043954 -- 45,187,544(-) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZSWIM5 Gene

Variant ID Type Subtype PubMed ID
nsv950707 CNV duplication 24416366
nsv945918 CNV duplication 23825009
nsv945917 CNV duplication 23825009
nsv945916 CNV duplication 23825009
nsv546157 CNV loss 21841781
nsv546156 CNV loss 21841781
nsv546155 CNV loss 21841781
nsv546149 CNV loss 21841781
nsv546148 CNV loss 21841781
nsv524385 CNV loss 19592680
nsv471868 CNV novel sequence insertion 20440878
nsv1146974 CNV deletion 26484159
nsv1133847 CNV deletion 24896259
nsv1126995 CNV deletion 24896259
nsv1126197 CNV deletion 24896259
nsv1122338 CNV deletion 24896259
nsv1078386 CNV deletion 25765185
esv3585900 CNV loss 21293372
esv3585898 CNV loss 21293372
esv3585895 CNV loss 21293372
esv3577836 CNV loss 25503493
esv3577835 CNV loss 25503493
esv3577832 CNV loss 25503493
esv3577831 CNV loss 25503493
esv2760743 CNV loss 21179565
esv2747785 CNV deletion 23290073
esv2674119 CNV deletion 23128226
esv2664539 CNV deletion 23128226
esv24105 CNV loss 19812545
dgv30e212 CNV loss 25503493
dgv256n54 CNV loss 21841781

Variation tolerance for ZSWIM5 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.03; 60.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSWIM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSWIM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSWIM5 Gene

Disorders for ZSWIM5 Gene

Additional Disease Information for ZSWIM5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZSWIM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSWIM5 Gene

Publications for ZSWIM5 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) Böhm D … Grus FH (Oncology reports 2012) 3 58

Products for ZSWIM5 Gene

Sources for ZSWIM5 Gene

Content
Loading form....