Aliases for ZSWIM4 Gene

Aliases for ZSWIM4 Gene

  • Zinc Finger SWIM-Type Containing 4 2 3 5
  • Zinc Finger SWIM Domain-Containing Protein 4 3 4
  • FLJ12221 2
  • ZSWIM4 5

External Ids for ZSWIM4 Gene

Previous GeneCards Identifiers for ZSWIM4 Gene

  • GC19P013767
  • GC19P013906
  • GC19P013477

Summaries for ZSWIM4 Gene

GeneCards Summary for ZSWIM4 Gene

ZSWIM4 (Zinc Finger SWIM-Type Containing 4) is a Protein Coding gene. Diseases associated with ZSWIM4 include Acromelic Frontonasal Dysostosis. An important paralog of this gene is ZSWIM5.

Additional gene information for ZSWIM4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSWIM4 Gene

Genomics for ZSWIM4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZSWIM4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSWIM4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZSWIM4

Top Transcription factor binding sites by QIAGEN in the ZSWIM4 gene promoter:
  • Egr-1
  • Lmo2
  • Pax-2
  • Sox9
  • SRF
  • SRF (504 AA)
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for ZSWIM4 Gene

Genomic Locations for ZSWIM4 Gene
chr19:13,795,424-13,832,254
(GRCh38/hg38)
Size:
36,831 bases
Orientation:
Plus strand
chr19:13,906,274-13,943,044
(GRCh37/hg19)
Size:
36,771 bases
Orientation:
Plus strand

Genomic View for ZSWIM4 Gene

Genes around ZSWIM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSWIM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSWIM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM4 Gene

Proteins for ZSWIM4 Gene

  • Protein details for ZSWIM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7M6-ZSWM4_HUMAN
    Recommended name:
    Zinc finger SWIM domain-containing protein 4
    Protein Accession:
    Q9H7M6

    Protein attributes for ZSWIM4 Gene

    Size:
    989 amino acids
    Molecular mass:
    110138 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15742.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZSWIM4 Gene

Post-translational modifications for ZSWIM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSWIM4 Gene

Domains & Families for ZSWIM4 Gene

Gene Families for ZSWIM4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ZSWIM4 Gene

InterPro:
Blocks:
  • SWIM Zn-finger
ProtoNet:

Suggested Antigen Peptide Sequences for ZSWIM4 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger SWIM domain-containing protein 4 (ZSWM4_HUMAN)
genes like me logo Genes that share domains with ZSWIM4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZSWIM4 Gene

Function for ZSWIM4 Gene

Phenotypes From GWAS Catalog for ZSWIM4 Gene

Gene Ontology (GO) - Molecular Function for ZSWIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSWIM4: view
genes like me logo Genes that share phenotypes with ZSWIM4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSWIM4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSWIM4 Gene

Localization for ZSWIM4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSWIM4 gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for ZSWIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031462 Cul2-RING ubiquitin ligase complex IBA 21873635
genes like me logo Genes that share ontologies with ZSWIM4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ZSWIM4 Gene

Pathways & Interactions for ZSWIM4 Gene

PathCards logo

SuperPathways for ZSWIM4 Gene

No Data Available

Interacting Proteins for ZSWIM4 Gene

Gene Ontology (GO) - Biological Process for ZSWIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902667 regulation of axon guidance IBA 21873635
genes like me logo Genes that share ontologies with ZSWIM4: view

No data available for Pathways by source and SIGNOR curated interactions for ZSWIM4 Gene

Drugs & Compounds for ZSWIM4 Gene

No Compound Related Data Available

Transcripts for ZSWIM4 Gene

mRNA/cDNA for ZSWIM4 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSWIM4

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - - -
SP3: -

Relevant External Links for ZSWIM4 Gene

GeneLoc Exon Structure for
ZSWIM4

Expression for ZSWIM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSWIM4 Gene

mRNA differential expression in normal tissues according to GTEx for ZSWIM4 Gene

This gene is overexpressed in Minor Salivary Gland (x4.6) and Esophagus - Mucosa (x4.4).

Protein differential expression in normal tissues from HIPED for ZSWIM4 Gene

This gene is overexpressed in Serum (36.0) and Heart (33.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZSWIM4 Gene



Protein tissue co-expression partners for ZSWIM4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZSWIM4

SOURCE GeneReport for Unigene cluster for ZSWIM4 Gene:

Hs.466015

Evidence on tissue expression from TISSUES for ZSWIM4 Gene

  • Spleen(4)
genes like me logo Genes that share expression patterns with ZSWIM4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSWIM4 Gene

Orthologs for ZSWIM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZSWIM4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZSWIM4 30 31
  • 99.49 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZSWIM4 30 31
  • 91 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZSWIM4 30 31
  • 90.17 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zswim4 30 17 31
  • 84.66 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zswim4 30
  • 84.03 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZSWIM4 31
  • 79 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZSWIM4 31
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 68 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia ZSWIM4 31
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zswim4 30
  • 74.97 (n)
Str.523 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.2486 30
Zebrafish
(Danio rerio)
Actinopterygii zswim5 31
  • 59 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea ebax-1 31
  • 12 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
OneToOne
Species where no ortholog for ZSWIM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZSWIM4 Gene

ENSEMBL:
Gene Tree for ZSWIM4 (if available)
TreeFam:
Gene Tree for ZSWIM4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSWIM4: view image

Paralogs for ZSWIM4 Gene

Paralogs for ZSWIM4 Gene

(2) SIMAP similar genes for ZSWIM4 Gene using alignment to 4 proteins:

  • ZSWM4_HUMAN
  • E7ERX2_HUMAN
  • K7EJI0_HUMAN
  • K7ERJ6_HUMAN
genes like me logo Genes that share paralogs with ZSWIM4: view

Variants for ZSWIM4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZSWIM4 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
737178 Benign: not provided 13,813,142(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ZSWIM4 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZSWIM4 Gene

Variant ID Type Subtype PubMed ID
esv2665506 CNV deletion 23128226
nsv1123222 CNV deletion 24896259
nsv833757 CNV loss 17160897
nsv953979 CNV deletion 24416366

Variation tolerance for ZSWIM4 Gene

Residual Variation Intolerance Score: 7.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.38; 76.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSWIM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSWIM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSWIM4 Gene

Disorders for ZSWIM4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZSWIM4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acromelic frontonasal dysostosis
  • afnd
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZSWIM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZSWIM4 Gene

Publications for ZSWIM4 Gene

  1. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4
  2. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  3. Colonic transcriptional response to 1α,25(OH)2 vitamin D3 in African- and European-Americans. (PMID: 28163244) Alleyne D … Kupfer SS (The Journal of steroid biochemistry and molecular biology 2017) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3

Products for ZSWIM4 Gene

Sources for ZSWIM4 Gene