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Aliases for ZSWIM4 Gene

Aliases for ZSWIM4 Gene

  • Zinc Finger SWIM-Type Containing 4 2 3 5

External Ids for ZSWIM4 Gene

Previous GeneCards Identifiers for ZSWIM4 Gene

  • GC19P013906
  • GC19P013477

Summaries for ZSWIM4 Gene

GeneCards Summary for ZSWIM4 Gene

ZSWIM4 (Zinc Finger SWIM-Type Containing 4) is a Protein Coding gene. An important paralog of this gene is ZSWIM5.

Additional gene information for ZSWIM4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSWIM4 Gene

Genomics for ZSWIM4 Gene

GeneHancer (GH) Regulatory Elements for ZSWIM4 Gene

Promoters and enhancers for ZSWIM4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I013793 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 413 5.5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 ZBTB7B IRF4 YY1 ENSG00000267582 GC19P013795 ZSWIM4 LOC284454 DDX39A C19orf53 MRI1 MIR23A MIR24-2 MIR27A
GH19I013860 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 5.4 +66.5 66450 2.6 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A FEZF1 YY1 ZNF207 ZNF143 FOS NANOS3 SNRPGP15 CCDC130 ZSWIM4 RFX1 DCAF15 IL27RA PRKACA GC19M013921
GH19I014080 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5 +286.0 285967 2.8 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 GC19M014079 PRKACA PALM3 ADGRE5 ZSWIM4 ADGRL1 CCDC130 RFX1 PKN1 DCAF15
GH19I014111 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3 +320.7 320700 9.3 HDGF PKNOX1 ARNT ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B YY1 ZNF766 PRKACA DDX39A DCAF15 LOC284454 RFX1 CCDC130 ADGRE5 PALM3 DNAJB1 PKN1
GH19I013833 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 3.3 +49.1 49139 23.1 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GC19M013921 CCDC130 ZNF333 MRI1 DDX39A TRMT1 RFX1 DCAF15 C19orf53 RPS6P25
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZSWIM4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZSWIM4 gene promoter:

Genomic Locations for ZSWIM4 Gene

Genomic Locations for ZSWIM4 Gene
chr19:13,795,434-13,832,254
(GRCh38/hg38)
Size:
36,821 bases
Orientation:
Plus strand
chr19:13,906,274-13,943,044
(GRCh37/hg19)

Genomic View for ZSWIM4 Gene

Genes around ZSWIM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSWIM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSWIM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM4 Gene

Proteins for ZSWIM4 Gene

  • Protein details for ZSWIM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7M6-ZSWM4_HUMAN
    Recommended name:
    Zinc finger SWIM domain-containing protein 4
    Protein Accession:
    Q9H7M6

    Protein attributes for ZSWIM4 Gene

    Size:
    989 amino acids
    Molecular mass:
    110138 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15742.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZSWIM4 Gene

Post-translational modifications for ZSWIM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSWIM4 Gene

Domains & Families for ZSWIM4 Gene

Gene Families for ZSWIM4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ZSWIM4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZSWIM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZSWIM4: view

No data available for UniProtKB/Swiss-Prot for ZSWIM4 Gene

Function for ZSWIM4 Gene

Phenotypes From GWAS Catalog for ZSWIM4 Gene

Gene Ontology (GO) - Molecular Function for ZSWIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSWIM4: view
genes like me logo Genes that share phenotypes with ZSWIM4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSWIM4 Gene

Localization for ZSWIM4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSWIM4 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ZSWIM4 Gene

Pathways & Interactions for ZSWIM4 Gene

SuperPathways for ZSWIM4 Gene

No Data Available

Interacting Proteins for ZSWIM4 Gene

Selected Interacting proteins: Q9H7M6-ZSWM4_HUMAN for ZSWIM4 Gene via IID

Symbol External ID(s) Details
SSBP3

Gene Ontology (GO) - Biological Process for ZSWIM4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZSWIM4 Gene

Drugs & Compounds for ZSWIM4 Gene

No Compound Related Data Available

Transcripts for ZSWIM4 Gene

Unigene Clusters for ZSWIM4 Gene

Zinc finger, SWIM-type containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - - -
SP3: -

Relevant External Links for ZSWIM4 Gene

GeneLoc Exon Structure for
ZSWIM4
ECgene alternative splicing isoforms for
ZSWIM4

Expression for ZSWIM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSWIM4 Gene

mRNA differential expression in normal tissues according to GTEx for ZSWIM4 Gene

This gene is overexpressed in Minor Salivary Gland (x4.6) and Esophagus - Mucosa (x4.4).

Protein differential expression in normal tissues from HIPED for ZSWIM4 Gene

This gene is overexpressed in Serum (36.0) and Heart (33.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZSWIM4 Gene



Protein tissue co-expression partners for ZSWIM4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZSWIM4 Gene:

ZSWIM4

SOURCE GeneReport for Unigene cluster for ZSWIM4 Gene:

Hs.466015

Evidence on tissue expression from TISSUES for ZSWIM4 Gene

  • Spleen(4)
genes like me logo Genes that share expression patterns with ZSWIM4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSWIM4 Gene

Orthologs for ZSWIM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZSWIM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSWIM4 33 34
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia ZSWIM4 33 34
  • 91 (n)
cow
(Bos Taurus)
Mammalia ZSWIM4 33 34
  • 90.17 (n)
mouse
(Mus musculus)
Mammalia Zswim4 33 16 34
  • 84.66 (n)
rat
(Rattus norvegicus)
Mammalia Zswim4 33
  • 84.03 (n)
oppossum
(Monodelphis domestica)
Mammalia ZSWIM4 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZSWIM4 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 68 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ZSWIM4 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zswim4 33
  • 74.97 (n)
Str.523 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2486 33
zebrafish
(Danio rerio)
Actinopterygii zswim5 34
  • 59 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ebax-1 34
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToOne
Species where no ortholog for ZSWIM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZSWIM4 Gene

ENSEMBL:
Gene Tree for ZSWIM4 (if available)
TreeFam:
Gene Tree for ZSWIM4 (if available)

Paralogs for ZSWIM4 Gene

Paralogs for ZSWIM4 Gene

(2) SIMAP similar genes for ZSWIM4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZSWIM4: view

Variants for ZSWIM4 Gene

Sequence variations from dbSNP and Humsavar for ZSWIM4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000062465 -- 13,827,201(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000178087 -- 13,808,300(+) T/C intron_variant
rs1000224605 -- 13,798,506(+) G/A intron_variant
rs1000298298 -- 13,798,192(+) G/A intron_variant
rs1000315952 -- 13,811,058(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZSWIM4 Gene

Variant ID Type Subtype PubMed ID
esv2665506 CNV deletion 23128226
nsv1123222 CNV deletion 24896259
nsv833757 CNV loss 17160897
nsv953979 CNV deletion 24416366

Variation tolerance for ZSWIM4 Gene

Residual Variation Intolerance Score: 7.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.38; 76.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSWIM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSWIM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSWIM4 Gene

Disorders for ZSWIM4 Gene

Additional Disease Information for ZSWIM4

No disorders were found for ZSWIM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSWIM4 Gene

Publications for ZSWIM4 Gene

  1. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  2. Colonic transcriptional response to 1α,25(OH)2 vitamin D3 in African- and European-Americans. (PMID: 28163244) Alleyne D … Kupfer SS (The Journal of steroid biochemistry and molecular biology 2017) 3 58
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for ZSWIM4 Gene

Sources for ZSWIM4 Gene

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