Aliases for ZSWIM3 Gene

Aliases for ZSWIM3 Gene

  • Zinc Finger SWIM-Type Containing 3 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 174 2 3
  • Zinc Finger SWIM Domain-Containing Protein 3 3 4
  • C20orf164 3 4
  • PPP1R174 2 3
  • Zinc Finger, SWIM Domain Containing 3 3
  • Chromosome 20 Open Reading Frame 164 2
  • DJ337O18.7 2
  • ZSWIM3 5

External Ids for ZSWIM3 Gene

Previous HGNC Symbols for ZSWIM3 Gene

  • C20orf164

Previous GeneCards Identifiers for ZSWIM3 Gene

  • GC20P045171
  • GC20P043919
  • GC20P044486
  • GC20P041227

Summaries for ZSWIM3 Gene

GeneCards Summary for ZSWIM3 Gene

ZSWIM3 (Zinc Finger SWIM-Type Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transposase activity. An important paralog of this gene is ZSWIM1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSWIM3 Gene

Genomics for ZSWIM3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZSWIM3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSWIM3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZSWIM3

Top Transcription factor binding sites by QIAGEN in the ZSWIM3 gene promoter:
  • AML1a
  • E47
  • Egr-1
  • Egr-2
  • Egr-3
  • Lmo2
  • MIF-1
  • Msx-1
  • PPAR-alpha
  • Tal-1beta

Genomic Locations for ZSWIM3 Gene

Latest Assembly
chr20:45,857,614-45,879,122
(GRCh38/hg38)
Size:
21,509 bases
Orientation:
Plus strand

Previous Assembly
chr20:44,486,253-44,507,761
(GRCh37/hg19 by Entrez Gene)
Size:
21,509 bases
Orientation:
Plus strand

chr20:44,486,256-44,507,761
(GRCh37/hg19 by Ensembl)
Size:
21,506 bases
Orientation:
Plus strand

Genomic View for ZSWIM3 Gene

Genes around ZSWIM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSWIM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSWIM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSWIM3 Gene

Proteins for ZSWIM3 Gene

  • Protein details for ZSWIM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MP5-ZSWM3_HUMAN
    Recommended name:
    Zinc finger SWIM domain-containing protein 3
    Protein Accession:
    Q96MP5
    Secondary Accessions:
    • Q9BR13

    Protein attributes for ZSWIM3 Gene

    Size:
    696 amino acids
    Molecular mass:
    79454 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSWIM3 Gene

Post-translational modifications for ZSWIM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSWIM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZSWIM3 Gene

Domains & Families for ZSWIM3 Gene

Gene Families for ZSWIM3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZSWIM3 Gene

InterPro:
Blocks:
  • SWIM Zn-finger
ProtoNet:

Suggested Antigen Peptide Sequences for ZSWIM3 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger SWIM domain-containing protein 3 (ZSWM3_HUMAN)
genes like me logo Genes that share domains with ZSWIM3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZSWIM3 Gene

Function for ZSWIM3 Gene

Phenotypes From GWAS Catalog for ZSWIM3 Gene

Gene Ontology (GO) - Molecular Function for ZSWIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSWIM3: view
genes like me logo Genes that share phenotypes with ZSWIM3: view

miRNA for ZSWIM3 Gene

miRTarBase miRNAs that target ZSWIM3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSWIM3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSWIM3 Gene

Localization for ZSWIM3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSWIM3 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZSWIM3 Gene

Pathways & Interactions for ZSWIM3 Gene

PathCards logo

SuperPathways for ZSWIM3 Gene

No Data Available

Interacting Proteins for ZSWIM3 Gene

Gene Ontology (GO) - Biological Process for ZSWIM3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZSWIM3 Gene

Drugs & Compounds for ZSWIM3 Gene

No Compound Related Data Available

Transcripts for ZSWIM3 Gene

mRNA/cDNA for ZSWIM3 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSWIM3

Alternative Splicing Database (ASD) splice patterns (SP) for ZSWIM3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for ZSWIM3 Gene

GeneLoc Exon Structure for
ZSWIM3

Expression for ZSWIM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSWIM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZSWIM3 Gene



Protein tissue co-expression partners for ZSWIM3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZSWIM3

SOURCE GeneReport for Unigene cluster for ZSWIM3 Gene:

Hs.292135

Evidence on tissue expression from TISSUES for ZSWIM3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZSWIM3: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSWIM3 Gene

Orthologs for ZSWIM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSWIM3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZSWIM3 30 31
  • 99.62 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZSWIM3 30 31
  • 86.95 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zswim3 30
  • 84.13 (n)
Mouse
(Mus musculus)
Mammalia Zswim3 30 17 31
  • 84.03 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZSWIM3 30 31
  • 83.87 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZSWIM3 31
  • 62 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZSWIM3 30 31
  • 56.63 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZSWIM3 31
  • 45 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zswim3 30
  • 53.53 (n)
Str.5469 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15174 30
Species where no ortholog for ZSWIM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZSWIM3 Gene

ENSEMBL:
Gene Tree for ZSWIM3 (if available)
TreeFam:
Gene Tree for ZSWIM3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSWIM3: view image

Paralogs for ZSWIM3 Gene

Paralogs for ZSWIM3 Gene

(1) SIMAP similar genes for ZSWIM3 Gene using alignment to 2 proteins:

  • ZSWM3_HUMAN
  • E7ETT6_HUMAN
genes like me logo Genes that share paralogs with ZSWIM3: view

Variants for ZSWIM3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZSWIM3 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs2903808 - p.Val259Ala
rs35928298 - p.Arg291Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZSWIM3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZSWIM3 Gene

Variant ID Type Subtype PubMed ID
esv2666503 CNV deletion 23128226
nsv1142992 CNV tandem duplication 24896259
nsv179037 CNV deletion 16902084
nsv458993 CNV loss 19166990
nsv517296 CNV loss 19592680
nsv586133 CNV loss 21841781
nsv833990 CNV loss 17160897

Variation tolerance for ZSWIM3 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSWIM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSWIM3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSWIM3 Gene

Disorders for ZSWIM3 Gene

Additional Disease Information for ZSWIM3

No disorders were found for ZSWIM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSWIM3 Gene

Publications for ZSWIM3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4
  4. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZSWIM3 Gene

Sources for ZSWIM3 Gene