Aliases for ZSCAN9 Gene

Aliases for ZSCAN9 Gene

  • Zinc Finger And SCAN Domain Containing 9 2 3 5
  • Zinc Finger Protein 193 2 3 4
  • PRD51 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 9 3 4
  • Cell Proliferation-Inducing Gene 12 Protein 3 4
  • ZNF193 3 4
  • Cell Proliferation-Inducing Protein 12 3
  • ZSCAN9 5

External Ids for ZSCAN9 Gene

Previous HGNC Symbols for ZSCAN9 Gene

  • ZNF193

Previous GeneCards Identifiers for ZSCAN9 Gene

  • GC06P028192
  • GC06P028212

Summaries for ZSCAN9 Gene

GeneCards Summary for ZSCAN9 Gene

ZSCAN9 (Zinc Finger And SCAN Domain Containing 9) is a Protein Coding gene. Diseases associated with ZSCAN9 include Spinocerebellar Ataxia, Autosomal Recessive 23 and Good Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZSCAN23.

UniProtKB/Swiss-Prot Summary for ZSCAN9 Gene

Gene Wiki entry for ZSCAN9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSCAN9 Gene

Genomics for ZSCAN9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZSCAN9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSCAN9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZSCAN9

Genomic Locations for ZSCAN9 Gene

Genomic Locations for ZSCAN9 Gene
chr6:28,224,702-28,233,487
(GRCh38/hg38)
Size:
8,786 bases
Orientation:
Plus strand
chr6:28,192,664-28,201,265
(GRCh37/hg19)
Size:
8,602 bases
Orientation:
Plus strand

Genomic View for ZSCAN9 Gene

Genes around ZSCAN9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN9 Gene

Proteins for ZSCAN9 Gene

  • Protein details for ZSCAN9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15535-ZSC9_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 9
    Protein Accession:
    O15535
    Secondary Accessions:
    • B4E1W6
    • E7EVQ2
    • Q2TTR1

    Protein attributes for ZSCAN9 Gene

    Size:
    394 amino acids
    Molecular mass:
    45954 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZSCAN9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN9 Gene

Post-translational modifications for ZSCAN9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN9 Gene

Domains & Families for ZSCAN9 Gene

Gene Families for ZSCAN9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN9 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • Transcriptional regulator SCAN
ProtoNet:

Suggested Antigen Peptide Sequences for ZSCAN9 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger and SCAN domain-containing protein 9 (ZN193_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15535

UniProtKB/Swiss-Prot:

ZSC9_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN9: view

Function for ZSCAN9 Gene

Molecular function for ZSCAN9 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZSCAN9 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN9: view
genes like me logo Genes that share phenotypes with ZSCAN9: view

Animal Model Products

CRISPR Products

miRNA for ZSCAN9 Gene

miRTarBase miRNAs that target ZSCAN9

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN9 Gene

Localization for ZSCAN9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN9 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZSCAN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN9: view

Pathways & Interactions for ZSCAN9 Gene

PathCards logo

SuperPathways for ZSCAN9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN9: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN9 Gene

Drugs & Compounds for ZSCAN9 Gene

No Compound Related Data Available

Transcripts for ZSCAN9 Gene

mRNA/cDNA for ZSCAN9 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN9

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - -

Relevant External Links for ZSCAN9 Gene

GeneLoc Exon Structure for
ZSCAN9

Expression for ZSCAN9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSCAN9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZSCAN9

SOURCE GeneReport for Unigene cluster for ZSCAN9 Gene:

Hs.100921

Evidence on tissue expression from TISSUES for ZSCAN9 Gene

  • Intestine(4.2)
  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with ZSCAN9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN9 Gene

Orthologs for ZSCAN9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF193 30 31
  • 99.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZSCAN9 31
  • 78 (a)
OneToOne
Species where no ortholog for ZSCAN9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZSCAN9 Gene

ENSEMBL:
Gene Tree for ZSCAN9 (if available)
TreeFam:
Gene Tree for ZSCAN9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSCAN9: view image

Paralogs for ZSCAN9 Gene

(429) SIMAP similar genes for ZSCAN9 Gene using alignment to 5 proteins:

  • ZSC9_HUMAN
  • E9PLJ4_HUMAN
  • E9PQL7_HUMAN
  • U3KQB2_HUMAN
  • U3KQV4_HUMAN
genes like me logo Genes that share paralogs with ZSCAN9: view

Variants for ZSCAN9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZSCAN9 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs148219046 - p.His254Arg

Additional dbSNP identifiers (rs#s) for ZSCAN9 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN9 Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV loss 17160897

Variation tolerance for ZSCAN9 Gene

Residual Variation Intolerance Score: 68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN9 Gene

Disorders for ZSCAN9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZSCAN9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spinocerebellar ataxia, autosomal recessive 23
  • scar23
good syndrome
  • thymoma with hypogammaglobulinemia
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZSCAN9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZSCAN9 Gene

Publications for ZSCAN9 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  3. Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain. (PMID: 9244436) Lee PL … Beutler E (Genomics 1997) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4

Products for ZSCAN9 Gene

Sources for ZSCAN9 Gene