Aliases for ZSCAN5A Gene

Aliases for ZSCAN5A Gene

  • Zinc Finger And SCAN Domain Containing 5A 2 3 5
  • Zinc Finger Protein 495 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 5A 3 4
  • Zinc Finger And SCAN Domain Containing 5 2 3
  • ZNF495 3 4
  • ZSCAN5 3 4

External Ids for ZSCAN5A Gene

Previous HGNC Symbols for ZSCAN5A Gene

  • ZNF495
  • ZSCAN5

Previous GeneCards Identifiers for ZSCAN5A Gene

  • GC19M061426
  • GC19M056732
  • GC19M053042

Summaries for ZSCAN5A Gene

GeneCards Summary for ZSCAN5A Gene

ZSCAN5A (Zinc Finger And SCAN Domain Containing 5A) is a Protein Coding gene. Diseases associated with ZSCAN5A include Dyskeratosis Congenita, Autosomal Recessive 2. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ZSCAN5C.

UniProtKB/Swiss-Prot Summary for ZSCAN5A Gene

Additional gene information for ZSCAN5A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSCAN5A Gene

Genomics for ZSCAN5A Gene

GeneHancer (GH) Regulatory Elements for ZSCAN5A Gene

Promoters and enhancers for ZSCAN5A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSCAN5A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZSCAN5A

Top Transcription factor binding sites by QIAGEN in the ZSCAN5A gene promoter:
  • AREB6
  • CUTL1
  • POU2F1
  • POU2F1a

Genomic Locations for ZSCAN5A Gene

Genomic Locations for ZSCAN5A Gene
chr19:56,219,670-56,368,383
(GRCh38/hg38)
Size:
148,714 bases
Orientation:
Minus strand
chr19:56,732,679-56,879,752
(GRCh37/hg19)
Size:
147,074 bases
Orientation:
Minus strand

Genomic View for ZSCAN5A Gene

Genes around ZSCAN5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN5A Gene

Proteins for ZSCAN5A Gene

  • Protein details for ZSCAN5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUG6-ZSA5A_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 5A
    Protein Accession:
    Q9BUG6
    Secondary Accessions:
    • B4DX98
    • Q49A73
    • Q53F04
    • Q8N7B3

    Protein attributes for ZSCAN5A Gene

    Size:
    496 amino acids
    Molecular mass:
    55865 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZSCAN5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN5A Gene

Post-translational modifications for ZSCAN5A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN5A Gene

Domains & Families for ZSCAN5A Gene

Gene Families for ZSCAN5A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN5A Gene

Blocks:
  • Transcriptional regulator SCAN
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZSCAN5A Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 495 (ZSA5A_HUMAN)
genes like me logo Genes that share domains with ZSCAN5A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZSCAN5A Gene

Function for ZSCAN5A Gene

Molecular function for ZSCAN5A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZSCAN5A Gene

Gene Ontology (GO) - Molecular Function for ZSCAN5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN5A: view
genes like me logo Genes that share phenotypes with ZSCAN5A: view

Animal Model Products

CRISPR Products

miRNA for ZSCAN5A Gene

miRTarBase miRNAs that target ZSCAN5A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN5A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN5A Gene

Localization for ZSCAN5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN5A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN5A gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSCAN5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN5A: view

Pathways & Interactions for ZSCAN5A Gene

PathCards logo

SuperPathways for ZSCAN5A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN5A: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN5A Gene

Drugs & Compounds for ZSCAN5A Gene

No Compound Related Data Available

Transcripts for ZSCAN5A Gene

mRNA/cDNA for ZSCAN5A Gene

16 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN5A

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN5A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1:
SP2: -
SP3:
SP4: -
SP5: - - - -

Relevant External Links for ZSCAN5A Gene

GeneLoc Exon Structure for
ZSCAN5A

Expression for ZSCAN5A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSCAN5A Gene

mRNA differential expression in normal tissues according to GTEx for ZSCAN5A Gene

This gene is overexpressed in Testis (x7.5).

Protein differential expression in normal tissues from HIPED for ZSCAN5A Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZSCAN5A Gene



Protein tissue co-expression partners for ZSCAN5A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZSCAN5A

SOURCE GeneReport for Unigene cluster for ZSCAN5A Gene:

Hs.177688
genes like me logo Genes that share expression patterns with ZSCAN5A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN5A Gene

Orthologs for ZSCAN5A Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN5A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN5A 31 30
  • 99.53 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 31
  • 46 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zscan5b 31
  • 37 (a)
OneToMany
Species where no ortholog for ZSCAN5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN5A Gene

ENSEMBL:
Gene Tree for ZSCAN5A (if available)
TreeFam:
Gene Tree for ZSCAN5A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSCAN5A: view image

Paralogs for ZSCAN5A Gene

(190) SIMAP similar genes for ZSCAN5A Gene using alignment to 8 proteins:

  • ZSA5A_HUMAN
  • B4DX98_HUMAN
  • K7EIX9_HUMAN
  • K7EMC4_HUMAN
  • K7EN85_HUMAN
  • K7EQW6_HUMAN
  • K7ESE4_HUMAN
  • K7ESN6_HUMAN
genes like me logo Genes that share paralogs with ZSCAN5A: view

Variants for ZSCAN5A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZSCAN5A Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769056 Benign: not provided 56,228,378(-) C/G MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
rs145011101 A colorectal cancer sample p.Glu146Gln
rs34187696 - p.Gly337Val

Additional dbSNP identifiers (rs#s) for ZSCAN5A Gene

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN5A Gene

Variant ID Type Subtype PubMed ID
dgv3681n100 CNV gain 25217958
dgv3683n100 CNV gain 25217958
dgv6583n54 CNV loss 21841781
esv2719027 CNV deletion 23290073
esv5726 OTHER inversion 19470904
esv7336 CNV loss 19470904
nsv828646 CNV loss 20364138
nsv828647 CNV loss 20364138
nsv978856 CNV duplication 23825009

Variation tolerance for ZSCAN5A Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.82; 67.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN5A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN5A Gene

Disorders for ZSCAN5A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZSCAN5A Gene - From: DISEASES

Disorder Aliases PubMed IDs
dyskeratosis congenita, autosomal recessive 2
  • dkcb2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZSCAN5A

genes like me logo Genes that share disorders with ZSCAN5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZSCAN5A Gene

Publications for ZSCAN5A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 54
  4. A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S … Beisel C (Cell reports 2016) 3 54
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 54

Products for ZSCAN5A Gene

Sources for ZSCAN5A Gene