Aliases for ZSCAN4 Gene
External Ids for ZSCAN4 Gene
Previous HGNC Symbols for ZSCAN4 Gene
Previous GeneCards Identifiers for ZSCAN4 Gene
The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]
GeneCards Summary for ZSCAN4 Gene
ZSCAN4 (Zinc Finger And SCAN Domain Containing 4) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF263.
UniProtKB/Swiss-Prot Summary for ZSCAN4 Gene
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).