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The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010] See more...
Aliases for ZSCAN4 Gene
Aliases for ZSCAN4 Gene
External Ids for ZSCAN4 Gene
- HGNC: 23709
- Entrez Gene: 201516
- Ensembl: ENSG00000180532
- OMIM: 613419
- UniProtKB: Q8NAM6
Previous HGNC Symbols for ZSCAN4 Gene
- ZNF494
Previous GeneCards Identifiers for ZSCAN4 Gene
- GC19P062874
- GC19P062875
- GC19P058180
- GC19P054492
- GC19P057668
Summaries for ZSCAN4 Gene
-
The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]
GeneCards Summary for ZSCAN4 Gene
ZSCAN4 (Zinc Finger And SCAN Domain Containing 4) is a Protein Coding gene. Diseases associated with ZSCAN4 include Facioscapulohumeral Muscular Dystrophy 1 and Facioscapulohumeral Muscular Dystrophy 2. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF263.
UniProtKB/Swiss-Prot Summary for ZSCAN4 Gene
-
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).
Additional gene information for ZSCAN4 Gene
- HGNC(23709)
- Entrez Gene(201516)
- Ensembl(ENSG00000180532)
- OMIM(613419)
- UniProtKB(Q8NAM6)
- Open Targets Platform(ENSG00000180532)
- Search for ZSCAN4 at DataMed
- Search for ZSCAN4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSCAN4 Gene
Genomics for ZSCAN4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZSCAN4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZSCAN4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZSCAN4
- Top Transcription factor binding sites by QIAGEN in the ZSCAN4 gene promoter:
-
- Elk-1
- FOXC1
- FOXF2
- FOXO1
- FOXO1a
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- SRF
- SRF (504 AA)
Genomic Locations for ZSCAN4 Gene
Genomic Locations for ZSCAN4 Gene
- chr19:57,651,497-57,679,152
- (GRCh38/hg38)
- Size:
- 27,656 bases
- Orientation:
- Plus strand
- chr19:58,180,303-58,190,520
- (GRCh37/hg19)
- Size:
- 10,218 bases
- Orientation:
- Plus strand
Genomic View for ZSCAN4 Gene
Genes around ZSCAN4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.43 by HGNC
- 19q13.43 by Entrez Gene
- 19q13.43 by Ensembl
ZSCAN4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZSCAN4 Gene
Proteins for ZSCAN4 Gene
-
Protein details for ZSCAN4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NAM6-ZSCA4_HUMAN
- Recommended name:
- Zinc finger and SCAN domain-containing protein 4
- Protein Accession:
- Q8NAM6
- Q3MIQ2
Protein attributes for ZSCAN4 Gene
- Size:
- 433 amino acids
- Molecular mass:
- 48957 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for ZSCAN4 Gene
Other Protein References for ZSCAN4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences ZSCAN4 Antibody
- Creative Diagnostics Anti-ZSCAN4 monoclonal antibody, clone 4C2
- Novus Biologicals Antibodies for ZSCAN4
-
Abcam antibodies for ZSCAN4
- Invitrogen Antibodies for ZSCAN4 (AFLGC-ZSCAN4)
-
Boster Bio Antibodies for ZSCAN4
-
Custom Antibody ServicesProSci Antibodies for ZSCAN4
Protein Products
-
OriGene Purified Proteins for ZSCAN4
- Search Origene for MassSpec and Protein Over-expression Lysates for ZSCAN4
- Origene Custom Protein Services for ZSCAN4
- antibodies-online: Show 7 available ZSCAN4 Proteins ranked by validation data
- Compare Top ZSCAN4 Proteins
-
Quality Products:
-
Abcam proteins for ZSCAN4
No data available for DME Specific Peptides for ZSCAN4 Gene
Domains & Families for ZSCAN4 Gene
Gene Families for ZSCAN4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZSCAN4 Gene
- InterPro:
- Blocks:
-
- Transcriptional regulator SCAN
- ProtoNet:
Suggested Antigen Peptide Sequences for ZSCAN4 Gene
- GenScript: Design optimal peptide antigens:
-
- Zinc finger protein 494 (ZSCA4_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZSCAN4 Gene
Function for ZSCAN4 Gene
Molecular function for ZSCAN4 Gene
- UniProtKB/Swiss-Prot Function:
- Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).
Phenotypes From GWAS Catalog for ZSCAN4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZSCAN4 Gene
- GenomeRNAi human phenotypes for ZSCAN4:
-
- no effect
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Upregulation of RLR pathway after Sendai virus (SeV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZSCAN4 - Select products 50% OFF >
- * ZSCAN4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZSCAN4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZSCAN4
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZSCAN4
miRNA for ZSCAN4 Gene
- miRTarBase miRNAs that target ZSCAN4
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for ZSCAN4 - Select products 50% OFF >
- * ZSCAN4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZSCAN4
- Addgene plasmids for ZSCAN4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZSCAN4
Cell Line Products
-
Horizon Cell Lines for ZSCAN4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN4 Gene
Localization for ZSCAN4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN4 Gene
- Nucleus. Chromosome, telomere.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000781 | chromosome, telomeric region | IEA | -- |
| GO:0000784 | nuclear chromosome, telomeric region | ISS | 20336070 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005694 | chromosome | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZSCAN4 Gene
Pathways & Interactions for ZSCAN4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Preimplantation Embryo | ||
Pathways by source for ZSCAN4 Gene
1 BioSystems pathway for ZSCAN4 Gene
Interacting Proteins for ZSCAN4 Gene
Selected Interacting proteins:
Q8NAM6-ZSCA4_HUMAN
ENSP00000321963
for ZSCAN4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ZSCAN4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0010833 | telomere maintenance via telomere lengthening | ISS | 20336070 |
| GO:0045950 | negative regulation of mitotic recombination | ISS | 20336070 |
No data available for SIGNOR curated interactions for ZSCAN4 Gene
Transcripts for ZSCAN4 Gene
mRNA/cDNA for ZSCAN4 Gene
- 1 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000318203 2246 nts (view in UCSC)
- ENST00000612521 1979 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZSCAN4 - Select products 50% OFF >
- * ZSCAN4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZSCAN4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZSCAN4
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZSCAN4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZSCAN4
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Clone Products
- Applied Biological Materials (abm): Clones for ZSCAN4 - Select products 50% OFF >
- * ZSCAN4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZSCAN4
- Addgene plasmids for ZSCAN4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZSCAN4
Relevant External Links for ZSCAN4 Gene
- GeneLoc Exon Structure for
- ZSCAN4
Expression for ZSCAN4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for ZSCAN4 Gene
This gene is overexpressed in Cervix - Endocervix (x6.4) and Bladder (x6.2).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZSCAN4
SOURCE GeneReport for Unigene cluster for ZSCAN4 Gene:
Hs.469663Evidence on tissue expression from TISSUES for ZSCAN4 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for ZSCAN4
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN4 Gene
Orthologs for ZSCAN4 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZSCAN4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZSCAN4 30 |
|
||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | ZSCAN4 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Zscan4e 31 |
|
OneToMany | |
| Zscan4d 31 |
|
OneToMany | |||
| Zscan4c 31 |
|
OneToMany | |||
| Zscan4b 31 |
|
OneToMany | |||
| Zscan4f 31 |
|
OneToMany |
- Species where no ortholog for ZSCAN4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for ZSCAN4 Gene
- ENSEMBL:
- Gene Tree for ZSCAN4 (if available)
- TreeFam:
- Gene Tree for ZSCAN4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZSCAN4: view image
Paralogs for ZSCAN4 Gene
Paralogs for ZSCAN4 Gene
(9) SIMAP similar genes for ZSCAN4 Gene using alignment to 1 proteins:
- ZSCA4_HUMAN
Variants for ZSCAN4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZSCAN4 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 777511 | Benign: not provided | 57,678,455(+) | G/C | MISSENSE_VARIANT | |
| rs11668570 | - | p.Glu387Lys |
Residual Variation Intolerance Score:
46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.79;
33.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZSCAN4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZSCAN4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN4 Gene
Disorders for ZSCAN4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| facioscapulohumeral muscular dystrophy 1 |
|
|
| facioscapulohumeral muscular dystrophy 2 |
|
|
Search ZSCAN4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZSCAN4
No data available for UniProtKB/Swiss-Prot and Genatlas for ZSCAN4 Gene
Publications for ZSCAN4 Gene
- Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. (PMID: 24735877) Dan J … Liu L (Developmental cell 2014) 2 3
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1. (PMID: 29712904) Zhang B … Sun Y (Nature communications 2018) 3
ExternalLinks
Products for ZSCAN4 Gene
- Custom Antibody ServicesOriGene Antibodies for ZSCAN4
- Browse OriGene ELISA Kits
- Custom Assay Services
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- OriGene qPCR primer pairs for ZSCAN4
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- High-throughput Antibody Production Service
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- Novus Biologicals proteins and lysates for ZSCAN4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
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- Abcam proteins for ZSCAN4
- Find your target
- Browse Primary Antibodies
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- Invitrogen Antibodies for ZSCAN4 (AFLGC-ZSCAN4)
- VectorBuilder Custom and pre-made DNA vectors for ZSCAN4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ZSCAN4 (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Virus packaging for ZSCAN4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ZSCAN4
- Addgene plasmids for ZSCAN4
- antibodies-online: Show 21 available ZSCAN4 Antibodies ranked by validation data
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- antibodies-online: Search results for available ZSCAN4 related products ranked by validation data
- antibodies-online: Show 7 available ZSCAN4 Proteins ranked by validation data
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- Quality Products:
- Custom Antibody ServicesProSci Antibodies for ZSCAN4
- Search for ZSCAN4 Proteins at ProSci
- Horizon Cell Lines for ZSCAN4
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- Boster Bio Antibodies for ZSCAN4
- Browse Boster Bio ELISA Kits
Sources for ZSCAN4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB