Aliases for ZSCAN4 Gene
External Ids for ZSCAN4 Gene
Previous HGNC Symbols for ZSCAN4 Gene
Previous GeneCards Identifiers for ZSCAN4 Gene
The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]
GeneCards Summary for ZSCAN4 Gene
ZSCAN4 (Zinc Finger And SCAN Domain Containing 4) is a Protein Coding gene. Diseases associated with ZSCAN4 include Facioscapulohumeral Muscular Dystrophy 1. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity.
UniProtKB/Swiss-Prot for ZSCAN4 Gene
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).