Aliases for ZSCAN4 Gene
Aliases for ZSCAN4 Gene
External Ids for ZSCAN4 Gene
- HGNC: 23709
- Entrez Gene: 201516
- Ensembl: ENSG00000180532
- OMIM: 613419
- UniProtKB: Q8NAM6
Previous HGNC Symbols for ZSCAN4 Gene
- ZNF494
Previous GeneCards Identifiers for ZSCAN4 Gene
- GC19P062874
- GC19P062875
- GC19P058180
- GC19P054492
- GC19P057668
Summaries for ZSCAN4 Gene
-
The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]
GeneCards Summary for ZSCAN4 Gene
ZSCAN4 (Zinc Finger And SCAN Domain Containing 4) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity.
UniProtKB/Swiss-Prot for ZSCAN4 Gene
-
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).
Additional gene information for ZSCAN4 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN4 Gene
Genomics for ZSCAN4 Gene
GeneHancer (GH) Regulatory Elements for ZSCAN4 Gene
Promoters and enhancers for ZSCAN4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZSCAN4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ZSCAN4 gene promoter:
-
- POU3F2 (N-Oct-5b)
- POU3F2 (N-Oct-5a)
- POU3F2
- SRF (504 AA)
- SRF
- Elk-1
- FOXF2
- FOXO1a
- FOXO1
- FOXC1
Regulatory Element Products
Genomic Locations for ZSCAN4 Gene
Genomic Locations for ZSCAN4 Gene
- chr19:57,651,504-57,679,152
- (GRCh38/hg38)
- Size:
- 27,649 bases
- Orientation:
- Plus strand
- chr19:58,180,303-58,190,520
- (GRCh37/hg19)
- Size:
- 10,218 bases
- Orientation:
- Plus strand
Genomic View for ZSCAN4 Gene
Genes around ZSCAN4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.43 by Entrez Gene
- 19q13.43 by HGNC
- 19q13.43 by Ensembl
ZSCAN4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZSCAN4 Gene
Proteins for ZSCAN4 Gene
-
Protein details for ZSCAN4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NAM6-ZSCA4_HUMAN
- Recommended name:
- Zinc finger and SCAN domain-containing protein 4
- Protein Accession:
- Q8NAM6
- Q3MIQ2
Protein attributes for ZSCAN4 Gene
- Size:
- 433 amino acids
- Molecular mass:
- 48957 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for ZSCAN4 Gene
Other Protein References for ZSCAN4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZSCAN4
-
Abcam antibodies for ZSCAN4
- Invitrogen Antibodies for ZSCAN4 (AFLGC-ZSCAN4)
- GeneTex ZSCAN4 Antibody for ZSCAN4
-
Custom Antibody ServicesProSci Antibodies for ZSCAN4
Protein Products
-
OriGene Purified Proteins for ZSCAN4
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-
Quality Products:
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-
Abcam proteins for ZSCAN4
Assay Products
No data available for DME Specific Peptides for ZSCAN4 Gene
Domains & Families for ZSCAN4 Gene
Gene Families for ZSCAN4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZSCAN4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZSCAN4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ZSCAN4 Gene
Function for ZSCAN4 Gene
Molecular function for ZSCAN4 Gene
- UniProtKB/Swiss-Prot Function:
- Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISA | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZSCAN4 Gene
- GenomeRNAi human phenotypes for ZSCAN4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
OriGene CRISPR knockouts for ZSCAN4
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- genomics-online: gRNA clones - Search results for 36 available ZSCAN4 gene related products
- Overview of 36 available ZSCAN4 gene related products
- Applied Biological Materials CRISPR for ZSCAN4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZSCAN4
- GenScript: Design CRISPR guide RNA sequences for ZSCAN4
miRNA for ZSCAN4 Gene
- miRTarBase miRNAs that target ZSCAN4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZSCAN4
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Clone Products
- Sino Biological Human cDNA Clone for ZSCAN4
- Addgene plasmids for ZSCAN4
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- Applied Biological Materials Clones for ZSCAN4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ZSCAN4
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN4 Gene
Localization for ZSCAN4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN4 Gene
- Nucleus. Chromosome, telomere.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000784 | nuclear chromosome, telomeric region | ISS | 20336070 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005694 | chromosome | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZSCAN4 Gene
Pathways & Interactions for ZSCAN4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Preimplantation Embryo | ||
Pathways by source for ZSCAN4 Gene
1 BioSystems pathway for ZSCAN4 Gene
Interacting Proteins for ZSCAN4 Gene
Selected Interacting proteins:
ENSP00000321963
Q8NAM6-ZSCA4_HUMAN
for ZSCAN4 Gene via
STRING
MINT
UniProtKB
IID
GPS-Prot Interaction Network for ZSCAN4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0010833 | telomere maintenance via telomere lengthening | ISS | 20336070 |
| GO:0045950 | negative regulation of mitotic recombination | ISS | 20336070 |
No data available for SIGNOR curated interactions for ZSCAN4 Gene
Transcripts for ZSCAN4 Gene
mRNA/cDNA for ZSCAN4 Gene
- (3) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (6) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000318203 2246 bps (uc002qpu.3)
- ENST00000612521 1979 bps (uc061dmg.1)
Unigene Clusters for ZSCAN4 Gene
- Zinc finger and SCAN domain containing 4:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ZSCAN4
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- Applied Biological Materials CRISPR for ZSCAN4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZSCAN4
- GenScript: Design CRISPR guide RNA sequences for ZSCAN4
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for ZSCAN4
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- Applied Biological Materials Clones for ZSCAN4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ZSCAN4 Gene
mRNA differential expression in normal tissues according to GTEx for ZSCAN4 Gene
This gene is overexpressed in Cervix - Endocervix (x6.4) and Bladder (x6.2).
NURSA nuclear receptor signaling pathways regulating expression of ZSCAN4 Gene:
ZSCAN4SOURCE GeneReport for Unigene cluster for ZSCAN4 Gene:
Hs.469663Evidence on tissue expression from TISSUES for ZSCAN4 Gene
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for ZSCAN4
- genomics-online: primer clones - Search results for 36 available ZSCAN4 gene related products
- Overview of 36 available ZSCAN4 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN4 Gene
Orthologs for ZSCAN4 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZSCAN4 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ZSCAN4 33 |
|
||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | ZSCAN4 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Zscan4e 34 |
|
OneToMany | |
| Zscan4d 34 |
|
OneToMany | |||
| Zscan4c 34 |
|
OneToMany | |||
| Zscan4b 34 |
|
OneToMany | |||
| Zscan4f 34 |
|
OneToMany |
- Species where no ortholog for ZSCAN4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for ZSCAN4 Gene
- ENSEMBL:
- Gene Tree for ZSCAN4 (if available)
- TreeFam:
- Gene Tree for ZSCAN4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZSCAN4: view image
Paralogs for ZSCAN4 Gene
(9) SIMAP similar genes for ZSCAN4 Gene using alignment to 1 proteins:
- ZSCA4_HUMAN
No data available for Paralogs for ZSCAN4 Gene
Variants for ZSCAN4 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000170822 | -- | 57,664,202(+) | A/C | downstream_transcript_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant | |
| rs1000342500 | -- | 57,657,954(+) | G/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000360902 | -- | 57,679,160(+) | G/C | downstream_transcript_variant | |
| rs1000576195 | -- | 57,667,913(+) | T/C | genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000587331 | -- | 57,650,612(+) | A/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.79;
33.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZSCAN4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZSCAN4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN4 Gene
Disorders for ZSCAN4 Gene
Additional Disease Information for ZSCAN4
No disorders were found for ZSCAN4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN4 Gene
Publications for ZSCAN4 Gene
- Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. (PMID: 24735877) Dan J … Liu L (Developmental cell 2014) 2 3 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- ZSCAN4 is negatively regulated by the ubiquitin-proteasome system and the E3 ubiquitin ligase RNF20. (PMID: 29477841) Portney BA … Zalzman M (Biochemical and biophysical research communications 2018) 3 58
- Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos. (PMID: 27699651) Ishiguro KI … Ko MS (In vitro cellular & developmental biology. Animal 2017) 3 58
Products for ZSCAN4 Gene
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Sources for ZSCAN4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
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