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Aliases for ZSCAN4 Gene

Aliases for ZSCAN4 Gene

  • Zinc Finger And SCAN Domain Containing 4 2 3 5
  • Zinc Finger Protein 494 2 3 4
  • ZNF494 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 4 3

External Ids for ZSCAN4 Gene

Previous HGNC Symbols for ZSCAN4 Gene

  • ZNF494

Previous GeneCards Identifiers for ZSCAN4 Gene

  • GC19P062874
  • GC19P062875
  • GC19P058180
  • GC19P054492
  • GC19P057668

Summaries for ZSCAN4 Gene

Entrez Gene Summary for ZSCAN4 Gene

  • The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]

GeneCards Summary for ZSCAN4 Gene

ZSCAN4 (Zinc Finger And SCAN Domain Containing 4) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for ZSCAN4 Gene

  • Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).

Additional gene information for ZSCAN4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN4 Gene

Genomics for ZSCAN4 Gene

GeneHancer (GH) Regulatory Elements for ZSCAN4 Gene

Promoters and enhancers for ZSCAN4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J057650 Enhancer 1 Ensembl ENCODE 650.7 +0.4 371 2.3 DRAP1 KLF1 TFAP4 FOXA2 SAP130 RAD21 ZNF335 ZNF791 NCOR1 POLR2A ZSCAN4 ZNF211 ZNF134 ZNF548 ENSG00000267216 ZNF550 ZNF417 ZNF551 ZNF264 ZNF671
GH19J058517 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 +868.2 868204 4.9 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZBTB45 PIR40518 SLC27A5 ZNF324B TRIM28 ZNF446 ZNF134 ZNF417 ZNF274 ZNF549
GH19J058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.3 +675.4 675367 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 LOC105372480 PIR44424 ZNF134 ZNF606 ZNF417 ZNF17 ZNF446 TRIM28 ZNF549
GH19J058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.3 +531.7 531732 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF417 ZNF606 ZNF17 ZNF550 ZNF549 TRIM28 ZNF264 ZNF773
GH19J057681 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.6 +30.6 30642 1.6 PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF416 ZNF207 ZNF143 ZNF551 ENSG00000269026 GC19P057683 ZNF17 ZNF549 ZNF304 ZNF134 ZNF773 ZNF446 ZNF211
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZSCAN4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZSCAN4 gene promoter:
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • SRF (504 AA)
  • SRF
  • Elk-1
  • FOXF2
  • FOXO1a
  • FOXO1
  • FOXC1

Genomic Locations for ZSCAN4 Gene

Genomic Locations for ZSCAN4 Gene
chr19:57,651,504-57,679,152
(GRCh38/hg38)
Size:
27,649 bases
Orientation:
Plus strand
chr19:58,180,303-58,190,520
(GRCh37/hg19)
Size:
10,218 bases
Orientation:
Plus strand

Genomic View for ZSCAN4 Gene

Genes around ZSCAN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN4 Gene

Proteins for ZSCAN4 Gene

  • Protein details for ZSCAN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAM6-ZSCA4_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 4
    Protein Accession:
    Q8NAM6
    Secondary Accessions:
    • Q3MIQ2

    Protein attributes for ZSCAN4 Gene

    Size:
    433 amino acids
    Molecular mass:
    48957 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSCAN4 Gene

Post-translational modifications for ZSCAN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN4 Gene

No data available for DME Specific Peptides for ZSCAN4 Gene

Domains & Families for ZSCAN4 Gene

Gene Families for ZSCAN4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN4 Gene

Suggested Antigen Peptide Sequences for ZSCAN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZSCAN4: view

No data available for UniProtKB/Swiss-Prot for ZSCAN4 Gene

Function for ZSCAN4 Gene

Molecular function for ZSCAN4 Gene

UniProtKB/Swiss-Prot Function:
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).

Gene Ontology (GO) - Molecular Function for ZSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN4: view
genes like me logo Genes that share phenotypes with ZSCAN4: view

Animal Model Products

miRNA for ZSCAN4 Gene

miRTarBase miRNAs that target ZSCAN4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN4 Gene

Localization for ZSCAN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN4 Gene

Nucleus. Chromosome, telomere.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN4 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region ISS 20336070
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with ZSCAN4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZSCAN4 Gene

Pathways & Interactions for ZSCAN4 Gene

SuperPathways for ZSCAN4 Gene

SuperPathway Contained pathways
1 Preimplantation Embryo
genes like me logo Genes that share pathways with ZSCAN4: view

Pathways by source for ZSCAN4 Gene

1 BioSystems pathway for ZSCAN4 Gene

Gene Ontology (GO) - Biological Process for ZSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0010833 telomere maintenance via telomere lengthening ISS 20336070
GO:0045950 negative regulation of mitotic recombination ISS 20336070
genes like me logo Genes that share ontologies with ZSCAN4: view

No data available for SIGNOR curated interactions for ZSCAN4 Gene

Drugs & Compounds for ZSCAN4 Gene

No Compound Related Data Available

Transcripts for ZSCAN4 Gene

mRNA/cDNA for ZSCAN4 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSCAN4 Gene

Zinc finger and SCAN domain containing 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN4 Gene

No ASD Table

Relevant External Links for ZSCAN4 Gene

GeneLoc Exon Structure for
ZSCAN4
ECgene alternative splicing isoforms for
ZSCAN4

Expression for ZSCAN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN4 Gene

mRNA differential expression in normal tissues according to GTEx for ZSCAN4 Gene

This gene is overexpressed in Cervix - Endocervix (x6.4) and Bladder (x6.2).

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN4 Gene:

ZSCAN4

SOURCE GeneReport for Unigene cluster for ZSCAN4 Gene:

Hs.469663

Evidence on tissue expression from TISSUES for ZSCAN4 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZSCAN4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN4 Gene

Orthologs for ZSCAN4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN4 34 33
  • 99.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZSCAN4 33
  • 75.18 (n)
-- 34
  • 56 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZSCAN4 34
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zscan4e 34
  • 36 (a)
OneToMany
Zscan4d 34
  • 36 (a)
OneToMany
Zscan4c 34
  • 36 (a)
OneToMany
Zscan4b 34
  • 36 (a)
OneToMany
Zscan4f 34
  • 36 (a)
OneToMany
Species where no ortholog for ZSCAN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN4 Gene

ENSEMBL:
Gene Tree for ZSCAN4 (if available)
TreeFam:
Gene Tree for ZSCAN4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSCAN4: view image

Paralogs for ZSCAN4 Gene

(9) SIMAP similar genes for ZSCAN4 Gene using alignment to 1 proteins:

  • ZSCA4_HUMAN
genes like me logo Genes that share paralogs with ZSCAN4: view

No data available for Paralogs for ZSCAN4 Gene

Variants for ZSCAN4 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000170822 -- 57,664,202(+) A/C downstream_transcript_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000342500 -- 57,657,954(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000360902 -- 57,679,160(+) G/C downstream_transcript_variant
rs1000576195 -- 57,667,913(+) T/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000587331 -- 57,650,612(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN4 Gene

Variant ID Type Subtype PubMed ID
nsv580402 CNV gain 21841781

Variation tolerance for ZSCAN4 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN4 Gene

Disorders for ZSCAN4 Gene

Additional Disease Information for ZSCAN4

No disorders were found for ZSCAN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN4 Gene

Publications for ZSCAN4 Gene

  1. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. (PMID: 24735877) Dan J … Liu L (Developmental cell 2014) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. ZSCAN4 is negatively regulated by the ubiquitin-proteasome system and the E3 ubiquitin ligase RNF20. (PMID: 29477841) Portney BA … Zalzman M (Biochemical and biophysical research communications 2018) 3 58
  5. Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos. (PMID: 27699651) Ishiguro KI … Ko MS (In vitro cellular & developmental biology. Animal 2017) 3 58

Products for ZSCAN4 Gene

Sources for ZSCAN4 Gene

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