Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZSCAN32 Gene

Aliases for ZSCAN32 Gene

  • Zinc Finger And SCAN Domain Containing 32 2 3 5
  • Zinc Finger Protein 434 2 3 4
  • Human Cervical Cancer Suppressor Gene 5 Protein 3 4
  • ZNF434 3 4
  • HCCS-5 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 32 3

External Ids for ZSCAN32 Gene

Previous HGNC Symbols for ZSCAN32 Gene

  • ZNF434

Previous GeneCards Identifiers for ZSCAN32 Gene

  • GC16M003457
  • GC16M003462
  • GC16M003466
  • GC16M003381

Summaries for ZSCAN32 Gene

GeneCards Summary for ZSCAN32 Gene

ZSCAN32 (Zinc Finger And SCAN Domain Containing 32) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZSCAN29.

UniProtKB/Swiss-Prot for ZSCAN32 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZSCAN32 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN32 Gene

Genomics for ZSCAN32 Gene

GeneHancer (GH) Regulatory Elements for ZSCAN32 Gene

Promoters and enhancers for ZSCAN32 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J003400 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.2 -154 2.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF174 ZSCAN32 ZNF597 ZNF200 TIGD7 ZNF75A CREBBP CLUAP1 MTCO1P28 AMDHD2
GH16J003019 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 27.6 +378.8 378762 5.2 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC THOC6 HCFC1R1 TNFRSF12A ZNF263 ENSG00000261938 SRRM2 E4F1 CREBBP TSC2 ERVK13-1
GH16J002602 Promoter/Enhancer 2.2 UCNEbase Ensembl ENCODE dbSUPER 18.2 +797.4 797374 1.8 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC LOC652276 PIR62164 ZNF597 TBL3 AMDHD2 ZNF174 CRAMP1 ZNF200 ENSG00000226890 SRRM2
GH16J003156 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.5 +242.3 242271 3.8 DMAP1 YY1 ZNF213 E2F8 SP3 MEF2D SSRP1 ZNF610 GLIS1 NBN GC16M003157 TRK-CTT3-1 TRP-TGG3-3 ZNF75A E4F1 ZNF213-AS1 ZNF205 ENSG00000261938 CREBBP ZNF263
GH16J003111 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.3 +288.2 288150 2.3 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF213 ZNF205 ZNF213-AS1 CLUAP1 TIGD7 ZSCAN32 ZNF75A ZNF174 ENSG00000260778 MTCO1P28 FLYWCH1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSCAN32 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZSCAN32 Gene

Genomic Locations for ZSCAN32 Gene
chr16:3,382,081-3,401,065
(GRCh38/hg38)
Size:
18,985 bases
Orientation:
Minus strand
chr16:3,432,085-3,451,065
(GRCh37/hg19)
Size:
18,981 bases
Orientation:
Minus strand

Genomic View for ZSCAN32 Gene

Genes around ZSCAN32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN32 Gene

Proteins for ZSCAN32 Gene

  • Protein details for ZSCAN32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX65-ZSC32_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 32
    Protein Accession:
    Q9NX65
    Secondary Accessions:
    • B4DWL5
    • C9JB03
    • Q6WMU8
    • Q7Z6G2
    • Q8NFX8
    • Q9BU74

    Protein attributes for ZSCAN32 Gene

    Size:
    697 amino acids
    Molecular mass:
    78728 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH02859.1; Type=Frameshift; Positions=254; Evidence={ECO:0000305}; Sequence=AAH02859.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 426.; Evidence={ECO:0000305}; Sequence=AAM73658.1; Type=Miscellaneous discrepancy; Note=The cDNA sequence has been translated in the reverse direction.; Evidence={ECO:0000305}; Sequence=BAA91155.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZSCAN32 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN32 Gene

Post-translational modifications for ZSCAN32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN32 Gene

Domains & Families for ZSCAN32 Gene

Gene Families for ZSCAN32 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN32 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NX65

UniProtKB/Swiss-Prot:

ZSC32_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN32: view

Function for ZSCAN32 Gene

Molecular function for ZSCAN32 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZSCAN32 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ZSCAN32: view
genes like me logo Genes that share phenotypes with ZSCAN32: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN32

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZSCAN32 Gene

Localization for ZSCAN32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN32 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN32 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZSCAN32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZSCAN32: view

Pathways & Interactions for ZSCAN32 Gene

SuperPathways for ZSCAN32 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZSCAN32: view

Pathways by source for ZSCAN32 Gene

2 Reactome pathways for ZSCAN32 Gene

Gene Ontology (GO) - Biological Process for ZSCAN32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZSCAN32: view

No data available for SIGNOR curated interactions for ZSCAN32 Gene

Drugs & Compounds for ZSCAN32 Gene

No Compound Related Data Available

Transcripts for ZSCAN32 Gene

Unigene Clusters for ZSCAN32 Gene

Zinc finger and SCAN domain containing 32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN32

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN32 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1:
SP2: -
SP3: -
SP4:
SP5: - - - -
SP6: - - -
SP7: - - - - - -

Relevant External Links for ZSCAN32 Gene

GeneLoc Exon Structure for
ZSCAN32
ECgene alternative splicing isoforms for
ZSCAN32

Expression for ZSCAN32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN32 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZSCAN32 Gene



Protein tissue co-expression partners for ZSCAN32 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN32 Gene:

ZSCAN32

SOURCE GeneReport for Unigene cluster for ZSCAN32 Gene:

Hs.592078
genes like me logo Genes that share expression patterns with ZSCAN32: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN32 Gene

Orthologs for ZSCAN32 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF434 33
  • 99.33 (n)
ZSCAN32 34
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9772 34
  • 44 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 27 (a)
OneToMany
-- 34
  • 17 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZSCAN32 34
  • 24 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 22 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 14 (a)
ManyToMany
Species where no ortholog for ZSCAN32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN32 Gene

ENSEMBL:
Gene Tree for ZSCAN32 (if available)
TreeFam:
Gene Tree for ZSCAN32 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSCAN32: view image

Paralogs for ZSCAN32 Gene

Paralogs for ZSCAN32 Gene

(331) SIMAP similar genes for ZSCAN32 Gene using alignment to 10 proteins:

  • ZSC32_HUMAN
  • B4DR24_HUMAN
  • B4DWL5_HUMAN
  • I3L1K0_HUMAN
  • I3L1S7_HUMAN
  • I3L2L7_HUMAN
  • I3L2V3_HUMAN
  • I3L3J2_HUMAN
  • I3L3Y8_HUMAN
  • I3L4W6_HUMAN
genes like me logo Genes that share paralogs with ZSCAN32: view

Variants for ZSCAN32 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN32 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000137071 -- 3,386,893(-) TAACTAAC/TAAC intron_variant
rs1000142330 -- 3,390,418(-) C/T intron_variant
rs1000252579 -- 3,390,655(-) C/A intron_variant
rs1000553807 -- 3,400,130(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000688036 -- 3,400,359(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN32 Gene

Variant ID Type Subtype PubMed ID
dgv2695n100 CNV gain 25217958
esv1219550 CNV insertion 17803354
nsv1044147 CNV loss 25217958
nsv1054969 CNV loss 25217958

Variation tolerance for ZSCAN32 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.19; 80.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN32 Gene

Disorders for ZSCAN32 Gene

Additional Disease Information for ZSCAN32

No disorders were found for ZSCAN32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN32 Gene

Publications for ZSCAN32 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ZSCAN32 Gene

Sources for ZSCAN32 Gene

Content
Loading form....