Aliases for ZSCAN32 Gene

Aliases for ZSCAN32 Gene

  • Zinc Finger And SCAN Domain Containing 32 2 3 5
  • Zinc Finger Protein 434 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 32 3 4
  • Human Cervical Cancer Suppressor Gene 5 Protein 3 4
  • HCCS-5 3 4
  • ZNF434 3 4
  • FLJ20417 2
  • ZSCAN32 5

External Ids for ZSCAN32 Gene

Previous HGNC Symbols for ZSCAN32 Gene

  • ZNF434

Previous GeneCards Identifiers for ZSCAN32 Gene

  • GC16M003457
  • GC16M003462
  • GC16M003466
  • GC16M003381
  • GC16M003383
  • GC16M003392
  • GC16M003404

Summaries for ZSCAN32 Gene

GeneCards Summary for ZSCAN32 Gene

ZSCAN32 (Zinc Finger And SCAN Domain Containing 32) is a Protein Coding gene. Diseases associated with ZSCAN32 include Ulcer Of Lower Limbs and Acute Cor Pulmonale. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ZKSCAN2.

UniProtKB/Swiss-Prot Summary for ZSCAN32 Gene

Additional gene information for ZSCAN32 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSCAN32 Gene

Genomics for ZSCAN32 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZSCAN32 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSCAN32 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZSCAN32

Genomic Locations for ZSCAN32 Gene

Genomic Locations for ZSCAN32 Gene
chr16:3,382,081-3,402,007
(GRCh38/hg38)
Size:
19,927 bases
Orientation:
Minus strand
chr16:3,432,085-3,451,065
(GRCh37/hg19)
Size:
18,981 bases
Orientation:
Minus strand

Genomic View for ZSCAN32 Gene

Genes around ZSCAN32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN32 Gene

Proteins for ZSCAN32 Gene

  • Protein details for ZSCAN32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX65-ZSC32_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 32
    Protein Accession:
    Q9NX65
    Secondary Accessions:
    • B4DWL5
    • C9JB03
    • Q6WMU8
    • Q7Z6G2
    • Q8NFX8
    • Q9BU74

    Protein attributes for ZSCAN32 Gene

    Size:
    697 amino acids
    Molecular mass:
    78728 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH02859.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH02859.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 426.; Evidence={ECO:0000305}; Sequence=AAM73658.1; Type=Miscellaneous discrepancy; Note=The cDNA sequence has been translated in the reverse direction.; Evidence={ECO:0000305}; Sequence=BAA91155.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZSCAN32 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN32 Gene

Post-translational modifications for ZSCAN32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN32 Gene

Domains & Families for ZSCAN32 Gene

Gene Families for ZSCAN32 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN32 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZSCAN32 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54133, highly similar to Zinc finger protein 434 (B4DR24_HUMAN)
  • cDNA FLJ54764, highly similar to Zinc finger protein 434 (B4DWL5_HUMAN)
  • cDNA FLJ77128, highly similar to Homo sapiens zinc finger protein 434 (ZNF434) mRNA (Q6WMU8_HUMAN)
  • ZNF434 protein (Q9BU74_HUMAN)
  • Human cervical cancer suppressor gene 5 protein (ZN434_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NX65

UniProtKB/Swiss-Prot:

ZSC32_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN32: view

Function for ZSCAN32 Gene

Molecular function for ZSCAN32 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZSCAN32 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN32: view
genes like me logo Genes that share phenotypes with ZSCAN32: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN32

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZSCAN32 Gene

Localization for ZSCAN32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN32 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN32 gene
Compartment Confidence
nucleus 4
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZSCAN32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN32: view

Pathways & Interactions for ZSCAN32 Gene

genes like me logo Genes that share pathways with ZSCAN32: view

Pathways by source for ZSCAN32 Gene

2 Reactome pathways for ZSCAN32 Gene
1 KEGG pathway for ZSCAN32 Gene

Gene Ontology (GO) - Biological Process for ZSCAN32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN32: view

No data available for SIGNOR curated interactions for ZSCAN32 Gene

Drugs & Compounds for ZSCAN32 Gene

No Compound Related Data Available

Transcripts for ZSCAN32 Gene

mRNA/cDNA for ZSCAN32 Gene

11 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN32

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN32 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1:
SP2: -
SP3: -
SP4:
SP5: - - - -
SP6: - - -
SP7: - - - - - -

Relevant External Links for ZSCAN32 Gene

GeneLoc Exon Structure for
ZSCAN32

Expression for ZSCAN32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSCAN32 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZSCAN32 Gene



Protein tissue co-expression partners for ZSCAN32 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZSCAN32

SOURCE GeneReport for Unigene cluster for ZSCAN32 Gene:

Hs.592078
genes like me logo Genes that share expression patterns with ZSCAN32: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN32 Gene

Orthologs for ZSCAN32 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN32 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF434 30
  • 99.33 (n)
ZSCAN32 31
  • 69 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm9772 31
  • 44 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 27 (a)
OneToMany
-- 31
  • 17 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia ZSCAN32 31
  • 24 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 22 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 14 (a)
ManyToMany
Species where no ortholog for ZSCAN32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZSCAN32 Gene

ENSEMBL:
Gene Tree for ZSCAN32 (if available)
TreeFam:
Gene Tree for ZSCAN32 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSCAN32: view image

Paralogs for ZSCAN32 Gene

(331) SIMAP similar genes for ZSCAN32 Gene using alignment to 10 proteins:

  • ZSC32_HUMAN
  • B4DR24_HUMAN
  • B4DWL5_HUMAN
  • I3L1K0_HUMAN
  • I3L1S7_HUMAN
  • I3L2L7_HUMAN
  • I3L2V3_HUMAN
  • I3L3J2_HUMAN
  • I3L3Y8_HUMAN
  • I3L4W6_HUMAN
genes like me logo Genes that share paralogs with ZSCAN32: view

Variants for ZSCAN32 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZSCAN32 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs17136369 - p.Ala266Val
rs27230 - p.Tyr332His

Additional dbSNP identifiers (rs#s) for ZSCAN32 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN32 Gene

Variant ID Type Subtype PubMed ID
dgv2695n100 CNV gain 25217958
esv1219550 CNV insertion 17803354
nsv1044147 CNV loss 25217958
nsv1054969 CNV loss 25217958

Variation tolerance for ZSCAN32 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.19; 80.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN32 Gene

Disorders for ZSCAN32 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZSCAN32 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ulcer of lower limbs
  • ulcer of ankle
acute cor pulmonale
acute pulmonary heart disease
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZSCAN32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZSCAN32 Gene

Publications for ZSCAN32 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZSCAN32 Gene

Sources for ZSCAN32 Gene