This gene encodes a protein containing multiple C2H2-type zinc finger motifs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] See more...

Aliases for ZSCAN31 Gene

Aliases for ZSCAN31 Gene

  • Zinc Finger And SCAN Domain Containing 31 2 3 5
  • Zinc Finger Protein 323 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 31 3 4
  • ZNF310P 3 4
  • ZNF323 3 4
  • Zinc Finger Protein 310 Pseudogene 2
  • ZNF20-Lp 3

External Ids for ZSCAN31 Gene

Previous HGNC Symbols for ZSCAN31 Gene

  • ZNF310P
  • ZNF323

Previous GeneCards Identifiers for ZSCAN31 Gene

  • GC06M028296
  • GC06M028325

Summaries for ZSCAN31 Gene

Entrez Gene Summary for ZSCAN31 Gene

  • This gene encodes a protein containing multiple C2H2-type zinc finger motifs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for ZSCAN31 Gene

ZSCAN31 (Zinc Finger And SCAN Domain Containing 31) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZSCAN12.

UniProtKB/Swiss-Prot Summary for ZSCAN31 Gene

  • May function as a transcription factor. May be involved in the development of multiple embryonic organs.

Additional gene information for ZSCAN31 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSCAN31 Gene

Genomics for ZSCAN31 Gene

GeneHancer (GH) Regulatory Elements for ZSCAN31 Gene

Promoters and enhancers for ZSCAN31 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSCAN31 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZSCAN31 Gene

Genomic Locations for ZSCAN31 Gene
chr6:28,312,837-28,356,271
(GRCh38/hg38)
Size:
43,435 bases
Orientation:
Minus strand
chr6:28,292,470-28,324,048
(GRCh37/hg19)
Size:
31,579 bases
Orientation:
Minus strand

Genomic View for ZSCAN31 Gene

Genes around ZSCAN31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN31 Gene

Proteins for ZSCAN31 Gene

  • Protein details for ZSCAN31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LW9-ZSC31_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 31
    Protein Accession:
    Q96LW9
    Secondary Accessions:
    • Q6P178
    • Q8WWS5

    Protein attributes for ZSCAN31 Gene

    Size:
    406 amino acids
    Molecular mass:
    47293 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZSCAN31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN31 Gene

Post-translational modifications for ZSCAN31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN31 Gene

Domains & Families for ZSCAN31 Gene

Gene Families for ZSCAN31 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZSCAN31 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 323, isoform CRA_b (Q6P178_HUMAN)
  • Zinc finger protein 323 (Q96QL1_HUMAN)
  • Zinc finger protein 323 (ZN323_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96LW9

UniProtKB/Swiss-Prot:

ZSC31_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN31: view

Function for ZSCAN31 Gene

Molecular function for ZSCAN31 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor. May be involved in the development of multiple embryonic organs.

Phenotypes From GWAS Catalog for ZSCAN31 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN31: view
genes like me logo Genes that share phenotypes with ZSCAN31: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN31

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZSCAN31 Gene

Localization for ZSCAN31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN31 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSCAN31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN31: view

Pathways & Interactions for ZSCAN31 Gene

PathCards logo

SuperPathways for ZSCAN31 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZSCAN31: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN31 Gene

Drugs & Compounds for ZSCAN31 Gene

No Compound Related Data Available

Transcripts for ZSCAN31 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN31

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN31 Gene

No ASD Table

Relevant External Links for ZSCAN31 Gene

GeneLoc Exon Structure for
ZSCAN31
ECgene alternative splicing isoforms for
ZSCAN31

Expression for ZSCAN31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZSCAN31 Gene

This gene is overexpressed in Skin (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZSCAN31 Gene



Protein tissue co-expression partners for ZSCAN31 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN31 Gene:

ZSCAN31

SOURCE GeneReport for Unigene cluster for ZSCAN31 Gene:

Hs.656413

mRNA Expression by UniProt/SwissProt for ZSCAN31 Gene:

Q96LW9-ZSC31_HUMAN
Tissue specificity: Expressed at high levels in the lung, liver, and kidney, while weakly expressed in intestine, brain, muscle, cholecyst, heart, and pancreas.

Evidence on tissue expression from TISSUES for ZSCAN31 Gene

  • Heart(4.2)
genes like me logo Genes that share expression patterns with ZSCAN31: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN31 Gene

Orthologs for ZSCAN31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF323 33 32
  • 99.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF323 33 32
  • 86.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZSCAN31 33
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 30 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 28 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZFP92 33
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 31 (a)
ManyToMany
Species where no ortholog for ZSCAN31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN31 Gene

ENSEMBL:
Gene Tree for ZSCAN31 (if available)
TreeFam:
Gene Tree for ZSCAN31 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSCAN31: view image

Paralogs for ZSCAN31 Gene

(525) SIMAP similar genes for ZSCAN31 Gene using alignment to 12 proteins:

  • ZSC31_HUMAN
  • C9IYT1_HUMAN
  • C9J1X2_HUMAN
  • C9J423_HUMAN
  • C9J6S7_HUMAN
  • C9JAI0_HUMAN
  • C9JBH3_HUMAN
  • C9JH14_HUMAN
  • C9JHB1_HUMAN
  • C9JIC2_HUMAN
  • C9JPM5_HUMAN
  • C9JUE1_HUMAN

Pseudogenes.org Pseudogenes for ZSCAN31 Gene

genes like me logo Genes that share paralogs with ZSCAN31: view

Variants for ZSCAN31 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN31 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000006131 -- 28,344,466(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000075038 -- 28,360,102(-) C/G upstream_transcript_variant
rs1000103709 -- 28,354,337(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000153942 -- 28,330,643(-) A/T intron_variant
rs1000194106 -- 28,330,940(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN31 Gene

Variant ID Type Subtype PubMed ID
esv3307746 CNV mobile element insertion 20981092
esv3309931 CNV mobile element insertion 20981092
esv3349303 CNV insertion 20981092
esv3416573 CNV insertion 20981092
nsv830620 CNV loss 17160897

Variation tolerance for ZSCAN31 Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN31 Gene

Disorders for ZSCAN31 Gene

Additional Disease Information for ZSCAN31

No disorders were found for ZSCAN31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN31 Gene

Publications for ZSCAN31 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 56
  3. A novel human SCAN/(Cys)2(His)2 zinc-finger transcription factor ZNF323 in early human embryonic development. (PMID: 12147252) Pi H … Liu M (Biochemical and biophysical research communications 2002) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 56

Products for ZSCAN31 Gene

Sources for ZSCAN31 Gene