Aliases for ZSCAN26 Gene

Aliases for ZSCAN26 Gene

  • Zinc Finger And SCAN Domain Containing 26 2 3 5
  • Zinc Finger Protein 187 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 26 3 4
  • SRE-ZBP 2 3
  • ZNF187 3 4
  • Protein SRE-ZBP 4
  • ZSCAN26 5
  • SREZBP 3

External Ids for ZSCAN26 Gene

Previous HGNC Symbols for ZSCAN26 Gene

  • ZNF187

Previous GeneCards Identifiers for ZSCAN26 Gene

  • GC06P028235
  • GC06P028310
  • GC06P028319
  • GC06P028325
  • GC06P028451
  • GC06P028268
  • GC06P028269
  • GC06P028277
  • GC06P028295

Summaries for ZSCAN26 Gene

GeneCards Summary for ZSCAN26 Gene

ZSCAN26 (Zinc Finger And SCAN Domain Containing 26) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZSCAN12.

UniProtKB/Swiss-Prot Summary for ZSCAN26 Gene

Additional gene information for ZSCAN26 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSCAN26 Gene

Genomics for ZSCAN26 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZSCAN26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J028266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 605.4 +1.1 1117 4.3 GATAD2A PRDM10 ZNF629 TFE3 IKZF1 ZNF692 RCOR2 POLR2A ZNF7 ZHX2 ZSCAN26 ENSG00000276302 NONHSAG043310.2-001 ZKSCAN3 ZKSCAN4 ZSCAN12 ZKSCAN8 ZSCAN9 ZSCAN31 ZNF603P
GH06J028265 Enhancer 0.7 Ensembl 600.7 -1.9 -1909 0.2 ZNF629 JUND MTA2 PKNOX1 MTA1 DPF2 HDAC1 SOX6 GATAD2B EP300 ZSCAN26 ZKSCAN3 ZSCAN31 ZSCAN16 ZKSCAN8 NKAPL
GH06J027834 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 86.3 -429.6 -429569 6.7 ZNF221 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 REST TFE3 H2BC15 H2AC15 ZSCAN12 ZKSCAN8 ZKSCAN3 ZSCAN9 ZSCAN26 ZKSCAN4 PGBD1 GUSBP2
GH06J028277 Promoter 0.3 EPDnew 600.4 +10.2 10175 0.1 ZSCAN26 NONHSAG043310.2-002 PGBD1 NONHSAG043310.2-001 ENSG00000276302
GH06J028921 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 40.7 +656.4 656404 4.1 ZNF221 SP1 HNRNPL CREB1 GATAD2A PRDM10 REST TFE3 LEF1 SOX13 TRIM27 lnc-OR2J1-16 lnc-ZNF311-2 ZSCAN26 ZSCAN12 ZSCAN23 ZSCAN9 PGBD1 ZFP57 ZKSCAN4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSCAN26 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZSCAN26

Genomic Locations for ZSCAN26 Gene

Genomic Locations for ZSCAN26 Gene
chr6:28,267,010-28,278,224
(GRCh38/hg38)
Size:
11,215 bases
Orientation:
Plus strand
chr6:28,234,788-28,245,981
(GRCh37/hg19)
Size:
11,194 bases
Orientation:
Plus strand

Genomic View for ZSCAN26 Gene

Genes around ZSCAN26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN26 Gene

Proteins for ZSCAN26 Gene

  • Protein details for ZSCAN26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16670-ZSC26_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 26
    Protein Accession:
    Q16670
    Secondary Accessions:
    • Q5JPG4
    • Q7Z3Q6
    • Q96A17

    Protein attributes for ZSCAN26 Gene

    Size:
    478 amino acids
    Molecular mass:
    55254 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD97775.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for ZSCAN26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN26 Gene

Post-translational modifications for ZSCAN26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN26 Gene

Domains & Families for ZSCAN26 Gene

Gene Families for ZSCAN26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN26 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • Transcriptional regulator SCAN
ProtoNet:

Suggested Antigen Peptide Sequences for ZSCAN26 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger and SCAN domain-containing protein 26 (ZN187_HUMAN)
genes like me logo Genes that share domains with ZSCAN26: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZSCAN26 Gene

Function for ZSCAN26 Gene

Molecular function for ZSCAN26 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
UniProtKB/Swiss-Prot Induction:
By serum stimulation.

Phenotypes From GWAS Catalog for ZSCAN26 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA,NAS 1569959
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN26: view
genes like me logo Genes that share phenotypes with ZSCAN26: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN26

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZSCAN26 Gene

Localization for ZSCAN26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN26 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN26 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSCAN26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,NAS 1569959
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZSCAN26: view

Pathways & Interactions for ZSCAN26 Gene

PathCards logo

SuperPathways for ZSCAN26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 1569959
genes like me logo Genes that share ontologies with ZSCAN26: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN26 Gene

Drugs & Compounds for ZSCAN26 Gene

No Compound Related Data Available

Transcripts for ZSCAN26 Gene

mRNA/cDNA for ZSCAN26 Gene

6 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN26

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN26 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d · 8e · 8f ·
SP1: - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - - - -
SP6: - -
SP7: -
SP8: - - -
SP9: -
SP10: -
SP11: - - - - - - - - - - - - - - -
SP12: - - -
SP13:

ExUns: 8g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ZSCAN26 Gene

GeneLoc Exon Structure for
ZSCAN26

Expression for ZSCAN26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSCAN26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZSCAN26 Gene

This gene is overexpressed in CD8 Tcells (47.6), Blymphocyte (11.7), and Ovary (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZSCAN26 Gene



Protein tissue co-expression partners for ZSCAN26 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZSCAN26

SOURCE GeneReport for Unigene cluster for ZSCAN26 Gene:

Hs.157883

Evidence on tissue expression from TISSUES for ZSCAN26 Gene

  • Kidney(4)
genes like me logo Genes that share expression patterns with ZSCAN26: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN26 Gene

Orthologs for ZSCAN26 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN26 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF187 30
  • 99.58 (n)
Cow
(Bos Taurus)
Mammalia ZSCAN26 30
  • 85.73 (n)
Dog
(Canis familiaris)
Mammalia ZSCAN26 30
  • 83.44 (n)
Rat
(Rattus norvegicus)
Mammalia Zfp187 30
  • 79.9 (n)
Mouse
(Mus musculus)
Mammalia Zscan26 30 17
  • 78.57 (n)
Species where no ortholog for ZSCAN26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZSCAN26 Gene

ENSEMBL:
Gene Tree for ZSCAN26 (if available)
TreeFam:
Gene Tree for ZSCAN26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSCAN26: view image

Paralogs for ZSCAN26 Gene

(446) SIMAP similar genes for ZSCAN26 Gene using alignment to 1 proteins:

  • ZSC26_HUMAN
genes like me logo Genes that share paralogs with ZSCAN26: view

Variants for ZSCAN26 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZSCAN26 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs11965538 - p.Arg73Gln
rs11965542 - p.Glu83Lys
rs16893892 - p.Tyr59Cys
rs17851075 - p.Arg220Ser

Additional dbSNP identifiers (rs#s) for ZSCAN26 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN26 Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV loss 17160897
nsv950146 CNV duplication 24416366

Additional Variant Information for ZSCAN26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZSCAN26 Gene

Disorders for ZSCAN26 Gene

No disorders were found for ZSCAN26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN26 Gene

Publications for ZSCAN26 Gene

  1. Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element. (PMID: 1569959) Attar RM … Gilman MZ (Molecular and cellular biology 1992) 2 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZSCAN26 Gene

Sources for ZSCAN26 Gene