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Aliases for ZSCAN25 Gene

Aliases for ZSCAN25 Gene

  • Zinc Finger And SCAN Domain Containing 25 2 3 5
  • Zinc Finger Protein 498 2 3 4
  • ZNF498 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 25 3

External Ids for ZSCAN25 Gene

Previous HGNC Symbols for ZSCAN25 Gene

  • ZNF498

Previous GeneCards Identifiers for ZSCAN25 Gene

  • GC07P099215

Summaries for ZSCAN25 Gene

Entrez Gene Summary for ZSCAN25 Gene

  • This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZSCAN25 Gene

ZSCAN25 (Zinc Finger And SCAN Domain Containing 25) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF263.

UniProtKB/Swiss-Prot for ZSCAN25 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZSCAN25 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN25 Gene

Genomics for ZSCAN25 Gene

GeneHancer (GH) Regulatory Elements for ZSCAN25 Gene

Promoters and enhancers for ZSCAN25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I099616 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 615.6 +1.7 1658 4.5 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF585B ZSCAN25 TRRAP ENSG00000242798 LOC100131859 AP4M1 PPP1R35 ZNF3 ZSCAN21 MEPCE PTCD1
GH07I100475 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 102.9 +861.1 861144 4.4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 TSC22D4 ZSCAN25 SRRT TRIM4 ZNF655 GIGYF1 ZNF3 ENSG00000242798 STAG3L5P PILRA
GH07I100427 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 87.1 +816.6 816588 10.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPP1R35 MEPCE PIR54054 ZCWPW1 ZSCAN25 TRIM4 SRRT GIGYF1 ZNF3 PILRA
GH07I099557 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 71.6 -55.6 -55625 7.9 ZFP64 DMAP1 YY1 E2F8 ZNF143 SP3 MEF2D SSRP1 GLIS1 NBN ZNF655 FAM200A ZSCAN25 ZNF3 TRIM4 PTCD1 LOC101927550 ZNF394 LOC100419643 TRRAP
GH07I099579 Enhancer 1.3 FANTOM5 Ensembl ENCODE 119.9 -36.2 -36210 1.2 ZNF529 ZNF2 ZBTB40 RAD21 ZNF335 ZNF213 ZNF354C ZNF366 ZNF202 ZNF680 ZSCAN25 TRRAP TRIM4 LOC100131859 ZNF3 ZNF655 ENSG00000242798 STAG3L5P AP4M1 LOC101927550
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZSCAN25 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZSCAN25 Gene

Genomic Locations for ZSCAN25 Gene
chr7:99,616,611-99,738,530
(GRCh38/hg38)
Size:
121,920 bases
Orientation:
Plus strand
chr7:99,214,569-99,230,030
(GRCh37/hg19)

Genomic View for ZSCAN25 Gene

Genes around ZSCAN25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN25 Gene

Proteins for ZSCAN25 Gene

  • Protein details for ZSCAN25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NSZ9-ZSC25_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 25
    Protein Accession:
    Q6NSZ9
    Secondary Accessions:
    • A4D290
    • D6W5T5
    • Q14C82
    • Q14C99
    • Q5EBM9
    • Q6DJZ0
    • Q6N032
    • Q6ZML3

    Protein attributes for ZSCAN25 Gene

    Size:
    544 amino acids
    Molecular mass:
    61474 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI14574.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI14942.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAD18712.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAL23869.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZSCAN25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN25 Gene

Post-translational modifications for ZSCAN25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN25 Gene

Domains & Families for ZSCAN25 Gene

Gene Families for ZSCAN25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

Q6NSZ9

UniProtKB/Swiss-Prot:

ZSC25_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN25: view

Function for ZSCAN25 Gene

Molecular function for ZSCAN25 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZSCAN25 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN25: view

Phenotypes for ZSCAN25 Gene

genes like me logo Genes that share phenotypes with ZSCAN25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN25 Gene

Localization for ZSCAN25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN25 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSCAN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN25: view

Pathways & Interactions for ZSCAN25 Gene

SuperPathways for ZSCAN25 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZSCAN25: view

Pathways by source for ZSCAN25 Gene

2 Reactome pathways for ZSCAN25 Gene

Gene Ontology (GO) - Biological Process for ZSCAN25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN25: view

No data available for SIGNOR curated interactions for ZSCAN25 Gene

Drugs & Compounds for ZSCAN25 Gene

No Compound Related Data Available

Transcripts for ZSCAN25 Gene

Unigene Clusters for ZSCAN25 Gene

Zinc finger and SCAN domain containing 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN25 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - -
SP2: -
SP3: -
SP4: - -
SP5: - - - - - - - - - - - - -
SP6: -
SP7: - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - -

Relevant External Links for ZSCAN25 Gene

GeneLoc Exon Structure for
ZSCAN25
ECgene alternative splicing isoforms for
ZSCAN25

Expression for ZSCAN25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN25 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZSCAN25 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZSCAN25 Gene:

ZSCAN25

SOURCE GeneReport for Unigene cluster for ZSCAN25 Gene:

Hs.446297

Evidence on tissue expression from TISSUES for ZSCAN25 Gene

  • Nervous system(4.2)
  • Lung(4.1)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with ZSCAN25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN25 Gene

Orthologs for ZSCAN25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF498 33 34
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia ZSCAN25 33 34
  • 86.58 (n)
mouse
(Mus musculus)
Mammalia Zscan25 33 16 34
  • 83.15 (n)
rat
(Rattus norvegicus)
Mammalia Zfp498 33
  • 83.09 (n)
cow
(Bos Taurus)
Mammalia ZSCAN25 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZSCAN25 34
  • 33 (a)
OneToOne
Species where no ortholog for ZSCAN25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN25 Gene

ENSEMBL:
Gene Tree for ZSCAN25 (if available)
TreeFam:
Gene Tree for ZSCAN25 (if available)

Paralogs for ZSCAN25 Gene

(239) SIMAP similar genes for ZSCAN25 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZSCAN25: view

Variants for ZSCAN25 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN25 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs4646450 association, appendicular lean mass relative to body height 99,668,695(+) G/A genic_downstream_transcript_variant, intron_variant
rs776746 drug-response, sirolimus response - Dosage, cyclosporine response - Dosage, Metabolism/PK, tacrolimus response - Dosage, Metabolism/PK, tacrolimus response due to donor genotype - Dosage, Metabolism/PK, tacrolimus response - Efficacy 99,672,916(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000006168 -- 99,642,880(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000093241 -- 99,683,083(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000111953 -- 99,680,238(+) C/T genic_downstream_transcript_variant, intron_variant

Variation tolerance for ZSCAN25 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN25 Gene

Human Gene Mutation Database (HGMD)
ZSCAN25
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZSCAN25 Gene

Disorders for ZSCAN25 Gene

Additional Disease Information for ZSCAN25

No disorders were found for ZSCAN25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN25 Gene

Publications for ZSCAN25 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  2. Zinc finger proteins: new insights into structural and functional diversity. (PMID: 11179890) Laity JH … Wright PE (Current opinion in structural biology 2001) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ZSCAN25 Gene

Sources for ZSCAN25 Gene

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