Aliases for ZSCAN23 Gene

Aliases for ZSCAN23 Gene

  • Zinc Finger And SCAN Domain Containing 23 2 3 5
  • Zinc Finger Protein 453 2 3 4
  • Zinc Finger Protein 390 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 23 3 4
  • DJ29K1.3.1 2 3
  • ZNF390 3 4
  • ZNF453 3 4
  • DJ29K1.3 3
  • ZSCAN23 5

External Ids for ZSCAN23 Gene

Previous HGNC Symbols for ZSCAN23 Gene

  • ZNF453
  • ZNF390

Previous GeneCards Identifiers for ZSCAN23 Gene

  • GC06M028513
  • GC06U901203
  • GC06M028399
  • GC06M028206

Summaries for ZSCAN23 Gene

GeneCards Summary for ZSCAN23 Gene

ZSCAN23 (Zinc Finger And SCAN Domain Containing 23) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZSCAN12.

UniProtKB/Swiss-Prot Summary for ZSCAN23 Gene

Additional gene information for ZSCAN23 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSCAN23 Gene

Genomics for ZSCAN23 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZSCAN23 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSCAN23 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZSCAN23

Top Transcription factor binding sites by QIAGEN in the ZSCAN23 gene promoter:
  • C/EBPalpha
  • CUTL1
  • En-1
  • FOXD1
  • FOXJ2
  • FOXJ2 (long isoform)
  • Nkx2-5
  • Pax-5
  • POU3F1

Genomic Locations for ZSCAN23 Gene

Genomic Locations for ZSCAN23 Gene
chr6:28,425,516-28,443,554
(GRCh38/hg38)
Size:
18,039 bases
Orientation:
Minus strand
chr6:28,399,707-28,411,279
(GRCh37/hg19)
Size:
11,573 bases
Orientation:
Minus strand

Genomic View for ZSCAN23 Gene

Genes around ZSCAN23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN23 Gene

Proteins for ZSCAN23 Gene

  • Protein details for ZSCAN23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MJ62-ZSC23_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 23
    Protein Accession:
    Q3MJ62
    Secondary Accessions:
    • Q96KV9

    Protein attributes for ZSCAN23 Gene

    Size:
    389 amino acids
    Molecular mass:
    44955 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSCAN23 Gene

Post-translational modifications for ZSCAN23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN23 Gene

No data available for DME Specific Peptides for ZSCAN23 Gene

Domains & Families for ZSCAN23 Gene

Gene Families for ZSCAN23 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN23 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • Transcriptional regulator SCAN
ProtoNet:

Suggested Antigen Peptide Sequences for ZSCAN23 Gene

GenScript: Design optimal peptide antigens:
  • DJ29K1.3.1 (Novel C2H2 type zinc finger protein (Isoform 1)) (Q96KW0_HUMAN)
  • Zinc finger protein 453 (ZSC23_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q3MJ62

UniProtKB/Swiss-Prot:

ZSC23_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN23: view

Function for ZSCAN23 Gene

Molecular function for ZSCAN23 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZSCAN23 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN23: view

Phenotypes for ZSCAN23 Gene

genes like me logo Genes that share phenotypes with ZSCAN23: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN23

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN23 Gene

Localization for ZSCAN23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN23 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZSCAN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN23: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZSCAN23 Gene

Pathways & Interactions for ZSCAN23 Gene

PathCards logo

SuperPathways for ZSCAN23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN23: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN23 Gene

Drugs & Compounds for ZSCAN23 Gene

No Compound Related Data Available

Transcripts for ZSCAN23 Gene

mRNA/cDNA for ZSCAN23 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN23

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN23 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4
SP1:
SP2: - -

Relevant External Links for ZSCAN23 Gene

GeneLoc Exon Structure for
ZSCAN23

Expression for ZSCAN23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSCAN23 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZSCAN23

SOURCE GeneReport for Unigene cluster for ZSCAN23 Gene:

Hs.721841
genes like me logo Genes that share expression patterns with ZSCAN23: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN23 Gene

Orthologs for ZSCAN23 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN23 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZSCAN23 30 31
  • 99.74 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZSCAN23 30 31
  • 86.08 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZSCAN23 30 31
  • 83.65 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZSCAN23 31
  • 72 (a)
OneToOne
Species where no ortholog for ZSCAN23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZSCAN23 Gene

ENSEMBL:
Gene Tree for ZSCAN23 (if available)
TreeFam:
Gene Tree for ZSCAN23 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSCAN23: view image

Paralogs for ZSCAN23 Gene

(427) SIMAP similar genes for ZSCAN23 Gene using alignment to 2 proteins:

  • ZSC23_HUMAN
  • G3V1D5_HUMAN

Pseudogenes.org Pseudogenes for ZSCAN23 Gene

genes like me logo Genes that share paralogs with ZSCAN23: view

Variants for ZSCAN23 Gene

Additional dbSNP identifiers (rs#s) for ZSCAN23 Gene

Variation tolerance for ZSCAN23 Gene

Gene Damage Index Score: 0.96; 19.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for ZSCAN23 Gene

Disorders for ZSCAN23 Gene

No disorders were found for ZSCAN23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN23 Gene

Publications for ZSCAN23 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for ZSCAN23 Gene

Sources for ZSCAN23 Gene