Aliases for ZSCAN22 Gene

Aliases for ZSCAN22 Gene

  • Zinc Finger And SCAN Domain Containing 22 2 3 5
  • Zinc Finger Protein 50 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 22 3 4
  • Krueppel-Related Zinc Finger Protein 2 3 4
  • GLI-Kruppel Family Member HKR2 2 3
  • ZNF50 3 4
  • HKR2 3 4
  • Oncogene HKR2 2
  • Protein HKR2 4
  • ZSCAN22 5

External Ids for ZSCAN22 Gene

Previous HGNC Symbols for ZSCAN22 Gene

  • ZNF50
  • HKR2

Previous GeneCards Identifiers for ZSCAN22 Gene

  • GC19P063531
  • GC19P058838
  • GC19P055147
  • GC19P058327
  • GC19P058329
  • GC19P058353

Summaries for ZSCAN22 Gene

GeneCards Summary for ZSCAN22 Gene

ZSCAN22 (Zinc Finger And SCAN Domain Containing 22) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF263.

UniProtKB/Swiss-Prot Summary for ZSCAN22 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSCAN22 Gene

Genomics for ZSCAN22 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZSCAN22 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSCAN22 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZSCAN22

Top Transcription factor binding sites by QIAGEN in the ZSCAN22 gene promoter:
  • C/EBPalpha
  • Egr-4
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • GATA-2
  • Ik-1
  • Ik-2
  • NRF-2

Genomic Locations for ZSCAN22 Gene

Latest Assembly
15,343 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
15,339 bases
Plus strand

(GRCh37/hg19 by Ensembl)
15,314 bases
Plus strand

Genomic View for ZSCAN22 Gene

Genes around ZSCAN22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN22 Gene

Proteins for ZSCAN22 Gene

  • Protein details for ZSCAN22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and SCAN domain-containing protein 22
    Protein Accession:
    Secondary Accessions:
    • Q15922
    • Q7Z3L8

    Protein attributes for ZSCAN22 Gene

    491 amino acids
    Molecular mass:
    54561 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSCAN22 Gene

Post-translational modifications for ZSCAN22 Gene

  • Ubiquitination at Lys133
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZSCAN22

No data available for DME Specific Peptides for ZSCAN22 Gene

Domains & Families for ZSCAN22 Gene

Gene Families for ZSCAN22 Gene

Protein Domains for ZSCAN22 Gene

  • C2H2-type zinc finger signature

Suggested Antigen Peptide Sequences for ZSCAN22 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 50 (ZSC22_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN22: view

Function for ZSCAN22 Gene

Molecular function for ZSCAN22 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZSCAN22 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZSCAN22: view
genes like me logo Genes that share phenotypes with ZSCAN22: view

miRNA for ZSCAN22 Gene

miRTarBase miRNAs that target ZSCAN22
Targeted motifs for ZSCAN22 Gene
HOMER Transcription Factor Regulatory Elements motif ZSCAN22
  • Consensus sequence: SMCAGTCWGAKGGAGGAGGC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN22

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZSCAN22 Gene

Localization for ZSCAN22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN22 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN22 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (1)
  • Cytosol (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSCAN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN22: view

Pathways & Interactions for ZSCAN22 Gene

PathCards logo

SuperPathways for ZSCAN22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZSCAN22: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN22 Gene

Drugs & Compounds for ZSCAN22 Gene

No Compound Related Data Available

Transcripts for ZSCAN22 Gene

mRNA/cDNA for ZSCAN22 Gene

8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN22

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN22 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -

Relevant External Links for ZSCAN22 Gene

GeneLoc Exon Structure for

Expression for ZSCAN22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSCAN22 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZSCAN22

SOURCE GeneReport for Unigene cluster for ZSCAN22 Gene:

genes like me logo Genes that share expression patterns with ZSCAN22: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN22 Gene

Orthologs for ZSCAN22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZSCAN22 30 31
  • 98.98 (n)
(Canis familiaris)
Mammalia ZSCAN22 30 31
  • 84.46 (n)
(Mus musculus)
Mammalia Zscan22 30 17 31
  • 78.8 (n)
(Rattus norvegicus)
Mammalia LOC102553294 30
  • 77.87 (n)
(Ornithorhynchus anatinus)
Mammalia ZSCAN22 31
  • 38 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 35 (a)
(Gallus gallus)
Aves ZFP92 31
  • 39 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 32 (a)
Species where no ortholog for ZSCAN22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZSCAN22 Gene

Gene Tree for ZSCAN22 (if available)
Gene Tree for ZSCAN22 (if available)
Evolutionary constrained regions (ECRs) for ZSCAN22: view image

Paralogs for ZSCAN22 Gene

(462) SIMAP similar genes for ZSCAN22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZSCAN22: view

Variants for ZSCAN22 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZSCAN22 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN22 Gene

Variant ID Type Subtype PubMed ID
nsv1058109 CNV gain 25217958
nsv515731 CNV gain+loss 19592680
nsv833886 CNV gain 17160897
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897

Variation tolerance for ZSCAN22 Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZSCAN22 Gene

Disorders for ZSCAN22 Gene

Additional Disease Information for ZSCAN22

No disorders were found for ZSCAN22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN22 Gene

Publications for ZSCAN22 Gene

  1. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 2 3 4
  2. The GLI-Kruppel family of human genes. (PMID: 2850480) Ruppert JM … Vogelstein B (Molecular and cellular biology 1988) 2 3 4
  3. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

Products for ZSCAN22 Gene

Sources for ZSCAN22 Gene