Aliases for ZSCAN20 Gene

Aliases for ZSCAN20 Gene

  • Zinc Finger And SCAN Domain Containing 20 2 3 5
  • Zinc Finger Protein 31 2 3 4
  • KOX29 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 20 3 4
  • Zinc Finger Protein KOX29 3 4
  • Zinc Finger Protein 360 3 4
  • ZNF360 3 4
  • ZNF31 3 4
  • Zinc Finger Protein 31 (KOX 29) 2
  • ZSCAN20 5
  • ZFP-31 3

External Ids for ZSCAN20 Gene

Previous HGNC Symbols for ZSCAN20 Gene

  • ZNF360
  • ZNF31

Previous GeneCards Identifiers for ZSCAN20 Gene

  • GC01P033710
  • GC01P033938
  • GC01P032054

Summaries for ZSCAN20 Gene

GeneCards Summary for ZSCAN20 Gene

ZSCAN20 (Zinc Finger And SCAN Domain Containing 20) is a Protein Coding gene. Diseases associated with ZSCAN20 include Atrial Tachyarrhythmia With Short Pr Interval. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is ZSCAN2.

UniProtKB/Swiss-Prot Summary for ZSCAN20 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSCAN20 Gene

Genomics for ZSCAN20 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZSCAN20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J033470 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 619.4 -0.7 -740 3.5 SP1 CREB1 GATAD2A CTCF PRDM10 REST SIX5 LEF1 IKZF1 POLR2A ZSCAN20 ZBTB8A AK2 CSMD2 ZNF362 RBBP4 PHC2 HPCA TLR12P
GH01J033474 Enhancer 0.2 dbSUPER 600.7 +1.9 1894 0.6 ZSCAN20 PHC2 lnc-ZSCAN20-4 HMGB4
GH01J033361 Enhancer 1.8 VISTA FANTOM5 ENCODE CraniofacialAtlas dbSUPER 47.8 -108.3 -108282 7 CTCF PRDM10 ZNF512 IKZF1 JUND PRDM1 ZNF143 ZIC2 ZNF776 ZSCAN4 ZBTB8A RBBP4 ZSCAN20 S100PBP BSDC1 PHC2 ZBTB8B CSMD2 ZBTB8OS A3GALT2
GH01J032648 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 28 -821.6 -821590 4.8 RNF2 SP1 CREB1 HNRNPL PRDM10 ZNF629 REST TFE3 SIX5 LEF1 RBBP4 ZBTB8OS lnc-ZBTB8OS-3 KHDRBS1 TXLNA TMEM39B ZBTB8A ZSCAN20 S100PBP TSSK3
GH01J032961 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 21.3 -509.4 -509390 5.2 ZNF221 GATAD2A HNRNPL ZNF629 PRDM10 REST TFE3 RFX1 NFKBIZ ZNF692 RNF19B lnc-HPCA-4 ZSCAN20 DCDC2B TMEM54 ENSG00000224066 RBBP4 S100PBP ZBTB8OS AK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSCAN20 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZSCAN20

Top Transcription factor binding sites by QIAGEN in the ZSCAN20 gene promoter:
  • AML1a
  • AREB6
  • c-Ets-1
  • E47
  • MZF-1
  • p300
  • SEF-1 (1)
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for ZSCAN20 Gene

Genomic Locations for ZSCAN20 Gene
chr1:33,472,591-33,504,253
(GRCh38/hg38)
Size:
31,663 bases
Orientation:
Plus strand
chr1:33,938,232-33,962,107
(GRCh37/hg19)
Size:
23,876 bases
Orientation:
Plus strand

Genomic View for ZSCAN20 Gene

Genes around ZSCAN20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN20 Gene

Proteins for ZSCAN20 Gene

  • Protein details for ZSCAN20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17040-ZSC20_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 20
    Protein Accession:
    P17040
    Secondary Accessions:
    • A8K2D0
    • B1ALI4
    • B1ALI5
    • B1ALI6
    • Q6ZN23
    • Q96FA9
    • Q96H84

    Protein attributes for ZSCAN20 Gene

    Size:
    1043 amino acids
    Molecular mass:
    117541 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZSCAN20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN20 Gene

Post-translational modifications for ZSCAN20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN20 Gene

Domains & Families for ZSCAN20 Gene

Gene Families for ZSCAN20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN20 Gene

InterPro:
Blocks:
  • KRAB box
  • Transcriptional regulator SCAN
ProtoNet:

Suggested Antigen Peptide Sequences for ZSCAN20 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein KOX29 (ZSC20_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17040

UniProtKB/Swiss-Prot:

ZSC20_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN20: view

Function for ZSCAN20 Gene

Molecular function for ZSCAN20 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZSCAN20 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN20: view
genes like me logo Genes that share phenotypes with ZSCAN20: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN20

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZSCAN20 Gene

Localization for ZSCAN20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN20 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN20 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZSCAN20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN20: view

Pathways & Interactions for ZSCAN20 Gene

PathCards logo

SuperPathways for ZSCAN20 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZSCAN20: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN20 Gene

Drugs & Compounds for ZSCAN20 Gene

No Compound Related Data Available

Transcripts for ZSCAN20 Gene

mRNA/cDNA for ZSCAN20 Gene

5 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN20

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN20 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: - - -
SP3:
SP4:

Relevant External Links for ZSCAN20 Gene

GeneLoc Exon Structure for
ZSCAN20

Expression for ZSCAN20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSCAN20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Lung (Respiratory System)
  • Heart (Cardiovascular System)

Protein differential expression in normal tissues from HIPED for ZSCAN20 Gene

This gene is overexpressed in Plasma (27.6), Monocytes (23.4), and Tlymphocyte (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZSCAN20 Gene



Protein tissue co-expression partners for ZSCAN20 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZSCAN20

SOURCE GeneReport for Unigene cluster for ZSCAN20 Gene:

Hs.442705

Evidence on tissue expression from TISSUES for ZSCAN20 Gene

  • Nervous system(4.3)
  • Muscle(4.1)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with ZSCAN20: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN20 Gene

Orthologs for ZSCAN20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN20 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZSCAN20 30 31
  • 99.62 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZSCAN20 30 31
  • 87.17 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZSCAN20 30 31
  • 85.37 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zscan20 30 17 31
  • 80.46 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zscan20 30
  • 80.2 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZSCAN20 31
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZSCAN20 31
  • 64 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 42 (a)
OneToMany
-- 31
  • 32 (a)
OneToMany
Species where no ortholog for ZSCAN20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZSCAN20 Gene

ENSEMBL:
Gene Tree for ZSCAN20 (if available)
TreeFam:
Gene Tree for ZSCAN20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSCAN20: view image

Paralogs for ZSCAN20 Gene

(390) SIMAP similar genes for ZSCAN20 Gene using alignment to 1 proteins:

  • ZSC20_HUMAN
genes like me logo Genes that share paralogs with ZSCAN20: view

Variants for ZSCAN20 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZSCAN20 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs34446695 - p.Asp248Asn
rs4403594 - p.Tyr432Asp

Additional dbSNP identifiers (rs#s) for ZSCAN20 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN20 Gene

Variant ID Type Subtype PubMed ID
esv3585686 CNV gain 21293372
esv3585687 CNV gain 21293372
esv3585689 CNV gain 21293372
nsv1137748 CNV deletion 24896259
nsv344 CNV insertion 18451855
nsv834613 CNV gain 17160897

Variation tolerance for ZSCAN20 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN20 Gene

Disorders for ZSCAN20 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZSCAN20 Gene - From: DISEASES

Disorder Aliases PubMed IDs
atrial tachyarrhythmia with short pr interval
  • lown-ganong-levine syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZSCAN20

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZSCAN20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZSCAN20 Gene

Publications for ZSCAN20 Gene

  1. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation. (PMID: 29883609) Choi SW … Kim YS (Molecular cell 2018) 3
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3

Products for ZSCAN20 Gene

  • Signalway Proteins for ZSCAN20

Sources for ZSCAN20 Gene