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Aliases for ZSCAN2 Gene

Aliases for ZSCAN2 Gene

  • Zinc Finger And SCAN Domain Containing 2 2 3 5
  • Zinc Finger Protein 29 Homolog 3 4
  • Zinc Finger Protein 854 3 4
  • Zfp-29 3 4
  • ZNF854 3 4
  • ZFP29 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 2 3
  • Zinc Finger Protein 29 2

External Ids for ZSCAN2 Gene

Previous HGNC Symbols for ZSCAN2 Gene

  • ZFP29

Previous GeneCards Identifiers for ZSCAN2 Gene

  • GC15P082945
  • GC15P085144
  • GC15P061230

Summaries for ZSCAN2 Gene

Entrez Gene Summary for ZSCAN2 Gene

  • The protein encoded by this gene contains several copies of zinc finger motif, which is commonly found in transcriptional regulatory proteins. Studies in mice show that this gene is expressed during embryonic development, and specifically in the testis in adult mice, suggesting that it may play a role in regulating genes in germ cells. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZSCAN2 Gene

ZSCAN2 (Zinc Finger And SCAN Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF629.

UniProtKB/Swiss-Prot for ZSCAN2 Gene

  • May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.

Additional gene information for ZSCAN2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN2 Gene

Genomics for ZSCAN2 Gene

GeneHancer (GH) Regulatory Elements for ZSCAN2 Gene

Promoters and enhancers for ZSCAN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I084597 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 550.8 -0.9 -935 4.3 PKNOX1 CLOCK FOXA2 ARID4B SIN3A ZBTB7B YY1 ZNF766 ZNF207 ZNF143 ZSCAN2 GOLGA6L4 NMB GOLGA6L5P SCAND2P WDR73 GOLGA6L3 RN7SL331P LOC101929479 ZNF592
GH15I084569 Promoter/Enhancer 1.6 Ensembl ENCODE 22.8 -30.1 -30124 2.5 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 LINC00933 UBE2Q2P1 WDR73 SCAND2P GOLGA6L4 ZSCAN2 GOLGA6L3 GOLGA6L5P ENSG00000256278 NMB
GH15I084142 Enhancer 1 Ensembl ENCODE 10.1 -458.0 -457956 0.5 HDGF ATF1 SIN3A ZNF2 IRF4 RAD21 RFX5 ZNF335 ARID2 SCRT2 WDR73 GOLGA6L4 SCAND2P ENSG00000256278 GOLGA6L5P ZSCAN2 DNM1P41 GC15M084077
GH15I084638 Enhancer 0.7 ENCODE 13.2 +37.3 37254 0.4 HDGF CTCF MXI1 ARID4B BACH1 MAX SIN3A RAD21 FOXK2 E2F8 ENSG00000256278 ZSCAN2 ZNF592 SEC11A ENSG00000275120 GC15M084641 PIR42481 SCAND2P
GH15I084884 Promoter/Enhancer 1.4 EPDnew ENCODE 4.6 +285.6 285643 5.7 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 RXRA NFYC MXD4 SLC28A1 NMB LINC00933 GOLGA6L4 GOLGA6L5P GOLGA6L3 ZNF592 ZSCAN2 GC15M084891
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZSCAN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZSCAN2 gene promoter:

Genomic Locations for ZSCAN2 Gene

Genomic Locations for ZSCAN2 Gene
chr15:84,600,986-84,627,796
(GRCh38/hg38)
Size:
26,811 bases
Orientation:
Plus strand
chr15:85,144,217-85,171,027
(GRCh37/hg19)

Genomic View for ZSCAN2 Gene

Genes around ZSCAN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN2 Gene

Proteins for ZSCAN2 Gene

  • Protein details for ZSCAN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7L9-ZSCA2_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 2
    Protein Accession:
    Q7Z7L9
    Secondary Accessions:
    • A6NG83
    • B2RMQ9
    • Q6ZQY9
    • Q9NWU4

    Protein attributes for ZSCAN2 Gene

    Size:
    614 amino acids
    Molecular mass:
    69547 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC87537.1; Type=Erroneous translation; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZSCAN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN2 Gene

Post-translational modifications for ZSCAN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN2 Gene

Domains & Families for ZSCAN2 Gene

Gene Families for ZSCAN2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN2 Gene

Suggested Antigen Peptide Sequences for ZSCAN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7L9

UniProtKB/Swiss-Prot:

ZSCA2_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN2: view

Function for ZSCAN2 Gene

Molecular function for ZSCAN2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.

Phenotypes From GWAS Catalog for ZSCAN2 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN2: view
genes like me logo Genes that share phenotypes with ZSCAN2: view

Animal Models for ZSCAN2 Gene

MGI Knock Outs for ZSCAN2:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZSCAN2 Gene

Localization for ZSCAN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN2: view

Pathways & Interactions for ZSCAN2 Gene

SuperPathways for ZSCAN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ZSCAN2: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN2 Gene

Drugs & Compounds for ZSCAN2 Gene

No Compound Related Data Available

Transcripts for ZSCAN2 Gene

Unigene Clusters for ZSCAN2 Gene

Zinc finger and SCAN domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - - - - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - - - - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - - - - - - - - - -
SP10: - -

Relevant External Links for ZSCAN2 Gene

GeneLoc Exon Structure for
ZSCAN2
ECgene alternative splicing isoforms for
ZSCAN2

Expression for ZSCAN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN2 Gene

Protein differential expression in normal tissues from HIPED for ZSCAN2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZSCAN2 Gene



Protein tissue co-expression partners for ZSCAN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN2 Gene:

ZSCAN2

SOURCE GeneReport for Unigene cluster for ZSCAN2 Gene:

Hs.594023

Evidence on tissue expression from TISSUES for ZSCAN2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZSCAN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN2 Gene

Orthologs for ZSCAN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100610406 33
  • 99.31 (n)
ZSCAN2 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zscan2 33 16 34
  • 85.78 (n)
rat
(Rattus norvegicus)
Mammalia Zscan2 33
  • 85.62 (n)
dog
(Canis familiaris)
Mammalia ZSCAN2 33 34
  • 84.12 (n)
cow
(Bos Taurus)
Mammalia ZSCAN2 33 34
  • 83.6 (n)
oppossum
(Monodelphis domestica)
Mammalia ZSCAN2 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZSCAN2 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 47 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
ZNF302 34
  • 41 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
ManyToMany
Species where no ortholog for ZSCAN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN2 Gene

ENSEMBL:
Gene Tree for ZSCAN2 (if available)
TreeFam:
Gene Tree for ZSCAN2 (if available)

Paralogs for ZSCAN2 Gene

Paralogs for ZSCAN2 Gene

(523) SIMAP similar genes for ZSCAN2 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for ZSCAN2 Gene

genes like me logo Genes that share paralogs with ZSCAN2: view

Variants for ZSCAN2 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs193921069 uncertain-significance, Malignant tumor of prostate 84,621,450(+) C/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs863223360 benign, Abnormality of neuronal migration 84,604,079(+) CT/ coding_sequence_variant, frameshift
rs1000029694 -- 84,616,411(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000033862 -- 84,622,220(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000074877 -- 84,607,882(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN2 Gene

Variant ID Type Subtype PubMed ID
esv2672879 CNV deletion 23128226
esv3569831 CNV gain 25503493
esv3637093 CNV gain 21293372
esv3637095 CNV gain 21293372
nsv1643 CNV insertion 18451855
nsv428310 CNV gain+loss 18775914

Variation tolerance for ZSCAN2 Gene

Residual Variation Intolerance Score: 4.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN2 Gene

Disorders for ZSCAN2 Gene

Additional Disease Information for ZSCAN2

No disorders were found for ZSCAN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN2 Gene

Publications for ZSCAN2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A zinc finger protein-encoding gene expressed in the post-meiotic phase of spermatogenesis. (PMID: 1937051) Denny P … Ashworth A (Gene 1991) 2 3 58
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58
  5. The functional interactome landscape of the human histone deacetylase family. (PMID: 23752268) Joshi P … Cristea IM (Molecular systems biology 2013) 3 58

Products for ZSCAN2 Gene

Sources for ZSCAN2 Gene

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