Aliases for ZSCAN16 Gene

Aliases for ZSCAN16 Gene

  • Zinc Finger And SCAN Domain Containing 16 2 3 5
  • Zinc Finger Protein 392 2 3 4
  • Zinc Finger Protein 435 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 16 3 4
  • DJ265C24.3 2 3
  • ZNF392 3 4
  • ZNF435 3 4
  • FLJ22191 2
  • ZSCAN16 5

External Ids for ZSCAN16 Gene

Previous HGNC Symbols for ZSCAN16 Gene

  • ZNF392
  • ZNF435

Previous GeneCards Identifiers for ZSCAN16 Gene

  • GC06P028201
  • GC06P028093
  • GC06P027900
  • GC06P028132
  • GC06P028433

Summaries for ZSCAN16 Gene

GeneCards Summary for ZSCAN16 Gene

ZSCAN16 (Zinc Finger And SCAN Domain Containing 16) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZSCAN31.

UniProtKB/Swiss-Prot Summary for ZSCAN16 Gene

Additional gene information for ZSCAN16 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSCAN16 Gene

Genomics for ZSCAN16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZSCAN16 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSCAN16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZSCAN16

Top Transcription factor binding sites by QIAGEN in the ZSCAN16 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CBF-C
  • CP1A
  • CP1C
  • NF-Y
  • NF-YA
  • NF-YB
  • NF-YC

Genomic Locations for ZSCAN16 Gene

Genomic Locations for ZSCAN16 Gene
chr6:28,123,753-28,130,082
(GRCh38/hg38)
Size:
6,330 bases
Orientation:
Plus strand
chr6:28,092,338-28,097,860
(GRCh37/hg19)
Size:
5,523 bases
Orientation:
Plus strand

Genomic View for ZSCAN16 Gene

Genes around ZSCAN16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN16 Gene

Proteins for ZSCAN16 Gene

  • Protein details for ZSCAN16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4T2-ZSC16_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 16
    Protein Accession:
    Q9H4T2
    Secondary Accessions:
    • Q9H6K2

    Protein attributes for ZSCAN16 Gene

    Size:
    348 amino acids
    Molecular mass:
    40792 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZSCAN16 Gene

neXtProt entry for ZSCAN16 Gene

Post-translational modifications for ZSCAN16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN16 Gene

No data available for DME Specific Peptides for ZSCAN16 Gene

Domains & Families for ZSCAN16 Gene

Gene Families for ZSCAN16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN16 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • Transcriptional regulator SCAN
ProtoNet:

Suggested Antigen Peptide Sequences for ZSCAN16 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 435 (ZSC16_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H4T2

UniProtKB/Swiss-Prot:

ZSC16_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN16: view

Function for ZSCAN16 Gene

Molecular function for ZSCAN16 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZSCAN16 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN16: view
genes like me logo Genes that share phenotypes with ZSCAN16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN16

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN16 Gene

Localization for ZSCAN16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN16 gene
Compartment Confidence
nucleus 4
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZSCAN16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN16: view

Pathways & Interactions for ZSCAN16 Gene

PathCards logo

SuperPathways for ZSCAN16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN16: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN16 Gene

Drugs & Compounds for ZSCAN16 Gene

No Compound Related Data Available

Transcripts for ZSCAN16 Gene

mRNA/cDNA for ZSCAN16 Gene

5 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN16

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN16 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2:
SP3: -
SP4: -

Relevant External Links for ZSCAN16 Gene

GeneLoc Exon Structure for
ZSCAN16

Expression for ZSCAN16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSCAN16 Gene

Protein differential expression in normal tissues from HIPED for ZSCAN16 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZSCAN16 Gene



Protein tissue co-expression partners for ZSCAN16 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZSCAN16

SOURCE GeneReport for Unigene cluster for ZSCAN16 Gene:

Hs.656641
genes like me logo Genes that share expression patterns with ZSCAN16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN16 Gene

Orthologs for ZSCAN16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN16 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZSCAN16 30 31
  • 99.43 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZSCAN16 30 31
  • 89.18 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZSCAN16 30 31
  • 84.1 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZSCAN16 31
  • 66 (a)
OneToOne
Species where no ortholog for ZSCAN16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZSCAN16 Gene

ENSEMBL:
Gene Tree for ZSCAN16 (if available)
TreeFam:
Gene Tree for ZSCAN16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSCAN16: view image

Paralogs for ZSCAN16 Gene

(355) SIMAP similar genes for ZSCAN16 Gene using alignment to 1 proteins:

  • ZSC16_HUMAN

Pseudogenes.org Pseudogenes for ZSCAN16 Gene

genes like me logo Genes that share paralogs with ZSCAN16: view

Variants for ZSCAN16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZSCAN16 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs750071607 A colorectal cancer sample p.Arg137Gln

Additional dbSNP identifiers (rs#s) for ZSCAN16 Gene

Variation tolerance for ZSCAN16 Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZSCAN16 Gene

Disorders for ZSCAN16 Gene

No disorders were found for ZSCAN16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN16 Gene

Publications for ZSCAN16 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZSCAN16 Gene

Sources for ZSCAN16 Gene