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Aliases for ZSCAN16 Gene

Aliases for ZSCAN16 Gene

  • Zinc Finger And SCAN Domain Containing 16 2 3 5
  • Zinc Finger Protein 392 2 3 4
  • Zinc Finger Protein 435 2 3 4
  • ZNF392 3 4
  • ZNF435 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 16 3
  • DJ265C24.3 3

External Ids for ZSCAN16 Gene

Previous HGNC Symbols for ZSCAN16 Gene

  • ZNF392
  • ZNF435

Previous GeneCards Identifiers for ZSCAN16 Gene

  • GC06P028201
  • GC06P028093
  • GC06P027900

Summaries for ZSCAN16 Gene

GeneCards Summary for ZSCAN16 Gene

ZSCAN16 (Zinc Finger And SCAN Domain Containing 16) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZKSCAN3.

UniProtKB/Swiss-Prot for ZSCAN16 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZSCAN16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN16 Gene

Genomics for ZSCAN16 Gene

GeneHancer (GH) Regulatory Elements for ZSCAN16 Gene

Promoters and enhancers for ZSCAN16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I028123 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 428 2.3 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF48 YY1 ETS1 GLIS2 ELK1 ZSCAN16 ZNF603P ZNF602P ZNF192P1 ZKSCAN8 ZSCAN16-AS1
GH06I028251 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 +127.5 127501 2.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 POLR2B ZKSCAN4 ZNF603P ZKSCAN3 ZSCAN9 ZKSCAN8 ZSCAN12 PGBD1 ZSCAN31 ZSCAN16 ZNF391
GH06I028161 Promoter/Enhancer 1.5 Ensembl ENCODE 10.7 +37.2 37150 1 SMAD1 ATF1 SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 POLR2B ZNF766 E2F8 ZNF192P1 ZNF603P ZNF602P ZSCAN16 NKAPL ZKSCAN4 ZSCAN12 ZKSCAN3 ZSCAN31 ZNF165
GH06I028217 Promoter/Enhancer 1.5 Ensembl ENCODE 10.5 +94.3 94301 1.9 HDGF ATF1 ARNT ARID4B DMAP1 ZNF2 ZNF48 POLR2B E2F8 ZNF143 GC06M028218 GC06M028219 PIR47699 PIR37135 TOB2P1 ZNF603P ZKSCAN4 NKAPL ZKSCAN8 PGBD1
GH06I028398 Promoter/Enhancer 1.6 Ensembl ENCODE 9.6 +274.8 274787 2.5 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D ZSCAN12 LOC105374998 ZKSCAN3 ZNF603P ZKSCAN8 ZKSCAN4 ZSCAN23 ZSCAN31 ZSCAN9 TRIM27
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZSCAN16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZSCAN16 gene promoter:

Genomic Locations for ZSCAN16 Gene

Genomic Locations for ZSCAN16 Gene
5,531 bases
Plus strand

Genomic View for ZSCAN16 Gene

Genes around ZSCAN16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN16 Gene

Proteins for ZSCAN16 Gene

  • Protein details for ZSCAN16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and SCAN domain-containing protein 16
    Protein Accession:
    Secondary Accessions:
    • Q9H6K2

    Protein attributes for ZSCAN16 Gene

    348 amino acids
    Molecular mass:
    40792 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZSCAN16 Gene

neXtProt entry for ZSCAN16 Gene

Post-translational modifications for ZSCAN16 Gene

No Post-translational modifications

Other Protein References for ZSCAN16 Gene

No data available for DME Specific Peptides for ZSCAN16 Gene

Domains & Families for ZSCAN16 Gene

Gene Families for ZSCAN16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZSCAN16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN16: view

Function for ZSCAN16 Gene

Molecular function for ZSCAN16 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZSCAN16 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN16: view
genes like me logo Genes that share phenotypes with ZSCAN16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN16 Gene

Localization for ZSCAN16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN16 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZSCAN16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN16: view

Pathways & Interactions for ZSCAN16 Gene

SuperPathways for ZSCAN16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN16: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN16 Gene

Drugs & Compounds for ZSCAN16 Gene

No Compound Related Data Available

Transcripts for ZSCAN16 Gene

mRNA/cDNA for ZSCAN16 Gene

Unigene Clusters for ZSCAN16 Gene

Zinc finger and SCAN domain containing 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN16 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP3: -
SP4: -

Relevant External Links for ZSCAN16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZSCAN16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN16 Gene

Protein differential expression in normal tissues from HIPED for ZSCAN16 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZSCAN16 Gene

Protein tissue co-expression partners for ZSCAN16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN16 Gene:


SOURCE GeneReport for Unigene cluster for ZSCAN16 Gene:

genes like me logo Genes that share expression patterns with ZSCAN16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN16 Gene

Orthologs for ZSCAN16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZSCAN16 33 34
  • 99.43 (n)
(Bos Taurus)
Mammalia ZSCAN16 33 34
  • 89.18 (n)
(Canis familiaris)
Mammalia ZSCAN16 33 34
  • 84.1 (n)
(Monodelphis domestica)
Mammalia ZSCAN16 34
  • 66 (a)
Species where no ortholog for ZSCAN16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN16 Gene

Gene Tree for ZSCAN16 (if available)
Gene Tree for ZSCAN16 (if available)

Paralogs for ZSCAN16 Gene

(355) SIMAP similar genes for ZSCAN16 Gene using alignment to 1 proteins: Pseudogenes for ZSCAN16 Gene

genes like me logo Genes that share paralogs with ZSCAN16: view

Variants for ZSCAN16 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN16 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs750071607 A colorectal cancer sample 28,126,805(+) G/A coding_sequence_variant, missense_variant
rs1000183590 -- 28,128,381(+) TTACATTAC/TTAC genic_downstream_transcript_variant, intron_variant
rs1000361029 -- 28,128,516(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000818028 -- 28,129,013(+) T/C genic_downstream_transcript_variant, intron_variant
rs1001466489 -- 28,122,498(+) C/T upstream_transcript_variant

Variation tolerance for ZSCAN16 Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZSCAN16 Gene

Disorders for ZSCAN16 Gene

Additional Disease Information for ZSCAN16

No disorders were found for ZSCAN16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN16 Gene

Publications for ZSCAN16 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ZSCAN16 Gene

Sources for ZSCAN16 Gene

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