Aliases for ZSCAN12 Gene

Aliases for ZSCAN12 Gene

  • Zinc Finger And SCAN Domain Containing 12 2 3 5
  • Zinc Finger Protein 305 2 3 4
  • Zinc Finger Protein 96 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 12 3 4
  • ZNF305 3 4
  • ZNF96 3 4
  • DJ29K1.2 3
  • KIAA0426 4
  • ZNF29K1 3
  • ZFP96 3

External Ids for ZSCAN12 Gene

Previous HGNC Symbols for ZSCAN12 Gene

  • ZNF305
  • ZNF96

Previous GeneCards Identifiers for ZSCAN12 Gene

  • GC06M028456
  • GC06M028346
  • GC06M028152

Summaries for ZSCAN12 Gene

GeneCards Summary for ZSCAN12 Gene

ZSCAN12 (Zinc Finger And SCAN Domain Containing 12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZSCAN30.

UniProtKB/Swiss-Prot Summary for ZSCAN12 Gene

Additional gene information for ZSCAN12 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSCAN12 Gene

Genomics for ZSCAN12 Gene

GeneHancer (GH) Regulatory Elements for ZSCAN12 Gene

Promoters and enhancers for ZSCAN12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSCAN12 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZSCAN12

Top Transcription factor binding sites by QIAGEN in the ZSCAN12 gene promoter:
  • ER-alpha
  • GATA-1
  • GCNF
  • GCNF-1
  • GCNF-2
  • HOXA3
  • Meis-1
  • Meis-1b
  • Olf-1
  • ZID

Genomic Locations for ZSCAN12 Gene

Genomic Locations for ZSCAN12 Gene
chr6:28,378,821-28,399,767
(GRCh38/hg38)
Size:
20,947 bases
Orientation:
Minus strand
chr6:28,346,598-28,367,544
(GRCh37/hg19)
Size:
20,947 bases
Orientation:
Minus strand

Genomic View for ZSCAN12 Gene

Genes around ZSCAN12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN12 Gene

Proteins for ZSCAN12 Gene

  • Protein details for ZSCAN12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43309-ZSC12_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 12
    Protein Accession:
    O43309
    Secondary Accessions:
    • O43724

    Protein attributes for ZSCAN12 Gene

    Size:
    604 amino acids
    Molecular mass:
    70222 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24856.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZSCAN12 Gene

Post-translational modifications for ZSCAN12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN12 Gene

No data available for DME Specific Peptides for ZSCAN12 Gene

Domains & Families for ZSCAN12 Gene

Gene Families for ZSCAN12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN12 Gene

Blocks:
  • C2H2-type zinc finger signature
  • Transcriptional regulator SCAN
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZSCAN12 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 96 (ZSC12_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43309

UniProtKB/Swiss-Prot:

ZSC12_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN12: view

Function for ZSCAN12 Gene

Molecular function for ZSCAN12 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZSCAN12 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN12: view

Phenotypes for ZSCAN12 Gene

genes like me logo Genes that share phenotypes with ZSCAN12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN12

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN12 Gene

Localization for ZSCAN12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN12 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSCAN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN12: view

Pathways & Interactions for ZSCAN12 Gene

PathCards logo

SuperPathways for ZSCAN12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN12: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN12 Gene

Drugs & Compounds for ZSCAN12 Gene

No Compound Related Data Available

Transcripts for ZSCAN12 Gene

mRNA/cDNA for ZSCAN12 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN12

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: -
SP3:
SP4: -
SP5: - - -
SP6:

Relevant External Links for ZSCAN12 Gene

GeneLoc Exon Structure for
ZSCAN12

Expression for ZSCAN12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSCAN12 Gene

Protein differential expression in normal tissues from HIPED for ZSCAN12 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZSCAN12 Gene



Protein tissue co-expression partners for ZSCAN12 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZSCAN12

SOURCE GeneReport for Unigene cluster for ZSCAN12 Gene:

Hs.134816

Evidence on tissue expression from TISSUES for ZSCAN12 Gene

  • Nervous system(4.2)
  • Skin(4)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with ZSCAN12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN12 Gene

Orthologs for ZSCAN12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN12 31 30
  • 99.4 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZSCAN12 31 30
  • 88.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZSCAN12 31 30
  • 84.55 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zscan12 30
  • 79.16 (n)
mouse
(Mus musculus)
Mammalia Zscan12 17 31 30
  • 78.25 (n)
Species where no ortholog for ZSCAN12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN12 Gene

ENSEMBL:
Gene Tree for ZSCAN12 (if available)
TreeFam:
Gene Tree for ZSCAN12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSCAN12: view image

Paralogs for ZSCAN12 Gene

(441) SIMAP similar genes for ZSCAN12 Gene using alignment to 1 proteins:

  • ZSC12_HUMAN

Pseudogenes.org Pseudogenes for ZSCAN12 Gene

genes like me logo Genes that share paralogs with ZSCAN12: view

Variants for ZSCAN12 Gene

Additional dbSNP identifiers (rs#s) for ZSCAN12 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN12 Gene

Variant ID Type Subtype PubMed ID
esv2182271 CNV deletion 18987734
esv2731752 CNV deletion 23290073
nsv830620 CNV loss 17160897

Variation tolerance for ZSCAN12 Gene

Gene Damage Index Score: 8.95; 87.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZSCAN12 Gene

Disorders for ZSCAN12 Gene

Additional Disease Information for ZSCAN12

No disorders were found for ZSCAN12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN12 Gene

Publications for ZSCAN12 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 54
  3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 54
  4. Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain. (PMID: 9244436) Lee PL … Beutler E (Genomics 1997) 2 3 54
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3 54

Products for ZSCAN12 Gene

Sources for ZSCAN12 Gene