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Aliases for ZSCAN12 Gene

Aliases for ZSCAN12 Gene

  • Zinc Finger And SCAN Domain Containing 12 2 3 5
  • Zinc Finger Protein 305 2 3 4
  • Zinc Finger Protein 96 2 3 4
  • ZNF305 3 4
  • ZNF96 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 12 3
  • DJ29K1.2 3
  • KIAA0426 4
  • ZNF29K1 3
  • ZFP96 3

External Ids for ZSCAN12 Gene

Previous HGNC Symbols for ZSCAN12 Gene

  • ZNF305
  • ZNF96

Previous GeneCards Identifiers for ZSCAN12 Gene

  • GC06M028456
  • GC06M028152

Summaries for ZSCAN12 Gene

GeneCards Summary for ZSCAN12 Gene

ZSCAN12 (Zinc Finger And SCAN Domain Containing 12) is a Protein Coding gene. Diseases associated with ZSCAN12 include Musculoskeletal System Benign Neoplasm. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZKSCAN8.

UniProtKB/Swiss-Prot for ZSCAN12 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZSCAN12 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN12 Gene

Genomics for ZSCAN12 Gene

GeneHancer (GH) Regulatory Elements for ZSCAN12 Gene

Promoters and enhancers for ZSCAN12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I028398 Promoter/Enhancer 1.6 Ensembl ENCODE 580.9 +0.4 424 2.5 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D ZSCAN12 LOC105374998 ZKSCAN3 ZNF603P ZKSCAN8 ZKSCAN4 ZSCAN23 ZSCAN31 ZSCAN9 TRIM27
GH06I027494 Enhancer 1.3 Ensembl ENCODE 150.9 +904.1 904118 1.7 FEZF1 ZNF213 E2F8 ZNF143 SP3 ZFP41 MEF2D SSRP1 ZNF610 RCOR2 TRS-AGA2-3 ZSCAN12 ZSCAN23 ZKSCAN8 PGBD1 ZNF322 ZKSCAN3 ZSCAN9 ZNF391 ENSG00000261839
GH06I028802 Enhancer 1.5 Ensembl ENCODE dbSUPER 87.7 -403.3 -403289 1.1 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF2 ZNF766 ZNF213 ZNF302 E2F8 GC06M028901 GC06M028919 TRA-TGC7-1 ZSCAN12 ZKSCAN3 ZSCAN23 ZKSCAN8 PGBD1 ZKSCAN4 ZSCAN9
GH06I027834 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 43 +562.5 562474 6.4 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 SP3 NFYC MEF2D HIST1H2BN HIST1H2AK GC06M027849 ZKSCAN3 ZKSCAN8 ZKSCAN4 ZSCAN9 ZSCAN12 HIST1H3J GUSBP2
GH06I028079 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 57.3 +319.1 319101 3.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF165 LOC102724889 ZNF603P ZKSCAN8 ZKSCAN3 ZSCAN12 ZSCAN9 ZKSCAN4 PGBD1 OR2B8P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZSCAN12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZSCAN12 gene promoter:

Genomic Locations for ZSCAN12 Gene

Genomic Locations for ZSCAN12 Gene
chr6:28,378,821-28,399,767
(GRCh38/hg38)
Size:
20,947 bases
Orientation:
Minus strand
chr6:28,346,598-28,367,544
(GRCh37/hg19)

Genomic View for ZSCAN12 Gene

Genes around ZSCAN12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN12 Gene

Proteins for ZSCAN12 Gene

  • Protein details for ZSCAN12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43309-ZSC12_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 12
    Protein Accession:
    O43309
    Secondary Accessions:
    • O43724

    Protein attributes for ZSCAN12 Gene

    Size:
    604 amino acids
    Molecular mass:
    70222 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24856.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZSCAN12 Gene

Post-translational modifications for ZSCAN12 Gene

No Post-translational modifications

Other Protein References for ZSCAN12 Gene

No data available for DME Specific Peptides for ZSCAN12 Gene

Domains & Families for ZSCAN12 Gene

Gene Families for ZSCAN12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZSCAN12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43309

UniProtKB/Swiss-Prot:

ZSC12_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN12: view

Function for ZSCAN12 Gene

Molecular function for ZSCAN12 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZSCAN12 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZSCAN12: view

Phenotypes for ZSCAN12 Gene

GenomeRNAi human phenotypes for ZSCAN12:
genes like me logo Genes that share phenotypes with ZSCAN12: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZSCAN12 Gene

Localization for ZSCAN12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN12 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSCAN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN12: view

Pathways & Interactions for ZSCAN12 Gene

SuperPathways for ZSCAN12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZSCAN12: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN12 Gene

Drugs & Compounds for ZSCAN12 Gene

No Compound Related Data Available

Transcripts for ZSCAN12 Gene

Unigene Clusters for ZSCAN12 Gene

Zinc finger and SCAN domain containing 12:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN12 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: -
SP3:
SP4: -
SP5: - - -
SP6:

Relevant External Links for ZSCAN12 Gene

GeneLoc Exon Structure for
ZSCAN12
ECgene alternative splicing isoforms for
ZSCAN12

Expression for ZSCAN12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN12 Gene

Protein differential expression in normal tissues from HIPED for ZSCAN12 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZSCAN12 Gene



Protein tissue co-expression partners for ZSCAN12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN12 Gene:

ZSCAN12

SOURCE GeneReport for Unigene cluster for ZSCAN12 Gene:

Hs.134816

Evidence on tissue expression from TISSUES for ZSCAN12 Gene

  • Nervous system(4.2)
  • Skin(4)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with ZSCAN12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN12 Gene

Orthologs for ZSCAN12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN12 33 34
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia ZSCAN12 33 34
  • 88.74 (n)
dog
(Canis familiaris)
Mammalia ZSCAN12 33 34
  • 84.55 (n)
rat
(Rattus norvegicus)
Mammalia Zscan12 33
  • 79.16 (n)
mouse
(Mus musculus)
Mammalia Zscan12 33 16 34
  • 78.25 (n)
Species where no ortholog for ZSCAN12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN12 Gene

ENSEMBL:
Gene Tree for ZSCAN12 (if available)
TreeFam:
Gene Tree for ZSCAN12 (if available)

Paralogs for ZSCAN12 Gene

(441) SIMAP similar genes for ZSCAN12 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZSCAN12 Gene

genes like me logo Genes that share paralogs with ZSCAN12: view

Variants for ZSCAN12 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN12 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000158810 -- 28,390,933(-) G/C/T coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000448916 -- 28,382,572(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000607880 -- 28,399,736(-) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant
rs1000610328 -- 28,391,421(-) A/G coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000725769 -- 28,383,820(-) AGGAGGA/AGGA 3_prime_UTR_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN12 Gene

Variant ID Type Subtype PubMed ID
esv2182271 CNV deletion 18987734
esv2731752 CNV deletion 23290073
nsv830620 CNV loss 17160897

Variation tolerance for ZSCAN12 Gene

Gene Damage Index Score: 8.95; 87.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN12 Gene

Disorders for ZSCAN12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZSCAN12 Gene - From: DISEASES

Disorder Aliases PubMed IDs
musculoskeletal system benign neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZSCAN12

genes like me logo Genes that share disorders with ZSCAN12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZSCAN12 Gene

Publications for ZSCAN12 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 58
  4. Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain. (PMID: 9244436) Lee PL … Beutler E (Genomics 1997) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZSCAN12 Gene

Sources for ZSCAN12 Gene

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