Aliases for ZSCAN10 Gene

Aliases for ZSCAN10 Gene

  • Zinc Finger And SCAN Domain Containing 10 2 3 5
  • Zinc Finger Protein 206 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 10 3 4
  • ZNF206 3 4
  • ZSCAN10 5
  • ZFP206 3

External Ids for ZSCAN10 Gene

Previous HGNC Symbols for ZSCAN10 Gene

  • ZNF206

Previous GeneCards Identifiers for ZSCAN10 Gene

  • GC16M003079
  • GC16M003138
  • GC16M003110

Summaries for ZSCAN10 Gene

GeneCards Summary for ZSCAN10 Gene

ZSCAN10 (Zinc Finger And SCAN Domain Containing 10) is a Protein Coding gene. Among its related pathways are Transcriptional regulation of pluripotent stem cells and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ZNF470.

UniProtKB/Swiss-Prot Summary for ZSCAN10 Gene

  • Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSCAN10 Gene

Genomics for ZSCAN10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZSCAN10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSCAN10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZSCAN10

Top Transcription factor binding sites by QIAGEN in the ZSCAN10 gene promoter:
  • Egr-1
  • HSF1 (long)
  • HSF1short
  • Ik-3
  • Lmo2
  • LUN-1
  • MIF-1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2

Genomic Locations for ZSCAN10 Gene

Latest Assembly
chr16:3,088,890-3,099,295
(GRCh38/hg38)
Size:
10,406 bases
Orientation:
Minus strand

Previous Assembly
chr16:3,138,891-3,149,295
(GRCh37/hg19 by Entrez Gene)
Size:
10,405 bases
Orientation:
Minus strand

chr16:3,138,891-3,149,318
(GRCh37/hg19 by Ensembl)
Size:
10,428 bases
Orientation:
Minus strand

Genomic View for ZSCAN10 Gene

Genes around ZSCAN10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN10 Gene

Proteins for ZSCAN10 Gene

  • Protein details for ZSCAN10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SZ4-ZSC10_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 10
    Protein Accession:
    Q96SZ4
    Secondary Accessions:
    • B3KQD3
    • H0YFS6
    • Q1WWM2

    Protein attributes for ZSCAN10 Gene

    Size:
    725 amino acids
    Molecular mass:
    80387 Da
    Quaternary structure:
    • Interacts with POU5F1/OCT4 and SOX2.
    SequenceCaution:
    • Sequence=AAI14453.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZSCAN10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN10 Gene

Post-translational modifications for ZSCAN10 Gene

No data available for DME Specific Peptides for ZSCAN10 Gene

Domains & Families for ZSCAN10 Gene

Gene Families for ZSCAN10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN10 Gene

InterPro:
Blocks:
  • Transcriptional regulator SCAN

Suggested Antigen Peptide Sequences for ZSCAN10 Gene

GenScript: Design optimal peptide antigens:
  • ZSCAN10 protein (Q1WWM2_HUMAN)
  • Zinc finger protein 206 (ZSC10_HUMAN)
genes like me logo Genes that share domains with ZSCAN10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZSCAN10 Gene

Function for ZSCAN10 Gene

Molecular function for ZSCAN10 Gene

UniProtKB/Swiss-Prot Function:
Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4.

Phenotypes From GWAS Catalog for ZSCAN10 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity ISS --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with ZSCAN10: view
genes like me logo Genes that share phenotypes with ZSCAN10: view

Animal Models for ZSCAN10 Gene

MGI Knock Outs for ZSCAN10:
  • Zscan10 Zscan10<tm2a(EUCOMM)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZSCAN10 Gene

Localization for ZSCAN10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN10 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Centrosome (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSCAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZSCAN10: view

Pathways & Interactions for ZSCAN10 Gene

genes like me logo Genes that share pathways with ZSCAN10: view

Pathways by source for ZSCAN10 Gene

Interacting Proteins for ZSCAN10 Gene

Gene Ontology (GO) - Biological Process for ZSCAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0035019 somatic stem cell population maintenance TAS --
GO:0045892 negative regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with ZSCAN10: view

No data available for SIGNOR curated interactions for ZSCAN10 Gene

Drugs & Compounds for ZSCAN10 Gene

No Compound Related Data Available

Transcripts for ZSCAN10 Gene

mRNA/cDNA for ZSCAN10 Gene

5 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN10

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1:
SP2: - -
SP3: -

Relevant External Links for ZSCAN10 Gene

GeneLoc Exon Structure for
ZSCAN10

Expression for ZSCAN10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSCAN10 Gene

mRNA differential expression in normal tissues according to GTEx for ZSCAN10 Gene

This gene is overexpressed in Brain - Cerebellum (x8.8), Brain - Cerebellar Hemisphere (x6.8), Muscle - Skeletal (x5.9), and Testis (x4.6).

Protein differential expression in normal tissues from HIPED for ZSCAN10 Gene

This gene is overexpressed in Liver, secretome (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZSCAN10 Gene



Protein tissue co-expression partners for ZSCAN10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZSCAN10

SOURCE GeneReport for Unigene cluster for ZSCAN10 Gene:

Hs.334515
genes like me logo Genes that share expression patterns with ZSCAN10: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN10 Gene

Orthologs for ZSCAN10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZSCAN10 29 30
  • 99.03 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZSCAN10 29 30
  • 84.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZSCAN10 29 30
  • 83.47 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zscan10 29
  • 76.04 (n)
Mouse
(Mus musculus)
Mammalia Zscan10 29 16 30
  • 75.37 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZSCAN10 30
  • 52 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 44 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii -- 29
Species where no ortholog for ZSCAN10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZSCAN10 Gene

ENSEMBL:
Gene Tree for ZSCAN10 (if available)
TreeFam:
Gene Tree for ZSCAN10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSCAN10: view image
Alliance of Genome Resources:
Additional Orthologs for ZSCAN10

Paralogs for ZSCAN10 Gene

Paralogs for ZSCAN10 Gene

(485) SIMAP similar genes for ZSCAN10 Gene using alignment to 6 proteins:

  • ZSC10_HUMAN
  • H0YFS6_HUMAN
  • I3L0Q3_HUMAN
  • I3L1J3_HUMAN
  • I3NI43_HUMAN
  • Q1WWM2_HUMAN
genes like me logo Genes that share paralogs with ZSCAN10: view

Variants for ZSCAN10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZSCAN10 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs11644978 Benign: not provided 3,092,910(-) C/G
NM_032805.3(ZSCAN10):c.28G>C (p.Val10Leu)
MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON
rs138053638 Benign: not provided 3,092,818(-) G/C
NM_032805.3(ZSCAN10):c.120C>G (p.Pro40=)
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON
rs140690870 Benign: not provided 3,090,600(-) C/T
NM_032805.3(ZSCAN10):c.834G>A (p.Glu278=)
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR
rs201495311 Benign: not provided 3,089,998(-) G/T
NM_032805.3(ZSCAN10):c.1436C>A (p.Ser479Tyr)
MISSENSE
rs61735554 Benign: not provided 3,092,668(-) C/T
NM_032805.3(ZSCAN10):c.270G>A (p.Glu90=)
MISSENSE_VARIANT,SYNONYMOUS_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZSCAN10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN10 Gene

Variant ID Type Subtype PubMed ID
esv3637652 CNV loss 21293372
nsv509589 CNV insertion 20534489
nsv571248 CNV loss 21841781
nsv833125 CNV loss 17160897

Variation tolerance for ZSCAN10 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN10
Leiden Open Variation Database (LOVD)
ZSCAN10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN10 Gene

Disorders for ZSCAN10 Gene

Additional Disease Information for ZSCAN10

No disorders were found for ZSCAN10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN10 Gene

Publications for ZSCAN10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A transcriptional Map of the FMF region. (PMID: 9653642) Bernot A … Weissenbach J (Genomics 1998) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Insights into the ubiquitin-proteasome system of human embryonic stem cells. (PMID: 29511261) Saez I … Vilchez D (Scientific reports 2018) 3
  5. ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. (PMID: 28846095) Skamagki M … Kim K (Nature cell biology 2017) 3

Products for ZSCAN10 Gene

Sources for ZSCAN10 Gene