Aliases for ZSCAN1 Gene

Aliases for ZSCAN1 Gene

  • Zinc Finger And SCAN Domain Containing 1 2 3 5
  • Zinc Finger And SCAN Domain-Containing Protein 1 3 4
  • Zinc Finger With SCAN Domain 1 2 3
  • ZNF915 3
  • MZF-1 3

External Ids for ZSCAN1 Gene

Previous GeneCards Identifiers for ZSCAN1 Gene

  • GC19P063238
  • GC19P063239
  • GC19P058547
  • GC19P054858

Summaries for ZSCAN1 Gene

GeneCards Summary for ZSCAN1 Gene

ZSCAN1 (Zinc Finger And SCAN Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ZNF274.

UniProtKB/Swiss-Prot Summary for ZSCAN1 Gene

Additional gene information for ZSCAN1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZSCAN1 Gene

Genomics for ZSCAN1 Gene

GeneHancer (GH) Regulatory Elements for ZSCAN1 Gene

Promoters and enhancers for ZSCAN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSCAN1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZSCAN1

Top Transcription factor binding sites by QIAGEN in the ZSCAN1 gene promoter:
  • AP-1
  • AP-4
  • ATF-2
  • c-Fos
  • c-Jun
  • E47
  • Pax-2a
  • STAT3
  • Tal-1

Genomic Locations for ZSCAN1 Gene

Genomic Locations for ZSCAN1 Gene
chr19:58,033,989-58,058,907
(GRCh38/hg38)
Size:
24,919 bases
Orientation:
Plus strand
chr19:58,545,400-58,565,999
(GRCh37/hg19)
Size:
20,600 bases
Orientation:
Plus strand

Genomic View for ZSCAN1 Gene

Genes around ZSCAN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN1 Gene

Proteins for ZSCAN1 Gene

  • Protein details for ZSCAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBB4-ZSCA1_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 1
    Protein Accession:
    Q8NBB4
    Secondary Accessions:
    • Q3B798
    • Q6WLH8
    • Q86WS8

    Protein attributes for ZSCAN1 Gene

    Size:
    408 amino acids
    Molecular mass:
    45286 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZSCAN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN1 Gene

Post-translational modifications for ZSCAN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZSCAN1 Gene

No data available for DME Specific Peptides for ZSCAN1 Gene

Domains & Families for ZSCAN1 Gene

Gene Families for ZSCAN1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN1 Gene

Blocks:
  • Transcriptional regulator SCAN
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZSCAN1 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger and SCAN domain-containing protein 1 (ZSCA1_HUMAN)
genes like me logo Genes that share domains with ZSCAN1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZSCAN1 Gene

Function for ZSCAN1 Gene

Molecular function for ZSCAN1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZSCAN1 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZSCAN1: view
genes like me logo Genes that share phenotypes with ZSCAN1: view

Animal Model Products

CRISPR Products

Transcription Factor Targets for ZSCAN1 Gene

Selected GeneGlobe predicted Target genes for ZSCAN1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for ZSCAN1 Gene

Localization for ZSCAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN1: view

Pathways & Interactions for ZSCAN1 Gene

PathCards logo

SuperPathways for ZSCAN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZSCAN1: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN1 Gene

Drugs & Compounds for ZSCAN1 Gene

No Compound Related Data Available

Transcripts for ZSCAN1 Gene

mRNA/cDNA for ZSCAN1 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN1

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN1 Gene

No ASD Table

Relevant External Links for ZSCAN1 Gene

GeneLoc Exon Structure for
ZSCAN1

Expression for ZSCAN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZSCAN1 Gene

mRNA differential expression in normal tissues according to GTEx for ZSCAN1 Gene

This gene is overexpressed in Pituitary (x7.6) and Testis (x4.7).

Protein differential expression in normal tissues from HIPED for ZSCAN1 Gene

This gene is overexpressed in Liver (45.9) and Fetal gut (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZSCAN1 Gene



Protein tissue co-expression partners for ZSCAN1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZSCAN1

SOURCE GeneReport for Unigene cluster for ZSCAN1 Gene:

Hs.643437

Evidence on tissue expression from TISSUES for ZSCAN1 Gene

  • Nervous system(4.3)
  • Lung(4)
  • Heart(2)
genes like me logo Genes that share expression patterns with ZSCAN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN1 Gene

Orthologs for ZSCAN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN1 31 30
  • 99.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZSCAN1 31 30
  • 73.18 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 21 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 28 (a)
OneToMany
Species where no ortholog for ZSCAN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN1 Gene

ENSEMBL:
Gene Tree for ZSCAN1 (if available)
TreeFam:
Gene Tree for ZSCAN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSCAN1: view image

Paralogs for ZSCAN1 Gene

(16) SIMAP similar genes for ZSCAN1 Gene using alignment to 2 proteins:

  • ZSCA1_HUMAN
  • L8E9B7_HUMAN
genes like me logo Genes that share paralogs with ZSCAN1: view

Variants for ZSCAN1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZSCAN1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
783854 Benign: not provided 58,038,004(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ZSCAN1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN1 Gene

Variant ID Type Subtype PubMed ID
nsv1066059 CNV gain 25217958
nsv1143929 CNV deletion 24896259
nsv833885 CNV loss 17160897

Variation tolerance for ZSCAN1 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN1 Gene

Disorders for ZSCAN1 Gene

Additional Disease Information for ZSCAN1

No disorders were found for ZSCAN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN1 Gene

Publications for ZSCAN1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 54

Products for ZSCAN1 Gene

Sources for ZSCAN1 Gene