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Aliases for ZSCAN1 Gene

Aliases for ZSCAN1 Gene

  • Zinc Finger And SCAN Domain Containing 1 2 3 5
  • Zinc Finger With SCAN Domain 1 2 3
  • Zinc Finger And SCAN Domain-Containing Protein 1 3
  • ZNF915 3
  • MZF-1 3

External Ids for ZSCAN1 Gene

Previous GeneCards Identifiers for ZSCAN1 Gene

  • GC19P063238
  • GC19P063239
  • GC19P058547
  • GC19P054858

Summaries for ZSCAN1 Gene

GeneCards Summary for ZSCAN1 Gene

ZSCAN1 (Zinc Finger And SCAN Domain Containing 1) is a Protein Coding gene. Diseases associated with ZSCAN1 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 1. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZSCAN18.

UniProtKB/Swiss-Prot for ZSCAN1 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZSCAN1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN1 Gene

Genomics for ZSCAN1 Gene

GeneHancer (GH) Regulatory Elements for ZSCAN1 Gene

Promoters and enhancers for ZSCAN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I058033 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 567.9 +0.2 174 1.6 SP1 MXI1 USF1 RFX1 POLR2A SIN3A ZSCAN1 LETM1P2
GH19I058379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19 +347.1 347096 2.9 ZFP64 FEZF1 DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF837 LOC100128398 ZNF606 ZNF329 ZNF135 TRIM28 ZNF132 ZNF446 ZSCAN18 ZNF548
GH19I057476 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.3 -556.5 -556511 1.5 PKNOX1 ATF1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 ZNF772 ENSG00000268163 ENSG00000268266 ZNF773 ZNF417 VN1R1 ZNF446 ZNF606 ZNF134 ZNF17
GH19I057388 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.3 -644.0 -643990 2.2 PKNOX1 FOXA2 SIN3A DMAP1 IRF4 YY1 ZNF143 FOS SP3 CEBPZ ZNF548 ENSG00000269533 ZNF264 ZSCAN18 ENSG00000269696 LOC100128398 ZNF835 ZNF470 ZNF805 ZNF582-AS1
GH19I058553 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 +523.1 523124 7.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 CHMP2A UBE2M TRIM28 ZNF417 ZNF134 ZNF606 ZNF274 MZF1 LOC100128398 ERVK3-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZSCAN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZSCAN1 gene promoter:

Genomic Locations for ZSCAN1 Gene

Genomic Locations for ZSCAN1 Gene
chr19:58,033,989-58,058,907
(GRCh38/hg38)
Size:
24,919 bases
Orientation:
Plus strand
chr19:58,545,400-58,565,999
(GRCh37/hg19)

Genomic View for ZSCAN1 Gene

Genes around ZSCAN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN1 Gene

Proteins for ZSCAN1 Gene

  • Protein details for ZSCAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBB4-ZSCA1_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 1
    Protein Accession:
    Q8NBB4
    Secondary Accessions:
    • Q3B798
    • Q6WLH8
    • Q86WS8

    Protein attributes for ZSCAN1 Gene

    Size:
    408 amino acids
    Molecular mass:
    45286 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZSCAN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZSCAN1 Gene

Post-translational modifications for ZSCAN1 Gene

No Post-translational modifications

Other Protein References for ZSCAN1 Gene

No data available for DME Specific Peptides for ZSCAN1 Gene

Domains & Families for ZSCAN1 Gene

Gene Families for ZSCAN1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZSCAN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZSCAN1: view

No data available for UniProtKB/Swiss-Prot for ZSCAN1 Gene

Function for ZSCAN1 Gene

Molecular function for ZSCAN1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZSCAN1: view
genes like me logo Genes that share phenotypes with ZSCAN1: view

Animal Model Products

CRISPR Products

Transcription Factor Targets for ZSCAN1 Gene

Selected GeneGlobe predicted Target genes for ZSCAN1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for ZSCAN1 Gene

Localization for ZSCAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZSCAN1: view

Pathways & Interactions for ZSCAN1 Gene

SuperPathways for ZSCAN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZSCAN1: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN1 Gene

Drugs & Compounds for ZSCAN1 Gene

No Compound Related Data Available

Transcripts for ZSCAN1 Gene

mRNA/cDNA for ZSCAN1 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZSCAN1 Gene

Zinc finger and SCAN domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN1 Gene

No ASD Table

Relevant External Links for ZSCAN1 Gene

GeneLoc Exon Structure for
ZSCAN1
ECgene alternative splicing isoforms for
ZSCAN1

Expression for ZSCAN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN1 Gene

mRNA differential expression in normal tissues according to GTEx for ZSCAN1 Gene

This gene is overexpressed in Pituitary (x7.6) and Testis (x4.7).

Protein differential expression in normal tissues from HIPED for ZSCAN1 Gene

This gene is overexpressed in Liver (45.9) and Fetal gut (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZSCAN1 Gene



Protein tissue co-expression partners for ZSCAN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN1 Gene:

ZSCAN1

SOURCE GeneReport for Unigene cluster for ZSCAN1 Gene:

Hs.643437

Evidence on tissue expression from TISSUES for ZSCAN1 Gene

  • Nervous system(4.3)
  • Lung(4)
  • Heart(2)
genes like me logo Genes that share expression patterns with ZSCAN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN1 Gene

Orthologs for ZSCAN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZSCAN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN1 33 34
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia ZSCAN1 33 34
  • 73.18 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 21 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 28 (a)
OneToMany
Species where no ortholog for ZSCAN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN1 Gene

ENSEMBL:
Gene Tree for ZSCAN1 (if available)
TreeFam:
Gene Tree for ZSCAN1 (if available)

Paralogs for ZSCAN1 Gene

Paralogs for ZSCAN1 Gene

(16) SIMAP similar genes for ZSCAN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZSCAN1: view

Variants for ZSCAN1 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000214354 -- 58,040,308(+) T/A intron_variant
rs1000263351 -- 58,034,352(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000336971 -- 58,045,009(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000375428 -- 58,035,958(+) A/C 5_prime_UTR_variant, intron_variant
rs1000604168 -- 58,035,670(+) G/A 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN1 Gene

Variant ID Type Subtype PubMed ID
nsv1066059 CNV gain 25217958
nsv1143929 CNV deletion 24896259
nsv833885 CNV loss 17160897

Variation tolerance for ZSCAN1 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN1 Gene

Disorders for ZSCAN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZSCAN1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZSCAN1

genes like me logo Genes that share disorders with ZSCAN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZSCAN1 Gene

Publications for ZSCAN1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58

Products for ZSCAN1 Gene

Sources for ZSCAN1 Gene

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