ZRANB3 Gene (Protein Coding)

Zinc Finger RANBP2-Type Containing 3

GC02M135136
GIFtS:
36
See more...

Aliases for ZRANB3 Gene

Aliases for ZRANB3 Gene

  • Zinc Finger RANBP2-Type Containing 3 2 3 5
  • Annealing Helicase 2 2 3 4
  • AH2 2 3 4
  • Zinc Finger Ran-Binding Domain-Containing Protein 3 3 4
  • DNA Annealing Helicase And Endonuclease ZRANB3 3 4
  • Zinc Finger, RAN-Binding Domain Containing 3 2 3
  • 4933425L19Rik 3
  • DKFZP434B1727 2
  • EC 3.6.1 51
  • ZRANB3 5

External Ids for ZRANB3 Gene

Previous GeneCards Identifiers for ZRANB3 Gene

  • GC02M135728
  • GC02M135894
  • GC02M127950

Summaries for ZRANB3 Gene

GeneCards Summary for ZRANB3 Gene

ZRANB3 (Zinc Finger RANBP2-Type Containing 3) is a Protein Coding gene. Diseases associated with ZRANB3 include Warburg Micro Syndrome and Amelogenesis Imperfecta, Type If. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and endonuclease activity. An important paralog of this gene is CHD9.

UniProtKB/Swiss-Prot Summary for ZRANB3 Gene

  • DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22705370, PubMed:22704558).

Additional gene information for ZRANB3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZRANB3 Gene

Genomics for ZRANB3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ZRANB3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J135529 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 -0.3 -288 5 CHD2 TBP MXD4 SP1 FEZF1 CEBPA SIX5 NR2C1 MNT BRCA1 R3HDM1 ZRANB3 CCNT2 UBXN4 MCM6 MAP3K19 lnc-UBXN4-11
GH02J136247 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 10 -716.9 -716934 1.7 ZBTB10 FEZF1 ZEB1 CEBPB ZNF513 ZNF623 ZNF639 EP300 EBF1 ZNF843 UBXN4 ZRANB3 R3HDM1 CXCR4 HSALNG0019102 lnc-UBXN4-14 lnc-UBXN4-13 THSD7B
GH02J135051 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 4.5 +477.7 477658 3.9 TBP ZBTB10 SP1 MXD4 MNT SMAD5 HES1 MBD2 ZNF217 POLR2A HSALNG0019045 RAB3GAP1 CCNT2 UBXN4 MAP3K19 MCM6 DARS1 ZRANB3 HSALNG0019046
GH02J135586 Promoter/Enhancer 0.8 EPDnew Ensembl 11.2 -54.8 -54783 1.2 CTCF CEBPB POLR2A RAD21 R3HDM1 ZRANB3 MAP3K19 RAB3GAP1 RF00017-3319 HSALNG0019064 UBXN4
GH02J135664 Enhancer 0.7 Ensembl 10.8 -134.8 -134783 3.6 SP1 BCL11A IRF4 EBF1 CBFB BATF MAFK NFATC1 IKZF1 TCF7 MIR128-1 R3HDM1 ZRANB3 RAB3GAP1 MAP3K19 DARS1 UBXN4 MCM6 NONHSAG029367.2 piR-61029-084
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZRANB3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZRANB3

Top Transcription factor binding sites by QIAGEN in the ZRANB3 gene promoter:
  • AML1a
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • E47
  • p300
  • Tal-1
  • USF-1
  • USF1

Genomic Locations for ZRANB3 Gene

Latest Assembly
chr2:135,136,916-135,531,218
(GRCh38/hg38)
Size:
394,303 bases
Orientation:
Minus strand

Previous Assembly
chr2:135,954,539-136,288,788
(GRCh37/hg19 by Entrez Gene)
Size:
334,250 bases
Orientation:
Minus strand

chr2:135,894,486-136,288,806
(GRCh37/hg19 by Ensembl)
Size:
394,321 bases
Orientation:
Minus strand

Genomic View for ZRANB3 Gene

Genes around ZRANB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZRANB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZRANB3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZRANB3 Gene

Proteins for ZRANB3 Gene

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  • Protein details for ZRANB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5FWF4-ZRAB3_HUMAN
    Recommended name:
    DNA annealing helicase and endonuclease ZRANB3
    Protein Accession:
    Q5FWF4
    Secondary Accessions:
    • B3KYA1
    • B4E375
    • B5MDI3
    • D3DP76
    • E9PBP0
    • Q53SM1
    • Q6P2C4
    • Q8N1P4
    • Q9H0E8

    Protein attributes for ZRANB3 Gene

    Size:
    1079 amino acids
    Molecular mass:
    123248 Da
    Quaternary structure:
    • Interacts (via PIP-box and RanBP2-type zinc finger) with PCNA (when PCNA is polyubiquitinated via 'Lys-63'-linked polyubiquitin).
    SequenceCaution:
    • Sequence=AAX93066.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG54763.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAG65387.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=EAX11631.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX11633.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
    Miscellaneous:
    • In contrast to classical helicases that unwing DNA, annealing helicases rewind it.

    Three dimensional structures from OCA and Proteopedia for ZRANB3 Gene

    Alternative splice isoforms for ZRANB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZRANB3 Gene

Protein Expression for ZRANB3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ZRANB3 Gene

Q5FWF4:
  • DEMGLGKT
  • KFLVFAHH
  • MGLGKTIQ
  • RAHRIGQ

Post-translational modifications for ZRANB3 Gene

  • Ubiquitination at Lys179
  • Modification sites at PhosphoSitePlus

Other Protein References for ZRANB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Boster Bio Antibodies for ZRANB3

Domains & Families for ZRANB3 Gene

Gene Families for ZRANB3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for ZRANB3 Gene

InterPro:
Blocks:
  • Zn-finger, Ran-binding
  • SNF2 related domain
  • HNH nuclease
ProtoNet:

Suggested Antigen Peptide Sequences for ZRANB3 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger, RAN-binding domain containing 3, isoform CRA_c (D3DP76_HUMAN)
  • ZRANB3 protein (Q6P2C4_HUMAN)
  • Zinc finger Ran-binding domain-containing protein 3 (ZRAB3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5FWF4

UniProtKB/Swiss-Prot:

ZRAB3_HUMAN :
  • The PIP-box mediates the interaction with PCNA, while the RanBP2-type zinc finger mediates binding to 'Lys-63'-linked polyubiquitin (PubMed:22704558, PubMed:22705370 and PubMed:22759634).
  • Belongs to the SNF2/RAD54 helicase family.
Domain:
  • The PIP-box mediates the interaction with PCNA, while the RanBP2-type zinc finger mediates binding to 'Lys-63'-linked polyubiquitin (PubMed:22704558, PubMed:22705370 and PubMed:22759634).
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with ZRANB3: view

Function for ZRANB3 Gene

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  6. Cell Lines for research

Molecular function for ZRANB3 Gene

UniProtKB/Swiss-Prot Function:
DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22705370, PubMed:22704558).

Enzyme Numbers (IUBMB) for ZRANB3 Gene

Phenotypes From GWAS Catalog for ZRANB3 Gene

Gene Ontology (GO) - Molecular Function for ZRANB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003678 NOT DNA helicase activity IDA 21078962
GO:0003824 catalytic activity IEA --
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with ZRANB3: view
genes like me logo Genes that share phenotypes with ZRANB3: view

Animal Models for research

  • Taconic Biosciences Mouse Models for ZRANB3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZRANB3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZRANB3 Gene

Localization for ZRANB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZRANB3 Gene

Nucleus. Chromosome. Note=Following DNA damage, recruited to sites of DNA damage and stalled replication forks by polyubiquitinated PCNA (PubMed:22704558, PubMed:22705370, PubMed:22759634). {ECO:0000269 PubMed:22704558, ECO:0000269 PubMed:22705370, ECO:0000269 PubMed:22759634}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZRANB3 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
golgi apparatus 2
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZRANB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0043596 nuclear replication fork IDA 22704558
genes like me logo Genes that share ontologies with ZRANB3: view

Pathways & Interactions for ZRANB3 Gene

PathCards logo

SuperPathways for ZRANB3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZRANB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000733 DNA strand renaturation IEA --
GO:0006281 DNA repair IBA,IDA 22759634
GO:0006974 cellular response to DNA damage stimulus IEA,IDA 22704558
GO:0008152 metabolic process IEA --
GO:0009411 response to UV IDA 22704558
genes like me logo Genes that share ontologies with ZRANB3: view

No data available for Pathways by source and SIGNOR curated interactions for ZRANB3 Gene

Drugs & Compounds for ZRANB3 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for ZRANB3 Gene

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mRNA/cDNA for ZRANB3 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZRANB3

Alternative Splicing Database (ASD) splice patterns (SP) for ZRANB3 Gene

No ASD Table

Relevant External Links for ZRANB3 Gene

GeneLoc Exon Structure for
ZRANB3

Expression for ZRANB3 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZRANB3 Gene

mRNA expression in normal human tissues for ZRANB3 Gene
mRNA expression by BioGPS for ZRANB3 GenemRNA expression by GTEx for ZRANB3 Gene

Protein differential expression in normal tissues from HIPED for ZRANB3 Gene

This gene is overexpressed in Plasma (42.0), Heart (17.9), and Adipocyte (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZRANB3 Gene



Protein tissue co-expression partners for ZRANB3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZRANB3

SOURCE GeneReport for Unigene cluster for ZRANB3 Gene:

Hs.658422

Evidence on tissue expression from TISSUES for ZRANB3 Gene

  • Skin(2.7)
  • Kidney(2.6)
  • Intestine(2.5)
  • Blood(2.2)
  • Thyroid gland(2.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with ZRANB3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZRANB3 Gene

Orthologs for ZRANB3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZRANB3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ZRANB3 30 31
  • 99.44 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ZRANB3 30 31
  • 88.45 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ZRANB3 30 31
  • 88.43 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Zranb3 30 17 31
  • 81.26 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Zranb3 30
  • 79.38 (n)
Oppossum
(Monodelphis domestica)
 Mammalia ZRANB3 31
  • 70 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia ZRANB3 31
  • 63 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves ZRANB3 30 31
  • 69.02 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia ZRANB3 31
  • 62 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia zranb3 30
  • 63.87 (n)
Str.7449 30
Zebrafish
(Danio rerio)
 Actinopterygii zranb3 31
  • 71 (a)
 OneToMany
LOC100331496 30
  • 57.73 (n)
CABZ01044943.1 31
  • 47 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea btf-1 31
  • 7 (a)
 ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes MOT1 31
  • 7 (a)
 OneToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT5G07810 30
  • 45.92 (n)
Rice
(Oryza sativa)
 Liliopsida Os07g0598300 30
  • 47.74 (n)
Species where no ortholog for ZRANB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZRANB3 Gene

ENSEMBL:
Gene Tree for ZRANB3 (if available)
TreeFam:
Gene Tree for ZRANB3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZRANB3: view image

Paralogs for ZRANB3 Gene

Paralogs for ZRANB3 Gene

(1) SIMAP similar genes for ZRANB3 Gene using alignment to 3 proteins:

  • ZRAB3_HUMAN
  • F5GYN7_HUMAN
  • F8WCT9_HUMAN
genes like me logo Genes that share paralogs with ZRANB3: view

Variants for ZRANB3 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZRANB3 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
892946 Uncertain Significance: Warburg micro syndrome 1 135,169,888(-) A/C
NM_012233.3(RAB3GAP1):c.*1107A>C 		THREE_PRIME_UTR
892947 Uncertain Significance: Warburg micro syndrome 1 135,169,990(-) T/C
NM_012233.3(RAB3GAP1):c.*1209T>C 		THREE_PRIME_UTR
892948 Uncertain Significance: Warburg micro syndrome 1 135,169,993(-) A/G
NM_012233.3(RAB3GAP1):c.*1212A>G 		THREE_PRIME_UTR
892949 Uncertain Significance: Warburg micro syndrome 1 135,170,028(-) T/C
NM_012233.3(RAB3GAP1):c.*1247T>C 		THREE_PRIME_UTR
892950 Uncertain Significance: Warburg micro syndrome 1 135,170,053(-) T/C
NM_012233.3(RAB3GAP1):c.*1272T>C 		THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZRANB3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZRANB3 Gene

Variant ID Type Subtype PubMed ID
esv2058333 CNV deletion 18987734
esv2410901 CNV deletion 18987734
esv2421388 CNV deletion 20811451
esv2467285 CNV deletion 19546169
esv2661092 CNV deletion 23128226
esv2664308 CNV deletion 23128226
esv2668909 CNV deletion 23128226
esv2720861 CNV deletion 23290073
esv2720863 CNV deletion 23290073
esv2762862 CNV loss 21179565
esv29203 CNV loss 19812545
esv3304011 CNV mobile element insertion 20981092
esv34026 CNV loss 18971310
esv3431049 CNV insertion 20981092
esv3592568 CNV loss 21293372
esv3592573 CNV loss 21293372
esv3592575 CNV loss 21293372
esv3592578 CNV gain 21293372
esv3893415 CNV loss 25118596
nsv1000750 CNV gain 25217958
nsv1003723 CNV loss 25217958
nsv1116796 CNV deletion 24896259
nsv1123396 CNV deletion 24896259
nsv1127766 CNV deletion 24896259
nsv2940 CNV deletion 18451855
nsv2941 CNV insertion 18451855
nsv441786 CNV gain 18776908
nsv472777 CNV novel sequence insertion 20440878
nsv476642 CNV novel sequence insertion 20440878
nsv498936 CNV loss 21111241
nsv514095 CNV loss 21397061
nsv583172 CNV gain 21841781
nsv834386 CNV gain 17160897

Variation tolerance for ZRANB3 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.81; 94.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZRANB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZRANB3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZRANB3 Gene

Disorders for ZRANB3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for ZRANB3 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZRANB3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZRANB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZRANB3 Gene

Publications for ZRANB3 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  2. Identification of a Substrate Recognition Domain in the Replication Stress Response Protein Zinc Finger Ran-binding Domain-containing Protein 3 (ZRANB3). (PMID: 26884333) Badu-Nkansah A … Cortez D (The Journal of biological chemistry 2016) 3 4
  3. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. (PMID: 22704558) Ciccia A … Elledge SJ (Molecular cell 2012) 3 4
  4. The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. (PMID: 22705370) Yuan J … Chen J (Molecular cell 2012) 3 4
  5. ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response. (PMID: 22759634) Weston R … Ahel D (Genes & development 2012) 3 4

ExternalLinks

View latest publications for ZRANB3 gene in Mastermind

Products for ZRANB3 Gene

Sources for ZRANB3 Gene