ZRANB2 Gene (Protein Coding)

Zinc Finger RANBP2-Type Containing 2

GC01M071063
GIFtS:
34
See more...

Aliases for ZRANB2 Gene

Aliases for ZRANB2 Gene

  • Zinc Finger RANBP2-Type Containing 2 2 3 5
  • Zinc Finger Protein 265 2 3 4
  • ZIS 2 3 4
  • Zinc Finger Ran-Binding Domain-Containing Protein 2 3 4
  • Zinc Finger, RAN-Binding Domain Containing 2 2 3
  • ZNF265 3 4
  • ZIS1 2 3
  • ZIS2 2 3
  • Zinc-Finger, Splicing 3
  • Zinc Finger, Splicing 4
  • ZRANB2 5

External Ids for ZRANB2 Gene

Previous HGNC Symbols for ZRANB2 Gene

  • ZNF265

Previous GeneCards Identifiers for ZRANB2 Gene

  • GC01M071301
  • GC01M071528
  • GC01M069639

Summaries for ZRANB2 Gene

GeneCards Summary for ZRANB2 Gene

ZRANB2 (Zinc Finger RANBP2-Type Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot Summary for ZRANB2 Gene

  • Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

Gene Wiki entry for ZRANB2 Gene

Additional gene information for ZRANB2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZRANB2 Gene

Genomics for ZRANB2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ZRANB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZRANB2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZRANB2

Top Transcription factor binding sites by QIAGEN in the ZRANB2 gene promoter:
  • AML1a
  • AP-4
  • C/EBPalpha
  • Evi-1
  • IRF-7A
  • ITF-2
  • RFX1
  • Sox5
  • Tal-1beta
  • YY1

Genomic Locations for ZRANB2 Gene

Genomic Locations for ZRANB2 Gene
chr1:71,063,291-71,081,289
(GRCh38/hg38)
Size:
17,999 bases
Orientation:
Minus strand
chr1:71,528,974-71,546,980
(GRCh37/hg19)
Size:
18,007 bases
Orientation:
Minus strand

Genomic View for ZRANB2 Gene

Genes around ZRANB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZRANB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZRANB2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZRANB2 Gene

Proteins for ZRANB2 Gene

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  1. Antibody
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  • Protein details for ZRANB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95218-ZRAB2_HUMAN
    Recommended name:
    Zinc finger Ran-binding domain-containing protein 2
    Protein Accession:
    O95218
    Secondary Accessions:
    • D3DQ75
    • Q53GS3
    • Q59F92
    • Q5VV33
    • Q5VV34
    • Q8IXN6
    • Q9UP63

    Protein attributes for ZRANB2 Gene

    Size:
    330 amino acids
    Molecular mass:
    37404 Da
    Quaternary structure:
    • Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.
    SequenceCaution:
    • Sequence=AAD09746.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAD09747.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAD92805.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAB66879.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZRANB2 Gene

    Alternative splice isoforms for ZRANB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZRANB2 Gene

Protein Expression for ZRANB2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZRANB2 Gene

  • Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.
  • Ubiquitination at Lys72
  • Modification sites at PhosphoSitePlus

Other Protein References for ZRANB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZRANB2 Gene

Domains & Families for ZRANB2 Gene

Gene Families for ZRANB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ZRANB2 Gene

InterPro:
Blocks:
  • Zn-finger, Ran-binding
ProtoNet:

Suggested Antigen Peptide Sequences for ZRANB2 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger, splicing (ZRAB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95218

UniProtKB/Swiss-Prot:

ZRAB2_HUMAN :
  • The RanBP2-type zinc fingers mediate binding to RNA.
  • Belongs to the ZRANB2 family.
Domain:
  • The RanBP2-type zinc fingers mediate binding to RNA.
Family:
  • Belongs to the ZRANB2 family.
genes like me logo Genes that share domains with ZRANB2: view

Function for ZRANB2 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ZRANB2 Gene

UniProtKB/Swiss-Prot Function:
Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

Phenotypes From GWAS Catalog for ZRANB2 Gene

Gene Ontology (GO) - Molecular Function for ZRANB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IBA 21873635
GO:0003700 DNA-binding transcription factor activity TAS 9931435
GO:0003723 RNA binding TAS,HDA 22658674
GO:0005515 protein binding IPI 16982639
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZRANB2: view
genes like me logo Genes that share phenotypes with ZRANB2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZRANB2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZRANB2 Gene

Localization for ZRANB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZRANB2 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZRANB2 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZRANB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9931435
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZRANB2: view

Pathways & Interactions for ZRANB2 Gene

PathCards logo

SuperPathways for ZRANB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZRANB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing TAS,IEA --
genes like me logo Genes that share ontologies with ZRANB2: view

No data available for Pathways by source and SIGNOR curated interactions for ZRANB2 Gene

Drugs & Compounds for ZRANB2 Gene

Products:

  1. Drug

(1) Drugs for ZRANB2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 1594
genes like me logo Genes that share compounds with ZRANB2: view

Transcripts for ZRANB2 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for ZRANB2 Gene

2 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZRANB2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZRANB2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:
SP6: - -
SP7: - - - - - - - - - - -
SP8:

Relevant External Links for ZRANB2 Gene

GeneLoc Exon Structure for
ZRANB2

Expression for ZRANB2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZRANB2 Gene

mRNA expression in normal human tissues for ZRANB2 Gene
mRNA expression by GTEx for ZRANB2 GenemRNA expression by BioGPS for ZRANB2 Gene

Protein differential expression in normal tissues from HIPED for ZRANB2 Gene

This gene is overexpressed in Adrenal (45.1) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZRANB2 Gene



Protein tissue co-expression partners for ZRANB2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZRANB2

SOURCE GeneReport for Unigene cluster for ZRANB2 Gene:

Hs.194718

Evidence on tissue expression from TISSUES for ZRANB2 Gene

  • Nervous system(4.9)
  • Liver(4.9)
  • Skin(4.5)
  • Muscle(3.1)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with ZRANB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZRANB2 Gene

Orthologs for ZRANB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZRANB2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ZRANB2 30 31
  • 99.8 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Zranb2 31
  • 97 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia ZRANB2 31
  • 97 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ZRANB2 30 31
  • 96.44 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia ZRANB2 31
  • 96 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ZRANB2 30 31
  • 95.28 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves ZRANB2 31
  • 94 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia ZRANB2 31
  • 93 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia zranb2 30
  • 69.73 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.520 30
Zebrafish
(Danio rerio)
 Actinopterygii zranb2 30 31
  • 75.14 (n)
 OneToOne
wufa96h03 30
Fruit Fly
(Drosophila melanogaster)
 Insecta CG3732 31
  • 45 (a)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea Y25C1A.8 31
  • 39 (a)
 OneToOne
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 57 (a)
 OneToOne
Species where no ortholog for ZRANB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZRANB2 Gene

ENSEMBL:
Gene Tree for ZRANB2 (if available)
TreeFam:
Gene Tree for ZRANB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZRANB2: view image

Paralogs for ZRANB2 Gene

No data available for Paralogs for ZRANB2 Gene

Variants for ZRANB2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZRANB2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs11583800 - p.Arg207Gly

Additional dbSNP identifiers (rs#s) for ZRANB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZRANB2 Gene

Variant ID Type Subtype PubMed ID
nsv546472 CNV gain 21841781

Variation tolerance for ZRANB2 Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZRANB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZRANB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZRANB2 Gene

Disorders for ZRANB2 Gene

Additional Disease Information for ZRANB2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZRANB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZRANB2 Gene

Publications for ZRANB2 Gene

  1. Identification, characterization and mapping of the human ZIS (zinc-finger, splicing) gene. (PMID: 9931435) Nakano M … Niikawa N (Gene 1998) 2 3 4
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  3. XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265. (PMID: 16982639) Mangs AH … Morris BJ (Nucleic acids research 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The structure of the zinc finger domain from human splicing factor ZNF265 fold. (PMID: 12657633) Plambeck CA … Mackay JP (The Journal of biological chemistry 2003) 3 4

ExternalLinks

View latest publications for ZRANB2 gene in Mastermind

Products for ZRANB2 Gene

  • Signalway Proteins for ZRANB2

Sources for ZRANB2 Gene