Aliases for ZRANB1 Gene
External Ids for ZRANB1 Gene
Previous GeneCards Identifiers for ZRANB1 Gene
GeneCards Summary for ZRANB1 Gene
ZRANB1 (Zinc Finger RANBP2-Type Containing 1) is a Protein Coding gene. Among its related pathways are Protein ubiquitination and Deubiquitination. Gene Ontology (GO) annotations related to this gene include thiol-dependent ubiquitin-specific protease activity and K63-linked polyubiquitin modification-dependent protein binding.
UniProtKB/Swiss-Prot Summary for ZRANB1 Gene
Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.