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Aliases for ZPBP2 Gene

Aliases for ZPBP2 Gene

  • Zona Pellucida Binding Protein 2 2 3 5
  • ZPBP-Like Protein 3 4
  • ZPBPL 3 4
  • Zona Pellucida-Binding Protein 2 3

External Ids for ZPBP2 Gene

Previous GeneCards Identifiers for ZPBP2 Gene

  • GC17P038399
  • GC17P035277
  • GC17P038024
  • GC17P033818

Summaries for ZPBP2 Gene

GeneCards Summary for ZPBP2 Gene

ZPBP2 (Zona Pellucida Binding Protein 2) is a Protein Coding gene. An important paralog of this gene is ZPBP.

UniProtKB/Swiss-Prot for ZPBP2 Gene

  • Is implicated in sperm-oocyte interaction during fertilization.

Additional gene information for ZPBP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZPBP2 Gene

Genomics for ZPBP2 Gene

GeneHancer (GH) Regulatory Elements for ZPBP2 Gene

Promoters and enhancers for ZPBP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I039859 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 -3.7 -3735 9.7 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IKZF3 ZPBP2 GSDMB ORMDL3 MED24 GSDMA TMEM99 LRRC3C MSL1 MED1
GH17I039790 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.8 -74.6 -74629 6.1 BATF KLF5 IRF4 ZNF121 ZNF207 ETV6 BCLAF1 IKZF2 RUNX3 CBFB GSDMA IKZF3 GSDMB LRRC3C ZPBP2 GRB7 MIEN1 ORMDL3 PGAP3 ERBB2
GH17I039842 Enhancer 0.7 ENCODE dbSUPER 12.3 -24.5 -24531 1.3 RNF2 NR2F1 JUNB EBF1 BATF GSDMA IKZF3 ZPBP2 LRRC3C ORMDL3 GSDMB RPL39P4
GH17I039784 Enhancer 0.6 dbSUPER 11.7 -81.3 -81272 5 ZNF146 PKNOX1 ZNF211 ZNF189 MZF1 ZNF623 ZNF843 ATF2 PRDM6 ZNF341 ORMDL3 GSDMA GSDMB IKZF3 ZPBP2 MIEN1 LRRC3C PGAP3 ERBB2 GC17P039774
GH17I040306 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.4 +449.4 449361 22.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RARA MED1 SMARCE1 SNORD124 CDK12 MED24 MSL1 TMEM99 CDC6 WIPF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZPBP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZPBP2 gene promoter:

Genomic Locations for ZPBP2 Gene

Genomic Locations for ZPBP2 Gene
chr17:39,868,164-39,877,896
(GRCh38/hg38)
Size:
9,733 bases
Orientation:
Plus strand
chr17:38,024,417-38,034,149
(GRCh37/hg19)

Genomic View for ZPBP2 Gene

Genes around ZPBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZPBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZPBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZPBP2 Gene

Proteins for ZPBP2 Gene

  • Protein details for ZPBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6X784-ZPBP2_HUMAN
    Recommended name:
    Zona pellucida-binding protein 2
    Protein Accession:
    Q6X784
    Secondary Accessions:
    • A8K8L8
    • Q6X783
    • Q86XL5

    Protein attributes for ZPBP2 Gene

    Size:
    338 amino acids
    Molecular mass:
    38652 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZPBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZPBP2 Gene

Post-translational modifications for ZPBP2 Gene

Other Protein References for ZPBP2 Gene

No data available for DME Specific Peptides for ZPBP2 Gene

Domains & Families for ZPBP2 Gene

Gene Families for ZPBP2 Gene

Protein Domains for ZPBP2 Gene

Suggested Antigen Peptide Sequences for ZPBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6X784

UniProtKB/Swiss-Prot:

ZPBP2_HUMAN :
  • Belongs to the zona pellucida-binding protein Sp38 family.
Family:
  • Belongs to the zona pellucida-binding protein Sp38 family.
genes like me logo Genes that share domains with ZPBP2: view

Function for ZPBP2 Gene

Molecular function for ZPBP2 Gene

UniProtKB/Swiss-Prot Function:
Is implicated in sperm-oocyte interaction during fertilization.

Phenotypes From GWAS Catalog for ZPBP2 Gene

genes like me logo Genes that share phenotypes with ZPBP2: view

Animal Models for ZPBP2 Gene

MGI Knock Outs for ZPBP2:

Animal Model Products

miRNA for ZPBP2 Gene

miRTarBase miRNAs that target ZPBP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZPBP2 Gene

Localization for ZPBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZPBP2 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted. Note=Released after the acrosomal reaction. {ECO:0000250 UniProtKB:Q6X786}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZPBP2 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 2
lysosome 1

Gene Ontology (GO) - Cellular Components for ZPBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0002199 zona pellucida receptor complex IEA --
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA,HDA 21630459
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ZPBP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZPBP2 Gene

Pathways & Interactions for ZPBP2 Gene

SuperPathways for ZPBP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZPBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly IEA --
GO:0007339 binding of sperm to zona pellucida IEA --
genes like me logo Genes that share ontologies with ZPBP2: view

No data available for Pathways by source and SIGNOR curated interactions for ZPBP2 Gene

Drugs & Compounds for ZPBP2 Gene

No Compound Related Data Available

Transcripts for ZPBP2 Gene

Unigene Clusters for ZPBP2 Gene

Zona pellucida binding protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZPBP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - - -

Relevant External Links for ZPBP2 Gene

GeneLoc Exon Structure for
ZPBP2
ECgene alternative splicing isoforms for
ZPBP2

Expression for ZPBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZPBP2 Gene

mRNA differential expression in normal tissues according to GTEx for ZPBP2 Gene

This gene is overexpressed in Testis (x51.0).

Protein differential expression in normal tissues from HIPED for ZPBP2 Gene

This gene is overexpressed in Testis (41.3) and Ovary (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZPBP2 Gene



Protein tissue co-expression partners for ZPBP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZPBP2 Gene:

ZPBP2

SOURCE GeneReport for Unigene cluster for ZPBP2 Gene:

Hs.367245

mRNA Expression by UniProt/SwissProt for ZPBP2 Gene:

Q6X784-ZPBP2_HUMAN
Tissue specificity: Expressed specifically in testis.
genes like me logo Genes that share expression patterns with ZPBP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZPBP2 Gene

Orthologs for ZPBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZPBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZPBP2 33 34
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia ZPBP2 33
  • 89.35 (n)
cow
(Bos Taurus)
Mammalia ZPBP2 33 34
  • 83.7 (n)
mouse
(Mus musculus)
Mammalia Zpbp2 33 16 34
  • 79.75 (n)
rat
(Rattus norvegicus)
Mammalia Zpbp2 33
  • 79.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZPBP2 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZPBP2 34
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZPBP2 33 34
  • 57.81 (n)
lizard
(Anolis carolinensis)
Reptilia ZPBP2 34
  • 48 (a)
OneToOne
Species where no ortholog for ZPBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZPBP2 Gene

ENSEMBL:
Gene Tree for ZPBP2 (if available)
TreeFam:
Gene Tree for ZPBP2 (if available)

Paralogs for ZPBP2 Gene

Paralogs for ZPBP2 Gene

(1) SIMAP similar genes for ZPBP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZPBP2: view

Variants for ZPBP2 Gene

Sequence variations from dbSNP and Humsavar for ZPBP2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000080399 -- 39,869,541(+) A/G intron_variant
rs1000182739 -- 39,875,424(+) T/C coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, synonymous_variant
rs1000342523 -- 39,869,025(+) C/A intron_variant
rs1000843575 -- 39,869,286(+) A/G intron_variant
rs1001246067 -- 39,876,977(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZPBP2 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for ZPBP2 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.04; 90.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZPBP2 Gene

Human Gene Mutation Database (HGMD)
ZPBP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZPBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZPBP2 Gene

Disorders for ZPBP2 Gene

Additional Disease Information for ZPBP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZPBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZPBP2 Gene

Publications for ZPBP2 Gene

  1. Identification and characterization of human ZPBP-like gene in silico. (PMID: 12883658) Katoh M … Katoh M (International journal of molecular medicine 2003) 2 3 4 22 58
  2. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 44 58
  3. Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. (PMID: 19732864) Verlaan DJ … Naumova AK (American journal of human genetics 2009) 3 44 58
  4. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. (PMID: 17664285) Lin YN … Matzuk MM (Molecular and cellular biology 2007) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ZPBP2 Gene

Sources for ZPBP2 Gene

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