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Aliases for ZPBP2 Gene
Aliases for ZPBP2 Gene
External Ids for ZPBP2 Gene
- HGNC: 20678
- Entrez Gene: 124626
- Ensembl: ENSG00000186075
- OMIM: 608499
- UniProtKB: Q6X784
Previous GeneCards Identifiers for ZPBP2 Gene
- GC17P038399
- GC17P035277
- GC17P038024
- GC17P033818
Summaries for ZPBP2 Gene
GeneCards Summary for ZPBP2 Gene
ZPBP2 (Zona Pellucida Binding Protein 2) is a Protein Coding gene. Diseases associated with ZPBP2 include Primary Biliary Cirrhosis. An important paralog of this gene is ZPBP.
UniProtKB/Swiss-Prot Summary for ZPBP2 Gene
-
Is implicated in sperm-oocyte interaction during fertilization.
Additional gene information for ZPBP2 Gene
- HGNC(20678)
- Entrez Gene(124626)
- Ensembl(ENSG00000186075)
- OMIM(608499)
- UniProtKB(Q6X784)
- Open Targets Platform(ENSG00000186075)
- Monarch Initiative
- Search for ZPBP2 at DataMed
- Search for ZPBP2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZPBP2 Gene
Genomics for ZPBP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZPBP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZPBP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZPBP2
- Top Transcription factor binding sites by QIAGEN in the ZPBP2 gene promoter:
-
- AML1a
- ATF-2
- E2F
- FAC1
- MAZR
- Pax-5
- RORalpha2
- SRF
- SRF (504 AA)
Genomic Locations for ZPBP2 Gene
Genomic Locations for ZPBP2 Gene
- chr17:39,868,164-39,877,896
- (GRCh38/hg38)
- Size:
- 9,733 bases
- Orientation:
- Plus strand
- chr17:38,024,417-38,034,149
- (GRCh37/hg19)
- Size:
- 9,733 bases
- Orientation:
- Plus strand
Genomic View for ZPBP2 Gene
Genes around ZPBP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.1 by HGNC
- 17q21.1 by Entrez Gene
- 17q21.1 by Ensembl
ZPBP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZPBP2 Gene
Proteins for ZPBP2 Gene
-
Protein details for ZPBP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6X784-ZPBP2_HUMAN
- Recommended name:
- Zona pellucida-binding protein 2
- Protein Accession:
- Q6X784
- A8K8L8
- Q6X783
- Q86XL5
Protein attributes for ZPBP2 Gene
- Size:
- 338 amino acids
- Molecular mass:
- 38652 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZPBP2 Gene
Post-translational modifications for ZPBP2 Gene
- N-glycosylated.
-
Glycosylation at Asn87, Asn221, Asn257, and Asn309
- NX_Q6X784 (NX_Q6X784-1)
Other Protein References for ZPBP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZPBP2
- Invitrogen Antibodies for ZPBP2 (AFLGC-ZPBP2)
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ZPBP2
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- antibodies-online: Show 5 available ZPBP2 Proteins ranked by validation data
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-
Quality Products:
-
Signalway Proteins for ZPBP2
-
Abcam proteins for ZPBP2
Assay Products
- antibodies-online: Show 6 available ZPBP2 Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for ZPBP2 Gene
Domains & Families for ZPBP2 Gene
Gene Families for ZPBP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for ZPBP2 Gene
- InterPro:
- Blocks:
-
- Zona-pellucida-binding
- ProtoNet:
Suggested Antigen Peptide Sequences for ZPBP2 Gene
- GenScript: Design optimal peptide antigens:
-
- ZPBP-like protein (ZPBP2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6X784- Family:
-
- Belongs to the zona pellucida-binding protein Sp38 family.
Function for ZPBP2 Gene
Molecular function for ZPBP2 Gene
- UniProtKB/Swiss-Prot Function:
- Is implicated in sperm-oocyte interaction during fertilization.
Phenotypes From GWAS Catalog for ZPBP2 Gene
Phenotypes for ZPBP2 Gene
- MGI mutant phenotypes for ZPBP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZPBP2:
Animal Models for ZPBP2 Gene
- MGI Knock Outs for ZPBP2:
-
- Zpbp2 Zpbp2<tm1Zuk>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZPBP2 - Select products 50% OFF >
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-
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miRNA for ZPBP2 Gene
- miRTarBase miRNAs that target ZPBP2
miRNA Products
Inhibitory RNA Products
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Clone Products
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- MG203246
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- RC207237
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- RC207237L3
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- RC217396
- RC217396L3
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- RG207237
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- RR208180
- RR208180L3
- RR208180L4
- MR203246L3V
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- MR218025L3V
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- RC217396L3V
- RC217396L4V
- RR208180L3V
- RR208180L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ZPBP2
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Cell Line Products
-
Horizon Cell Lines for ZPBP2
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZPBP2 Gene
Localization for ZPBP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZPBP2 Gene
- Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted. Note=Released after the acrosomal reaction. {ECO:0000250 UniProtKB:Q6X786}.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| nucleus | 4 |
| plasma membrane | 2 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001669 | acrosomal vesicle | IBA | 21873635 |
| GO:0002199 | zona pellucida receptor complex | IBA | 21873635 |
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0031410 | cytoplasmic vesicle | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZPBP2 Gene
Pathways & Interactions for ZPBP2 Gene
Interacting Proteins for ZPBP2 Gene
GPS-Prot Interaction Network for ZPBP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001675 | acrosome assembly | IBA | 21873635 |
| GO:0002638 | negative regulation of immunoglobulin production | IEA | -- |
| GO:0006665 | sphingolipid metabolic process | IEA | -- |
| GO:0007339 | binding of sperm to zona pellucida | IBA | 21873635 |
| GO:0046466 | membrane lipid catabolic process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZPBP2 Gene
Transcripts for ZPBP2 Gene
mRNA/cDNA for ZPBP2 Gene
- 2 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000348931 1543 nts (view in UCSC)
- ENST00000377940 2177 nts (view in UCSC)
- ENST00000583811 795 nts (view in UCSC)
- ENST00000584588 1277 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZPBP2 - Select products 50% OFF >
- * ZPBP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZPBP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZPBP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZPBP2
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Clone Products
- Applied Biological Materials (abm): Clones for ZPBP2 - Select products 50% OFF >
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-
- MG203246
- MG218025
- MG218034
- MG218040
- MR203246
- MR203246L3
- MR203246L4
- MR218025
- MR218025L3
- MR218025L4
- MR218034
- MR218034L3
- MR218034L4
- MR218040
- MR218040L3
- MR218040L4
- RC207237
- RC207237L1
- RC207237L2
- RC207237L3
- RC207237L4
- RC217396
- RC217396L3
- RC217396L4
- RG207237
- RG217396
- RR208180
- RR208180L3
- RR208180L4
- MR203246L3V
- MR203246L4V
- MR218025L3V
- MR218025L4V
- MR218034L3V
- MR218034L4V
- MR218040L3V
- MR218040L4V
- RC207237L1V
- RC207237L2V
- RC207237L3V
- RC207237L4V
- RC217396L3V
- RC217396L4V
- RR208180L3V
- RR208180L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ZPBP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZPBP2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: | - | ||||||||||||||||
| SP3: | - | - | - |
Relevant External Links for ZPBP2 Gene
- GeneLoc Exon Structure for
- ZPBP2
Expression for ZPBP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ZPBP2 Gene
This gene is overexpressed in Testis (x51.0).
This gene is overexpressed in Testis (41.3) and Ovary (26.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZPBP2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZPBP2
SOURCE GeneReport for Unigene cluster for ZPBP2 Gene:
Hs.367245mRNA Expression by UniProt/SwissProt for ZPBP2 Gene:
Q6X784-ZPBP2_HUMAN
Tissue specificity:
Expressed specifically in testis.
Primer Products
-
OriGene qPCR primer pairs for ZPBP2
-
OriGene qPCR primer pairs and template standards for ZPBP2
Gene Expression Assay Products
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZPBP2 Gene
Orthologs for ZPBP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZPBP2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZPBP2 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | ZPBP2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Zpbp2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Zpbp2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ZPBP2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ZPBP2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ZPBP2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ZPBP2 31 |
|
OneToOne |
- Species where no ortholog for ZPBP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for ZPBP2 Gene
- ENSEMBL:
- Gene Tree for ZPBP2 (if available)
- TreeFam:
- Gene Tree for ZPBP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZPBP2: view image
Paralogs for ZPBP2 Gene
Variants for ZPBP2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZPBP2 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 719398 | Likely Benign: not provided | 39,875,395(+) | A/G | MISSENSE_VARIANT | |
| 781282 | Benign: not provided | 39,871,571(+) | G/A | MISSENSE_VARIANT | |
| 781283 | Benign: not provided | 39,872,382(+) | T/C | SYNONYMOUS_VARIANT | |
| rs11557467 | - | p.Ser173Ile | |||
| rs189660050 | - | p.Thr69Ile |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1146669 | OTHER | inversion | 26484159 |
Residual Variation Intolerance Score:
55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.04;
90.10% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZPBP2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZPBP2 Gene
Disorders for ZPBP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| primary biliary cirrhosis |
|
|
Search ZPBP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZPBP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ZPBP2 Gene
Publications for ZPBP2 Gene
- Identification and characterization of human ZPBP-like gene in silico. (PMID: 12883658) Katoh M … Katoh M (International journal of molecular medicine 2003) 2 3 4 23
- Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 41
- Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. (PMID: 19732864) Verlaan DJ … Naumova AK (American journal of human genetics 2009) 3 41
- Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. (PMID: 17664285) Lin YN … Matzuk MM (Molecular and cellular biology 2007) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for ZPBP2 Gene
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- RC207237L1V
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- antibodies-online: Show 6 available ZPBP2 Antibodies ranked by validation data
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- antibodies-online: Show 5 available ZPBP2 Proteins ranked by validation data
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- Signalway Proteins for ZPBP2
Sources for ZPBP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
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