Aliases for ZPBP2 Gene

Aliases for ZPBP2 Gene

  • Zona Pellucida Binding Protein 2 2 3 5
  • ZPBPL 2 3 4
  • Zona Pellucida-Binding Protein 2 3 4
  • ZPBP-Like Protein 3 4
  • MGC41930 2
  • ZPBP2 5

External Ids for ZPBP2 Gene

Previous GeneCards Identifiers for ZPBP2 Gene

  • GC17P038399
  • GC17P035277
  • GC17P038024
  • GC17P033818

Summaries for ZPBP2 Gene

GeneCards Summary for ZPBP2 Gene

ZPBP2 (Zona Pellucida Binding Protein 2) is a Protein Coding gene. Diseases associated with ZPBP2 include Primary Biliary Cirrhosis. An important paralog of this gene is ZPBP.

UniProtKB/Swiss-Prot Summary for ZPBP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZPBP2 Gene

Genomics for ZPBP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZPBP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J039859 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 600.7 -3.7 -3735 9.7 SP1 GATAD2A ZNF629 TFE3 ZNF512 SOX13 IKZF1 NFKBIZ CTCF POLR2A IKZF3 ZPBP2 GSDMB ORMDL3 MED24 TMEM99 MSL1 MED1 GSDMA CDK12
GH17J039842 Enhancer 0.7 ENCODE dbSUPER 12.3 -24.5 -24531 1.3 RNF2 NR2F1 JUNB BATF EBF1 TBL1XR1 EZH2 GSDMA ZPBP2 IKZF3 LRRC3C ORMDL3 GSDMB RPL39P4 GRB7
GH17J039839 Promoter/Enhancer 0.5 EPDnew dbSUPER 12.3 -28.6 -28571 0.1 IKZF3 ENSG00000226117 RPL39P4 ZPBP2 LRRC3C ORMDL3 GSDMA GRB7
GH17J039890 Enhancer 0.4 Ensembl 11.9 +22.8 22837 0.8 ZNF600 ZNF580 NFIC NFIB lnc-ZPBP2-2 lnc-ZPBP2-3 GSDMB LRRC3C ORMDL3 ZPBP2 IKZF3 GSDMA MED24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZPBP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZPBP2

Top Transcription factor binding sites by QIAGEN in the ZPBP2 gene promoter:
  • AML1a
  • ATF-2
  • E2F
  • FAC1
  • MAZR
  • Pax-5
  • RORalpha2
  • SRF
  • SRF (504 AA)

Genomic Locations for ZPBP2 Gene

Genomic Locations for ZPBP2 Gene
9,733 bases
Plus strand
9,733 bases
Plus strand

Genomic View for ZPBP2 Gene

Genes around ZPBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZPBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZPBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZPBP2 Gene

Proteins for ZPBP2 Gene

  • Protein details for ZPBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zona pellucida-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K8L8
    • Q6X783
    • Q86XL5

    Protein attributes for ZPBP2 Gene

    338 amino acids
    Molecular mass:
    38652 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZPBP2 Gene


neXtProt entry for ZPBP2 Gene

Post-translational modifications for ZPBP2 Gene

Other Protein References for ZPBP2 Gene

No data available for DME Specific Peptides for ZPBP2 Gene

Domains & Families for ZPBP2 Gene

Gene Families for ZPBP2 Gene

Protein Domains for ZPBP2 Gene

  • Zona-pellucida-binding

Suggested Antigen Peptide Sequences for ZPBP2 Gene

GenScript: Design optimal peptide antigens:
  • ZPBP-like protein (ZPBP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zona pellucida-binding protein Sp38 family.
  • Belongs to the zona pellucida-binding protein Sp38 family.
genes like me logo Genes that share domains with ZPBP2: view

Function for ZPBP2 Gene

Molecular function for ZPBP2 Gene

UniProtKB/Swiss-Prot Function:
Is implicated in sperm-oocyte interaction during fertilization.

Phenotypes From GWAS Catalog for ZPBP2 Gene

genes like me logo Genes that share phenotypes with ZPBP2: view

Animal Models for ZPBP2 Gene

MGI Knock Outs for ZPBP2:

Animal Model Products

CRISPR Products

miRNA for ZPBP2 Gene

miRTarBase miRNAs that target ZPBP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZPBP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZPBP2 Gene

Localization for ZPBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZPBP2 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted. Note=Released after the acrosomal reaction. {ECO:0000250 UniProtKB:Q6X786}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZPBP2 gene
Compartment Confidence
extracellular 4
nucleus 4
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1
lysosome 0

Gene Ontology (GO) - Cellular Components for ZPBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IBA 21873635
GO:0002199 zona pellucida receptor complex IBA 21873635
GO:0005576 extracellular region IEA --
GO:0005634 nucleus HDA 21630459
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ZPBP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZPBP2 Gene

Pathways & Interactions for ZPBP2 Gene

PathCards logo

SuperPathways for ZPBP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZPBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly IBA 21873635
GO:0002638 negative regulation of immunoglobulin production IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0007339 binding of sperm to zona pellucida IBA 21873635
GO:0046466 membrane lipid catabolic process IEA --
genes like me logo Genes that share ontologies with ZPBP2: view

No data available for Pathways by source and SIGNOR curated interactions for ZPBP2 Gene

Drugs & Compounds for ZPBP2 Gene

No Compound Related Data Available

Transcripts for ZPBP2 Gene

mRNA/cDNA for ZPBP2 Gene

5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZPBP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZPBP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP2: -
SP3: - - -

Relevant External Links for ZPBP2 Gene

GeneLoc Exon Structure for

Expression for ZPBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZPBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for ZPBP2 Gene

This gene is overexpressed in Testis (x51.0).

Protein differential expression in normal tissues from HIPED for ZPBP2 Gene

This gene is overexpressed in Testis (41.3) and Ovary (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZPBP2 Gene

Protein tissue co-expression partners for ZPBP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZPBP2

SOURCE GeneReport for Unigene cluster for ZPBP2 Gene:


mRNA Expression by UniProt/SwissProt for ZPBP2 Gene:

Tissue specificity: Expressed specifically in testis.
genes like me logo Genes that share expression patterns with ZPBP2: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZPBP2 Gene

Orthologs for ZPBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZPBP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZPBP2 30 31
  • 99.41 (n)
(Canis familiaris)
Mammalia ZPBP2 30
  • 89.35 (n)
(Bos Taurus)
Mammalia ZPBP2 30 31
  • 83.7 (n)
(Mus musculus)
Mammalia Zpbp2 30 17 31
  • 79.75 (n)
(Rattus norvegicus)
Mammalia Zpbp2 30
  • 79.55 (n)
(Ornithorhynchus anatinus)
Mammalia ZPBP2 31
  • 61 (a)
(Monodelphis domestica)
Mammalia ZPBP2 31
  • 54 (a)
(Gallus gallus)
Aves ZPBP2 30 31
  • 57.81 (n)
(Anolis carolinensis)
Reptilia ZPBP2 31
  • 48 (a)
Species where no ortholog for ZPBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZPBP2 Gene

Gene Tree for ZPBP2 (if available)
Gene Tree for ZPBP2 (if available)
Evolutionary constrained regions (ECRs) for ZPBP2: view image

Paralogs for ZPBP2 Gene

Paralogs for ZPBP2 Gene

(1) SIMAP similar genes for ZPBP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZPBP2: view

Variants for ZPBP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZPBP2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
719398 Likely Benign: not provided 39,875,395(+) A/G MISSENSE_VARIANT
781282 Benign: not provided 39,871,571(+) G/A MISSENSE_VARIANT
781283 Benign: not provided 39,872,382(+) T/C SYNONYMOUS_VARIANT
rs11557467 - p.Ser173Ile
rs189660050 - p.Thr69Ile

Additional dbSNP identifiers (rs#s) for ZPBP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZPBP2 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for ZPBP2 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.04; 90.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZPBP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZPBP2 Gene

Disorders for ZPBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZPBP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
primary biliary cirrhosis
  • pbc
- elite association - COSMIC cancer census association via MalaCards
Search ZPBP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZPBP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZPBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZPBP2 Gene

Publications for ZPBP2 Gene

  1. Identification and characterization of human ZPBP-like gene in silico. (PMID: 12883658) Katoh M … Katoh M (International journal of molecular medicine 2003) 2 3 4 23
  2. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 41
  3. Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. (PMID: 19732864) Verlaan DJ … Naumova AK (American journal of human genetics 2009) 3 41
  4. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. (PMID: 17664285) Lin YN … Matzuk MM (Molecular and cellular biology 2007) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ZPBP2 Gene

  • Signalway Proteins for ZPBP2

Sources for ZPBP2 Gene