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ZPBP2 (Zona Pellucida Binding Protein 2) is a Protein Coding gene. Diseases associated with ZPBP2 include Primary Biliary Cirrhosis. An important paralog of this gene is ZPBP.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001669 | acrosomal vesicle | IBA | 21873635 |
GO:0002199 | zona pellucida receptor complex | IBA | 21873635 |
GO:0005576 | extracellular region | IEA | -- |
GO:0005634 | nucleus | HDA | 21630459 |
GO:0031410 | cytoplasmic vesicle | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001675 | acrosome assembly | IBA | 21873635 |
GO:0002638 | negative regulation of immunoglobulin production | IEA | -- |
GO:0006665 | sphingolipid metabolic process | IEA | -- |
GO:0007339 | binding of sperm to zona pellucida | IBA | 21873635 |
GO:0046466 | membrane lipid catabolic process | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||
SP2: | - | ||||||||||||||||
SP3: | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZPBP2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZPBP2 30 |
|
||
Cow (Bos Taurus) |
Mammalia | ZPBP2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Zpbp2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zpbp2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ZPBP2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ZPBP2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ZPBP2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ZPBP2 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
719398 | Likely Benign: not provided | 39,875,395(+) | A/G | MISSENSE_VARIANT | |
781282 | Benign: not provided | 39,871,571(+) | G/A | MISSENSE_VARIANT | |
781283 | Benign: not provided | 39,872,382(+) | T/C | SYNONYMOUS_VARIANT | |
rs11557467 | - | p.Ser173Ile | |||
rs189660050 | - | p.Thr69Ile |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1146669 | OTHER | inversion | 26484159 |
Disorder | Aliases | PubMed IDs |
---|---|---|
primary biliary cirrhosis |
|
|