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Aliases for ZPBP Gene

Aliases for ZPBP Gene

  • Zona Pellucida Binding Protein 2 3 5
  • Inner Acrosomal Membrane IAM38 3 4
  • ZPBP1 3 4
  • Zona Pellucida-Binding Protein 1 3
  • Sp38 4

External Ids for ZPBP Gene

Previous GeneCards Identifiers for ZPBP Gene

  • GC07M049526
  • GC07M049687
  • GC07M049721
  • GC07M049754
  • GC07M049947

Summaries for ZPBP Gene

Entrez Gene Summary for ZPBP Gene

  • ZPBP is one of several proteins that are thought to participate in secondary binding between acrosome-reacted sperm and the egg-specific extracellular matrix, the zona pellucida (McLeskey et al., 1998 [PubMed 9378618]).[supplied by OMIM, Aug 2008]

GeneCards Summary for ZPBP Gene

ZPBP (Zona Pellucida Binding Protein) is a Protein Coding gene. An important paralog of this gene is ZPBP2.

UniProtKB/Swiss-Prot for ZPBP Gene

  • Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity).

Additional gene information for ZPBP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZPBP Gene

Genomics for ZPBP Gene

GeneHancer (GH) Regulatory Elements for ZPBP Gene

Promoters and enhancers for ZPBP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I050092 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 557.4 +28.0 28001 2.4 CTCF PKNOX1 USF1 MAX SIN3A ZBTB40 RAD21 ETS1 POLR2A SCRT2 ZPBP SPATA48 GNL2P1
GH07I050341 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -234.5 -234468 28.8 HDGF PKNOX1 ARNT ZNF2 IRF4 ZNF766 ZNF143 FOS JUNB REST IKZF1 FIGNL1 ENSG00000228005 ZPBP GC07P050382
GH07I050145 Enhancer 1 FANTOM5 ENCODE 17.6 -26.9 -26896 5.1 HDGF PKNOX1 SMAD1 NFIB CHD4 CEBPG EBF1 BATF RELA POLR2A SPATA48 ZPBP IKZF1 ENSG00000228005 ENSG00000231681
GH07I050409 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -289.3 -289262 3 MAX EBF1 BATF RELA POLR2A NFATC1 ZNF143 ATF7 BCLAF1 IKZF2 FIGNL1 RNU6-1091P ENSG00000228005 ZPBP IKZF1 GC07P050435 GC07P050382
GH07I050067 Enhancer 0.8 Ensembl ENCODE 18.3 +52.2 52188 3 SMARCE1 CTCF PKNOX1 HLF REST IRF4 SP1 GATA3 IKZF1 ZFP36 SPATA48 ZPBP GNL2P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZPBP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZPBP gene promoter:

Genomic Locations for ZPBP Gene

Genomic Locations for ZPBP Gene
271,008 bases
Minus strand

Genomic View for ZPBP Gene

Genes around ZPBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZPBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZPBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZPBP Gene

Proteins for ZPBP Gene

  • Protein details for ZPBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zona pellucida-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • A4D253
    • C9JPU1
    • Q15941
    • Q75KX9
    • Q75MI3

    Protein attributes for ZPBP Gene

    351 amino acids
    Molecular mass:
    40142 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAS07517.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZPBP Gene


neXtProt entry for ZPBP Gene

Post-translational modifications for ZPBP Gene

No data available for DME Specific Peptides for ZPBP Gene

Domains & Families for ZPBP Gene

Gene Families for ZPBP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ZPBP Gene

Suggested Antigen Peptide Sequences for ZPBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zona pellucida-binding protein Sp38 family.
  • Belongs to the zona pellucida-binding protein Sp38 family.
genes like me logo Genes that share domains with ZPBP: view

Function for ZPBP Gene

Molecular function for ZPBP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity).

Phenotypes From GWAS Catalog for ZPBP Gene

genes like me logo Genes that share phenotypes with ZPBP: view

Animal Models for ZPBP Gene

MGI Knock Outs for ZPBP:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZPBP Gene

Localization for ZPBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZPBP Gene

Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Peripheral membrane protein. Secreted. Note=First localized in acrosome granule, later migrates to the inner and outer acrosomal membrane. Released after the acrosomal reaction. {ECO:0000250 UniProtKB:Q62522}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZPBP gene
Compartment Confidence
nucleus 5
extracellular 4
plasma membrane 2
mitochondrion 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA,HDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZPBP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZPBP Gene

Pathways & Interactions for ZPBP Gene

No Data Available

Interacting Proteins for ZPBP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9BS86-ZPBP1_HUMAN ENSP00000046087 for ZPBP Gene via IID STRING

Gene Ontology (GO) - Biological Process for ZPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007339 binding of sperm to zona pellucida IEA --
genes like me logo Genes that share ontologies with ZPBP: view

No data available for Pathways by source and SIGNOR curated interactions for ZPBP Gene

Drugs & Compounds for ZPBP Gene

No Compound Related Data Available

Transcripts for ZPBP Gene

Unigene Clusters for ZPBP Gene

Zona pellucida binding protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZPBP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2: -
SP3: - -

Relevant External Links for ZPBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZPBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZPBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZPBP Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for ZPBP Gene

This gene is overexpressed in Testis (30.9), Ovary (21.1), and Heart (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZPBP Gene

Protein tissue co-expression partners for ZPBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZPBP Gene:


SOURCE GeneReport for Unigene cluster for ZPBP Gene:


mRNA Expression by UniProt/SwissProt for ZPBP Gene:

Tissue specificity: Expressed specifically in testis.

Evidence on tissue expression from TISSUES for ZPBP Gene

  • Pancreas(4)
genes like me logo Genes that share expression patterns with ZPBP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZPBP Gene

Orthologs for ZPBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZPBP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZPBP 33 34
  • 99.15 (n)
(Canis familiaris)
Mammalia ZPBP 33 34
  • 87.39 (n)
(Bos Taurus)
Mammalia ZPBP 33 34
  • 86.81 (n)
(Mus musculus)
Mammalia Zpbp 33 16 34
  • 81.81 (n)
(Rattus norvegicus)
Mammalia Zpbp 33
  • 81.62 (n)
(Ornithorhynchus anatinus)
Mammalia ZPBP 34
  • 67 (a)
(Monodelphis domestica)
Mammalia ZPBP 34
  • 57 (a)
(Gallus gallus)
Aves ZPBP 33 34
  • 66.87 (n)
(Anolis carolinensis)
Reptilia ZPBP 34
  • 41 (a)
Species where no ortholog for ZPBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZPBP Gene

Gene Tree for ZPBP (if available)
Gene Tree for ZPBP (if available)

Paralogs for ZPBP Gene

Paralogs for ZPBP Gene

(1) SIMAP similar genes for ZPBP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZPBP: view

Variants for ZPBP Gene

Sequence variations from dbSNP and Humsavar for ZPBP Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000000584 -- 50,094,801(-) T/C upstream_transcript_variant
rs1000012260 -- 49,949,496(-) A/C intron_variant
rs1000018716 -- 49,882,754(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000023447 -- 49,929,704(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000028091 -- 49,996,821(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZPBP Gene

Variant ID Type Subtype PubMed ID
dgv11330n54 CNV loss 21841781
dgv11331n54 CNV loss 21841781
esv1138876 CNV deletion 17803354
esv1958519 CNV deletion 18987734
esv2141038 CNV deletion 18987734
esv22697 CNV loss 19812545
esv2547949 CNV deletion 19546169
esv2576953 CNV loss 19546169
esv2658187 CNV deletion 23128226
esv2665122 CNV deletion 23128226
esv2669911 CNV deletion 23128226
esv3400481 CNV insertion 20981092
esv3431840 CNV insertion 20981092
esv3448606 CNV insertion 20981092
esv3541615 CNV deletion 23714750
esv3613117 CNV loss 21293372
esv3613118 CNV gain 21293372
esv3613119 CNV loss 21293372
esv3613121 CNV loss 21293372
esv6775 CNV gain 19470904
nsv1074502 CNV deletion 25765185
nsv1137216 CNV deletion 24896259
nsv1140768 CNV deletion 24896259
nsv366512 CNV deletion 16902084
nsv477601 CNV novel sequence insertion 20440878
nsv510079 OTHER sequence alteration 20534489
nsv606897 CNV gain 21841781
nsv606898 CNV loss 21841781
nsv830997 CNV gain 17160897
nsv830998 CNV loss 17160897

Variation tolerance for ZPBP Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZPBP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZPBP Gene

Disorders for ZPBP Gene

Additional Disease Information for ZPBP

No disorders were found for ZPBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZPBP Gene

Publications for ZPBP Gene

  1. Molecules involved in mammalian sperm-egg interaction. (PMID: 9378618) McLeskey SB … Saling PM (International review of cytology 1998) 2 3 4 22 58
  2. Association of mutations in the zona pellucida binding protein 1 (ZPBP1) gene with abnormal sperm head morphology in infertile men. (PMID: 21911476) Yatsenko AN … Matzuk MM (Molecular human reproduction 2012) 3 4 58
  3. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. (PMID: 17664285) Lin YN … Matzuk MM (Molecular and cellular biology 2007) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for ZPBP Gene

Sources for ZPBP Gene

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