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Aliases for ZP4 Gene

Aliases for ZP4 Gene

  • Zona Pellucida Glycoprotein 4 2 3 4 5
  • Zona Pellucida Protein B 3 4
  • Zp-4 3 4
  • ZPB 3 4
  • Zona Pellucida Sperm-Binding Protein 4 3
  • ZBP 3
  • ZP1 3

External Ids for ZP4 Gene

Previous GeneCards Identifiers for ZP4 Gene

  • GC01M236178
  • GC01M233499
  • GC01M234342
  • GC01M235086
  • GC01M234371
  • GC01M236112
  • GC01M238045
  • GC01M208497

Summaries for ZP4 Gene

Entrez Gene Summary for ZP4 Gene

  • The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZP4 Gene

ZP4 (Zona Pellucida Glycoprotein 4) is a Protein Coding gene. Diseases associated with ZP4 include Ovarian Disease and Glaucoma, Primary Open Angle. Among its related pathways are Reproduction. Gene Ontology (GO) annotations related to this gene include signal transducer activity and acrosin binding. An important paralog of this gene is ZP1.

UniProtKB/Swiss-Prot for ZP4 Gene

  • The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.

Gene Wiki entry for ZP4 Gene

Additional gene information for ZP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZP4 Gene

Genomics for ZP4 Gene

GeneHancer (GH) Regulatory Elements for ZP4 Gene

Promoters and enhancers for ZP4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I237891 Enhancer 0.2 ENCODE 550.8 -1.3 -1285 1.6 ZP4 ENSG00000243781 LOC100130331
GH01I237864 Enhancer 1.2 Ensembl ENCODE 11.2 +26.4 26421 0.6 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 ZP4 LOC100130331
GH01I237926 Promoter 0.5 Ensembl 11.5 -36.1 -36079 0.4 ENSG00000243781 ZP4 ENSG00000283174 LOC100130331
GH01I237932 Enhancer 0.4 ENCODE 11 -42.1 -42104 0.2 ATF4 CEBPG ZP4 ENSG00000283174 ENSG00000243781
GH01I238018 Enhancer 0.2 FANTOM5 11.4 -127.8 -127794 0.2 ZP4 MTND5P18 YWHAQP9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZP4 gene promoter:

Genomic Locations for ZP4 Gene

Genomic Locations for ZP4 Gene
13,059 bases
Minus strand

Genomic View for ZP4 Gene

Genes around ZP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZP4 Gene

Proteins for ZP4 Gene

  • Protein details for ZP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zona pellucida sperm-binding protein 4
    Protein Accession:
    Secondary Accessions:
    • B2RAE1

    Protein attributes for ZP4 Gene

    540 amino acids
    Molecular mass:
    59400 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZP4 Gene

Post-translational modifications for ZP4 Gene

  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
  • Glycosylation at isoforms=69, posLast=202202, isoforms=219, isoforms=267, posLast=302302, posLast=470470, and isoforms=474

Other Protein References for ZP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZP4 Gene

Domains & Families for ZP4 Gene

Gene Families for ZP4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ZP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
  • Belongs to the ZP domain family. ZPB subfamily.
genes like me logo Genes that share domains with ZP4: view

Function for ZP4 Gene

Molecular function for ZP4 Gene

UniProtKB/Swiss-Prot Function:
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.

Phenotypes From GWAS Catalog for ZP4 Gene

Gene Ontology (GO) - Molecular Function for ZP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23355646
GO:0032190 acrosin binding IPI 15950651
GO:0042802 identical protein binding IPI 26879157
genes like me logo Genes that share ontologies with ZP4: view
genes like me logo Genes that share phenotypes with ZP4: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZP4 Gene

Localization for ZP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZP4 Gene

Processed zona pellucida sperm-binding protein 4: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida. {ECO:0000305}.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZP4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZP4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZP4 Gene

Pathways & Interactions for ZP4 Gene

SuperPathway Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with ZP4: view

Pathways by source for ZP4 Gene

Gene Ontology (GO) - Biological Process for ZP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002922 positive regulation of humoral immune response IDA 19004505
GO:0007338 single fertilization IEA --
GO:0007339 binding of sperm to zona pellucida TAS --
GO:0042102 positive regulation of T cell proliferation IDA 19004505
GO:0060478 acrosomal vesicle exocytosis IMP 19004505
genes like me logo Genes that share ontologies with ZP4: view

No data available for SIGNOR curated interactions for ZP4 Gene

Drugs & Compounds for ZP4 Gene

No Compound Related Data Available

Transcripts for ZP4 Gene

mRNA/cDNA for ZP4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZP4 Gene

Zona pellucida glycoprotein 4:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZP4 Gene

No ASD Table

Relevant External Links for ZP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZP4 Gene

mRNA differential expression in normal tissues according to GTEx for ZP4 Gene

This gene is overexpressed in Ovary (x45.9).

NURSA nuclear receptor signaling pathways regulating expression of ZP4 Gene:


SOURCE GeneReport for Unigene cluster for ZP4 Gene:


mRNA Expression by UniProt/SwissProt for ZP4 Gene:

Tissue specificity: Oocytes.
genes like me logo Genes that share expression patterns with ZP4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZP4 Gene

Orthologs for ZP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZP4 33 34
  • 98.89 (n)
(Canis familiaris)
Mammalia ZP4 33 34
  • 80.29 (n)
(Bos Taurus)
Mammalia ZP4 33 34
  • 79.99 (n)
(Rattus norvegicus)
Mammalia Zp4 33
  • 73.63 (n)
(Ornithorhynchus anatinus)
Mammalia ZP4 34
  • 40 (a)
(Gallus gallus)
Aves ZP4 33 34
  • 63.62 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 14 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zp4 33
  • 53.83 (n)
(Danio rerio)
Actinopterygii zp2l1 34
  • 36 (a)
si:zfos-1505d6.3 34
  • 34 (a)
zp2.1 34
  • 34 (a)
zp2.2 34
  • 34 (a)
zp2.3 34
  • 34 (a)
zp2.5 34
  • 34 (a)
zp2.6 34
  • 34 (a)
zp2l2 34
  • 31 (a)
CABZ01074647.1 34
  • 20 (a)
CABZ01051901.1 34
  • 11 (a)
Species where no ortholog for ZP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZP4 Gene

Gene Tree for ZP4 (if available)
Gene Tree for ZP4 (if available)

Paralogs for ZP4 Gene

Paralogs for ZP4 Gene

(2) SIMAP similar genes for ZP4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZP4: view

Variants for ZP4 Gene

Sequence variations from dbSNP and Humsavar for ZP4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs193920872 uncertain-significance, Malignant tumor of prostate 237,890,138(-) C/A/T coding_sequence_variant, missense_variant
rs1000056763 -- 237,885,640(-) CAC/CACAC intron_variant
rs1000847358 -- 237,887,113(-) A/G intron_variant
rs1000926223 -- 237,884,568(-) T/C intron_variant
rs1000978407 -- 237,891,710(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZP4 Gene

Variant ID Type Subtype PubMed ID
esv3589241 CNV gain 21293372
esv34468 CNV gain 17911159
esv2759008 CNV gain 17122850
esv2725729 CNV deletion 23290073

Variation tolerance for ZP4 Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.90; 83.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZP4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZP4 Gene

Disorders for ZP4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZP4 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
ovarian disease
  • ovarian dysfunction
glaucoma, primary open angle
  • poag
- elite association - COSMIC cancer census association via MalaCards
Search ZP4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZP4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZP4 Gene

Publications for ZP4 Gene

  1. Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families. (PMID: 7841460) Harris JD … Sacco AG (DNA sequence : the journal of DNA sequencing and mapping 1994) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N … Nonalcoholic Steatohepatitis Clinical Research Network (Gastroenterology 2010) 3 44 58
  4. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. (PMID: 19626040) McCauley JL … Haines JL (Genes and immunity 2009) 3 44 58
  5. Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population. (PMID: 19625618) Nakano M … Tashiro K (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 44 58

Products for ZP4 Gene

Sources for ZP4 Gene

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