The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reactio... See more...

Aliases for ZP3 Gene

Aliases for ZP3 Gene

  • Zona Pellucida Glycoprotein 3 2 3 4 5
  • ZPC 2 3 4
  • Zona Pellucida Sperm-Binding Protein 3 3 4
  • Zona Pellucida Protein C 3 4
  • Sperm Receptor 3 4
  • ZP3A/ZP3B 3 4
  • ZP3A 3 4
  • ZP3B 3 4
  • Zp-3 3 4
  • Zona Pellucida Glycoprotein 3A (Sperm Receptor) 2
  • Zona Pellucida Glycoprotein ZP3 3
  • Zona Pellucida Glycoprotein 3B 3
  • ZP3-424 2
  • ZP3-372 2
  • OOMD3 3
  • ZP3 5

External Ids for ZP3 Gene

Previous HGNC Symbols for ZP3 Gene

  • ZP3A
  • ZP3B

Previous GeneCards Identifiers for ZP3 Gene

  • GC07P074589
  • GC07P071749
  • GC07P071763
  • GC07P075638
  • GC07P075671
  • GC07P075864
  • GC07P076026
  • GC07P071113

Summaries for ZP3 Gene

Entrez Gene Summary for ZP3 Gene

  • The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZP3 Gene

ZP3 (Zona Pellucida Glycoprotein 3) is a Protein Coding gene. Diseases associated with ZP3 include Oocyte Maturation Defect 3 and Female Infertility Due To Zona Pellucida Defect. Among its related pathways are Ovarian Infertility Genes and Reproduction. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and store-operated calcium channel activity. An important paralog of this gene is POMZP3.

UniProtKB/Swiss-Prot Summary for ZP3 Gene

  • Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

Gene Wiki entry for ZP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZP3 Gene

Genomics for ZP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J076395 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 -0.6 -571 2.9 NCOR1 ZNF600 IKZF1 MYC ZNF592 NFIC ZBTB10 CEBPB SMAD5 BHLHE40 ZP3 POMZP3 UPK3B SPDYE5 LOC100133091 lnc-SSC4D-2 RF00017-5873 SSC4D RF00017-5871 YWHAG
GH07J076626 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 65.9 +229.6 229583 2.6 ZNF341 MNT ARNT TAF9B SIN3B NBN NKRF GABPB1 SIN3A SUPT5H POMZP3 ZP3 LOC100133091 piR-47675-102 SPDYE16
GH07J076400 Promoter 0.5 EPDnew 250.7 +3.0 3012 0.1 HNRNPL RBFOX2 ZP3 RF00017-5875 SSC4D RF00017-5873 RF00017-5871
GH07J076548 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 58.7 +152.4 152383 3 SP1 ZNF207 NCOR1 MYC IKZF1 ZNF580 ZNF592 ZNF10 YY1 MXD4 LOC100133091 ZP3 UPK3B POMZP3 SPDYE16 RF00994-1005
GH07J076582 Enhancer 0.9 Ensembl ENCODE dbSUPER 79.5 +184.2 184183 6.6 ZIC2 FEZF1 ZNF146 MLLT1 ZNF398 MEIS2 ZNF366 ZNF629 ZNF660 OSR2 ZP3 UPK3B POMZP3 LOC100133091 piR-32158-002 piR-33605-412 SPDYE16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZP3

Top Transcription factor binding sites by QIAGEN in the ZP3 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • SRY

Genomic Locations for ZP3 Gene

Latest Assembly
chr7:76,397,518-76,442,071
(GRCh38/hg38)
Size:
44,554 bases
Orientation:
Plus strand

Previous Assembly
chr7:76,026,839-76,071,386
(GRCh37/hg19 by Entrez Gene)
Size:
44,548 bases
Orientation:
Plus strand

chr7:76,026,835-76,071,388
(GRCh37/hg19 by Ensembl)
Size:
44,554 bases
Orientation:
Plus strand

Genomic View for ZP3 Gene

Genes around ZP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZP3 Gene

Proteins for ZP3 Gene

  • Protein details for ZP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21754-ZP3_HUMAN
    Recommended name:
    Zona pellucida sperm-binding protein 3
    Protein Accession:
    P21754
    Secondary Accessions:
    • Q06633
    • Q29RW0

    Protein attributes for ZP3 Gene

    Size:
    424 amino acids
    Molecular mass:
    47018 Da
    Quaternary structure:
    • Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By similarity). Interacts with ZP1 and ZP2 (PubMed:28886344).
    Miscellaneous:
    • [Isoform ZP3B]: Found in a second polymorphic locus which, due to an extra G residue in exon 8, has the potential to encode a truncated protein of 372 amino acids.

    Alternative splice isoforms for ZP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZP3 Gene

Post-translational modifications for ZP3 Gene

  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
  • N-glycosylated.
  • O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.
  • Glycosylation at Asn125, Asn147, Thr156, Thr162, Thr163, and Asn272
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ZP3_HUMAN (634)

Other Protein References for ZP3 Gene

No data available for DME Specific Peptides for ZP3 Gene

Domains & Families for ZP3 Gene

Gene Families for ZP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for ZP3 Gene

InterPro:
Blocks:
  • Endoglin/CD105 antigen

Suggested Antigen Peptide Sequences for ZP3 Gene

GenScript: Design optimal peptide antigens:
  • ZP3-474 (Q2XN66_HUMAN)
  • Zona pellucida protein C (ZP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P21754

UniProtKB/Swiss-Prot:

ZP3_HUMAN :
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Domain:
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
  • Belongs to the ZP domain family. ZPC subfamily.
genes like me logo Genes that share domains with ZP3: view

Function for ZP3 Gene

Molecular function for ZP3 Gene

UniProtKB/Swiss-Prot Function:
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

Phenotypes From GWAS Catalog for ZP3 Gene

Gene Ontology (GO) - Molecular Function for ZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent HDA 28344315
GO:0005515 protein binding IPI 15950651
GO:0030246 carbohydrate binding IDA 19246320
GO:0032190 acrosin binding IBA,IPI 15950651
GO:0035804 structural constituent of egg coat IEA --
genes like me logo Genes that share ontologies with ZP3: view
genes like me logo Genes that share phenotypes with ZP3: view

Human Phenotype Ontology for ZP3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZP3 Gene

MGI Knock Outs for ZP3:
  • Zp3 Zp3<tm1Dean>
  • Zp3 Zp3<tm1Pmw>

miRNA for ZP3 Gene

miRTarBase miRNAs that target ZP3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZP3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ZP3 Gene

Localization for ZP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZP3 Gene

[Processed zona pellucida sperm-binding protein 3]: Secreted, extracellular space, extracellular matrix. Note=Located in oocyte zona pellucida. {ECO:0000269 PubMed:29895852}.
Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZP3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 2
nucleus 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IMP 19246320
GO:0005886 plasma membrane IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZP3 Gene

Pathways & Interactions for ZP3 Gene

PathCards logo

SuperPathways for ZP3 Gene

genes like me logo Genes that share pathways with ZP3: view

Pathways by source for ZP3 Gene

1 BioSystems pathway for ZP3 Gene
1 Qiagen pathway for ZP3 Gene
  • Sperm Motility

Gene Ontology (GO) - Biological Process for ZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001809 positive regulation of type IV hypersensitivity ISS --
GO:0001825 blastocyst formation ISS --
GO:0002455 humoral immune response mediated by circulating immunoglobulin ISS --
GO:0002687 positive regulation of leukocyte migration ISS --
GO:0002922 positive regulation of humoral immune response IDA 19004505
genes like me logo Genes that share ontologies with ZP3: view

No data available for SIGNOR curated interactions for ZP3 Gene

Drugs & Compounds for ZP3 Gene

(7) Drugs for ZP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for ZP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZP3: view

Transcripts for ZP3 Gene

mRNA/cDNA for ZP3 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZP3

Alternative Splicing Database (ASD) splice patterns (SP) for ZP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2:
SP3: - -

Relevant External Links for ZP3 Gene

GeneLoc Exon Structure for
ZP3

Expression for ZP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZP3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZP3 Gene



Protein tissue co-expression partners for ZP3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZP3

SOURCE GeneReport for Unigene cluster for ZP3 Gene:

Hs.656137

mRNA Expression by UniProt/SwissProt for ZP3 Gene:

P21754-ZP3_HUMAN
Tissue specificity: Expressed in oocytes (at protein level).

Evidence on tissue expression from TISSUES for ZP3 Gene

  • Nervous system(4.6)
  • Lung(4.3)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with ZP3: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZP3 Gene

Orthologs for ZP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZP3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZP3 29 30
  • 99.46 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZP3 29 30
  • 79.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZP3 29 30
  • 79.17 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zp3 29 16 30
  • 74.54 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Zp3 29
  • 73.99 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 52 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 51 (a)
OneToMany
Chicken
(Gallus gallus)
Aves ZP3 29
  • 61.78 (n)
-- 30
  • 46 (a)
ManyToMany
-- 30
  • 42 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 44 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC394444 29
  • 55.95 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3715 29
Zebrafish
(Danio rerio)
Actinopterygii zp3a.2 29 30
  • 52.13 (n)
ManyToMany
zgc:171779 30
  • 27 (a)
ManyToMany
zgc:173556 30
  • 27 (a)
ManyToMany
zp3a.1 30
  • 27 (a)
ManyToMany
zp3.2 30 30
  • 26 (a)
ManyToMany
zp3b 30
  • 22 (a)
ManyToMany
Species where no ortholog for ZP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZP3 Gene

ENSEMBL:
Gene Tree for ZP3 (if available)
TreeFam:
Gene Tree for ZP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZP3: view image
Alliance of Genome Resources:
Additional Orthologs for ZP3

Paralogs for ZP3 Gene

Paralogs for ZP3 Gene

(2) SIMAP similar genes for ZP3 Gene using alignment to 3 proteins:

  • ZP3_HUMAN
  • E9PFI9_HUMAN
  • H0Y3M4_HUMAN

Pseudogenes.org Pseudogenes for ZP3 Gene

genes like me logo Genes that share paralogs with ZP3: view

Variants for ZP3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZP3 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
1032627 Pathogenic: Oocyte maturation defect 3 76,425,274(+) C/T
NM_001110354.2(ZP3):c.310C>T (p.Gln104Ter)
NONSENSE
rs117869702 Benign: not provided 76,425,072(+) G/C
NM_001110354.2(ZP3):c.108G>C (p.Glu36Asp)
MISSENSE_VARIANT,FIVE_PRIME_UTR
rs1375640377 Pathogenic: Oocyte maturation defect 3 76,434,087(+) C/G
NM_001110354.2(ZP3):c.763C>G (p.Arg255Gly)
MISSENSE
rs139729790 Benign: not provided 76,433,596(+) C/G
NM_001110354.2(ZP3):c.662C>G (p.Pro221Arg)
MISSENSE
rs140647241 Likely Benign: not provided 76,425,226(+) G/T
NM_001110354.2(ZP3):c.262G>T (p.Asp88Tyr)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZP3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZP3 Gene

Variant ID Type Subtype PubMed ID
dgv120n16 CNV deletion 17901297
dgv21n31 CNV gain 19718026
dgv232e55 CNV gain 17911159
dgv233e55 CNV loss 17911159
dgv234e55 CNV gain 17911159
dgv235e55 CNV loss 17911159
esv23516 CNV gain 19812545
esv2422494 CNV duplication 17116639
esv2584656 CNV insertion 19546169
esv2669174 CNV deletion 23128226
esv33074 CNV gain 17666407
esv3541928 CNV deletion 23714750
esv3613762 CNV loss 21293372
esv3613763 CNV loss 21293372
nsv1028665 CNV gain 25217958
nsv1119226 CNV duplication 24896259
nsv1128344 CNV deletion 24896259
nsv428174 CNV gain 18775914
nsv517634 CNV gain+loss 19592680
nsv528969 CNV gain 19592680
nsv607585 CNV gain 21841781
nsv7403 OTHER inversion 18451855
nsv970893 CNV duplication 23825009

Variation tolerance for ZP3 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.75; 73.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZP3 Gene

Human Gene Mutation Database (HGMD)
ZP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZP3
Leiden Open Variation Database (LOVD)
ZP3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZP3 Gene

Disorders for ZP3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for ZP3 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search ZP3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ZP3_HUMAN
  • Oocyte maturation defect 3 (OOMD3) [MIM:617712]: An autosomal dominant infertility disorder characterized by abnormal oocytes that lack the zona pellucida, and oocytes degeneration. {ECO:0000269 PubMed:28886344}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for ZP3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZP3: view

No data available for Genatlas for ZP3 Gene

Publications for ZP3 Gene

  1. Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations. (PMID: 1478648) van Duin M … Aitken RJ (Genomics 1992) 2 3 4 22
  2. A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility. (PMID: 28886344) Chen T … Chen ZJ (American journal of human genetics 2017) 3 4 72
  3. Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells. (PMID: 15379548) Zhao M … Dean J (Biochemistry 2004) 3 4 22
  4. Human homolog of the mouse sperm receptor. (PMID: 2385582) Chamberlin ME … Dean J (Proceedings of the National Academy of Sciences of the United States of America 1990) 3 4 22
  5. ZP2 pathogenic variants cause in vitro fertilization failure and female infertility. (PMID: 29895852) Dai C … Lin G (Genetics in medicine : official journal of the American College of Medical Genetics 2019) 3 4

Products for ZP3 Gene

Sources for ZP3 Gene