Aliases for ZP2 Gene
External Ids for ZP2 Gene
Previous GeneCards Identifiers for ZP2 Gene
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
GeneCards Summary for ZP2 Gene
ZP2 (Zona Pellucida Glycoprotein 2) is a Protein Coding gene. Diseases associated with ZP2 include Oocyte Maturation Defect 6 and Female Infertility Due To Zona Pellucida Defect. Among its related pathways are Fertilization and Ovarian Infertility Genes. Gene Ontology (GO) annotations related to this gene include coreceptor activity and acrosin binding. An important paralog of this gene is ZP4.
UniProtKB/Swiss-Prot Summary for ZP2 Gene
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy (PubMed:29895852). The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor (PubMed:29895852).