Aliases for ZNRF3 Gene
External Ids for ZNRF3 Gene
Previous GeneCards Identifiers for ZNRF3 Gene
GeneCards Summary for ZNRF3 Gene
ZNRF3 (Zinc And Ring Finger 3) is a Protein Coding gene. Diseases associated with ZNRF3 include Osteoblastoma and Pseudosarcomatous Fibromatosis. Among its related pathways are Signaling by GPCR and Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Gene Ontology (GO) annotations related to this gene include ligase activity and frizzled binding. An important paralog of this gene is RNF43.
UniProtKB/Swiss-Prot for ZNRF3 Gene
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.