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Aliases for ZNRF3 Gene
Aliases for ZNRF3 Gene
External Ids for ZNRF3 Gene
- HGNC: 18126
- NCBI Entrez Gene: 84133
- Ensembl: ENSG00000183579
- OMIM®: 612062
- UniProtKB/Swiss-Prot: Q9ULT6
Previous GeneCards Identifiers for ZNRF3 Gene
- GC22P027605
- GC22P029279
- GC22P012347
- GC22P028883
Summaries for ZNRF3 Gene
GeneCards Summary for ZNRF3 Gene
ZNRF3 (Zinc And Ring Finger 3) is a Protein Coding gene. Diseases associated with ZNRF3 include Adrenal Carcinoma and Skin Carcinoma. Among its related pathways are Signaling by GPCR and Wnt signaling pathway. Gene Ontology (GO) annotations related to this gene include ligase activity and frizzled binding. An important paralog of this gene is RNF43.
UniProtKB/Swiss-Prot Summary for ZNRF3 Gene
-
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).
Additional gene information for ZNRF3 Gene
- HGNC (18126)
- NCBI Entrez Gene (84133)
- Ensembl (ENSG00000183579)
- OMIM® (612062)
- UniProtKB/Swiss-Prot (Q9ULT6)
- Open Targets Platform(ENSG00000183579)
- Monarch Initiative
- Search for ZNRF3 at DataMed
- Search for ZNRF3 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNRF3 Gene
Genomics for ZNRF3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZNRF3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNRF3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNRF3
- Top Transcription factor binding sites by QIAGEN in the ZNRF3 gene promoter:
-
- AML1a
- c-Myb
- Evi-1
- FOXL1
- HNF-3beta
- p300
- RORalpha1
Genomic Locations for ZNRF3 Gene
Latest Assembly
- chr22:28,800,657-29,057,488
- (GRCh38/hg38)
- Size:
- 256,832 bases
- Orientation:
- Plus strand
Previous Assembly
- chr22:29,279,560-29,453,476
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 173,917 bases
- Orientation:
- Plus strand
- chr22:29,279,580-29,453,475
- (GRCh37/hg19 by Ensembl)
- Size:
- 173,896 bases
- Orientation:
- Plus strand
Genomic View for ZNRF3 Gene
Genes around ZNRF3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.1 by HGNC
- 22q12.1 by Entrez Gene
- 22q12.1 by Ensembl
ZNRF3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNRF3 Gene
Proteins for ZNRF3 Gene
-
Protein details for ZNRF3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULT6-ZNRF3_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase ZNRF3
- Protein Accession:
- Q9ULT6
- B3KU18
- Q6ICH1
- Q6NTF8
- Q8WU18
Protein attributes for ZNRF3 Gene
- Size:
- 936 amino acids
- Molecular mass:
- 100574 Da
- Quaternary structure:
-
- Interacts with LRP6, FZD4, FZD5, FZD6 and FZD8 (PubMed:22575959). Interacts with RSPO1; interaction promotes indirect interaction with LGR4 and membrane clearance of ZNRF3 (PubMed:22575959). Also interacts with RSPO2 (PubMed:29769720). Interacts with LMBR1L (PubMed:31073040).
- SequenceCaution:
-
- Sequence=CAG30283.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for ZNRF3 Gene
Post-translational modifications for ZNRF3 Gene
Other Protein References for ZNRF3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for ZNRF3
- Invitrogen Antibodies for ZNRF3 (AFLGC-ZNRF3)
-
Custom Antibody ServicesProSci Antibodies for ZNRF3
Protein products for research
-
OriGene Purified Proteins for ZNRF3
- Search Origene for MassSpec and Protein Over-expression Lysates for ZNRF3
- Origene Custom Protein Services for ZNRF3
Assay products for research
No data available for DME Specific Peptides for ZNRF3 Gene
Domains & Families for ZNRF3 Gene
Gene Families for ZNRF3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
Protein Domains for ZNRF3 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNRF3 Gene
- GenScript: Design optimal peptide antigens:
-
- ZNRF3 protein (Q96GS9_HUMAN)
- RING finger protein 203 (ZNRF3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9ULT6- Family:
-
- Belongs to the ZNRF3 family.
Function for ZNRF3 Gene
Molecular function for ZNRF3 Gene
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Negatively regulated by R-spondin proteins such as RSPO1: interaction with RSPO1 induces the indirect association between ZNRF3 and LGR4, promoting membrane clearance of ZNRF3.
Enzyme Numbers (IUBMB) for ZNRF3 Gene
Phenotypes From GWAS Catalog for ZNRF3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IDA | 22575959 |
| GO:0005109 | frizzled binding | IPI | 22575959 |
| GO:0005515 | protein binding | IPI | 22575959 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNRF3 Gene
- MGI mutant phenotypes for ZNRF3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ZNRF3:
Animal Models for ZNRF3 Gene
- MGI Knock Outs for ZNRF3:
-
- Znrf3 Znrf3<tm1.1Fcon>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ZNRF3 - Starting at $85 >
- * ZNRF3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ZNRF3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNRF3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNRF3
miRNA for ZNRF3 Gene
- miRTarBase miRNAs that target ZNRF3
-
- mmu-miR-223-3p (MIRT009593)
- mmu-miR-15a-5p (MIRT011538)
- hsa-miR-103a-3p (MIRT027017)
- hsa-miR-16-5p (MIRT031450)
- hsa-miR-339-5p (MIRT042789)
- mmu-miR-155-5p (MIRT053267)
- hsa-miR-15a-5p (MIRT087424)
- hsa-miR-15b-5p (MIRT087425)
- hsa-miR-195-5p (MIRT087426)
- hsa-miR-424-5p (MIRT087428)
- hsa-miR-497-5p (MIRT087429)
- hsa-miR-4524a-5p (MIRT087431)
- hsa-miR-4524b-5p (MIRT087433)
- hsa-miR-6838-5p (MIRT087435)
- hsa-miR-940 (MIRT370506)
- hsa-miR-1910-3p (MIRT370507)
- hsa-miR-6511a-5p (MIRT370516)
- hsa-miR-6808-5p (MIRT370517)
- hsa-miR-6893-5p (MIRT370519)
- hsa-miR-146b-5p (MIRT438327)
- hsa-miR-215-5p (MIRT444118)
- hsa-miR-192-5p (MIRT444119)
- hsa-miR-376b-3p (MIRT444120)
- hsa-miR-376a-3p (MIRT444121)
- hsa-miR-631 (MIRT444122)
- hsa-miR-3661 (MIRT444123)
- hsa-miR-103b (MIRT444124)
- hsa-miR-646 (MIRT444125)
- hsa-miR-503-5p (MIRT444126)
- hsa-miR-6516-5p (MIRT462897)
- hsa-miR-4535 (MIRT462898)
- hsa-miR-4776-5p (MIRT462899)
- hsa-miR-455-3p (MIRT462900)
- hsa-miR-4325 (MIRT462901)
- hsa-miR-7703 (MIRT462902)
- hsa-miR-1294 (MIRT462903)
- hsa-miR-650 (MIRT462904)
- hsa-miR-3612 (MIRT462905)
- hsa-miR-711 (MIRT462906)
- hsa-miR-6499-3p (MIRT462907)
- hsa-miR-4722-5p (MIRT462908)
- hsa-miR-2467-3p (MIRT462909)
- hsa-miR-6086 (MIRT462910)
- hsa-miR-377-5p (MIRT462911)
- hsa-miR-6134 (MIRT462912)
- hsa-miR-7854-3p (MIRT462913)
- hsa-miR-1827 (MIRT462914)
- hsa-miR-4649-3p (MIRT462915)
- hsa-miR-1292-3p (MIRT462916)
- hsa-miR-1247-3p (MIRT462917)
- hsa-miR-4768-3p (MIRT462918)
- hsa-miR-4257 (MIRT462919)
- hsa-miR-6500-3p (MIRT462920)
- hsa-miR-3614-5p (MIRT462921)
- hsa-miR-92b-3p (MIRT462922)
- hsa-miR-92a-3p (MIRT462923)
- hsa-miR-367-3p (MIRT462924)
- hsa-miR-363-3p (MIRT462925)
- hsa-miR-32-5p (MIRT462926)
- hsa-miR-25-3p (MIRT462927)
- hsa-miR-890 (MIRT462928)
- hsa-miR-34b-3p (MIRT462929)
- mmu-miR-466d-5p (MIRT579699)
- mmu-miR-466i-5p (MIRT579700)
- mmu-miR-466k (MIRT579701)
- mmu-miR-466l-5p (MIRT579702)
- mmu-miR-1198-5p (MIRT593397)
- mmu-miR-511-3p (MIRT593398)
- mmu-miR-466a-5p (MIRT593399)
- mmu-miR-466p-5p (MIRT593400)
- mmu-miR-1187 (MIRT593401)
- mmu-miR-466e-5p (MIRT593402)
- hsa-miR-93-5p (MIRT734875)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNRF3
- Browse OriGene Inhibitory RNA Products For ZNRF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNRF3
Clone products for research
- Applied Biological Materials (abm): Clones for ZNRF3 - Starting at $45 >
- * ZNRF3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ZNRF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNRF3
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNRF3 Gene
Localization for ZNRF3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNRF3 Gene
- Cell membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Golgi apparatus (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA,IDA | 22575959 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for ZNRF3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by Wnt |
.71
|
|
| 2 | Wnt signaling pathway | ||
| 3 | Regulation of FZD by ubiquitination | ||
| 4 | Signaling by GPCR | ||
Pathways by source for ZNRF3 Gene
4 Reactome pathways for ZNRF3 Gene
1 KEGG pathway for ZNRF3 Gene
UniProtKB/Swiss-Prot Q9ULT6-ZNRF3_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for ZNRF3 Gene
Selected Interacting proteins:
Q9ULT6-ZNRF3_HUMAN
ENSP00000443824
for ZNRF3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ZNRF3
SIGNOR curated interactions for ZNRF3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process | IBA,IMP | 22575959 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0016055 | Wnt signaling pathway | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0030178 | negative regulation of Wnt signaling pathway | IEA | -- |
Transcripts for ZNRF3 Gene
mRNA/cDNA for ZNRF3 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000402174 2667 nts (view in UCSC)
- ENST00000406323 2878 nts (view in UCSC)
- ENST00000544604 6872 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ZNRF3 - Starting at $85 >
- * ZNRF3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ZNRF3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNRF3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNRF3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNRF3
- Browse OriGene Inhibitory RNA Products For ZNRF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNRF3
Clone products for research
- Applied Biological Materials (abm): Clones for ZNRF3 - Starting at $45 >
- * ZNRF3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ZNRF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNRF3
Relevant External Links for ZNRF3 Gene
- GeneLoc Exon Structure for
- ZNRF3
Expression for ZNRF3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNRF3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNRF3
SOURCE GeneReport for Unigene cluster for ZNRF3 Gene:
Hs.655242Evidence on tissue expression from TISSUES for ZNRF3 Gene
- Nervous system(4.5)
- Muscle(4.3)
- Intestine(2.5)
- Adrenal gland(2.2)
- Liver(2.1)
- Lung(2.1)
- Kidney(2)
- Stomach(2)
Primer products for research
-
OriGene qPCR primer pairs for ZNRF3
-
OriGene qPCR primer pairs and template standards for ZNRF3
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNRF3 Gene
Orthologs for ZNRF3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZNRF3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZNRF3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Znrf3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Znrf3 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ZNRF3 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ZNRF3 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ZNRF3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ZNRF3 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | znrf3 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | znrf3 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | Y47D3B.11 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8714 31 |
|
OneToMany |
- Species where no ortholog for ZNRF3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ZNRF3 Gene
- ENSEMBL:
- Gene Tree for ZNRF3 (if available)
- TreeFam:
- Gene Tree for ZNRF3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNRF3: view image
Paralogs for ZNRF3 Gene
Paralogs for ZNRF3 Gene
Variants for ZNRF3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNRF3 Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs189590137 | Benign: not provided | 29,050,413(+) |
C/T NM_001206998.2(ZNRF3):c.2232C>T (p.Gly744=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2657238 | CNV | deletion | 23128226 |
| esv26777 | CNV | loss | 19812545 |
| esv3647523 | CNV | loss | 21293372 |
| nsv1064079 | CNV | gain | 25217958 |
| nsv1072633 | CNV | deletion | 25765185 |
| nsv3589 | CNV | deletion | 18451855 |
| nsv471980 | CNV | novel sequence insertion | 20440878 |
| nsv476091 | CNV | novel sequence insertion | 20440878 |
| nsv834169 | CNV | loss | 17160897 |
| nsv953066 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.10;
38.27% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNRF3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNRF3 Gene
Disorders for ZNRF3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| adrenal carcinoma |
|
|
| skin carcinoma |
|
|
| contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a |
|
|
| adrenal cortex disease |
|
|
| carney complex variant |
|
|
Search ZNRF3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZNRF3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ZNRF3 Gene
Publications for ZNRF3 Gene
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
- LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. (PMID: 31073040) Choi JH … Beutler B (Science (New York, N.Y.) 2019) 3 4
- RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6. (PMID: 29769720) Szenker-Ravi E … Reversade B (Nature 2018) 3 4
- ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. (PMID: 22575959) Hao HX … Cong F (Nature 2012) 3 4
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
ExternalLinks
Products for ZNRF3 Gene
- View all 3 R&D Systems ZNRF3 (ZNRF3) Products
- View all R&D Systems ZNRF3 (ZNRF3) Proteins and Enzymes
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- View all R&D Systems ZNRF3 (ZNRF3) cDNA Clones
- Learn more about R&D Systems custom ZNRF3 antibody, protein, and immunoassay development services
- Browse OriGene Antibodies
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- Search Origene for MassSpec and Protein Over-expression Lysates for ZNRF3
- Origene Custom Protein Services for ZNRF3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNRF3
- Browse OriGene Inhibitory RNA Products For ZNRF3
- OriGene qPCR primer pairs for ZNRF3
- OriGene qPCR primer pairs and template standards for ZNRF3
- OriGene CRISPR knockouts for ZNRF3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ZNRF3
- Sino Biological Human cDNA Clone for ZNRF3
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
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- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ZNRF3
- Browse Antibodies
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- Invitrogen Antibodies for ZNRF3 (AFLGC-ZNRF3)
- VectorBuilder Custom and pre-made DNA vectors for ZNRF3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ZNRF3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ZNRF3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ZNRF3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ZNRF3
- antibodies-online: Show 23 available ZNRF3 Antibodies ranked by validation data
- Compare Top ZNRF3 Antibodies
- antibodies-online: Search results for available ZNRF3 related products ranked by validation data
- antibodies-online: Show 3 available ZNRF3 Proteins ranked by validation data
- Compare Top ZNRF3 Proteins
- Custom Antibody ServicesProSci Antibodies for ZNRF3
- Search for ZNRF3 Proteins at ProSci
- Horizon Cell Lines for ZNRF3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNRF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNRF3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ZNRF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNRF3
Sources for ZNRF3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB