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ZNRF3 (Zinc And Ring Finger 3) is a Protein Coding gene. Diseases associated with ZNRF3 include Adrenal Carcinoma and Skin Carcinoma. Among its related pathways are Signaling by GPCR and Wnt signaling pathway. Gene Ontology (GO) annotations related to this gene include ligase activity and frizzled binding. An important paralog of this gene is RNF43.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | IDA | 22575959 |
GO:0005109 | frizzled binding | IPI | 22575959 |
GO:0005515 | protein binding | IPI | 22575959 |
GO:0016740 | transferase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA,IDA | 22575959 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by Wnt |
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2 | Wnt signaling pathway | ||
3 | Regulation of FZD by ubiquitination | ||
4 | Signaling by GPCR |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006511 | ubiquitin-dependent protein catabolic process | IBA,IMP | 22575959 |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0016055 | Wnt signaling pathway | IEA | -- |
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0030178 | negative regulation of Wnt signaling pathway | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZNRF3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZNRF3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Znrf3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Znrf3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ZNRF3 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ZNRF3 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ZNRF3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ZNRF3 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | znrf3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | znrf3 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | Y47D3B.11 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8714 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs189590137 | Benign: not provided | 29,050,413(+) |
C/T NM_001206998.2(ZNRF3):c.2232C>T (p.Gly744=) |
SYNONYMOUS |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2657238 | CNV | deletion | 23128226 |
esv26777 | CNV | loss | 19812545 |
esv3647523 | CNV | loss | 21293372 |
nsv1064079 | CNV | gain | 25217958 |
nsv1072633 | CNV | deletion | 25765185 |
nsv3589 | CNV | deletion | 18451855 |
nsv471980 | CNV | novel sequence insertion | 20440878 |
nsv476091 | CNV | novel sequence insertion | 20440878 |
nsv834169 | CNV | loss | 17160897 |
nsv953066 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
adrenal carcinoma |
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skin carcinoma |
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contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a |
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adrenal cortex disease |
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carney complex variant |
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