This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren's syndrome. Subcellular localization has not yet been established. [provided by RefSeq, Jul 2008] See more...

Aliases for ZNRD2 Gene

Aliases for ZNRD2 Gene

  • Zinc Ribbon Domain Containing 2 2 3 5
  • Sjogren'S Syndrome/Scleroderma Autoantigen 1 2 3
  • Sjoegren Syndrome/Scleroderma Autoantigen 1 3 4
  • Sjogren Syndrome/Scleroderma Autoantigen 1 2 3
  • Zinc Ribbon Domain-Containing Protein 2 3 4
  • Autoantigen P27 3 4
  • Protein ZNRD2 3 4
  • SSSCA1 3 4
  • P27 2 3
  • Centromeric Autoantigen (27kD) 3
  • ZNRD2 5

External Ids for ZNRD2 Gene

Previous HGNC Symbols for ZNRD2 Gene

  • SSSCA1

Previous GeneCards Identifiers for ZNRD2 Gene

  • GC11P065573
  • GC11P065575
  • GC11P065596
  • GC11P065626
  • GC11P065813

Summaries for ZNRD2 Gene

Entrez Gene Summary for ZNRD2 Gene

  • This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren's syndrome. Subcellular localization has not yet been established. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNRD2 Gene

ZNRD2 (Zinc Ribbon Domain Containing 2) is a Protein Coding gene. Diseases associated with ZNRD2 include Sjogren Syndrome.

UniProtKB/Swiss-Prot Summary for ZNRD2 Gene

  • Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNRD2 Gene

Genomics for ZNRD2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNRD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNRD2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNRD2

Genomic Locations for ZNRD2 Gene

Latest Assembly
chr11:65,570,460-65,573,942
(GRCh38/hg38)
Size:
3,483 bases
Orientation:
Plus strand

Previous Assembly
chr11:65,337,948-65,339,359
(GRCh37/hg19 by Entrez Gene)
Size:
1,412 bases
Orientation:
Plus strand

chr11:65,337,901-65,341,413
(GRCh37/hg19 by Ensembl)
Size:
3,513 bases
Orientation:
Plus strand

Genomic View for ZNRD2 Gene

Genes around ZNRD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNRD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNRD2 Gene

Proteins for ZNRD2 Gene

  • Protein details for ZNRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60232-ZNRD2_HUMAN
    Recommended name:
    Protein ZNRD2
    Protein Accession:
    O60232

    Protein attributes for ZNRD2 Gene

    Size:
    199 amino acids
    Molecular mass:
    21474 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZNRD2 Gene

neXtProt entry for ZNRD2 Gene

Post-translational modifications for ZNRD2 Gene

  • Ubiquitination at Lys22, Lys64, and Lys67
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNRD2 Gene

No data available for DME Specific Peptides for ZNRD2 Gene

Domains & Families for ZNRD2 Gene

Gene Families for ZNRD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNRD2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNRD2 Gene

GenScript: Design optimal peptide antigens:
  • Autoantigen p27 (SSA27_HUMAN)
genes like me logo Genes that share domains with ZNRD2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNRD2 Gene

Function for ZNRD2 Gene

Molecular function for ZNRD2 Gene

UniProtKB/Swiss-Prot Function:
Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

Phenotypes From GWAS Catalog for ZNRD2 Gene

Gene Ontology (GO) - Molecular Function for ZNRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ZNRD2: view
genes like me logo Genes that share phenotypes with ZNRD2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNRD2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNRD2 Gene

Localization for ZNRD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNRD2 gene
Compartment Confidence
extracellular 2
cytosol 2
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNRD2 Gene

Pathways & Interactions for ZNRD2 Gene

PathCards logo

SuperPathways for ZNRD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS 9486406
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ZNRD2: view

No data available for Pathways by source and SIGNOR curated interactions for ZNRD2 Gene

Drugs & Compounds for ZNRD2 Gene

No Compound Related Data Available

Transcripts for ZNRD2 Gene

mRNA/cDNA for ZNRD2 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNRD2

Alternative Splicing Database (ASD) splice patterns (SP) for ZNRD2 Gene

No ASD Table

Relevant External Links for ZNRD2 Gene

GeneLoc Exon Structure for
ZNRD2

Expression for ZNRD2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNRD2

SOURCE GeneReport for Unigene cluster for ZNRD2 Gene:

Hs.25723

Evidence on tissue expression from TISSUES for ZNRD2 Gene

  • Muscle(2.5)
  • Nervous system(2.3)
  • Intestine(2)
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNRD2 Gene

Orthologs for ZNRD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNRD2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SSSCA1 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia SSSCA1 30 31
  • 90.79 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SSSCA1 30 31
  • 90.62 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sssca1 30
  • 86.26 (n)
Mouse
(Mus musculus)
Mammalia Sssca1 30 31
  • 84.76 (n)
OneToOne
Znrd2 17
Oppossum
(Monodelphis domestica)
Mammalia SSSCA1 31
  • 63 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SSSCA1 31
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sssca1 30
  • 56.76 (n)
Zebrafish
(Danio rerio)
Actinopterygii sssca1 30 31
  • 65.62 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea Y39A1A.3 31
  • 23 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6817 31
  • 22 (a)
OneToOne
Species where no ortholog for ZNRD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZNRD2 Gene

ENSEMBL:
Gene Tree for ZNRD2 (if available)
TreeFam:
Gene Tree for ZNRD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNRD2: view image

Paralogs for ZNRD2 Gene

No data available for Paralogs for ZNRD2 Gene

Variants for ZNRD2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNRD2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs35971725 Benign: not provided. - 65,570,646(+) C/Tp.Thr21Met
NM_006396.3(ZNRD2):c.62C>T (p.Thr21Met)
MISSENSE_VARIANT,FIVE_PRIME_UTR
rs7940495 Benign: not provided 65,570,520(+) T/C
NM_006396.3(ZNRD2):c.19+10T>C
FIVE_PRIME_UTR_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNRD2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNRD2 Gene

Variant ID Type Subtype PubMed ID
dgv1969n54 CNV loss 21841781
nsv951018 CNV deletion 24416366

Variation tolerance for ZNRD2 Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNRD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNRD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNRD2 Gene

Disorders for ZNRD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNRD2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
sjogren syndrome
  • sicca syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ZNRD2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZNRD2

genes like me logo Genes that share disorders with ZNRD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNRD2 Gene

Publications for ZNRD2 Gene

  1. cDNA cloning of a novel autoantigen targeted by a minor subset of anti-centromere antibodies. (PMID: 9486406) Muro Y … Sugimoto K (Clinical and experimental immunology 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. (PMID: 33060197) Gordon DE … Krogan NJ (Science (New York, N.Y.) 2020) 3
  4. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. (PMID: 32203420) Müller PM … Rocks O (Nature cell biology 2020) 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNRD2 Gene

Sources for ZNRD2 Gene