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This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren's syndrome. Subcellular localization has not yet been established. [provided by RefSeq, Jul 2008]
ZNRD2 (Zinc Ribbon Domain Containing 2) is a Protein Coding gene. Diseases associated with ZNRD2 include Sjogren Syndrome.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000278 | mitotic cell cycle | TAS | 9486406 |
GO:0007049 | cell cycle | IEA | -- |
GO:0051301 | cell division | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SSSCA1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SSSCA1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SSSCA1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sssca1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Sssca1 30 31 |
|
OneToOne | |
Znrd2 17 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | SSSCA1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SSSCA1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sssca1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | sssca1 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | Y39A1A.3 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6817 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs35971725 | Benign: not provided. - | 65,570,646(+) |
C/Tp.Thr21Met NM_006396.3(ZNRD2):c.62C>T (p.Thr21Met) |
MISSENSE_VARIANT,FIVE_PRIME_UTR | |
rs7940495 | Benign: not provided | 65,570,520(+) |
T/C NM_006396.3(ZNRD2):c.19+10T>C |
FIVE_PRIME_UTR_VARIANT,INTRON |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1969n54 | CNV | loss | 21841781 |
nsv951018 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
sjogren syndrome |
|
|