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Aliases for ZNHIT6 Gene

Aliases for ZNHIT6 Gene

  • Zinc Finger HIT-Type Containing 6 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-75 3 4
  • Zinc Finger HIT Domain-Containing Protein 6 3 4
  • Zinc Finger, HIT Type 6 2 3
  • C1orf181 3 4
  • BCD1 3 4
  • Box C/D SnoRNA Essential 1 Homolog (S. Cerevisiae) 2
  • Chromosome 1 Open Reading Frame 181 2
  • Box C/D SnoRNA Essential 1 Homolog 3
  • Box C/D SnoRNA Protein 1 3
  • NY-BR-75 3

External Ids for ZNHIT6 Gene

Previous HGNC Symbols for ZNHIT6 Gene

  • C1orf181

Previous GeneCards Identifiers for ZNHIT6 Gene

  • GC01M085891
  • GC01M086118
  • GC01M084225

Summaries for ZNHIT6 Gene

GeneCards Summary for ZNHIT6 Gene

ZNHIT6 (Zinc Finger HIT-Type Containing 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding and enzyme binding.

UniProtKB/Swiss-Prot for ZNHIT6 Gene

  • Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.

Additional gene information for ZNHIT6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNHIT6 Gene

Genomics for ZNHIT6 Gene

GeneHancer (GH) Regulatory Elements for ZNHIT6 Gene

Promoters and enhancers for ZNHIT6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I085706 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 572.5 +0.3 256 2.8 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZNHIT6 ODF2L CYR61 DDAH1 PIR53460
GH01I085575 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.7 +127.7 127662 11.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 DDAH1 CYR61 ODF2L ZNHIT6 C1orf52 BCL10 ENSG00000272691 GC01P085583 ENSG00000282057
GH01I085520 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 28.8 +184.4 184362 7.6 HDGF PKNOX1 ZNF133 NEUROD1 FEZF1 ZNF2 BRCA1 ZNF121 FOS ATF7 ZNHIT6 CYR61 DDAH1 C1orf52 ENSG00000282057 ENSG00000273264
GH01I085604 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +98.9 98910 10 PKNOX1 FOXA2 ARID4B SIN3A ETS1 YY1 GLIS2 ZNF143 FOS RXRA CYR61 ZNHIT6 DDAH1 ODF2L ENSG00000230285 GC01P085628
GH01I085047 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.9 +659.5 659514 3.1 FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF213 KLF7 SP3 REST TSHZ1 MCOLN3 ENSG00000271576 MCOLN2 ZNHIT6 WDR63 MIR4423
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNHIT6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNHIT6 gene promoter:

Genomic Locations for ZNHIT6 Gene

Genomic Locations for ZNHIT6 Gene
59,041 bases
Minus strand

Genomic View for ZNHIT6 Gene

Genes around ZNHIT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNHIT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNHIT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNHIT6 Gene

Proteins for ZNHIT6 Gene

  • Protein details for ZNHIT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Box C/D snoRNA protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RBA1
    • B4DP13
    • D3DT20
    • Q9H278
    • Q9H3X3
    • Q9NWN0

    Protein attributes for ZNHIT6 Gene

    470 amino acids
    Molecular mass:
    53918 Da
    Quaternary structure:
    • Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9.
    • Sequence=AAG48263.1; Type=Frameshift; Positions=365, 412, 416, 419, 432; Evidence={ECO:0000305}; Sequence=BAA91349.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNHIT6 Gene


neXtProt entry for ZNHIT6 Gene

Post-translational modifications for ZNHIT6 Gene

  • Ubiquitination at posLast=229229, isoforms=2362, and isoforms=2424
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNHIT6 Gene

No data available for DME Specific Peptides for ZNHIT6 Gene

Domains & Families for ZNHIT6 Gene

Gene Families for ZNHIT6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNHIT6 Gene


Suggested Antigen Peptide Sequences for ZNHIT6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BCD1 family.
  • Belongs to the BCD1 family.
genes like me logo Genes that share domains with ZNHIT6: view

Function for ZNHIT6 Gene

Molecular function for ZNHIT6 Gene

UniProtKB/Swiss-Prot Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.

Phenotypes From GWAS Catalog for ZNHIT6 Gene

Gene Ontology (GO) - Molecular Function for ZNHIT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001094 TFIID-class transcription factor binding IPI 17636026
GO:0005515 protein binding IPI 17636026
GO:0019899 enzyme binding IPI 23382074
GO:0042802 identical protein binding IPI 17636026
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNHIT6: view

Phenotypes for ZNHIT6 Gene

genes like me logo Genes that share phenotypes with ZNHIT6: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNHIT6 Gene

Localization for ZNHIT6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNHIT6 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNHIT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA,IDA 19056867
GO:0070761 pre-snoRNP complex IDA 17636026
genes like me logo Genes that share ontologies with ZNHIT6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNHIT6 Gene

Pathways & Interactions for ZNHIT6 Gene

SuperPathways for ZNHIT6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNHIT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000492 box C/D snoRNP assembly IMP 17636026
GO:0042254 ribosome biogenesis IEA --
GO:0048254 snoRNA localization IMP 17636026
GO:0051259 protein oligomerization IMP 17636026
genes like me logo Genes that share ontologies with ZNHIT6: view

No data available for Pathways by source and SIGNOR curated interactions for ZNHIT6 Gene

Drugs & Compounds for ZNHIT6 Gene

No Compound Related Data Available

Transcripts for ZNHIT6 Gene

mRNA/cDNA for ZNHIT6 Gene

Unigene Clusters for ZNHIT6 Gene

Zinc finger, HIT-type containing 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11

Relevant External Links for ZNHIT6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNHIT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNHIT6 Gene

Protein differential expression in normal tissues from HIPED for ZNHIT6 Gene

This gene is overexpressed in Lung (43.3), Liver (13.9), and Fetal Liver (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNHIT6 Gene

Protein tissue co-expression partners for ZNHIT6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNHIT6 Gene:


SOURCE GeneReport for Unigene cluster for ZNHIT6 Gene:


Evidence on tissue expression from TISSUES for ZNHIT6 Gene

  • Liver(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with ZNHIT6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNHIT6 Gene

Orthologs for ZNHIT6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNHIT6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNHIT6 33 34
  • 99.65 (n)
(Bos Taurus)
Mammalia ZNHIT6 33 34
  • 86.02 (n)
(Canis familiaris)
Mammalia ZNHIT6 33 34
  • 84.63 (n)
(Mus musculus)
Mammalia Znhit6 33 16 34
  • 79.21 (n)
(Rattus norvegicus)
Mammalia Znhit6 33
  • 77.95 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
-- 34
  • 54 (a)
(Monodelphis domestica)
Mammalia ZNHIT6 34
  • 48 (a)
(Gallus gallus)
Aves ZNHIT6 33 34
  • 68.87 (n)
(Anolis carolinensis)
Reptilia ZNHIT6 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znhit6 33
  • 64.8 (n)
Str.6177 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25224 33
(Danio rerio)
Actinopterygii ZNHIT6 34
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004678 33
  • 50 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1463 33 34
  • 44.35 (n)
(Caenorhabditis elegans)
Secernentea zhit-3 34
  • 16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BCD1 34 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.448 34
  • 31 (a)
-- 34
  • 27 (a)
Species where no ortholog for ZNHIT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNHIT6 Gene

Gene Tree for ZNHIT6 (if available)
Gene Tree for ZNHIT6 (if available)

Paralogs for ZNHIT6 Gene

No data available for Paralogs for ZNHIT6 Gene

Variants for ZNHIT6 Gene

Sequence variations from dbSNP and Humsavar for ZNHIT6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035721 A colorectal cancer sample p.Leu455His
rs1000154701 -- 85,680,076(-) T/G intron_variant
rs1000231408 -- 85,673,908(-) C/T intron_variant
rs1000242561 -- 85,680,065(-) G/A intron_variant
rs1000398591 -- 85,666,003(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNHIT6 Gene

Variant ID Type Subtype PubMed ID
nsv506942 OTHER sequence alteration 20534489
nsv509369 CNV insertion 20534489

Variation tolerance for ZNHIT6 Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNHIT6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNHIT6 Gene

Disorders for ZNHIT6 Gene

Additional Disease Information for ZNHIT6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNHIT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNHIT6 Gene

Publications for ZNHIT6 Gene

  1. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan MJ … Old LJ (Cancer immunity 2001) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. (PMID: 17636026) McKeegan KS … Watkins NJ (Molecular and cellular biology 2007) 3 4 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ZNHIT6 Gene

Sources for ZNHIT6 Gene

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