Aliases for ZNHIT6 Gene
Aliases for ZNHIT6 Gene
External Ids for ZNHIT6 Gene
- HGNC: 26089
- Entrez Gene: 54680
- Ensembl: ENSG00000117174
- UniProtKB: Q9NWK9
Previous HGNC Symbols for ZNHIT6 Gene
- C1orf181
Previous GeneCards Identifiers for ZNHIT6 Gene
- GC01M085891
- GC01M086118
- GC01M084225
Summaries for ZNHIT6 Gene
GeneCards Summary for ZNHIT6 Gene
ZNHIT6 (Zinc Finger HIT-Type Containing 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding and enzyme binding.
UniProtKB/Swiss-Prot for ZNHIT6 Gene
-
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Additional gene information for ZNHIT6 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNHIT6 Gene
Genomics for ZNHIT6 Gene
GeneHancer (GH) Regulatory Elements for ZNHIT6 Gene
Promoters and enhancers for ZNHIT6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZNHIT6 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ZNHIT6 Gene
Genomic Locations for ZNHIT6 Gene
- chr1:85,649,423-85,708,463
- (GRCh38/hg38)
- Size:
- 59,041 bases
- Orientation:
- Minus strand
- chr1:86,115,106-86,174,116
- (GRCh37/hg19)
Genomic View for ZNHIT6 Gene
Genes around ZNHIT6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p22.3 by Ensembl
- 1p22.3 by Entrez Gene
- 1p22.3 by HGNC
ZNHIT6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNHIT6 Gene
Proteins for ZNHIT6 Gene
-
Protein details for ZNHIT6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NWK9-BCD1_HUMAN
- Recommended name:
- Box C/D snoRNA protein 1
- Protein Accession:
- Q9NWK9
- B2RBA1
- B4DP13
- D3DT20
- Q9H278
- Q9H3X3
- Q9NWN0
Protein attributes for ZNHIT6 Gene
- Size:
- 470 amino acids
- Molecular mass:
- 53918 Da
- Quaternary structure:
-
- Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9.
- SequenceCaution:
-
- Sequence=AAG48263.1; Type=Frameshift; Positions=365, 412, 416, 419, 432; Evidence={ECO:0000305}; Sequence=BAA91349.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ZNHIT6 Gene
Post-translational modifications for ZNHIT6 Gene
Other Protein References for ZNHIT6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZNHIT6
- Invitrogen Antibodies for ZNHIT6
- GeneTex ZNHIT6 antibody for ZNHIT6
Protein Products
-
OriGene Purified Proteins for ZNHIT6
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-
Abcam proteins for ZNHIT6
Assay Products
No data available for DME Specific Peptides for ZNHIT6 Gene
Domains & Families for ZNHIT6 Gene
Gene Families for ZNHIT6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ZNHIT6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNHIT6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NWK9- Family:
-
- Belongs to the BCD1 family.
Function for ZNHIT6 Gene
Molecular function for ZNHIT6 Gene
- UniProtKB/Swiss-Prot Function:
- Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.
Phenotypes From GWAS Catalog for ZNHIT6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001094 | TFIID-class transcription factor binding | IPI | 17636026 |
| GO:0005515 | protein binding | IPI | 17636026 |
| GO:0019899 | enzyme binding | IPI | 23382074 |
| GO:0042802 | identical protein binding | IPI | 17636026 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNHIT6 Gene
- GenomeRNAi human phenotypes for ZNHIT6:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ZNHIT6 gene
-
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CRISPR Products
-
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- Overview of 107 available ZNHIT6 gene related products
- Applied Biological Materials CRISPR for ZNHIT6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNHIT6
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miRNA for ZNHIT6 Gene
- miRTarBase miRNAs that target ZNHIT6
miRNA Products
- Search ViGene Biosciences for ZNHIT6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ZNHIT6
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- Overview of 107 available ZNHIT6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNHIT6 gene
Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ZNHIT6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ZNHIT6 gene
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ViGene Biosciences lentiviral particle packaged cDNA for ZNHIT6 gene
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNHIT6 Gene
Localization for ZNHIT6 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 4 |
| nucleus | 3 |
- Nuclear speckles (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0070062 | extracellular exosome | HDA,IDA | 19056867 |
| GO:0070761 | pre-snoRNP complex | IDA | 17636026 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNHIT6 Gene
Pathways & Interactions for ZNHIT6 Gene
No Data Available
Interacting Proteins for ZNHIT6 Gene
Selected Interacting proteins:
Q9NWK9-BCD1_HUMAN
ENSP00000359606
for ZNHIT6 Gene via
IID
MINT
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000492 | box C/D snoRNP assembly | IMP | 17636026 |
| GO:0042254 | ribosome biogenesis | IEA | -- |
| GO:0048254 | snoRNA localization | IMP | 17636026 |
| GO:0051259 | protein oligomerization | IMP | 17636026 |
No data available for Pathways by source and SIGNOR curated interactions for ZNHIT6 Gene
Transcripts for ZNHIT6 Gene
mRNA/cDNA for ZNHIT6 Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (108) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNHIT6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZNHIT6
- genomics-online: gRNA clones - Search results for 107 available ZNHIT6 gene related products
- Overview of 107 available ZNHIT6 gene related products
- Applied Biological Materials CRISPR for ZNHIT6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNHIT6
- GenScript: Design CRISPR guide RNA sequences for ZNHIT6
miRNA Products
- Search ViGene Biosciences for ZNHIT6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ZNHIT6
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- genomics-online: shRNA clones - Search results for 107 available ZNHIT6 gene related products
- Overview of 107 available ZNHIT6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNHIT6 gene
Clone Products
- Sino Biological Human cDNA Clone for ZNHIT6
- VectorBuilder custom plasmid, inducible vectors for ZNHIT6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNHIT6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ZNHIT6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: |
Expression for ZNHIT6 Gene
This gene is overexpressed in Lung (43.3), Liver (13.9), and Fetal Liver (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNHIT6 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZNHIT6 Gene:
ZNHIT6SOURCE GeneReport for Unigene cluster for ZNHIT6 Gene:
Hs.5111Evidence on tissue expression from TISSUES for ZNHIT6 Gene
- Liver(4.2)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs for ZNHIT6
-
OriGene qPCR primer pairs and template standards for ZNHIT6
- genomics-online: primer clones - Search results for 107 available ZNHIT6 gene related products
- Overview of 107 available ZNHIT6 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNHIT6 Gene
Orthologs for ZNHIT6 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNHIT6 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ZNHIT6 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ZNHIT6 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Znhit6 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Znhit6 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | ZNHIT6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZNHIT6 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ZNHIT6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | znhit6 33 |
|
||
| Str.6177 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.25224 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ZNHIT6 34 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004678 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG1463 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | zhit-3 34 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BCD1 34 36 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.448 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany |
- Species where no ortholog for ZNHIT6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ZNHIT6 Gene
No data available for Paralogs for ZNHIT6 Gene
Variants for ZNHIT6 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035721 | A colorectal cancer sample | p.Leu455His | |||
| rs1000154701 | -- | 85,680,076(-) | T/G | intron_variant | |
| rs1000231408 | -- | 85,673,908(-) | C/T | intron_variant | |
| rs1000242561 | -- | 85,680,065(-) | G/A | intron_variant | |
| rs1000398591 | -- | 85,666,003(-) | T/G | intron_variant |
Residual Variation Intolerance Score:
63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.68;
46.00% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNHIT6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNHIT6
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNHIT6 Gene
Disorders for ZNHIT6 Gene
Additional Disease Information for ZNHIT6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ZNHIT6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNHIT6 Gene
Publications for ZNHIT6 Gene
- Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan MJ … Old LJ (Cancer immunity 2001) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. (PMID: 17636026) McKeegan KS … Watkins NJ (Molecular and cellular biology 2007) 3 4 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for ZNHIT6 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for ZNHIT6
- VectorBuilder custom plasmid, inducible vectors for ZNHIT6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNHIT6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 41 available ZNHIT6 Antibodies ranked by validation data
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- GeneTex ZNHIT6 antibody for ZNHIT6
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- ViGene Biosciences adenoviral particle packaged cDNA for ZNHIT6 gene
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- Overview of 107 available ZNHIT6 gene related products
Sources for ZNHIT6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems