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Aliases for ZNHIT2 Gene

Aliases for ZNHIT2 Gene

  • Zinc Finger HIT-Type Containing 2 2 3 5
  • Zinc Finger, HIT Domain Containing 2 2 3
  • C11orf5 3 4
  • Zinc Finger HIT Domain-Containing Protein 2 3
  • Chromosome 11 Open Reading Frame 5 2
  • Zinc Finger, HIT Type 2 3
  • Protein FON 4
  • FON 3

External Ids for ZNHIT2 Gene

Previous HGNC Symbols for ZNHIT2 Gene

  • C11orf5

Previous GeneCards Identifiers for ZNHIT2 Gene

  • GC11M064640
  • GC11M064883
  • GC11M061210

Summaries for ZNHIT2 Gene

GeneCards Summary for ZNHIT2 Gene

ZNHIT2 (Zinc Finger HIT-Type Containing 2) is a Protein Coding gene. Diseases associated with ZNHIT2 include Triple-Receptor Negative Breast Cancer.

Additional gene information for ZNHIT2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNHIT2 Gene

Genomics for ZNHIT2 Gene

GeneHancer (GH) Regulatory Elements for ZNHIT2 Gene

Promoters and enhancers for ZNHIT2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I065115 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 374 3.5 HDGF FOXA2 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 ENSG00000255173 ENSG00000278952 ZNHIT2 ZFPL1 MEN1 ENSG00000257086 TRMT112 EIF1AD FAU VPS51
GH11I065470 Promoter/Enhancer 2.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 33.2 -372.3 -372346 40 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 LOC105369346 SF1 PCNX3 POLA2 ZFPL1 EIF1AD SART1 MUS81 LOC105369352 KAT5
GH11I065414 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 25.4 -306.4 -306443 18.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NEAT1 ENSG00000277599 ENSG00000278050 ENSG00000278144 GC11P065529 SF1 ZFPL1 EIF1AD POLA2 PCNX3
GH11I065886 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -777.7 -777720 18.4 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 FOSL1 FIBP CCDC85B SNX32 ENSG00000258297 EIF1AD RBM14 MUS81 SART1 POLA2
GH11I065910 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -798.0 -797989 11.4 CLOCK MLX ZFP64 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D SSRP1 DRAP1 C11orf68 RBM14 LOC105369352 ZFPL1 ENSG00000254461 MUS81 ENSG00000258297 EIF1AD PCNX3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNHIT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNHIT2 gene promoter:

Genomic Locations for ZNHIT2 Gene

Genomic Locations for ZNHIT2 Gene
1,336 bases
Minus strand

Genomic View for ZNHIT2 Gene

Genes around ZNHIT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNHIT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNHIT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNHIT2 Gene

Proteins for ZNHIT2 Gene

  • Protein details for ZNHIT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger HIT domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q3SY14
    • Q8IUV0

    Protein attributes for ZNHIT2 Gene

    403 amino acids
    Molecular mass:
    42884 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZNHIT2 Gene

neXtProt entry for ZNHIT2 Gene

Post-translational modifications for ZNHIT2 Gene

  • Ubiquitination at isoforms=303
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNHIT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNHIT2 Gene

Domains & Families for ZNHIT2 Gene

Gene Families for ZNHIT2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNHIT2 Gene


Suggested Antigen Peptide Sequences for ZNHIT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNHIT2: view

No data available for UniProtKB/Swiss-Prot for ZNHIT2 Gene

Function for ZNHIT2 Gene

Phenotypes From GWAS Catalog for ZNHIT2 Gene

Gene Ontology (GO) - Molecular Function for ZNHIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNHIT2: view

Phenotypes for ZNHIT2 Gene

GenomeRNAi human phenotypes for ZNHIT2:
genes like me logo Genes that share phenotypes with ZNHIT2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZNHIT2

CRISPR Products

miRNA for ZNHIT2 Gene

miRTarBase miRNAs that target ZNHIT2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNHIT2 Gene

Localization for ZNHIT2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNHIT2 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ZNHIT2 Gene

Pathways & Interactions for ZNHIT2 Gene

SuperPathways for ZNHIT2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNHIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022008 neurogenesis IBA --
genes like me logo Genes that share ontologies with ZNHIT2: view

No data available for Pathways by source and SIGNOR curated interactions for ZNHIT2 Gene

Drugs & Compounds for ZNHIT2 Gene

No Compound Related Data Available

Transcripts for ZNHIT2 Gene

mRNA/cDNA for ZNHIT2 Gene

Unigene Clusters for ZNHIT2 Gene

Zinc finger, HIT-type containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT2 Gene

No ASD Table

Relevant External Links for ZNHIT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNHIT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNHIT2 Gene

mRNA differential expression in normal tissues according to GTEx for ZNHIT2 Gene

This gene is overexpressed in Testis (x6.7).

Protein differential expression in normal tissues from HIPED for ZNHIT2 Gene

This gene is overexpressed in Testis (41.2) and Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNHIT2 Gene

Protein tissue co-expression partners for ZNHIT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNHIT2 Gene:


SOURCE GeneReport for Unigene cluster for ZNHIT2 Gene:


mRNA Expression by UniProt/SwissProt for ZNHIT2 Gene:

Tissue specificity: Low expression in most tissues; highly expressed in testis.

Evidence on tissue expression from TISSUES for ZNHIT2 Gene

  • Pancreas(4.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with ZNHIT2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNHIT2 Gene

Orthologs for ZNHIT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZNHIT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNHIT2 33 34
  • 99.42 (n)
(Bos Taurus)
Mammalia ZNHIT2 33 34
  • 86.35 (n)
(Canis familiaris)
Mammalia ZNHIT2 33 34
  • 85.61 (n)
(Mus musculus)
Mammalia Znhit2 33 16 34
  • 81.36 (n)
(Rattus norvegicus)
Mammalia Znhit2 33
  • 80.82 (n)
(Monodelphis domestica)
Mammalia ZNHIT2 34
  • 65 (a)
(Anolis carolinensis)
Reptilia ZNHIT2 34
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znhit2 33
  • 45.42 (n)
(Danio rerio)
Actinopterygii znhit2 33 34
  • 45.96 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001270 33
  • 44.36 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31223 33
(Caenorhabditis elegans)
Secernentea zhit-2 34
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G63830 33
  • 39.76 (n)
(Oryza sativa)
Liliopsida Os10g0520700 33
  • 44.44 (n)
Species where no ortholog for ZNHIT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNHIT2 Gene

Gene Tree for ZNHIT2 (if available)
Gene Tree for ZNHIT2 (if available)

Paralogs for ZNHIT2 Gene

No data available for Paralogs for ZNHIT2 Gene

Variants for ZNHIT2 Gene

Sequence variations from dbSNP and Humsavar for ZNHIT2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
VAR_035720 A breast cancer sample p.Ala59Pro
rs1001542660 -- 65,117,560(-) G/A coding_sequence_variant, synonymous_variant
rs1002431275 -- 65,117,519(-) G/T coding_sequence_variant, missense_variant
rs1002573048 -- 65,118,280(-) G/C upstream_transcript_variant
rs1002948993 -- 65,118,624(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNHIT2 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680

Variation tolerance for ZNHIT2 Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNHIT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNHIT2 Gene

Disorders for ZNHIT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNHIT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
triple-receptor negative breast cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNHIT2

genes like me logo Genes that share disorders with ZNHIT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNHIT2 Gene

Publications for ZNHIT2 Gene

  1. Solution structure of the zinc finger HIT domain in protein FON. (PMID: 17656577) He F … Yokoyama S (Protein science : a publication of the Protein Society 2007) 3 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Molecular characterization of human and murine C11orf5, a new member of the FAUNA gene cluster. (PMID: 10602999) Lemmens IH … Kas K (Mammalian genome : official journal of the International Mammalian Genome Society 2000) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ZNHIT2 Gene

Sources for ZNHIT2 Gene

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