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Aliases for ZNHIT1 Gene

Aliases for ZNHIT1 Gene

  • Zinc Finger HIT-Type Containing 1 2 3 5
  • Zinc Finger Protein, Subfamily 4A (HIT Domain Containing), Member 1 2 3
  • Zinc Finger Protein Subfamily 4A Member 1 3 4
  • Putative Cyclin G1 Interacting Protein 2 3
  • Zinc Finger, HIT Domain Containing 1 2 3
  • Cyclin-G1-Binding Protein 1 3 4
  • P18 Hamlet 3 4
  • ZNFN4A1 3 4
  • Zinc Finger HIT Domain-Containing Protein 1 3
  • Zinc Finger, HIT Type 1 3
  • H_DJ0747G18.14 3
  • P18Hamlet 3
  • CGBP1 4
  • CG1I 3

External Ids for ZNHIT1 Gene

Previous HGNC Symbols for ZNHIT1 Gene

  • ZNFN4A1

Previous GeneCards Identifiers for ZNHIT1 Gene

  • GC07P100407
  • GC07P100421
  • GC07P100454
  • GC07P100647
  • GC07P100860
  • GC07P095454

Summaries for ZNHIT1 Gene

GeneCards Summary for ZNHIT1 Gene

ZNHIT1 (Zinc Finger HIT-Type Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chromatin binding and nucleosome binding.

UniProtKB/Swiss-Prot for ZNHIT1 Gene

  • Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.

Additional gene information for ZNHIT1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNHIT1 Gene

Genomics for ZNHIT1 Gene

GeneHancer (GH) Regulatory Elements for ZNHIT1 Gene

Promoters and enhancers for ZNHIT1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I101215 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 555.5 +0.5 515 4.7 FOXA2 PKNOX1 CLOCK ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF213 ZNHIT1 PLOD3 FIS1 GIGYF1 SRRT STAG3L5P PILRB PPP1R35 NAT16 EPHB4
GH07I101192 Enhancer 1.4 Ensembl ENCODE dbSUPER 13.7 -25.1 -25081 1.2 HDGF ATF1 ARNT ARID4B IRF4 ZNF48 YY1 ARID2 ZNF143 ATF7 AP1S1 PLOD3 ZNHIT1 VGF NAT16
GH07I101283 Enhancer 0.8 ENCODE 12.2 +65.5 65487 0.2 RB1 ARID4B SIN3A ZNF2 RAD21 RFX5 ZNF335 ZNF121 ARID2 ZNF143 PLOD3 ZNHIT1 VGF AP1S1 NAT16 FIS1 LOC101927746 ENSG00000278683 AZGP1P2
GH07I101185 Enhancer 0.7 ENCODE 13.7 -32.3 -32273 0.2 FOXA2 TEAD4 JUN FOSL1 ZNF335 TCF12 EGR1 CBFA2T2 TRIM24 FOS ZNHIT1 PLOD3 AP1S1 NAT16 VGF
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNHIT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNHIT1 gene promoter:

Genomic Locations for ZNHIT1 Gene

Genomic Locations for ZNHIT1 Gene
6,525 bases
Plus strand

Genomic View for ZNHIT1 Gene

Genes around ZNHIT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNHIT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNHIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNHIT1 Gene

Proteins for ZNHIT1 Gene

  • Protein details for ZNHIT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger HIT domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6IB12

    Protein attributes for ZNHIT1 Gene

    154 amino acids
    Molecular mass:
    17536 Da
    Quaternary structure:
    • Interacts with MAPK11 and MAPK14. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. Interacts with NR1D1 and NR2D2.

neXtProt entry for ZNHIT1 Gene

Post-translational modifications for ZNHIT1 Gene

Other Protein References for ZNHIT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNHIT1 Gene

Domains & Families for ZNHIT1 Gene

Gene Families for ZNHIT1 Gene

Protein Domains for ZNHIT1 Gene


Suggested Antigen Peptide Sequences for ZNHIT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZNHIT1 family.
  • Belongs to the ZNHIT1 family.
genes like me logo Genes that share domains with ZNHIT1: view

Function for ZNHIT1 Gene

Molecular function for ZNHIT1 Gene

UniProtKB/Swiss-Prot Function:
Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.
UniProtKB/Swiss-Prot Induction:
Induced by DNA damage.

Phenotypes From GWAS Catalog for ZNHIT1 Gene

Gene Ontology (GO) - Molecular Function for ZNHIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15647280
GO:0031491 nucleosome binding IBA --
GO:0042826 histone deacetylase binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNHIT1: view
genes like me logo Genes that share phenotypes with ZNHIT1: view

Animal Model Products

CRISPR Products

miRNA for ZNHIT1 Gene

miRTarBase miRNAs that target ZNHIT1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNHIT1 Gene

Localization for ZNHIT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNHIT1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNHIT1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNHIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IBA --
GO:0005634 nucleus IEA,IDA 17892483
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNHIT1: view

Pathways & Interactions for ZNHIT1 Gene

SuperPathways for ZNHIT1 Gene

No Data Available

SIGNOR curated interactions for ZNHIT1 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for ZNHIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031063 regulation of histone deacetylation IBA --
GO:0043486 histone exchange IBA --
genes like me logo Genes that share ontologies with ZNHIT1: view

No data available for Pathways by source for ZNHIT1 Gene

Drugs & Compounds for ZNHIT1 Gene

No Compound Related Data Available

Transcripts for ZNHIT1 Gene

Unigene Clusters for ZNHIT1 Gene

Zinc finger, HIT-type containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - -
SP6: - - -

Relevant External Links for ZNHIT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNHIT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNHIT1 Gene

Protein differential expression in normal tissues from HIPED for ZNHIT1 Gene

This gene is overexpressed in Heart (26.4), Testis (14.4), Blymphocyte (12.2), Placenta (8.3), and NK cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNHIT1 Gene

Protein tissue co-expression partners for ZNHIT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNHIT1 Gene:


SOURCE GeneReport for Unigene cluster for ZNHIT1 Gene:


mRNA Expression by UniProt/SwissProt for ZNHIT1 Gene:

Tissue specificity: Expressed abundantly in liver, but weakly in skeletal muscle, ovary and small intestine.

Evidence on tissue expression from TISSUES for ZNHIT1 Gene

  • Eye(4.2)
  • Nervous system(2.7)
  • Skin(2.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with ZNHIT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNHIT1 Gene

Orthologs for ZNHIT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNHIT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNHIT1 33 34
  • 99.35 (n)
(Monodelphis domestica)
Mammalia ZNHIT1 34
  • 98 (a)
(Bos Taurus)
Mammalia ZNHIT1 33 34
  • 93.29 (n)
(Canis familiaris)
Mammalia ZNHIT1 33 34
  • 91.99 (n)
(Mus musculus)
Mammalia Znhit1 33 16 34
  • 88.66 (n)
(Rattus norvegicus)
Mammalia Znhit1 33
  • 87.53 (n)
(Ornithorhynchus anatinus)
Mammalia ZNHIT1 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znhit1 33
  • 75.38 (n)
Str.1370 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6977 33
(Danio rerio)
Actinopterygii znhit1 33 34
  • 72.51 (n)
Dr.16573 33
fruit fly
(Drosophila melanogaster)
Insecta CG31917 33 34
  • 57.76 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007853 33
  • 56.08 (n)
(Caenorhabditis elegans)
Secernentea zhit-1 33 34
  • 46.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
Species where no ortholog for ZNHIT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNHIT1 Gene

Gene Tree for ZNHIT1 (if available)
Gene Tree for ZNHIT1 (if available)

Paralogs for ZNHIT1 Gene Pseudogenes for ZNHIT1 Gene

genes like me logo Genes that share paralogs with ZNHIT1: view

No data available for Paralogs for ZNHIT1 Gene

Variants for ZNHIT1 Gene

Sequence variations from dbSNP and Humsavar for ZNHIT1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs369664812 A colorectal cancer sample 101,223,799(+) C/T coding_sequence_variant, missense_variant
rs138623639 likely-benign, not specified 101,216,767(+) A/G upstream_transcript_variant
rs368123704 likely-benign, not specified 101,216,029(+) G/A upstream_transcript_variant
rs112321807 benign, not specified 101,216,773(+) C/T upstream_transcript_variant
rs184771174 benign, not specified 101,216,939(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNHIT1 Gene

Variant ID Type Subtype PubMed ID
nsv831076 CNV loss 17160897
nsv831075 CNV loss 17160897
nsv607978 CNV loss 21841781
nsv607974 CNV loss 21841781
nsv607973 CNV loss 21841781
nsv1030604 CNV gain 25217958
nsv1018841 CNV gain 25217958
esv3614321 CNV gain 21293372
esv3614319 CNV gain 21293372
esv3614318 CNV loss 21293372
esv2752134 CNV gain 17911159
esv2734888 CNV deletion 23290073
esv2422376 CNV duplication 17116639
esv2422326 CNV duplication 17116639
dgv11534n54 CNV loss 21841781

Variation tolerance for ZNHIT1 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNHIT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNHIT1 Gene

Disorders for ZNHIT1 Gene

Additional Disease Information for ZNHIT1

No disorders were found for ZNHIT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNHIT1 Gene

Publications for ZNHIT1 Gene

  1. A zinc finger HIT domain-containing protein, ZNHIT-1, interacts with orphan nuclear hormone receptor Rev-erbbeta and removes Rev-erbbeta-induced inhibition of apoCIII transcription. (PMID: 17892483) Wang J … Lu H (The FEBS journal 2007) 3 4 58
  2. A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis. (PMID: 17380123) Cuadrado A … Nebreda AR (The EMBO journal 2007) 3 4 58
  3. The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. (PMID: 15647280) Cai Y … Conaway JW (The Journal of biological chemistry 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for ZNHIT1 Gene

Sources for ZNHIT1 Gene

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