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ZNFX1 (Zinc Finger NFX1-Type Containing 1) is a Protein Coding gene. Diseases associated with ZNFX1 include Parotid Gland Cancer and Parotid Disease. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is AQR.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0003700 | DNA-binding transcription factor activity | IEA | -- |
GO:0003723 | RNA binding | IBA | 21873635 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000775 | chromosome, centromeric region | IEA | -- |
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0031380 | nuclear RNA-directed RNA polymerase complex | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0030702 | chromatin silencing at centromere | IBA | -- |
GO:0031048 | chromatin silencing by small RNA | IBA | 21873635 |
GO:0031508 | pericentric heterochromatin assembly | IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZNFX1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZNFX1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ZNFX1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Znfx1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Znfx1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ZNFX1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | ZNFX1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100486840 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100536767 30 |
|
||
ZNFX1 31 |
|
OneToOne | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006235 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG6204 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | ZK1067.2 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SEN1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
712140 | Benign: not provided | 49,249,307(-) | C/T | SYNONYMOUS_VARIANT | |
715384 | Benign: not provided | 49,257,441(-) | C/T | SYNONYMOUS_VARIANT | |
721132 | Likely Benign: not provided | 49,270,631(-) | C/T | MISSENSE_VARIANT | |
739842 | Likely Benign: not provided | 49,249,019(-) | A/G | SYNONYMOUS_VARIANT | |
755686 | Likely Benign: not provided | 49,270,858(-) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1248e212 | CNV | loss | 25503493 |
esv1336829 | CNV | deletion | 17803354 |
esv3445061 | CNV | duplication | 20981092 |
nsv1064443 | CNV | gain | 25217958 |
nsv1067146 | CNV | loss | 25217958 |
nsv1072545 | CNV | deletion | 25765185 |
nsv437839 | CNV | loss | 16327808 |
nsv476410 | CNV | novel sequence insertion | 20440878 |
Disorder | Aliases | PubMed IDs |
---|---|---|
parotid gland cancer |
|
|
parotid disease |
|
|