Aliases for ZNFX1 Gene

Aliases for ZNFX1 Gene

  • Zinc Finger NFX1-Type Containing 1 2 3 5
  • NFX1-Type Zinc Finger-Containing Protein 1 3 4
  • Zinc Finger, NFX1-Type Containing 1 2
  • KIAA1404 4

External Ids for ZNFX1 Gene

Previous GeneCards Identifiers for ZNFX1 Gene

  • GC20M047287
  • GC20M047296
  • GC20M047854
  • GC20M044611

Summaries for ZNFX1 Gene

GeneCards Summary for ZNFX1 Gene

ZNFX1 (Zinc Finger NFX1-Type Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is SETX.

Additional gene information for ZNFX1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNFX1 Gene

Genomics for ZNFX1 Gene

GeneHancer (GH) Regulatory Elements for ZNFX1 Gene

Promoters and enhancers for ZNFX1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNFX1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNFX1

Top Transcription factor binding sites by QIAGEN in the ZNFX1 gene promoter:
  • AML1a
  • ATF6
  • Bach1
  • HFH-1
  • HOXA3
  • HTF
  • Ik-3
  • LCR-F1
  • Sp1

Genomic Locations for ZNFX1 Gene

Genomic Locations for ZNFX1 Gene
chr20:49,237,946-49,278,426
(GRCh38/hg38)
Size:
40,481 bases
Orientation:
Minus strand
chr20:47,854,483-47,894,963
(GRCh37/hg19)
Size:
40,481 bases
Orientation:
Minus strand

Genomic View for ZNFX1 Gene

Genes around ZNFX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNFX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNFX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNFX1 Gene

Proteins for ZNFX1 Gene

  • Protein details for ZNFX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2E3-ZNFX1_HUMAN
    Recommended name:
    NFX1-type zinc finger-containing protein 1
    Protein Accession:
    Q9P2E3
    Secondary Accessions:
    • Q9BQM7
    • Q9BQM8
    • Q9H8C1
    • Q9H9S2
    • Q9NUM1
    • Q9NWW1

    Protein attributes for ZNFX1 Gene

    Size:
    1918 amino acids
    Molecular mass:
    220227 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91264.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92642.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14149.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14696.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNFX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNFX1 Gene

Post-translational modifications for ZNFX1 Gene

  • Ubiquitination at Lys544
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNFX1 Gene

No data available for DME Specific Peptides for ZNFX1 Gene

Domains & Families for ZNFX1 Gene

Gene Families for ZNFX1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNFX1 Gene

Blocks:
  • TNFR/CD27/30/40/95 cysteine-rich region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNFX1 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger, NFX1-type containing 1, isoform CRA_b (E1P614_HUMAN)
  • ZNFX1 protein (Q2TAK0_HUMAN)
  • Zinc finger, NFX1-type containing 1 (Q5JXR5_HUMAN)
  • Zinc finger, NFX1-type containing 1 (Q5JXR6_HUMAN)
  • Zinc finger, NFX1-type containing 1 (Q5JXR7_HUMAN)
genes like me logo Genes that share domains with ZNFX1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNFX1 Gene

Function for ZNFX1 Gene

Phenotypes From GWAS Catalog for ZNFX1 Gene

Gene Ontology (GO) - Molecular Function for ZNFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0003723 RNA binding IBA 21873635
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNFX1: view
genes like me logo Genes that share phenotypes with ZNFX1: view

Animal Model Products

CRISPR Products

miRNA for ZNFX1 Gene

miRTarBase miRNAs that target ZNFX1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNFX1 Gene

Localization for ZNFX1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNFX1 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0031380 nuclear RNA-directed RNA polymerase complex IBA 21873635
genes like me logo Genes that share ontologies with ZNFX1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNFX1 Gene

Pathways & Interactions for ZNFX1 Gene

PathCards logo

SuperPathways for ZNFX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0030702 chromatin silencing at centromere IBA 21873635
GO:0031048 chromatin silencing by small RNA IBA 21873635
genes like me logo Genes that share ontologies with ZNFX1: view

No data available for Pathways by source and SIGNOR curated interactions for ZNFX1 Gene

Drugs & Compounds for ZNFX1 Gene

No Compound Related Data Available

Transcripts for ZNFX1 Gene

mRNA/cDNA for ZNFX1 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNFX1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7: - -

Relevant External Links for ZNFX1 Gene

GeneLoc Exon Structure for
ZNFX1

Expression for ZNFX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNFX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNFX1 Gene

This gene is overexpressed in Heart (18.3), Adrenal (13.7), and Plasma (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNFX1 Gene



Protein tissue co-expression partners for ZNFX1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNFX1

SOURCE GeneReport for Unigene cluster for ZNFX1 Gene:

Hs.371794

mRNA Expression by UniProt/SwissProt for ZNFX1 Gene:

Q9P2E3-ZNFX1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for ZNFX1 Gene

  • Nervous system(4.4)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with ZNFX1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNFX1 Gene

Orthologs for ZNFX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNFX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNFX1 31 30
  • 99.57 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNFX1 31 30
  • 89.93 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNFX1 31 30
  • 88.62 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Znfx1 30
  • 86.04 (n)
mouse
(Mus musculus)
Mammalia Znfx1 17 31 30
  • 85.98 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNFX1 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 77 (a)
OneToMany
-- 31
  • 54 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZNFX1 31 30
  • 67.95 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 61 (a)
OneToMany
-- 31
  • 55 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
-- 31
  • 43 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486840 30
  • 62.54 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100536767 30
  • 59.25 (n)
ZNFX1 31
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006235 30
  • 47.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6204 31 30
  • 45.61 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK1067.2 31
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEN1 31
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 52 (a)
OneToMany
-- 31
  • 49 (a)
OneToMany
-- 31
  • 42 (a)
OneToMany
Species where no ortholog for ZNFX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNFX1 Gene

ENSEMBL:
Gene Tree for ZNFX1 (if available)
TreeFam:
Gene Tree for ZNFX1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNFX1: view image

Paralogs for ZNFX1 Gene

Paralogs for ZNFX1 Gene

genes like me logo Genes that share paralogs with ZNFX1: view

Variants for ZNFX1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNFX1 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs2273148 - p.Thr910Ala
rs238209 - p.Thr1351Ile
rs238221 - p.Gln924His
rs2664578 - p.Leu864Val
rs36068952 - p.Gly1297Ser

Additional dbSNP identifiers (rs#s) for ZNFX1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNFX1 Gene

Variant ID Type Subtype PubMed ID
dgv1248e212 CNV loss 25503493
esv1336829 CNV deletion 17803354
esv3445061 CNV duplication 20981092
nsv1064443 CNV gain 25217958
nsv1067146 CNV loss 25217958
nsv1072545 CNV deletion 25765185
nsv437839 CNV loss 16327808
nsv476410 CNV novel sequence insertion 20440878

Variation tolerance for ZNFX1 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.49; 71.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNFX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNFX1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNFX1 Gene

Disorders for ZNFX1 Gene

Additional Disease Information for ZNFX1

No disorders were found for ZNFX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNFX1 Gene

Publications for ZNFX1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 54
  4. Circulating long noncoding RNA ZNFX1 antisense RNA negatively correlates with disease risk, severity, inflammatory markers, and predicts poor prognosis in sepsis patients. (PMID: 30817573) Xu Y … Shao B (Medicine 2019) 3 54
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54

Products for ZNFX1 Gene

Sources for ZNFX1 Gene