Aliases for ZNF99 Gene

Aliases for ZNF99 Gene

  • Zinc Finger Protein 99 2 3 4 5
  • C19orf9 3 4
  • Zinc Finger Protein ENSP00000375192 3
  • Chromosome 19 Open Reading Frame 9 2
  • Zinc Finger Protein 99 (F8281) 2
  • MGC24986 2
  • F8281 3
  • ZNF99 5

External Ids for ZNF99 Gene

Previous HGNC Symbols for ZNF99 Gene

  • C19orf9

Previous GeneCards Identifiers for ZNF99 Gene

  • GC19U990119
  • GC19M022730
  • GC19M022939
  • GC19M022478
  • GC19M022753
  • GC19M022864
  • GC19M022861
  • GC19M022852
  • GC19M023723
  • GC19M022755

Summaries for ZNF99 Gene

GeneCards Summary for ZNF99 Gene

ZNF99 (Zinc Finger Protein 99) is a Protein Coding gene. Diseases associated with ZNF99 include Adult Hepatocellular Carcinoma. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF729.

UniProtKB/Swiss-Prot Summary for ZNF99 Gene

Additional gene information for ZNF99 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF99 Gene

Genomics for ZNF99 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF99 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J022783 Promoter/Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 600.7 +0.1 50 1.4 GATA3 ZNF99 ZNF492 BNIP3P34 lnc-ZNF723-3
GH19J022633 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 0.1 +149.7 149650 2.6 GABPA PKNOX1 SP2 DDX20 SIN3A ZNF335 ZBTB40 POLR2A ZNF492 LINC01859 piR-31534-332 ZNF99 lnc-ZNF492-2 NONHSAG045689.2-002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF99 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF99

Top Transcription factor binding sites by QIAGEN in the ZNF99 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • NF-Y
  • NF-YA
  • NF-YB
  • PPAR-alpha
  • PPAR-gamma2
  • TBP

Genomic Locations for ZNF99 Gene

Genomic Locations for ZNF99 Gene
31,969 bases
Minus strand
27,903 bases
Minus strand

Genomic View for ZNF99 Gene

Genes around ZNF99 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF99 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF99 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF99 Gene

Proteins for ZNF99 Gene

  • Protein details for ZNF99 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 99
    Protein Accession:
    Secondary Accessions:
    • M0R335

    Protein attributes for ZNF99 Gene

    864 amino acids
    Molecular mass:
    100791 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF99 Gene

Post-translational modifications for ZNF99 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF99 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF99 Gene

Domains & Families for ZNF99 Gene

Gene Families for ZNF99 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF99 Gene

Suggested Antigen Peptide Sequences for ZNF99 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 99 (ZNF99_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF99: view

Function for ZNF99 Gene

Molecular function for ZNF99 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF99 Gene

Gene Ontology (GO) - Molecular Function for ZNF99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA,IEA --
GO:0003700 DNA-binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF99: view

Phenotypes for ZNF99 Gene

genes like me logo Genes that share phenotypes with ZNF99: view

Animal Model Products

CRISPR Products

miRNA for ZNF99 Gene

miRTarBase miRNAs that target ZNF99

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF99

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF99 Gene

Localization for ZNF99 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF99 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF99 gene
Compartment Confidence
nucleus 4
cytosol 1
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for ZNF99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
genes like me logo Genes that share ontologies with ZNF99: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF99 Gene

Pathways & Interactions for ZNF99 Gene

genes like me logo Genes that share pathways with ZNF99: view

Pathways by source for ZNF99 Gene

2 Reactome pathways for ZNF99 Gene
1 KEGG pathway for ZNF99 Gene

Gene Ontology (GO) - Biological Process for ZNF99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF99: view

No data available for SIGNOR curated interactions for ZNF99 Gene

Drugs & Compounds for ZNF99 Gene

No Compound Related Data Available

Transcripts for ZNF99 Gene

mRNA/cDNA for ZNF99 Gene

1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF99

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF99 Gene

No ASD Table

Relevant External Links for ZNF99 Gene

GeneLoc Exon Structure for

Expression for ZNF99 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF99 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF99 Gene

This gene is overexpressed in Testis (x21.6).

Protein differential expression in normal tissues from HIPED for ZNF99 Gene

This gene is overexpressed in Bone (46.6) and Plasma (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF99 Gene

Protein tissue co-expression partners for ZNF99 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF99

SOURCE GeneReport for Unigene cluster for ZNF99 Gene:

genes like me logo Genes that share expression patterns with ZNF99: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF99 Gene

Orthologs for ZNF99 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF99 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC101902880 30
  • 69.68 (n)
-- 31
  • 52 (a)
(Pan troglodytes)
Mammalia ZNF99 31
  • 66 (a)
(Canis familiaris)
Mammalia ZNF252 30
  • 57.39 (n)
-- 31
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 57 (a)
(Mus musculus)
Mammalia Zfp458 31
  • 57 (a)
Zfp457 31
  • 56 (a)
Zfp759 31
  • 54 (a)
Zfp738 31
  • 52 (a)
A530054K11Rik 31
  • 47 (a)
Zfp748 31
  • 44 (a)
AA987161 31
  • 43 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 55 (a)
Species where no ortholog for ZNF99 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF99 Gene

Gene Tree for ZNF99 (if available)
Gene Tree for ZNF99 (if available)
Evolutionary constrained regions (ECRs) for ZNF99: view image

Paralogs for ZNF99 Gene

(503) SIMAP similar genes for ZNF99 Gene using alignment to 2 proteins:

  • M0R335_HUMAN
genes like me logo Genes that share paralogs with ZNF99: view

Variants for ZNF99 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF99 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
768980 Benign: not provided 22,757,390(-) A/AG FRAMESHIFT_VARIANT
768981 Benign: not provided 22,758,025(-) T/C SYNONYMOUS_VARIANT
rs34726149 - p.Trp7Arg
rs7255780 - p.Ala129Gly

Additional dbSNP identifiers (rs#s) for ZNF99 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF99 Gene

Variant ID Type Subtype PubMed ID
dgv138e55 CNV gain 17911159
dgv140n111 CNV duplication 26073780
dgv3n43 CNV gain 19587683
dgv511e201 CNV deletion 23290073
dgv512e201 CNV deletion 23290073
dgv633e199 CNV deletion 23128226
esv1007183 CNV insertion 20482838
esv1611747 CNV insertion 17803354
esv1780124 CNV deletion 17803354
esv2126648 CNV deletion 18987734
esv2284083 CNV deletion 18987734
esv2662471 CNV deletion 23128226
esv2751784 CNV gain 17911159
esv2758750 CNV gain+loss 17122850
esv34340 CNV loss 17911159
esv3556194 CNV deletion 23714750
esv3556196 CNV deletion 23714750
esv3643967 CNV loss 21293372
esv3643968 CNV gain 21293372
esv3643969 CNV loss 21293372
esv3893182 CNV gain 25118596
esv4924 OTHER complex 18987735
esv990916 CNV deletion 20482838
nsv1146618 CNV deletion 26484159
nsv436853 CNV insertion 17901297
nsv507892 OTHER sequence alteration 20534489
nsv509729 CNV insertion 20534489
nsv510881 OTHER complex 20534489
nsv525240 CNV gain 19592680
nsv978795 CNV duplication 23825009

Variation tolerance for ZNF99 Gene

Residual Variation Intolerance Score: 98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.91; 83.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF99 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF99 Gene

Disorders for ZNF99 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF99 Gene - From: DISEASES

Disorder Aliases PubMed IDs
adult hepatocellular carcinoma
  • adult hepatoma
- elite association - COSMIC cancer census association via MalaCards
Search ZNF99 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZNF99

genes like me logo Genes that share disorders with ZNF99: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF99 Gene

Publications for ZNF99 Gene

  1. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid EJ … Szpirer C (The EMBO journal 1993) 3 4
  2. A Novel Interacting Protein SERP1 Regulates the N-Linked Glycosylation and Function of GLP-1 Receptor in the Liver. (PMID: 28597972) Xiao Y … Wei L (Journal of cellular biochemistry 2017) 3
  3. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4

Products for ZNF99 Gene

Sources for ZNF99 Gene