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Aliases for ZNF99 Gene

Aliases for ZNF99 Gene

  • Zinc Finger Protein 99 2 3 5
  • C19orf9 3 4
  • Zinc Finger Protein ENSP00000375192 3
  • Chromosome 19 Open Reading Frame 9 2
  • Zinc Finger Protein 99 (F8281) 2
  • F8281 3

External Ids for ZNF99 Gene

Previous HGNC Symbols for ZNF99 Gene

  • C19orf9

Previous GeneCards Identifiers for ZNF99 Gene

  • GC19U990119
  • GC19M022730
  • GC19M022939
  • GC19M022478

Summaries for ZNF99 Gene

GeneCards Summary for ZNF99 Gene

ZNF99 (Zinc Finger Protein 99) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF841.

UniProtKB/Swiss-Prot for ZNF99 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF99 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF99 Gene

Genomics for ZNF99 Gene

GeneHancer (GH) Regulatory Elements for ZNF99 Gene

Promoters and enhancers for ZNF99 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I022783 Promoter/Enhancer 0.8 EPDnew ENCODE 550.8 0.0 -9 1.2 GATA3 ZNF99 ZNF492 BNIP3P34 GC19P022800
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF99 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF99 gene promoter:

Genomic Locations for ZNF99 Gene

Genomic Locations for ZNF99 Gene
31,989 bases
Minus strand

Genomic View for ZNF99 Gene

Genes around ZNF99 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF99 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF99 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF99 Gene

Proteins for ZNF99 Gene

  • Protein details for ZNF99 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 99
    Protein Accession:
    Secondary Accessions:
    • M0R335

    Protein attributes for ZNF99 Gene

    864 amino acids
    Molecular mass:
    100791 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF99 Gene

Post-translational modifications for ZNF99 Gene

No Post-translational modifications

Other Protein References for ZNF99 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF99 Gene

Domains & Families for ZNF99 Gene

Gene Families for ZNF99 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF99 Gene

Suggested Antigen Peptide Sequences for ZNF99 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF99: view

Function for ZNF99 Gene

Molecular function for ZNF99 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF99: view

Phenotypes for ZNF99 Gene

GenomeRNAi human phenotypes for ZNF99:
genes like me logo Genes that share phenotypes with ZNF99: view

miRNA for ZNF99 Gene

miRTarBase miRNAs that target ZNF99

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF99 Gene

Localization for ZNF99 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF99 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF99 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZNF99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF99: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF99 Gene

Pathways & Interactions for ZNF99 Gene

SuperPathways for ZNF99 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF99: view

Pathways by source for ZNF99 Gene

2 Reactome pathways for ZNF99 Gene

Interacting Proteins for ZNF99 Gene

Gene Ontology (GO) - Biological Process for ZNF99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF99: view

No data available for SIGNOR curated interactions for ZNF99 Gene

Drugs & Compounds for ZNF99 Gene

No Compound Related Data Available

Transcripts for ZNF99 Gene

mRNA/cDNA for ZNF99 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF99 Gene

No ASD Table

Relevant External Links for ZNF99 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF99 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF99 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF99 Gene

This gene is overexpressed in Testis (x21.6).

Protein differential expression in normal tissues from HIPED for ZNF99 Gene

This gene is overexpressed in Bone (46.6) and Plasma (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF99 Gene

Protein tissue co-expression partners for ZNF99 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF99 Gene:


SOURCE GeneReport for Unigene cluster for ZNF99 Gene:

genes like me logo Genes that share expression patterns with ZNF99: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF99 Gene

Orthologs for ZNF99 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF99 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC101902880 33
  • 69.68 (n)
-- 34
  • 52 (a)
(Pan troglodytes)
Mammalia ZNF99 34
  • 66 (a)
(Canis familiaris)
Mammalia ZNF252 33
  • 57.39 (n)
-- 34
  • 50 (a)
(Mus musculus)
Mammalia Zfp458 34
  • 57 (a)
Zfp457 34
  • 56 (a)
Zfp759 34
  • 54 (a)
Zfp738 34
  • 52 (a)
A530054K11Rik 34
  • 47 (a)
Zfp748 34
  • 44 (a)
AA987161 34
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 55 (a)
Species where no ortholog for ZNF99 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF99 Gene

Gene Tree for ZNF99 (if available)
Gene Tree for ZNF99 (if available)

Paralogs for ZNF99 Gene

Paralogs for ZNF99 Gene

(503) SIMAP similar genes for ZNF99 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF99: view

Variants for ZNF99 Gene

Sequence variations from dbSNP and Humsavar for ZNF99 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000179427 -- 22,768,967(-) T/C intron_variant
rs1000201581 -- 22,754,905(-) A/G 3_prime_UTR_variant
rs1000286838 -- 22,774,888(-) A/C intron_variant
rs1000537393 -- 22,770,644(-) C/T intron_variant
rs1000630032 -- 22,761,694(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF99 Gene

Variant ID Type Subtype PubMed ID
nsv978795 CNV duplication 23825009
nsv525240 CNV gain 19592680
nsv510881 OTHER complex 20534489
nsv509729 CNV insertion 20534489
nsv507892 OTHER sequence alteration 20534489
nsv436853 CNV insertion 17901297
nsv1146618 CNV deletion 26484159
esv990916 CNV deletion 20482838
esv4924 OTHER complex 18987735
esv3893182 CNV gain 25118596
esv3643969 CNV loss 21293372
esv3643968 CNV gain 21293372
esv3643967 CNV loss 21293372
esv3556196 CNV deletion 23714750
esv3556194 CNV deletion 23714750
esv34340 CNV loss 17911159
esv2758750 CNV gain+loss 17122850
esv2751784 CNV gain 17911159
esv2662471 CNV deletion 23128226
esv2284083 CNV deletion 18987734
esv2126648 CNV deletion 18987734
esv1780124 CNV deletion 17803354
esv1611747 CNV insertion 17803354
esv1007183 CNV insertion 20482838
dgv633e199 CNV deletion 23128226
dgv512e201 CNV deletion 23290073
dgv511e201 CNV deletion 23290073
dgv3n43 CNV gain 19587683
dgv140n111 CNV duplication 26073780
dgv138e55 CNV gain 17911159

Variation tolerance for ZNF99 Gene

Residual Variation Intolerance Score: 98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.91; 83.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF99 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF99 Gene

Disorders for ZNF99 Gene

Additional Disease Information for ZNF99

No disorders were found for ZNF99 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF99 Gene

Publications for ZNF99 Gene

  1. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid EJ … Szpirer C (The EMBO journal 1993) 3 4 58
  2. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ZNF99 Gene

Sources for ZNF99 Gene

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