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Aliases for ZNF98 Gene

Aliases for ZNF98 Gene

  • Zinc Finger Protein 98 2 3 5
  • Zinc Finger Protein 739 2 3 4
  • Zinc Finger Protein F7175 3 4
  • ZNF739 3 4
  • F7175 3

External Ids for ZNF98 Gene

Previous GeneCards Identifiers for ZNF98 Gene

  • GC19U990118
  • GC19M022365
  • GC19M022573
  • GC19P022354

Summaries for ZNF98 Gene

GeneCards Summary for ZNF98 Gene

ZNF98 (Zinc Finger Protein 98) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF492.

UniProtKB/Swiss-Prot for ZNF98 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF98 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF98 Gene

Genomics for ZNF98 Gene

GeneHancer (GH) Regulatory Elements for ZNF98 Gene

Promoters and enhancers for ZNF98 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I022422 Promoter 0.6 EPDnew 550.1 +110.1 110119 0.1 PKNOX1 ENSG00000269796 ZNF98 RPL34P34
GH19I022531 Enhancer 0.3 ENCODE 550.8 +0.0 31 1.6 SP2 LINC01233 ZNF98 LOC105376917 ENSG00000270317 LOC101929124
GH19I022286 Promoter 0.5 EPDnew 12.1 +246.1 246061 0.1 ZNF729 ZNF98 GC19P022293
GH19I022421 Enhancer 0.2 Ensembl 27.5 +110.5 110484 0.4 ENSG00000269796 ZNF98 RPL34P34
GH19I022429 Enhancer 0.3 FANTOM5 8.5 +104.9 104882 0.3 ZNF208 ZNF98 ZNF257 ZNF492 ZNF676 GC19M022427 ENSG00000269796
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF98 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF98 gene promoter:

Genomic Locations for ZNF98 Gene

Genomic Locations for ZNF98 Gene
chr19:22,391,011-22,532,485
(GRCh38/hg38)
Size:
141,475 bases
Orientation:
Minus strand
chr19:22,573,821-22,715,287
(GRCh37/hg19)

Genomic View for ZNF98 Gene

Genes around ZNF98 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF98 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF98 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF98 Gene

Proteins for ZNF98 Gene

  • Protein details for ZNF98 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NK75-ZNF98_HUMAN
    Recommended name:
    Zinc finger protein 98
    Protein Accession:
    A6NK75

    Protein attributes for ZNF98 Gene

    Size:
    572 amino acids
    Molecular mass:
    65799 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI10577.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI29811.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF98 Gene

Post-translational modifications for ZNF98 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF98 Gene

No data available for DME Specific Peptides for ZNF98 Gene

Domains & Families for ZNF98 Gene

Gene Families for ZNF98 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transcription factors

Protein Domains for ZNF98 Gene

Suggested Antigen Peptide Sequences for ZNF98 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NK75

UniProtKB/Swiss-Prot:

ZNF98_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF98: view

Function for ZNF98 Gene

Molecular function for ZNF98 Gene

GENATLAS Biochemistry:
zinc finger protein 98,KRAB subfamily
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF98 Gene

Gene Ontology (GO) - Molecular Function for ZNF98 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF98: view

Phenotypes for ZNF98 Gene

genes like me logo Genes that share phenotypes with ZNF98: view

Animal Model Products

CRISPR Products

miRNA for ZNF98 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF98 Gene

Localization for ZNF98 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF98 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF98 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF98 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF98: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF98 Gene

Pathways & Interactions for ZNF98 Gene

SuperPathways for ZNF98 Gene

No Data Available

Interacting Proteins for ZNF98 Gene

Gene Ontology (GO) - Biological Process for ZNF98 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF98: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF98 Gene

Drugs & Compounds for ZNF98 Gene

No Compound Related Data Available

Transcripts for ZNF98 Gene

mRNA/cDNA for ZNF98 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF98 Gene

Zinc finger protein 98:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF98 Gene

No ASD Table

Relevant External Links for ZNF98 Gene

GeneLoc Exon Structure for
ZNF98
ECgene alternative splicing isoforms for
ZNF98

Expression for ZNF98 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF98 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF98 Gene

This gene is overexpressed in Pancreas (x10.0), Testis (x5.8), and Brain - Caudate (basal ganglia) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of ZNF98 Gene:

ZNF98

SOURCE GeneReport for Unigene cluster for ZNF98 Gene:

Hs.667355
genes like me logo Genes that share expression patterns with ZNF98: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF98 Gene

Orthologs for ZNF98 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF98 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 97 (a)
OneToMany
LOC100611724 33
  • 95.5 (n)
mouse
(Mus musculus)
Mammalia Zfp71-rs1 34
  • 59 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 57 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
Species where no ortholog for ZNF98 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF98 Gene

ENSEMBL:
Gene Tree for ZNF98 (if available)
TreeFam:
Gene Tree for ZNF98 (if available)

Paralogs for ZNF98 Gene

(518) SIMAP similar genes for ZNF98 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ZNF98 Gene

genes like me logo Genes that share paralogs with ZNF98: view

Variants for ZNF98 Gene

Sequence variations from dbSNP and Humsavar for ZNF98 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000141332 -- 22,390,777(-) C/A downstream_transcript_variant
rs1000201478 -- 22,390,580(-) AAAAAAAAA/AAAAAAAA downstream_transcript_variant
rs1000285273 -- 22,403,042(-) T/C intron_variant
rs1000311900 -- 22,396,648(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000443447 -- 22,402,649(-) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF98 Gene

Variant ID Type Subtype PubMed ID
dgv140n111 CNV duplication 26073780
dgv3476n100 CNV gain 25217958
dgv3477n100 CNV gain 25217958
dgv3n43 CNV gain 19587683
dgv511e201 CNV deletion 23290073
dgv512e201 CNV deletion 23290073
dgv633e199 CNV deletion 23128226
esv1314456 CNV deletion 17803354
esv2718335 CNV deletion 23290073
esv2751784 CNV gain 17911159
esv2758750 CNV gain+loss 17122850
esv34340 CNV loss 17911159
esv3643950 CNV loss 21293372
esv3893182 CNV gain 25118596
esv4924 OTHER complex 18987735
nsv1061327 CNV gain 25217958
nsv1078307 OTHER inversion 25765185
nsv1120056 OTHER inversion 24896259
nsv436853 CNV insertion 17901297
nsv525240 CNV gain 19592680
nsv978792 CNV duplication 23825009

Variation tolerance for ZNF98 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF98 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF98

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF98 Gene

Disorders for ZNF98 Gene

Additional Disease Information for ZNF98

No disorders were found for ZNF98 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF98 Gene

Publications for ZNF98 Gene

  1. Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. (PMID: 22331829) Chasman DI … Ridker PM (Circulation. Cardiovascular genetics 2012) 3 44 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid EJ … Szpirer C (The EMBO journal 1993) 3 4 58
  5. GWAS of dental caries patterns in the permanent dentition. (PMID: 23064961) Shaffer JR … Marazita ML (Journal of dental research 2013) 3 58

Products for ZNF98 Gene

Sources for ZNF98 Gene

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