Aliases for ZNF93 Gene

Aliases for ZNF93 Gene

  • Zinc Finger Protein 93 2 3 4 5
  • Zinc Finger Protein 505 2 3 4
  • Zinc Finger Protein HTF34 3 4
  • ZNF505 3 4
  • HPF34 2 3
  • TF34 2 3
  • Zinc Finger Protein 93 (HTF34) 2
  • FLJ12488 2
  • HTF34 3
  • ZNF93 5

External Ids for ZNF93 Gene

Previous HGNC Symbols for ZNF93 Gene

  • ZNF505

Previous GeneCards Identifiers for ZNF93 Gene

  • GC19U990113
  • GC19M020417
  • GC19P019871
  • GC19P019887
  • GC19P019805
  • GC19P019873
  • GC19P019979
  • GC19P020012
  • GC19P019901
  • GC19P020516
  • GC19P020658
  • GC19P020829
  • GC19P022270
  • GC19P019908
  • GC19P020086
  • GC19P020092
  • GC19P020376

Summaries for ZNF93 Gene

GeneCards Summary for ZNF93 Gene

ZNF93 (Zinc Finger Protein 93) is a Protein Coding gene. Diseases associated with ZNF93 include Pyruvate Dehydrogenase E1-Alpha Deficiency. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot Summary for ZNF93 Gene

  • Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).

Additional gene information for ZNF93 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF93 Gene

Genomics for ZNF93 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF93 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF93 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF93

Top Transcription factor binding sites by QIAGEN in the ZNF93 gene promoter:
  • Evi-1
  • LCR-F1
  • XBP-1

Genomic Locations for ZNF93 Gene

Genomic Locations for ZNF93 Gene
chr19:19,900,913-19,963,464
(GRCh38/hg38)
Size:
62,552 bases
Orientation:
Plus strand
chr19:20,011,722-20,046,384
(GRCh37/hg19)
Size:
34,663 bases
Orientation:
Plus strand

Genomic View for ZNF93 Gene

Genes around ZNF93 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF93 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF93 Gene

Proteins for ZNF93 Gene

  • Protein details for ZNF93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35789-ZNF93_HUMAN
    Recommended name:
    Zinc finger protein 93
    Protein Accession:
    P35789
    Secondary Accessions:
    • A6NMY2
    • B9EGT2
    • Q8N8Q4
    • Q9H9X5
    • Q9Y2N8

    Protein attributes for ZNF93 Gene

    Size:
    620 amino acids
    Molecular mass:
    70971 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD22981.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB14093.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • ZNF93 is only present in primates and evolved to repress the primate L1 lineage until 12.5 million years. Evolution stopped when the L1PA3-subfamily of retrotransposons, that escape repression by ZNF93 through the removal of the ZNF93-binding site, appeared (PubMed:25274305).
    • Confers resistance to ET-743 (trabectedin, Yondelis) and PM00104 (Zalypsis), 2 marine derived compounds with antitumor activity in cancer cell lines.

    Alternative splice isoforms for ZNF93 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF93 Gene

Post-translational modifications for ZNF93 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF93 Gene

No data available for DME Specific Peptides for ZNF93 Gene

Domains & Families for ZNF93 Gene

Gene Families for ZNF93 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF93 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF93 Gene

GenScript: Design optimal peptide antigens:
  • ZNF93 protein (Q6NS90_HUMAN)
  • Zinc finger protein HTF34 (ZNF93_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35789

UniProtKB/Swiss-Prot:

ZNF93_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF93: view

Function for ZNF93 Gene

Molecular function for ZNF93 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).
GENATLAS Biochemistry:
zinc finger protein 93 (HTF34),KRAB subfamily

Phenotypes From GWAS Catalog for ZNF93 Gene

Gene Ontology (GO) - Molecular Function for ZNF93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS 2023909
GO:0008270 zinc ion binding NAS 2023909
genes like me logo Genes that share ontologies with ZNF93: view
genes like me logo Genes that share phenotypes with ZNF93: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF93

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF93 Gene

Localization for ZNF93 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF93 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF93 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ZNF93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF93: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF93 Gene

Pathways & Interactions for ZNF93 Gene

PathCards logo

SuperPathways for ZNF93 Gene

genes like me logo Genes that share pathways with ZNF93: view

Pathways by source for ZNF93 Gene

1 KEGG pathway for ZNF93 Gene

Gene Ontology (GO) - Biological Process for ZNF93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 25274305
GO:0070895 negative regulation of transposon integration IDA 25274305
genes like me logo Genes that share ontologies with ZNF93: view

No data available for SIGNOR curated interactions for ZNF93 Gene

Drugs & Compounds for ZNF93 Gene

No Compound Related Data Available

Transcripts for ZNF93 Gene

mRNA/cDNA for ZNF93 Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF93

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF93 Gene

No ASD Table

Relevant External Links for ZNF93 Gene

GeneLoc Exon Structure for
ZNF93

Expression for ZNF93 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF93 Gene

Protein differential expression in normal tissues from HIPED for ZNF93 Gene

This gene is overexpressed in Liver (42.0) and Lymph node (27.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF93 Gene



Protein tissue co-expression partners for ZNF93 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF93

SOURCE GeneReport for Unigene cluster for ZNF93 Gene:

Hs.301059

Evidence on tissue expression from TISSUES for ZNF93 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF93: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF93 Gene

Orthologs for ZNF93 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF93 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF93 30
  • 95.86 (n)
Mouse
(Mus musculus)
Mammalia Zfp457 30 17
  • 65.73 (n)
Zfp386 31
  • 37 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 57 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 52 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 40 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 55 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
Species where no ortholog for ZNF93 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF93 Gene

ENSEMBL:
Gene Tree for ZNF93 (if available)
TreeFam:
Gene Tree for ZNF93 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF93: view image

Paralogs for ZNF93 Gene

Paralogs for ZNF93 Gene

(526) SIMAP similar genes for ZNF93 Gene using alignment to 6 proteins:

  • ZNF93_HUMAN
  • K7EPG7_HUMAN
  • K7EPV7_HUMAN
  • K7EQ36_HUMAN
  • K7ES58_HUMAN
  • Q6NS90_HUMAN
genes like me logo Genes that share paralogs with ZNF93: view

Variants for ZNF93 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF93 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
710763 Benign: not provided 19,933,609(+) A/T SYNONYMOUS_VARIANT
710764 Benign: not provided 19,934,460(+) T/A MISSENSE_VARIANT
717087 Benign: not provided 19,934,801(+) AC/A FRAMESHIFT_VARIANT
rs12151060 - p.Asp93Tyr

Additional dbSNP identifiers (rs#s) for ZNF93 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF93 Gene

Variant ID Type Subtype PubMed ID
dgv3456n100 CNV gain 25217958
dgv509e201 CNV deletion 23290073
esv2656893 CNV deletion 23128226
esv2718296 CNV deletion 23290073
esv2718298 CNV deletion 23290073
esv2718300 CNV deletion 23290073
esv2718301 CNV deletion 23290073
esv3556152 CNV deletion 23714750
esv3643861 CNV gain 21293372
esv3893169 CNV loss 25118596
nsv1061846 CNV loss 25217958
nsv458376 CNV gain 19166990
nsv519535 CNV gain 19592680
nsv578800 CNV gain 21841781
nsv961192 CNV duplication 23825009

Variation tolerance for ZNF93 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.86; 83.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF93 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF93

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF93 Gene

Disorders for ZNF93 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF93 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pyruvate dehydrogenase e1-alpha deficiency
  • pdhad
- elite association - COSMIC cancer census association via MalaCards
Search ZNF93 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZNF93

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZNF93: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF93 Gene

Publications for ZNF93 Gene

  1. The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid EJ … Martial JA (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4
  2. An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons. (PMID: 25274305) Jacobs FM … Haussler D (Nature 2014) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines. (PMID: 19742314) Duan Z … Hornicek FJ (PloS one 2009) 3 4
  5. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PMID: 19247474) Caporaso N … Bergen AW (PloS one 2009) 3 41

Products for ZNF93 Gene

Sources for ZNF93 Gene