Aliases for ZNF93 Gene
External Ids for ZNF93 Gene
Previous HGNC Symbols for ZNF93 Gene
Previous GeneCards Identifiers for ZNF93 Gene
GeneCards Summary for ZNF93 Gene
ZNF93 (Zinc Finger Protein 93) is a Protein Coding gene. Diseases associated with ZNF93 include Pyruvate Dehydrogenase E1-Alpha Deficiency. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF85.
UniProtKB/Swiss-Prot Summary for ZNF93 Gene
Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).