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Aliases for ZNF92 Gene

Aliases for ZNF92 Gene

  • Zinc Finger Protein 92 2 3 5
  • Zinc Finger Protein HTF12 3 4
  • Zinc Finger Protein 92 (HTF12) 2
  • Epididymis Luminal Protein 203 3
  • HEL-203 3
  • HPF12 3
  • HTF12 3
  • TF12 3

External Ids for ZNF92 Gene

Previous GeneCards Identifiers for ZNF92 Gene

  • GC19U990112
  • GC07P064236
  • GC07P064250
  • GC07P064282
  • GC07P064476
  • GC07P064838
  • GC07P061127

Summaries for ZNF92 Gene

GeneCards Summary for ZNF92 Gene

ZNF92 (Zinc Finger Protein 92) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot for ZNF92 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF92 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF92 Gene

Genomics for ZNF92 Gene

GeneHancer (GH) Regulatory Elements for ZNF92 Gene

Promoters and enhancers for ZNF92 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I065373 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 456 2.1 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 FOS SP3 ZNF92 GTF2IP14 GUSB CCT6P1 ZNF107 CCT6P3 ERV3-1 ENSG00000238124
GH07I065385 Promoter 0.5 EPDnew 550.4 +11.6 11623 0.1 ZNF92 ENSG00000238124
GH07I065397 Enhancer 0.8 ENCODE 12.1 +24.2 24205 0.9 ELF3 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 RAD21 ZSCAN9 RFX5 ZNF92 ENSG00000238124
GH07I066204 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4 +831.8 831827 2.2 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS SP3 SP5 TPST1 LOC100996437 ZNF92 PIR59576
GH07I066351 Enhancer 1 Ensembl ENCODE dbSUPER 7.3 +981.2 981161 6.1 CTCF FOXA2 FOXA3 MAX CEBPB ZNF384 CEBPG RAD21 TEAD3 ATF4 PIR34160 LOC100996437 VKORC1L1 GS1-124K5.4 RABGEF1 ZNF92 GC07P066346 RNU6-313P TPST1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF92 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF92 gene promoter:

Genomic Locations for ZNF92 Gene

Genomic Locations for ZNF92 Gene
chr7:65,373,799-65,401,135
(GRCh38/hg38)
Size:
27,337 bases
Orientation:
Plus strand
chr7:64,838,712-64,866,038
(GRCh37/hg19)

Genomic View for ZNF92 Gene

Genes around ZNF92 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF92 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF92 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF92 Gene

Proteins for ZNF92 Gene

  • Protein details for ZNF92 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03936-ZNF92_HUMAN
    Recommended name:
    Zinc finger protein 92
    Protein Accession:
    Q03936
    Secondary Accessions:
    • A6NNF9
    • Q8N492
    • Q8NB35

    Protein attributes for ZNF92 Gene

    Size:
    586 amino acids
    Molecular mass:
    68487 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF92 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF92 Gene

Post-translational modifications for ZNF92 Gene

No Post-translational modifications

Other Protein References for ZNF92 Gene

No data available for DME Specific Peptides for ZNF92 Gene

Domains & Families for ZNF92 Gene

Gene Families for ZNF92 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF92 Gene

Suggested Antigen Peptide Sequences for ZNF92 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q03936

UniProtKB/Swiss-Prot:

ZNF92_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF92: view

Function for ZNF92 Gene

Molecular function for ZNF92 Gene

GENATLAS Biochemistry:
zinc finger protein 92 (HTF12),KRAB subfamily
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS 2023909
GO:0008270 zinc ion binding NAS 2023909
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF92: view
genes like me logo Genes that share phenotypes with ZNF92: view

Animal Model Products

CRISPR Products

miRNA for ZNF92 Gene

miRTarBase miRNAs that target ZNF92

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF92 Gene

Localization for ZNF92 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF92 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF92 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF92: view

Pathways & Interactions for ZNF92 Gene

SuperPathways for ZNF92 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF92: view

Pathways by source for ZNF92 Gene

2 Reactome pathways for ZNF92 Gene

Gene Ontology (GO) - Biological Process for ZNF92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF92: view

No data available for SIGNOR curated interactions for ZNF92 Gene

Drugs & Compounds for ZNF92 Gene

No Compound Related Data Available

Transcripts for ZNF92 Gene

Unigene Clusters for ZNF92 Gene

Zinc finger protein 92:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF92 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for ZNF92 Gene

GeneLoc Exon Structure for
ZNF92
ECgene alternative splicing isoforms for
ZNF92

Expression for ZNF92 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF92 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF92 Gene:

ZNF92

SOURCE GeneReport for Unigene cluster for ZNF92 Gene:

Hs.9521

Evidence on tissue expression from TISSUES for ZNF92 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF92: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF92 Gene

Orthologs for ZNF92 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF92 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF92 33 34
  • 99.6 (n)
mouse
(Mus musculus)
Mammalia Zfp493 34
  • 61 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 56 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
Species where no ortholog for ZNF92 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF92 Gene

ENSEMBL:
Gene Tree for ZNF92 (if available)
TreeFam:
Gene Tree for ZNF92 (if available)

Paralogs for ZNF92 Gene

(525) SIMAP similar genes for ZNF92 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF92 Gene

genes like me logo Genes that share paralogs with ZNF92: view

Variants for ZNF92 Gene

Sequence variations from dbSNP and Humsavar for ZNF92 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000028222 -- 65,379,380(+) T/C intron_variant
rs1000106137 -- 65,377,994(+) G/C intron_variant
rs1000115516 -- 65,394,599(+) T/G intron_variant
rs1000160015 -- 65,384,625(+) C/T intron_variant
rs1000301266 -- 65,387,393(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF92 Gene

Variant ID Type Subtype PubMed ID
nsv435849 CNV deletion 17901297
nsv464530 CNV loss 19166990
nsv464534 CNV loss 19166990
nsv1161551 CNV deletion 26073780
nsv1143347 CNV deletion 24896259
nsv1029796 CNV gain 25217958
nsv1020004 CNV gain 25217958
esv3891133 CNV gain+loss 25118596
esv3613459 CNV gain 21293372
esv3613458 CNV loss 21293372
esv3613457 CNV gain 21293372
esv3613456 CNV loss 21293372
esv3613439 CNV loss 21293372
esv33731 CNV gain+loss 17666407
esv3101086 CNV deletion 24192839
esv2764020 CNV gain+loss 21179565
esv2761084 CNV loss 21179565
esv2759534 CNV gain+loss 17122850
dgv819n27 CNV gain 19166990
dgv818n27 CNV loss 19166990
dgv6442n100 CNV loss 25217958
dgv6441n100 CNV gain+loss 25217958
dgv6440n100 CNV gain 25217958
dgv6439n100 CNV loss 25217958
dgv6438n100 CNV gain 25217958
dgv6437n100 CNV gain+loss 25217958
dgv6436n100 CNV gain 25217958
dgv6435n100 CNV loss 25217958
dgv439e215 CNV deletion 23714750
dgv229e55 CNV loss 17911159
dgv228e55 CNV gain 17911159
dgv227e55 CNV loss 17911159
dgv226e55 CNV loss 17911159
dgv1917e212 CNV gain 25503493
dgv1916e212 CNV loss 25503493
dgv1213e199 CNV deletion 23128226
dgv11n29 CNV loss 16826518
dgv11428n54 CNV loss 21841781
dgv11419n54 CNV loss 21841781
dgv11418n54 CNV loss 21841781
dgv11417n54 CNV loss 21841781
dgv11416n54 CNV loss 21841781
dgv1099e201 CNV deletion 23290073
nsv981501 CNV duplication 23825009
nsv831016 CNV loss 17160897
nsv7400 OTHER inversion 18451855
nsv607390 CNV gain 21841781
nsv607389 CNV loss 21841781
nsv607388 CNV gain 21841781
nsv607387 CNV gain+loss 21841781
nsv607340 CNV gain 21841781
nsv607318 CNV gain+loss 21841781
nsv607316 CNV loss 21841781
nsv517778 CNV gain+loss 19592680
nsv470277 CNV loss 18288195
nsv470266 CNV gain 18288195

Variation tolerance for ZNF92 Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.71; 83.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF92 Gene

Human Gene Mutation Database (HGMD)
ZNF92
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF92

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF92 Gene

Disorders for ZNF92 Gene

Additional Disease Information for ZNF92

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF92 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF92 Gene

Publications for ZNF92 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid EJ … Szpirer C (The EMBO journal 1993) 2 3 58

Products for ZNF92 Gene

Sources for ZNF92 Gene

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