Aliases for ZNF92 Gene

Aliases for ZNF92 Gene

  • Zinc Finger Protein 92 2 3 4 5
  • Zinc Finger Protein HTF12 3 4
  • HPF12 2 3
  • TF12 2 3
  • Zinc Finger Protein 92 (HTF12) 2
  • Epididymis Luminal Protein 203 3
  • HEL-203 3
  • HTF12 3
  • ZNF92 5

External Ids for ZNF92 Gene

Previous GeneCards Identifiers for ZNF92 Gene

  • GC19U990112
  • GC07P064236
  • GC07P064250
  • GC07P064282
  • GC07P064476
  • GC07P064838
  • GC07P061127

Summaries for ZNF92 Gene

GeneCards Summary for ZNF92 Gene

ZNF92 (Zinc Finger Protein 92) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF98.

UniProtKB/Swiss-Prot Summary for ZNF92 Gene

Additional gene information for ZNF92 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF92 Gene

Genomics for ZNF92 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF92 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF92 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF92

Top Transcription factor binding sites by QIAGEN in the ZNF92 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • Ik-2
  • IRF-7A
  • NF-Y
  • NF-YA
  • NF-YB
  • STAT5B

Genomic Locations for ZNF92 Gene

Genomic Locations for ZNF92 Gene
chr7:65,373,799-65,401,136
(GRCh38/hg38)
Size:
27,338 bases
Orientation:
Plus strand
chr7:64,838,712-64,866,038
(GRCh37/hg19)
Size:
27,327 bases
Orientation:
Plus strand

Genomic View for ZNF92 Gene

Genes around ZNF92 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF92 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF92 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF92 Gene

Proteins for ZNF92 Gene

  • Protein details for ZNF92 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03936-ZNF92_HUMAN
    Recommended name:
    Zinc finger protein 92
    Protein Accession:
    Q03936
    Secondary Accessions:
    • A6NNF9
    • Q8N492
    • Q8NB35

    Protein attributes for ZNF92 Gene

    Size:
    586 amino acids
    Molecular mass:
    68487 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF92 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF92 Gene

Post-translational modifications for ZNF92 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF92 Gene

No data available for DME Specific Peptides for ZNF92 Gene

Domains & Families for ZNF92 Gene

Gene Families for ZNF92 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF92 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF92 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein HTF12 (ZNF92_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q03936

UniProtKB/Swiss-Prot:

ZNF92_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF92: view

Function for ZNF92 Gene

Molecular function for ZNF92 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 92 (HTF12),KRAB subfamily

Phenotypes From GWAS Catalog for ZNF92 Gene

Gene Ontology (GO) - Molecular Function for ZNF92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS 2023909
GO:0008270 zinc ion binding NAS 2023909
genes like me logo Genes that share ontologies with ZNF92: view
genes like me logo Genes that share phenotypes with ZNF92: view

Animal Model Products

CRISPR Products

miRNA for ZNF92 Gene

miRTarBase miRNAs that target ZNF92

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF92

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF92 Gene

Localization for ZNF92 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF92 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF92 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF92: view

Pathways & Interactions for ZNF92 Gene

PathCards logo

SuperPathways for ZNF92 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF92: view

Pathways by source for ZNF92 Gene

2 Reactome pathways for ZNF92 Gene

Gene Ontology (GO) - Biological Process for ZNF92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF92: view

No data available for SIGNOR curated interactions for ZNF92 Gene

Drugs & Compounds for ZNF92 Gene

No Compound Related Data Available

Transcripts for ZNF92 Gene

mRNA/cDNA for ZNF92 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF92

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF92 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for ZNF92 Gene

GeneLoc Exon Structure for
ZNF92

Expression for ZNF92 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF92 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF92

SOURCE GeneReport for Unigene cluster for ZNF92 Gene:

Hs.9521

Evidence on tissue expression from TISSUES for ZNF92 Gene

  • Nervous system(4.5)
  • Kidney(2)
genes like me logo Genes that share expression patterns with ZNF92: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF92 Gene

Orthologs for ZNF92 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF92 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF92 30 31
  • 99.6 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp493 31
  • 61 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 56 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 51 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 40 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 52 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
Species where no ortholog for ZNF92 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF92 Gene

ENSEMBL:
Gene Tree for ZNF92 (if available)
TreeFam:
Gene Tree for ZNF92 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF92: view image

Paralogs for ZNF92 Gene

(525) SIMAP similar genes for ZNF92 Gene using alignment to 2 proteins:

  • ZNF92_HUMAN
  • C9IZS8_HUMAN

Pseudogenes.org Pseudogenes for ZNF92 Gene

genes like me logo Genes that share paralogs with ZNF92: view

Variants for ZNF92 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF92 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs10239197 - p.Arg527His
rs10265083 - p.Ala122Val
rs17853615 - p.Gln492Arg

Additional dbSNP identifiers (rs#s) for ZNF92 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF92 Gene

Variant ID Type Subtype PubMed ID
dgv1099e201 CNV deletion 23290073
dgv11416n54 CNV loss 21841781
dgv11417n54 CNV loss 21841781
dgv11418n54 CNV loss 21841781
dgv11419n54 CNV loss 21841781
dgv11428n54 CNV loss 21841781
dgv11n29 CNV loss 16826518
dgv1213e199 CNV deletion 23128226
dgv1916e212 CNV loss 25503493
dgv1917e212 CNV gain 25503493
dgv226e55 CNV loss 17911159
dgv227e55 CNV loss 17911159
dgv228e55 CNV gain 17911159
dgv229e55 CNV loss 17911159
dgv439e215 CNV deletion 23714750
dgv6435n100 CNV loss 25217958
dgv6436n100 CNV gain 25217958
dgv6437n100 CNV gain+loss 25217958
dgv6438n100 CNV gain 25217958
dgv6439n100 CNV loss 25217958
dgv6440n100 CNV gain 25217958
dgv6441n100 CNV gain+loss 25217958
dgv6442n100 CNV loss 25217958
dgv818n27 CNV loss 19166990
dgv819n27 CNV gain 19166990
esv2759534 CNV gain+loss 17122850
esv2761084 CNV loss 21179565
esv2764020 CNV gain+loss 21179565
esv3101086 CNV deletion 24192839
esv33731 CNV gain+loss 17666407
esv3613439 CNV loss 21293372
esv3613456 CNV loss 21293372
esv3613457 CNV gain 21293372
esv3613458 CNV loss 21293372
esv3613459 CNV gain 21293372
esv3891133 CNV gain+loss 25118596
nsv1020004 CNV gain 25217958
nsv1029796 CNV gain 25217958
nsv1143347 CNV deletion 24896259
nsv1161551 CNV deletion 26073780
nsv435849 CNV deletion 17901297
nsv464530 CNV loss 19166990
nsv464534 CNV loss 19166990
nsv470266 CNV gain 18288195
nsv470277 CNV loss 18288195
nsv517778 CNV gain+loss 19592680
nsv607316 CNV loss 21841781
nsv607318 CNV gain+loss 21841781
nsv607340 CNV gain 21841781
nsv607387 CNV gain+loss 21841781
nsv607388 CNV gain 21841781
nsv607389 CNV loss 21841781
nsv607390 CNV gain 21841781
nsv7400 OTHER inversion 18451855
nsv831016 CNV loss 17160897
nsv981501 CNV duplication 23825009

Variation tolerance for ZNF92 Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.71; 83.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF92 Gene

Human Gene Mutation Database (HGMD)
ZNF92
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF92

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF92 Gene

Disorders for ZNF92 Gene

Additional Disease Information for ZNF92

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZNF92 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF92 Gene

Publications for ZNF92 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid EJ … Szpirer C (The EMBO journal 1993) 2 3

Products for ZNF92 Gene

Sources for ZNF92 Gene